Patrick G Harran

Laboratory Address:
Mol Sci Bldg 5210

Work Address:
Mol Sci Bldg 5505A

Affiliations
Affiliations
Professor and Cram Chair, Chemistry and Biochemistry
Lab Director, Harran Lab
Professor, Organic
Biography

Professor Harran was raised in the Adirondacks region of Upstate New York and trained in chemistry at Skidmore College. He spent three years working with Raymond Giguere on the use of sequenced bimolecular ene / intramolecular Diels-Alder reactions. He carried out doctoral studies with Frederick Ziegler at Yale University. There they explored behavior of photochemically-generated radical intermediates in the synthesis of optically active pyrroloindoles related to mitomycins. He then moved to Stanford University as an NIH sponsored postdoctoral fellow, working with Paul Wender to create simplified, functional analogs of bryostatin. In late 1997 Professor Harran accepted his first independent appointment in the Biochemistry Department at the University of Texas Southwestern Medical Center. He was promoted to Associate Professor with tenure in 2002 and Full Professor in 2005. During his time at Southwestern, the institution built a nationally recognized program in organic chemistry. The chemistry faculty at UTSW continues to grow and train students in a uniquely interdisciplinary environment. In the summer of 2008 Professor Harran accepted the inaugural D.J. & J.M. Cram Chair in Organic Chemistry at UCLA. The group relocated to Los Angeles with a strong sense of possibilities and excitement for the years ahead.

