Margot E Quinlan

Laboratory Address:
Paul Boyer Hall 459

Work Address:
Paul Boyer Hall 459A

Affiliations
Affiliations
Associate Professor, Chemistry and Biochemistry, Biochemistry, Molecular Biology
Member, Biochemistry, Biophysics & Structural Biology GPB Home Area, Graduate Program in Biochemistry, Molecular and Structural Biology
Biography:

Dr. Quinlan obtained her B.A. at Reed College in 1991. She then spent two years in Germany doing research at the University of Erlangen-Nurnberg. She went to graduate school at the University of Pennsylvania where she worked with Yale Goldman and received her Ph.D. in 2002. She worked as a postdoctoral fellow at UCSF with Dyche Mullins until 2008 when she joined the faculty in the Department of Chemistry and Biochemistry at UCLA.

Dr. Quinlan accepts graduate students through the Biochemistry and Molecular Biology (BMB) Graduate Program and the UCLA ACCESS Ph.D. Program.

Publications

A selected list of publications:

Quinlan Margot E, Kerkhoff Eugen   Actin nucleation: bacteria get in-Spired Nat. Cell Biol, 2008; 10(1): 13-5.
Quinlan Margot E, Hilgert Susanne, Bedrossian Anaid, Mullins R Dyche, Kerkhoff Eugen   Regulatory interactions between two actin nucleators, Spire and Cappuccino J. Cell Biol, 2007; 179(1): 117-28.
Quinlan Margot E, Heuser John E, Kerkhoff Eugen, Mullins R Dyche   Drosophila Spire is an actin nucleation factor Nature, 2005; 433(7024): 382-8.
Forkey Joseph N, Quinlan Margot E, Goldman Yale E   Measurement of single macromolecule orientation by total internal reflection fluorescence polarization microscopy Biophys. J, 2005; 89(2): 1261-71.
Quinlan Margot E, Forkey Joseph N, Goldman Yale E   Orientation of the myosin light chain region by single molecule total internal reflection fluorescence polarization microscopy Biophys. J, 2005; 89(2): 1132-42.
Rosenberg Stephanie A, Quinlan Margot E, Forkey Joseph N, Goldman Yale E   Rotational motions of macro-molecules by single-molecule fluorescence microscopy Accounts of chemical research, 2005; 38(7): 583-93.
Forkey Joseph N, Quinlan Margot E, Shaw M Alexander, Corrie John E T, Goldman Yale E   Three-dimensional structural dynamics of myosin V by single-molecule fluorescence polarization Nature, 2003; 422(6930): 399-404.
Quinlan M E, Forkey J N, Goldman Y E   Kinesin-ADP: whole lotta shakin' goin' on Nature structural biology, 2001; 8(6): 478-80.
Forkey J N, Quinlan M E, Goldman Y E   Protein structural dynamics by single-molecule fluorescence polarization Progress in biophysics and molecular biology, 2000; 74(1-2): 1-35.
Beausang John F, Sun Yujie, Quinlan Margot E, Forkey Joseph N, Goldman Yale E   Fluorescent labeling of calmodulin with bifunctional rhodamine Cold Spring Harbor protocols, 2012; 2012(5): .
Beausang John F, Sun Yujie, Quinlan Margot E, Forkey Joseph N, Goldman Yale E   The acquisition and analysis of polarized total internal reflection fluorescence microscopy (polTIRFM) data Cold Spring Harbor protocols, 2012; 2012(6): 722-5.
Chen Christine K, Sawaya Michael R, Phillips Martin L, Reisler Emil, Quinlan Margot E   Multiple forms of Spire-actin complexes and their functional consequences The Journal of biological chemistry, 2012; 287(13): 10684-92.
Beausang John F, Sun Yujie, Quinlan Margot E, Forkey Joseph N, Goldman Yale E   Orientation and rotational motions of single molecules by polarized total internal reflection fluorescence microscopy (polTIRFM) Cold Spring Harbor protocols, 2012; 2012(5): .
Beausang John F, Sun Yujie, Quinlan Margot E, Forkey Joseph N, Goldman Yale E   The polarized total internal reflection fluorescence microscopy (polTIRFM) twirling filament assay Cold Spring Harbor protocols, 2012; 2012(6): 719-21.
