Aleksey Matveyenko, Ph.D.
Professor, Medicine
Research Interests
Dr. Matveyenko's current research is focused on the role of circadian clocks in pancreatic beta-cell function and survival with particular reemphasis on the link between circadian rhythms and metabolic syndrome. To accomplish these research goals the laboratory uses an integrative approach ranging from cellular and molecular level studies to translational in-vivo approaches.The work in Dr. Matveyenko's laboratory is funded by the National Institute of Diabetes and Digestive Disease and the Larry L. Hillblom Foundation.

Dr. Aleksey Matveyenko is a molecular physiologist who has served on the faculty at the University Of California Los Angeles Department Of Medicine since 2008. Dr. Matveyenko received his doctoral training at the University of Southern California where he studied physiological and molecular mechanisms of glycemic control in diabetes mellitus. Following completion of his Ph.D studies he undertook post-doctoral fellowship training at the Larry Hillblom Islet Research center at UCLA where his research focused on understanding the pathophysiology of Type 2 diabetes with specific emphasis on mechanisms regulating pancreatic beta-cell mass, turnover and function.


A selected list of publications:

Dhawan Sangeeta, Tschen Shuen-Ing, Zeng Chun, Guo Tingxia, Hebrok Matthias, Matveyenko Aleksey, Bhushan Anil   DNA methylation directs functional maturation of pancreatic β cells The Journal of clinical investigation, 2015; 125(7): 2851-60.
Costes Safia, Boss Marti, Thomas Anthony P, Matveyenko Aleksey V   Activation of Melatonin Signaling Promotes β-Cell Survival and Function Molecular endocrinology (Baltimore, Md.), 2015; 29(5): 682-92.
Shu Luan, Matveyenko Aleksey V, Kerr-Conte Julie, Cho Jae-Hyoung, McIntosh Christopher H S, Maedler Kathrin   Decreased TCF7L2 protein levels in type 2 diabetes mellitus correlate with downregulation of GIP- and GLP-1 receptors and impaired beta-cell function Human molecular genetics, 2015; 24(10): 3004.
Matveyenko Aleksey, Vella Adrian   Regenerative medicine in diabetes Mayo Clinic proceedings, 2015; 90(4): 546-54.
Bohland MaryAnn, Matveyenko Aleksey V, Saberi Maziyar, Khan Arshad M, Watts Alan G, Donovan Casey M   Activation of hindbrain neurons is mediated by portal-mesenteric vein glucosensors during slow-onset hypoglycemia Diabetes, 2014; 63(8): 2866-75.
Colwell Christopher S, Matveyenko Aleksey V   Timing is everything: implications for metabolic consequences of sleep restriction Diabetes, 2014; 63(6): 1826-8.
Rakshit Kuntol, Thomas Anthony P, Matveyenko Aleksey V   Does disruption of circadian rhythms contribute to beta-cell failure in type 2 diabetes? Current diabetes reports, 2014; 14(4): 474.
Qian Jingyi, Block Gene D, Colwell Christopher S, Matveyenko Aleksey V   Consequences of exposure to light at night on the pancreatic islet circadian clock and function in rats Diabetes, 2013; 62(10): 3469-78.
Beaven Simon W, Matveyenko Aleksey, Wroblewski Kevin, Chao Lily, Wilpitz Damien, Hsu Tu Wen, Lentz Jacob, Drew Brian, Hevener Andrea L, Tontonoz Peter   Reciprocal regulation of hepatic and adipose lipogenesis by liver X receptors in obesity and insulin resistance Cell metabolism, 2013; 18(1): 106-17.
Costes Safia, Langen Ralf, Gurlo Tatyana, Matveyenko Aleksey V, Butler Peter C   β-Cell failure in type 2 diabetes: a case of asking too much of too few? Diabetes, 2013; 62(2): 327-35.