Rachel R Ogorzalek Loo, Ph.D.
Researcher, Biological Chemistry
Research Interests
Her research interests include the development of bioanalytical mass spectrometry methods for the structural characterization of proteins and the elucidation of ionization mechanisms for mass spectrometry. She is also interested in developing the Virtual 2D Gel method, a matrix-assisted laser desorption/ionization (MALDI) MS-based surface scanning method in which proteins are desorbed directly from polyacrylamide gels for identifying and characterizing protein isoforms and for measuring protein expression profiles from complex biological samples.

She is an author of over 85 scientific publications and currently serves as secretary for the American Society of Mass Spectrometry. Rachel has been a member of various working committees with the Association of Biomedical Resource Facilities (ABRF), serves on the editorial board of the Journal of Biomolecular Techniques, and has been on the Features Editorial Board of Analytical Chemistry. Before joining UCLA, she was Director of Mass Spectrometry for the University of Michigan Protein and Carbohydrate Structure Facility, University of Michigan (Ann Arbor, MI), and later moved to Parke-Davis Pharmaceutical (Pfizer Global Research, Ann Arbor, MI) as a Research Associate.


A selected list of publications:

Loo Rachel R Ogorzalek, Loo Joseph A   Salt Bridge Rearrangement (SaBRe) Explains the Dissociation Behavior of Noncovalent Complexes Journal of the American Society for Mass Spectrometry, 2016; 27(6): 975-90.
Wongkongkathep Piriya, Li Huilin, Zhang Xing, Loo Rachel R Ogorzalek, Julian Ryan R, Loo Joseph A   Enhancing Protein Disulfide Bond Cleavage by UV Excitation and Electron Capture Dissociation for Top-Down Mass Spectrometry International journal of mass spectrometry, 2015; 390(6): 137-145.
Shen Sean, Loo Rachel R Ogorzalek, Wanner Ina-Beate, Loo Joseph A   Addressing the needs of traumatic brain injury with clinical proteomics Clinical proteomics, 2014; 11(1): 11.
Erde Jonathan, Loo Rachel R Ogorzalek, Loo Joseph A   Enhanced FASP (eFASP) to increase proteome coverage and sample recovery for quantitative proteomic experiments Journal of proteome research, 2014; 13(4): 1885-95.
Shen-Miller J, Lindner Petra, Xie Yongming, Villa Sarah, Wooding Kerry, Clarke Steven G, Loo Rachel R O, Loo Joseph A   Thermal-stable proteins of fruit of long-living Sacred Lotus Nelumbo nucifera Gaertn var. China Antique Tropical plant biology, 2013; 6(2-3): .
Chen Christine K, Benchaar Sabrina A, Phan Mai, Grintsevich Elena E, Loo Rachel R Ogorzalek, Loo Joseph A, Reisler Emil   Cofilin-induced changes in F-actin detected via cross-linking with benzophenone-4-maleimide Biochemistry, 2013; 52(32): 5503-9.
Loo Rachel R Ogorzalek, Loo Joseph A   Protein complexes: breaking up is hard to do well Structure (London, England : 1993), 2013; 21(8): 1265-6.
Zhang Lifeng, Pang Eric, Loo Rachel R Ogorzalek, Rao Jianyu, Go Vay-Liang W, Loo Joseph A, Lu Qing-Yi   Concomitant inhibition of HSP90, its mitochondrial localized homologue TRAP1 and HSP27 by green tea in pancreatic cancer HPAF-II cells Proteomics, 2011; 11(24): 4638-47.
Lomeli Shirley H, Peng Ivory X, Yin Sheng, Loo Rachel R Ogorzalek, Loo Joseph A   New reagents for increasing ESI multiple charging of proteins and protein complexes Journal of the American Society for Mass Spectrometry, 2010; 21(1): 127-31.
Gonzalez Oscar, Fontanes Vanessa, Raychaudhuri Santanu, Loo Rachel, Loo Joseph, Arumugaswami Vaithilingaraja, Sun Ren, Dasgupta Asim, French Samuel W   The heat shock protein inhibitor Quercetin attenuates hepatitis C virus production Hepatology (Baltimore, Md.), 2009; 50(6): 1756-64.
Tao Lei, Kaddis Catherine S, Loo Rachel R Ogorzalek, Grover Gregory N, Loo Joseph A, Maynard Heather D   Synthesis of Maleimide-End Functionalized Star Polymers and Multimeric Protein-Polymer Conjugates Macromolecules, 2009; 42(21): 8028-8033.
Tienson Heather L, Dabir Deepa V, Neal Sonya E, Loo Rachel, Hasson Samuel A, Boontheung Pinmanee, Kim Sung-Kun, Loo Joseph A, Koehler Carla M   Reconstitution of the mia40-erv1 oxidative folding pathway for the small tim proteins Molecular biology of the cell, 2009; 20(15): 3481-90.
Francoleon Deborah R, Boontheung Pinmanee, Yang Yanan, Kin UnMi, Ytterberg A Jimmy, Denny Patricia A, Denny Paul C, Loo Joseph A, Gunsalus Robert P, Loo Rachel R Ogorzalek   S-layer, surface-accessible, and concanavalin A binding proteins of Methanosarcina acetivorans and Methanosarcina mazei Journal of proteome research, 2009; 8(4): 1972-82.
Kudryashov Dmitri S, Durer Zeynep A Oztug, Ytterberg A Jimmy, Sawaya Michael R, Pashkov Inna, Prochazkova Katerina, Yeates Todd O, Loo Rachel R Ogorzalek, Loo Joseph A, Satchell Karla J Fullner, Reisler Emil   Connecting actin monomers by iso-peptide bond is a toxicity mechanism of the Vibrio cholerae MARTX toxin Proceedings of the National Academy of Sciences of the United States of America, 2008; 105(47): 18537-42.