Stephanie Correa, Ph.D.
Assistant Professor, Integrative Biology and Physiology

The Correa lab is broadly interested in understanding how reproductive hormones affect temperature and energy balance. In women, the menopausal transition is associated with hot flashes and increased visceral body fat. Our research aims to understand how estrogens act on the hypothalamus to alter temperature homeostasis and metabolic health. To understand the mechanisms by which estrogen alters the homeostasis, we focus on the following broad questions: How does the brain regulate temperature and energy balance? How do homeostatic neural circuits differ between males and females? How are homeostatic circuits modulated by estrogens? We use genetically engineered mice and new viral tools to define the neurons that drive estrogen-responsive and sex-specific changes in energy balance. This approach allows us to dissect the effects of estrogen on distinct neuronal populations with spatial, molecular, and temporal specificity. These studies can help us better understand weight gain and hot flashes in postmenopausal women


A selected list of publications:

Kammel Laura G, Correa Stephanie M   Selective sexual differentiation of neurone populations may contribute to sex-specific outputs of the ventromedial nucleus of the hypothalamus Journal of neuroendocrinology, 2020; 32(1): e12801.
Lee Stephen D, Priest Christina, Bjursell Mikael, Gao Jie, Arneson Douglas V, Ahn In Sook, Diamante Graciel, van Veen J Edward, Massa Megan G, Calkin Anna C, Kim Jason, Andersén Harriet, Rajbhandari Prashant, Porritt Michelle, Carreras Alba, Ahnmark Andrea, Seeliger Frank, Maxvall Ingela, Eliasson Pernilla, Althage Magnus, Åkerblad Peter, Lindén Daniel, Cole Tracy A, Lee Richard, Boyd Helen, Bohlooly-Y Mohammad, Correa Stephanie M, Yang Xia, Tontonoz Peter, Hong Cynthia   IDOL regulates systemic energy balance through control of neuronal VLDLR expression Nature metabolism, 2019; 1(11): 1089-1100.
Herber Candice B, Krause William C, Wang Liping, Bayrer James R, Li Alfred, Schmitz Matthew, Fields Aaron, Ford Breanna, Zhang Zhi, Reid Michelle S, Nomura Daniel K, Nissenson Robert A, Correa Stephanie M, Ingraham Holly A   Estrogen signaling in arcuate Kiss1 neurons suppresses a sex-dependent female circuit promoting dense strong bones Nature communications, 2019; 10(1): 163.
Correa Stephanie M, Newstrom David W, Warne James P, Flandin Pierre, Cheung Clement C, Lin-Moore Alexander T, Pierce Andrew A, Xu Allison W, Rubenstein John L, Ingraham Holly A   An estrogen-responsive module in the ventromedial hypothalamus selectively drives sex-specific activity in females Cell reports, 2015; 10(1): 62-74.
Correa Stephanie M, Washburn Linda L, Kahlon Ravi S, Musson Michelle C, Bouma Gerrit J, Eicher Eva M, Albrecht Kenneth H   Sex reversal in C57BL/6J XY mice caused by increased expression of ovarian genes and insufficient activation of the testis determining pathway PLoS genetics, 2012; 8(4): e1002569.
Correa Stephanie M, Horan Claire M, Johnson Patricia A, Adkins-Regan Elizabeth   Copulatory behaviors and body condition predict post-mating female hormone concentrations, fertilization success, and primary sex ratios in Japanese quail Hormones and behavior, 2011; 59(4): 556-64.
Correa Stephanie M, Adkins-Regan Elizabeth, Johnson Patricia A   High progesterone during avian meiosis biases sex ratios toward females Biology letters, 2005; 1(2): 215-8.