Publications
Allred Tyler K, Manoni Francesco, Harran Patrick G Exploring the Boundaries of "Practical": De Novo Syntheses of Complex Natural Product-Based Drug Candidates. Chemical reviews. 2017; .
Wieczorek Michal, Tcherkezian Joseph, Bernier Cynthia, Prota Andrea E, Chaaban Sami, Rolland Yannève, Godbout Claude, Hancock Mark A, Arezzo Joseph C, Ocal Ozhan, Rocha Cecilia, Olieric Natacha, Hall Anita, Ding Hui, Bramoullé Alexandre, Annis Matthew G, Zogopoulos George, Harran Patrick G, Wilkie Thomas M, Brekken Rolf A, Siegel Peter M, Steinmetz Michel O, Shore Gordon C, Brouhard Gary J, Roulston Anne The synthetic diazonamide DZ-2384 has distinct effects on microtubule curvature and dynamics without neurotoxicity. Science translational medicine. 2016; 8(365): 365ra159.
Bracken Jack D, Carlson Andrew D, Frederich James H, Nguyen Mai, Shore Gordon C, Harran Patrick G Tailored fragments of roseophilin selectively antagonize Mcl-1 in vitro. Tetrahedron letters. 2015; 56(23): 3612-3616.
Ding Hui, DeRoy Patrick L, Perreault Christian, Larivée Alexandre, Siddiqui Arshad, Caldwell Charles G, Harran Susan, Harran Patrick G Electrolytic macrocyclizations: scalable synthesis of a diazonamide-based drug development candidate. Angewandte Chemie (International ed. in English). 2015; 54(16): 4818-22.
Lawson Kenneth V, Rose Tristan E, Harran Patrick G Template-constrained macrocyclic peptides prepared from native, unprotected precursors. Proceedings of the National Academy of Sciences of the United States of America. 2013; 110(40): E3753-60.
Lawson Kenneth V, Rose Tristan E, Harran Patrick G Template-induced macrocycle diversity through large ring-forming alkylations of tryptophan. Tetrahedron. 2013; 69(36): 7683-7691.
Frederich James H, Matsui Jennifer K, Chang Randy O, Harran Patrick G Substituted 2,2'-bipyrroles and pyrrolylfurans via intermediate isoxazolylpyrroles. Tetrahedron letters. 2013; 54(21): 2645-2647.
Frederich James H, Harran Patrick G Modular access to complex prodiginines: total synthesis of (+)-roseophilin via its 2-azafulvene prototropisomer. Journal of the American Chemical Society. 2013; 135(10): 3788-91.
Wang Gelin, Wang Xiaoming, Yu Hong, Wei Shuguang, Williams Noelle, Holmes Daniel L, Halfmann Randal, Naidoo Jacinth, Wang Lai, Li Lin, Chen She, Harran Patrick, Lei Xiaoguang, Wang Xiaodong Small-molecule activation of the TRAIL receptor DR5 in human cancer cells. Nature chemical biology. 2013; 9(2): 84-9.
Ding Hui, Roberts Andrew G, Harran Patrick G Total Synthesis of Ageliferin via Acyl N-amidinyliminium Ion Rearrangement. Chemical science. 2013; 4(1): 303-306.
Ding Hui, Roberts Andrew G, Harran Patrick G Synthetic (±)-axinellamines deficient in halogen. Angewandte Chemie (International ed. in English). 2012; 51(18): 4340-3.
Greer Rachel M, Peyton Michael, Larsen Jill E, Girard Luc, Xie Yang, Gazdar Adi F, Harran Patrick, Wang Lai, Brekken Rolf A, Wang Xiaodong, Minna John D SMAC mimetic (JP1201) sensitizes non-small cell lung cancers to multiple chemotherapy agents in an IAP-dependent but TNF-α-independent manner. Cancer research. 2011; 71(24): 7640-8.
Patrick G. Harran, Xiaodong Wang, Jef K. De Brabander, Lin Li, Ranny Matthew Thomas, and Hidetaka Suzuki Dimeric Small Molecule Potentiators of Apoptosis. US Patent # 7,816,538 B2 ; issued October 19, 2010.
Kenneth V. Lawson, Tristan E. Rose, and Patrick G. Harran Synthesis of a Designed Sesquiterpenoid that Forms Useful Composites with Peptides and Related Oligomers. Tetrahedron Lett 2010; in press.
Qingyi Li, Paul Hurley, Hui Ding, Andrew G. Roberts, Radha Akella, and Patrick G. Harran Exploring Symmetry-Based Logic for a Synthesis of Palau'amine. J. Org. Chem 2009; 74: 5909-5919.
Tongjin Zhao, Michael S. Brown, Joseph L. Goldstein and Patrick G. Harran Small Molecule Inhibitors of the Ghrelin O-Acyltransferase. US Patent Application - Serial No. 61/102,353 2008; Filed October 3, 2008.
Hongda Zhao, Lidet Negash, Qi Wei, Thomas G LaCour, Sandi Jo Estill, Emanuela Capota, Andrew A. Pieper and Patrick G. Harran Acid Promoted Cinnamyl Ion Mobility Within Peptide Derived Macrocycles . J. Am. Chem. Soc 2008; 130: 13864-13866.
Petersen Sean L, Wang Lai, Yalcin-Chin Asligul, Li Lin, Peyton Michael, Minna John, Harran Patrick, Wang Xiaodong Autocrine TNFalpha signaling renders human cancer cells susceptible to Smac-mimetic-induced apoptosis. Cancer cell. 2007; 12(5): 445-56.
Sean L. Petersen, Lai Wang, Asligul Yalcin-Chin, Lin Li, Michael Peyton, John Minna, Patrick G. Harran and Xiaodong Wang Autocrine TNFα Signaling Renders Human Cancer Cells Susceptible to Smac-Mimetic-Induced Apoptosis. Cancer Cell 2007; 12: 445-456.
