Jeffrey Michael Donlea, Ph.D.

Mailing Address:
650 Charles E. Young Drive South, CHS 63-251
Los Angeles, CA 90095

Affiliations
Affiliations
Assistant Professor, Neurobiology
Member, Molecular, Cellular & Integrative Physiology GPB Home Area, Neuroscience GPB Home Area
Biography:

Sleep disruptions are common and pose a significant public health risk – insufficient sleep causes cognitive deficits that increase the risk of severe motor vehicle accidents, medical mistakes, workplace injuries, and other serious events. Although the causes of these cognitive deficits are not known, comparable behavioral impairments have also been detected after sleep loss in smaller animals, including the fruit fly. Dr. Donlea has studied the regulation and functions of sleep in flies as a PhD student in Paul Shaw’s lab at Washington University in St. Louis and as a postdoctoral researcher in Gero Miesenböck’s lab at the University of Oxford. He is now a member of the Department of Neurobiology and uses a combination of behavioral genetics and in vivo electrophysiology to examine sleep’s basic neural functions.

Publications

A selected list of publications:

Diogo Pimentel*, Jeffrey M. Donlea*, Clifford B. Talbot, Seoho M. Song, Alexander J. F. Thurston & Gero Miesenböck   Operation of a homeostatic sleep switch Nature, 2016; .
Stephane Dissel, Veena Angadi, Leonie Kirszenblat, Yasuko Suzuki, Jeff Donlea, Markus Klose, Zachary Koch, Denis English, Raphaelle Winsky-Sommerer, Bruno van Swinderen, Paul J Shaw   Sleep restores behavioral plasticity to Drosophila mutants Current biology, 2015; 25(10): 1270-81.
Jeffrey M Donlea, Narendrakumar Ramanan, Neal Silverman, Paul J Shaw   Genetic rescue of functional senescence in synaptic and behavioral plasticity Sleep, 2014; 37(9): 1427-37.
Jeffrey M Donlea*, Diogo Pimentel*, Gero Miesenboeck   Neuronal machinery of sleep homeostasis in Drosophila Neuron, 2014; 81(4): 860-72.
Jeffrey Donlea*, Averi Leahy*, Matthew S Thimgan, Yasuo Suzuki, Bryon N Hughson, Marla B Sokolowski, Paul J Shaw   Foraging alters resilience/vulnerability to sleep disruption and starvation in Drosophila Proceedings of the National Academy of Sciences of the United States of America, 2012; 109(7): 2613-8.
Jeffrey M Donlea, Matthew S Thimgan, Yasuo Suzuki, Laura Gottschalk, Paul J Shaw   Inducing sleep by remote control facilitates memory consolidation in Drosophila Science, 2011; 332(6037): 1571-6.
Laurent Seugnet, Yasuo Suzuki, Jeff M Donlea, Laura Gottschalk, Paul J Shaw   Sleep deprivation during early-adult development results in long-lasting learning deficits in adult Drosophila Sleep, 2011; 34(2): 137-46.
Jeffrey M Donlea, Paul J Shaw   Sleeping together using social interactions to understand the role of sleep in plasticity Advances in genetics, 2009; 68(5923): 57-81.
Jeffrey M Donlea, Narendrakumar Ramanan, Paul J Shaw   Use-dependent plasticity in clock neurons regulates sleep need in Drosophila Science, 2009; 324(5923): 105-8.
Indrani Ganguly-Fitzgerald, Jeff Donlea, Paul J Shaw   Waking experience affects sleep need in Drosophila Science, 2006; 313(5794): 1775-81.