Bor Batbileg, Vizcarra Christina L, Phillips Martin L, Quinlan Margot E   Autoinhibition of the formin Cappuccino in the absence of canonical autoinhibitory domains Molecular biology of the cell, 2012; 23(19): 3801-13.
Vizcarra Christina L, Kreutz Barry, Rodal Avital A, Toms Angela V, Lu Jun, Zheng Wei, Quinlan Margot E, Eck Michael J   Structure and function of the interacting domains of Spire and Fmn-family formins Proceedings of the National Academy of Sciences of the United States of America, 2011; 108(29): 11884-9.
Beausang John F, Sun Yujie, Quinlan Margot E, Forkey Joseph N, Goldman Yale E   Preparation of filamentous actin for polarized total internal reflection fluorescence microscopy (polTIRFM) motility assays Cold Spring Harbor protocols, 2012; 2012(5): .
Beausang John F, Sun Yujie, Quinlan Margot E, Forkey Joseph N, Goldman Yale E   The polarized total internal reflection fluorescence microscopy (polTIRFM) processive motility assay for myosin V Cold Spring Harbor protocols, 2012; 2012(6): 716-8.
Beausang John F, Sun Yujie, Quinlan Margot E, Forkey Joseph N, Goldman Yale E   Fluorescent labeling of myosin V for polarized total internal reflection fluorescence microscopy (polTIRFM) motility assays Cold Spring Harbor protocols, 2012; 2012(5): .
Beausang John F, Sun Yujie, Quinlan Margot E, Forkey Joseph N, Goldman Yale E   Construction of flow chambers for polarized total internal reflection fluorescence microscopy (polTIRFM) motility assays Cold Spring Harbor protocols, 2012; 2012(6): 712-5.
Roth-Johnson Elizabeth A, Vizcarra Christina L, Bois Justin S, Quinlan Margot E   Interaction between microtubules and the Drosophila formin Cappuccino and its effect on actin assembly The Journal of biological chemistry, 2014; 289(7): 4395-404.
Fattouh Ramzi, Kwon Hyunwoo, Czuczman Mark A, Copeland John W, Pelletier Laurence, Quinlan Margot E, Muise Aleixo M, Higgins Darren E, Brumell John H   The diaphanous-related formins promote protrusion formation and cell-to-cell spread of Listeria monocytogenes The Journal of infectious diseases, 2015; 211(7): 1185-95.
Quinlan Margot E   Direct interaction between two actin nucleators is required in Drosophila oogenesis Development (Cambridge, England), 2013; 140(21): 4417-25.
Rasson Amy S, Bois Justin S, Pham Duy Stephen L, Yoo Haneul, Quinlan Margot E   Filament assembly by Spire: key residues and concerted actin binding Journal of molecular biology, 2015; 427(4): 824-39.
Quinlan Margot E   Cytoplasmic Streaming in the Drosophila Oocyte Annual review of cell and developmental biology, 2016; .
Bor Batbileg, Bois Justin S, Quinlan Margot E   Regulation of the formin Cappuccino is critical for polarity of Drosophila oocytes Cytoskeleton (Hoboken, N.J.), 2015; 72(1): 1-15.
Oztug Durer Zeynep A, McGillivary Rebecca M, Kang Hyeran, Elam W Austin, Vizcarra Christina L, Hanein Dorit, De La Cruz Enrique M, Reisler Emil, Quinlan Margot E   Metavinculin Tunes the Flexibility and the Architecture of Vinculin-Induced Bundles of Actin Filaments Journal of molecular biology, 2015; 427(17): 2782-98.
Vizcarra Christina L, Bor Batbileg, Quinlan Margot E   The role of formin tails in actin nucleation, processive elongation, and filament bundling The Journal of biological chemistry, 2014; 289(44): 30602-13.
Yoo Haneul, Roth-Johnson Elizabeth A, Bor Batbileg, Quinlan Margot E   Drosophila Cappuccino alleles provide insight into formin mechanism and role in oogenesis Molecular biology of the cell, 2015; 26(10): 1875-86.