Nicholas G Nickols, M.D., Ph.D.
Affiliations
Affiliations
Assistant Professor In-Residence, Radiation Oncology
Research Interests
Dr. Nicholas Nickols is interested in exploring a chemical biology approach to modulation of ionizing radiotherapy, overcoming treatment resistance mechanisms and conducting combined therapy clinical trials for locally advanced prostate cancer.
Publications

A selected list of publications:

Yang Fei, Nickols Nicholas G, Li Benjamin C, Szablowski Jerzy O, Hamilton Shari R, Meier Jordan L, Wang Chieh-Mei, Dervan Peter B   Animal toxicity of hairpin pyrrole-imidazole polyamides varies with the turn unit Journal of medicinal chemistry, 2013; 56(18): 7449-57.
Nickols Nicholas G, Szablowski Jerzy O, Hargrove Amanda E, Li Benjamin C, Raskatov Jevgenij A, Dervan Peter B   Activity of a Py-Im polyamide targeted to the estrogen response element Molecular cancer therapeutics, 2013; 12(5): 675-84.
Yang Fei, Nickols Nicholas G, Li Benjamin C, Marinov Georgi K, Said Jonathan W, Dervan Peter B   Antitumor activity of a pyrrole-imidazole polyamide Proceedings of the National Academy of Sciences of the United States of America, 2013; 110(5): 1863-8.
Raskatov Jevgenij A, Nickols Nicholas G, Hargrove Amanda E, Marinov Georgi K, Wold Barbara, Dervan Peter B   Gene expression changes in a tumor xenograft by a pyrrole-imidazole polyamide Proceedings of the National Academy of Sciences of the United States of America, 2012; 109(40): 16041-5.
Synold Timothy W, Xi Bixin, Wu Jun, Yen Yun, Li Benjamin C, Yang Fei, Phillips John W, Nickols Nicholas G, Dervan Peter B   Single-dose pharmacokinetic and toxicity analysis of pyrrole-imidazole polyamides in mice Cancer chemotherapy and pharmacology, 2012; 70(4): 617-25.
Muzikar Katy A, Nickols Nicholas G, Dervan Peter B   Repression of DNA-binding dependent glucocorticoid receptor-mediated gene expression Proceedings of the National Academy of Sciences of the United States of America, 2009; 106(39): 16598-603.
Nickols Nicholas G, Jacobs Claire S, Farkas Michelle E, Dervan Peter B   Improved nuclear localization of DNA-binding polyamides Nucleic acids research, 2007; 35(2): 363-70.
Edelson Benjamin S, Best Timothy P, Olenyuk Bogdan, Nickols Nicholas G, Doss Raymond M, Foister Shane, Heckel Alexander, Dervan Peter B   Influence of structural variation on nuclear localization of DNA-binding polyamide-fluorophore conjugates Nucleic acids research, 2004; 32(9): 2802-18.
Olenyuk Bogdan Z, Zhang Guo-Jun, Klco Jeffery M, Nickols Nicholas G, Kaelin William G, Dervan Peter B   Inhibition of vascular endothelial growth factor with a sequence-specific hypoxia response element antagonist Proceedings of the National Academy of Sciences of the United States of America, 2004; 101(48): 16768-73.
Best Timothy P, Edelson Benjamin S, Nickols Nicholas G, Dervan Peter B   Nuclear localization of pyrrole-imidazole polyamide-fluorescein conjugates in cell culture Proceedings of the National Academy of Sciences of the United States of America, 2003; 100(21): 12063-8.