Peter M Clark, Ph.D.

Work Address:
UCLA, Crump Institute for Molecular Imaging
CNSI, 570 Westwood Plaza, Building 114, Room 4333
Box 951770, Mail Code: 177010
Los Angeles, CA 90095

Affiliations
Affiliations
Assistant Professor, Molecular & Medical Pharmacology
Member, CTSI, Crump Institute for Molecular Imaging, Molecular Pharmacology GPB Home Area, themes
Faculty, Physics & Biology in Medicine GPB Home Area
Research Interests
The Clark Lab studies immune and cancer metabolism using high-throughput screening and molecular imaging technologies.
Biography

Dr. Clark attended Cornell University, earning highest honors in Chemistry, high honors in Biology, and honors in Mathematics. Dr. Clark earned his PhD in Chemistry from the California Institute of Technology where he received the Herbert Newby McCoy Award in Chemistry. His graduate work focused on the post-translational modification N-acetyl-D-glucosamine, which has been implicated in diseases such as diabetes and Alzheimer's disease.

Dr. Clark's research focuses on using the molecular imaging technique positron emission tomography (PET) to improve the diagnosis and understanding of human diseases. His current focus is on the sugar ribose, which is important for the structure of RNA but which is also present in the diet and blood. Using a new PET imaging probe that he developed, Dr. Clark has shown that ribose metabolism is dysregulated in mouse models of metabolic syndrome.

Publications

A selected list of publications:

Shin Bo-Chul, Cepeda Carlos, María Estrada-Sánchez Ana, Levine Michael S, Hodaei Laya, Dai Yun, Jung Jai, Ganguly Amit, Clark Peter, Devaskar Sherin U   Neural Deletion of Glucose Transporter Isoform 3 Creates Distinct Postnatal and Adult Neurobehavioral Phenotypes The Journal of neuroscience : the official journal of the Society for Neuroscience, 2018; .
Salas Jessica R, Chen Bao Ying, Wong Alicia, Duarte Sergio, Angarita Stephanie A K, Lipshutz Gerald S, Witte Owen N, Clark Peter M   Noninvasive Imaging of Drug-Induced Liver Injury with Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2018; 59(8): 1308-1315.
Nakano Haruko, Minami Itsunari, Braas Daniel, Pappoe Herman, Wu Xiuju, Sagadevan Addelynn, Vergnes Laurent, Fu Kai, Morselli Marco, Dunham Christopher, Ding Xueqin, Stieg Adam Z, Gimzewski James K, Pellegrini Matteo, Clark Peter M, Reue Karen, Lusis Aldons J, Ribalet Bernard, Kurdistani Siavash K, Christofk Heather, Nakatsuji Norio, Nakano Atsushi   Glucose inhibits cardiac muscle maturation through nucleotide biosynthesis eLife, 2017; 6(5): 1317-1318.
Mai Wilson X, Gosa Laura, Daniels Veerle W, Ta Lisa, Tsang Jonathan E, Higgins Brian, Gilmore W Blake, Bayley Nicholas A, Harati Mitra Dehghan, Lee Jason T, Yong William H, Kornblum Harley I, Bensinger Steven J, Mischel Paul S, Rao P Nagesh, Clark Peter M, Cloughesy Timothy F, Letai Anthony, Nathanson David A   Cytoplasmic p53 couples oncogene-driven glucose metabolism to apoptosis and is a therapeutic target in glioblastoma Nature medicine, 2017; 23(11): 1342-1351.
Clark Peter M, Ebiana Victoria A, Gosa Laura, Cloughesy Timothy F, Nathanson David A   Harnessing Preclinical Molecular Imaging to Inform Advances in Personalized Cancer Medicine Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2017; 58(5): 689-696.
Dai Yun, Zhao Yuanzi, Tomi Masatoshi, Shin Bo-Chul, Thamotharan Shanthie, Mazarati Andrey, Sankar Raman, Wang Elizabeth A, Cepeda Carlos, Levine Michael S, Zhang Jingjing, Frew Andrew, Alger Jeffry R, Clark Peter M, Sondhi Monica, Kositamongkol Sudatip, Leibovitch Leah, Devaskar Sherin U   Sex-Specific Life Course Changes in the Neuro-Metabolic Phenotype of Glut3 Null Heterozygous Mice: Ketogenic Diet Ameliorates Electroencephalographic Seizures and Improves Sociability Endocrinology, 2017; 158(4): 936-949.
Clark Peter M, Mai Wilson X, Cloughesy Timothy F, Nathanson David A   Emerging Approaches for Targeting Metabolic Vulnerabilities in Malignant Glioma Current neurology and neuroscience reports, 2016; 16(2): 17.
Faltermeier Claire M, Drake Justin M, Clark Peter M, Smith Bryan A, Zong Yang, Volpe Carmen, Mathis Colleen, Morrissey Colm, Castor Brandon, Huang Jiaoti, Witte Owen N   Functional screen identifies kinases driving prostate cancer visceral and bone metastasis Proceedings of the National Academy of Sciences of the United States of America, 2016; 113(2): E172-81.
Evdokimov Nikolai M, Clark Peter M, Flores Graciela, Chai Timothy, Faull Kym F, Phelps Michael E, Witte Owen N, Jung Michael E   Development of 2-Deoxy-2-[(18)F]fluororibose for Positron Emission Tomography Imaging Liver Function in Vivo Journal of medicinal chemistry, 2015; 58(14): 5538-47.
Clark Peter M, Flores Graciela, Evdokimov Nikolai M, McCracken Melissa N, Chai Timothy, Nair-Gill Evan, O'Mahony Fiona, Beaven Simon W, Faull Kym F, Phelps Michael E, Jung Michael E, Witte Owen N   Positron emission tomography probe demonstrates a striking concentration of ribose salvage in the liver Proceedings of the National Academy of Sciences of the United States of America, 2014; 111(28): E2866-74.
Ramakrishnan Parameswaran, Clark Peter M, Mason Daniel E, Peters Eric C, Hsieh-Wilson Linda C, Baltimore David   Activation of the transcriptional function of the NF-κB protein c-Rel by O-GlcNAc glycosylation Science signaling, 2013; 6(290): ra75.
Clark Peter M, Rexach Jessica E, Hsieh-Wilson Linda C   Visualization of O-GlcNAc glycosylation stoichiometry and dynamics using resolvable poly(ethylene glycol) mass tags Current protocols in chemical biology, 2013; 5(4): 281-302.
Yi Wen, Clark Peter M, Mason Daniel E, Keenan Marie C, Hill Collin, Goddard William A, Peters Eric C, Driggers Edward M, Hsieh-Wilson Linda C   Phosphofructokinase 1 glycosylation regulates cell growth and metabolism Science (New York, N.Y.), 2012; 337(6097): 975-80.
Rogers Claude J, Clark Peter M, Tully Sarah E, Abrol Ravinder, Garcia K Christopher, Goddard William A, Hsieh-Wilson Linda C   Elucidating glycosaminoglycan-protein-protein interactions using carbohydrate microarray and computational approaches Proceedings of the National Academy of Sciences of the United States of America, 2011; 108(24): 9747-52.