Yvonne Y. Chen, Ph.D.

Laboratory Address:
420 Westwood Plaza Boelter Hall 5531
Los Angeles, CA 90095

Assistant Professor, Chemical and Biomolecular Engineering
Member, Molecular Biology Institute

Prof. Yvonne Chen received her B.S. in Chemical Engineering from Stanford University and her Ph.D. in Chemical Engineering form the California Institute of Technology. Her laboratory's research focuses on applying synthetic biology and biomolecular engineering techniques to the development of robust cell-based immunotherapy for cancer, particularly T cells expressing tumor-targeting chimeric antigen receptors. Yvonne was a Junior Fellow at the Harvard Society of Fellows as well as a recipient of the NIH Director’s Early Independence Award, NSF CAREER Award, Hellman Fellowship, and the ACGT New Investigator Award in Cell and Gene Therapy for Cancer.


A selected list of publications:

Zah Eugenia, Lin Meng-Yin, Silva-Benedict Anne, Jensen Michael C, Chen Yvonne Y   T cells expressing CD19/CD20 bi-specific chimeric antigen receptors prevent antigen escape by malignant B cells Cancer immunology research, 2016; 16(5): .
Ede Christopher, Chen Ximin, Lin Meng-Yin, Chen Yvonne Y   Quantitative Analyses of Core Promoters Enable Precise Engineering of Regulated Gene Expression in Mammalian Cells ACS synthetic biology, 2016; 17(5): .
Chen Yvonne Y   Efficient Gene Editing in Primary Human T Cells Trends in immunology, 2015; 36(11): 667-9.
Chang ZeNan L, Silver Pamela A, Chen Yvonne Y   Identification and selective expansion of functionally superior T cells expressing chimeric antigen receptors Journal of translational medicine, 2015; 13(1): 161.
Wei Kathy Y, Chen Yvonne Y, Smolke Christina D   A yeast-based rapid prototype platform for gene control elements in mammalian cells Biotechnology and bioengineering, 2013; 110(4): 1201-10.
Chen Yvonne Y, Galloway Kate E, Smolke Christina D   Synthetic biology: advancing biological frontiers by building synthetic systems Genome biology, 2012; 13(2): 240.
Chen Yvonne Y, Smolke Christina D   From DNA to targeted therapeutics: bringing synthetic biology to the clinic Science translational medicine, 2011; 3(106): 106ps42.
Beisel Chase L, Chen Yvonne Y, Culler Stephanie J, Hoff Kevin G, Smolke Christina D   Design of small molecule-responsive microRNAs based on structural requirements for Drosha processing Nucleic acids research, 2011; 39(7): 2981-94.
Chen Yvonne Y, Jensen Michael C, Smolke Christina D   Genetic control of mammalian T-cell proliferation with synthetic RNA regulatory systems Proceedings of the National Academy of Sciences of the United States of America, 2010; 107(19): 8531-6.
Jewett Michael C, Miller Mark L, Chen Yvonne, Swartz James R   Continued protein synthesis at low [ATP] and [GTP] enables cell adaptation during energy limitation Journal of bacteriology, 2009; 191(3): 1083-91.