Gelin Wang, Anthony Burgett, Patrick G. Harran and Xiaodong Wang Diazonamide Toxins Reveal an Unexpected Function for Ornithine δ-Aminotransferase in Mitotic Cell Division. Proc. Nat. Acad. Sci. (USA) 2007; 104: 2068-2073.
Noelle Williams, Anthony Burgett, Ashley Atkins, Xiaodong Wang, Patrick G. Harran and Steven McKnight Therapeutic Anti-Cancer Efficiacy of a Synthetic Diazonamide Analog in the Absence of Overt Toxicity . Proc. Nat. Acad. Sci . (USA) 2007; 104: 2074-2079.
Williams Noelle S, Burgett Anthony W G, Atkins Ashley S, Wang Xiaodong, Harran Patrick G, McKnight Steven L Therapeutic anticancer efficacy of a synthetic diazonamide analog in the absence of overt toxicity. Proceedings of the National Academy of Sciences of the United States of America. 2007; 104(7): 2074-9.
Zubovych Iryna, Doundoulakis Thomas, Harran Patrick G, Roth Michael G A missense mutation in Caenorhabditis elegans prohibitin 2 confers an atypical multidrug resistance. Proceedings of the National Academy of Sciences of the United States of America. 2006; 103(42): 15523-8.
Iryna Zubovych, Thomas Doundoulakis, Patrick G Harran and Michael G Roth A Missense Mutation in C.elegans Prohibitin 2 Confers an Atypical Multidrug Resistance. Proc. Nat. Acad. Sci 2006; (103): 15523-15528.
Hugo Garrido-Hernandez, Masakazu Nakadai, Marc Vimolratana, Qingyi Li, Thomas Doundoulakis and Patrick G. Harran Spirocycloisomerization of Tethered Alkylidene Glycocyamidines: Synthesis of a Base Template Common to Palau’amine Family Alkaloids . Angew. Chem. Intl. Ed. Engl 2005; 44: 765-769.
Li Lin, Thomas Ranny Mathew, Suzuki Hidetaka, De Brabander Jef K, Wang Xiaodong, Harran Patrick G A small molecule Smac mimic potentiates TRAIL- and TNFalpha-mediated cell death. Science (New York, N.Y.). 2004; 305(5689): 1471-4.
Lin Li, Ranny Thomas, Hidetaka Suzuki, Jef K. De Brabander, Xiaodong Wang and Patrick G. Harran A Small Molecule Smac Mimic Potentiates TRAIL and TNFa-Mediated Cell Death. Science 2004; 305: 1471-1474.
Anthony Burgett, Qingyi Li, Qi Wei, and Patrick G. Harran A Concise and Flexible Total Synthesis of (–)-Diazonamide A. Angew. Chem Intl. Ed. Engl 2003; (42): 4961-4966.
Zobeida Cruz-Monserrate, Jeffrey T. Mullaney, Patrick G. Harran, George R. Pettit and ErnestHamel Dolastatin 15 Binds in the Vinca Domain of Tubulin as Demonstrated by Hummel-Dreyer Chromatography. Eur. J. Biochem 2003; 3822-3828.
Qi Wei, Susan Harran, Patrick Harran Methods to Initiate Synthetic Re-structuring of Peptides. Tetrahedron (symposium in print) 2003; 59: 8947-8954.
Li Jing, Burgett Anthony W. G., Esser Lothar, Amezcua Carlos, Harran Patrick G. Preview. Angewandte Chemie (International ed. in English). 2001; 40(24): 4776.
Li Jing, Jeong Susan, Esser Lothar, Harran Patrick G. Total Synthesis of Nominal Diazonamides-Part 1: Convergent Preparation of the Structure Proposed for (-)-Diazonamide A Funding provided by the NIH (RO1-GM60591), the NSF (CAREER 9984282), the Howard Hughes Medical Institute (junior faculty support), the Robert A. Welch Foundation, and the Advanced Research Program of the Texas Higher Education Coordinating Board. Angewandte Chemie (International ed. in English). 2001; 40(24): 4765-4769.
Li Jing, Burgett Anthony W. G., Esser Lothar, Amezcua Carlos, Harran Patrick G. Total Synthesis of Nominal Diazonamides-Part 2: On the True Structure and Origin of Natural Isolates Funding provided by the NIH (RO1-GM60591), the NSF (CAREER 9984282), the Howard Hughes Medical Institute (junior faculty support), the Robert A. Welch Foundation, and the Advanced Research Program of the Texas Higher Education Coordinating Board. We are grateful to Professor Michael Roth for his time, insight, and advice. Angewandte Chemie (International ed. in English). 2001; 40(24): 4770-4773.
Li Jing, Chen Xin, Burgett Anthony W. G., Harran Patrick G. Synthetic seco Forms of (-)-Diazonamide A We thank Prof. Michael Roth for advice and insight and Ms. Susan Jeong for invaluable experimental assistance. Funding was provided by the NIH (RO1-GM60591), the NSF (CAREER 9984282), the Howard Hughes Medical Institute (junior faculty support), and the Robert A. Welch Foundation. Angewandte Chemie (International ed. in English). 2001; 40(14): 2682-2685.
Jing Li, Susan Jeong, Lothar Esser, Patrick Harran Total Synthesis of Nominal Diazonamides: Part 1. Convergent Preparation of the Structure Proposed for (-)-Diazonamide A. Angew. Chem. Intl. Ed. Engl 2001; 40: 4765-4770.
Jing Li, Anthony Burgett, Lothar Esser, Carlos Amezcua, Patrick Harran Total Synthesis of Nominal Diazonamides: Part 2. On the True Structure and Origin of Natural Isolates. Angew. Chem. Intl. Ed. Engl 2001; 40: 4770-4773.
Download