Louis Bouchard, Ph.D.

Laboratory Address:
Young Hall 2104 and 2042
Student Office: Young Hall 3085

Work Address:
Department of Chemistry and Biochemistry
607 Charles E Young Dr East / Young Hall 3048B
University of California, Los Angeles, CA 90095

Associate Professor, Biophysics and Structural Biology, Chemistry and Biochemistry, Nanoscience and Materials, Physical, Physical Chemistry
Member, California NanoSystems Institute, JCCC Cancer and Stem Cell Biology Program Area, Jonsson Comprehensive Cancer Center

Dr. Bouchard obtained a bachelor’s degree in physics and business management from McGill University in Montréal, Canada, a Master’s degree in medical biophysics from the University of Toronto and a Ph.D. in Chemistry from Princeton University. His doctoral dissertation explores the use of multiple quantum coherence and long-range dipolar interactions in condensed matter to characterize heterogeneous material microstructure. During his stay in the laboratory of Alex Pines at the University of California, Berkeley he developed novel approaches and methodologies to portable, low-field NMR and MRI, microfluidics and hyperpolarization methods to the study of chemical reactions. He joined the UCLA faculty during the summer of 2008 to pursue research in physical chemistry.

Awards and Honors:

Spectroscopy Society of Pittsburgh (SSP) Starter Grant Award (2010); Camille and Henry Dreyfus New Faculty Award (2008); Charlotte Elizabeth Procter University Honorific Fellowship at Princeton University (2003); University of Toronto Fellowship (1998).


A selected list of publications:

Taylor RE, Alyahyaei HM, Wang Z, Shi J, Wang KL, Bouchard LS   77Se NMR Investigation of Fe0.05Bi1.95Se3, , ; .
Compton R, Osher S, Bouchard L   Hybrid regulatization for MRI reconstruction with field inhomogeneity correction, (submitted) , ; .
Sharma R, Bouchard LS   Maximally hyperpolarized gas from parahydrogen by rational design of ligand-capped nanoparticles, (submitted) , ; .
Youssef K, Mack JJ, Iruela-Arispe ML, Bouchard LS   Macro-scale Topology Optimization for Controlling Internal Shear Stress in a Porous Scaffold Bioreactor (submitted), 2011; .
Soulez Gilles, Therasse Eric, Giroux Marie-France, Bouchard Louis, Gilbert Patrick, Perreault Pierre, Cloutier Guy, Oliva Vincent L   Management of peripheral arterial disease: role of computed tomography angiography and magnetic resonance angiography Presse médicale (Paris, France : 1983), 2011; 40(9 Pt 2): e437-52.
Bouchard LS, Acosta VM, Bauch E, Budker D   Detection of the Meissner effect with a diamond magnetometer New J. Phys, 2011; 13: 025017.
Sharma R, Taylor RE, Bouchard LS   Intramolecular Ligand Dynamics in d15-(PPh3)-Capped Gold Nanoparticles Investigated by 2H NMR The Journal of Physical Chemistry C, 2011; 115(8): 3297-3303.
Michalak DJ, Xu S, Lowery TJ, Crawford CW, Ledbetter M, Bouchard LS, Wemmer DW, Budker D, Pines A   Relaxivity of Gadolinium Complexes Detected by Atomic Magnetometry Magn. Reson. Med, 2011; Epub ahead of print: .
Robson SA, Peterson R, Bouchard LS, Villareal VA, Clubb RT   Heteronuclear Zero Quantum Coherence Nz-Exchange Experiment That Resolves Resonance Overlap and Its Application To Measure the Rates of Heme Binding to the IsdC Protein J. Am. Chem. Soc, 2010; 132(28): 9522-9523.
Acosta VM, Bauch E, Ledbetter MP, Waxman A, Bouchard LS, Budker D   Temperature dependence of the nitrogen-vacancy magnetic resonance in diamond, Phys. Rev. Lett, 2010; 104: 070801.
McFadden C, Bouchard LS   Universality of Cluster Dynamics Physical Review E, 2010; 82(6 Pt. 1): 061125.
Bouchard LS   "Shimming pulses" in Magnetic Resonance Microscopy: Spatially Resolved NMR Techniques and Applications Wiley-VCH, 2009; Ed. Joseph D. Seymour and Sarah Codd: .
Demas V, Franck JM, Bouchard LS, Sakellariou D, Meriles CA, Martin R, Prado PJ, Bussandri A, Reimer JA, Pines A   'Ex-Situ' magnetic resonance volume imaging, Chemical Physics Letters, 2009; 467: 398-401.
Kelso N, Lee SK, Bouchard LS, Demas V, Muck M, Pines A, Clarke JC   Distortion-Free Magnetic Resonance Imaging in the Zero-Field Limit, Journal of Magnetic Resonance, 2009; 200: 285-290.
Bouchard LS, Anwar MS, Liu GL, Hann B, Xie H, Gray JW, Wang X, Pines A, Chen FF   Picomolar Sensitivity MRI and Photoacoustic Imaging of Cobalt Nanoparticles, Proc. Natl. Acad. Sci. USA, 2009; 106: 4085-4089.
Franck JM, Demas V, Martin RW, Bouchard LS, Pines A   Shimmed matching pulses: Simultaneous control of rf and static gradients for inhomogeneity correction, Journal of Chemical Physics, 2009; 131: 234506.
Paulsen Jeffrey L, Bouchard Louis S, Graziani Dominic, Blümich Bernhard, Pines Alexander   Volume-selective magnetic resonance imaging using an adjustable, single-sided, portable sensor Proceedings of the National Academy of Sciences of the United States of America, 2008; 105(52): 20601-4.
Paulsen JL, Franck J, Demas V, Bouchard LS   Least squares magnetic-field optimization for portable nuclear magnetic resonance magnet design, IEEE Transactions on Magnetics, 2008; 44: 4582-4590.
Bouchard LS, Burt SR, Anwar MS, Kovtunov KV, Koptyug IV, Pines A   NMR imaging of catalytic hydrogenation in microreactors with the use of parahydrogen, Science , 2008; 319: 442–445 .
Bouchard LS, Sushkov AO, Budker D, Ford JJ, Lipton AS   Nuclear-spin relaxation of 207Pb in ferroelectric powders, Physical Review A, 2008; 77: 022102.
Verpillat F, Ledbetter MP, Budker D, Xu S, Michalak M, Hilty C, Bouchard LS, Antonijevic S, Pines A   Remote detection of nuclear magnetic resonance with an anisotropic magnetoresistive sensor , Proc. Natl. Acad. Sci. USA, 2008; 105: 2271–2273 .
Paulsen JL, Bouchard, LS, Graziani N, Bluemich B, Pines A   Volume selective magnetic resonance imaging using an adjustable, single-sided, portable sensor, Proc. Natl. Acad. Sci. USA, 2008; 105: 20601-20604.
Jachmann RC, Trease D, Bouchard LS, Sakellariou D, Martin R, Schlueter RD, Budinger, TF, Pines A   Multipole shimming of permanent magnets using harmonic corrector rings, Review of Scientific Instruments , 2007; 78: 035115.
Bouchard LS, Kovtunov KV, Burt SR, Anwar MS, Koptyug IV, Sagdeev RZ, Pines A   Parahydrogen-enhanced gas-phase magnetic resonance imaging, Angewandte Chemie Intl Ed , 2007; 46: 4064–4068 (ranked Very Important Paper).
Anwar MS, Hilty C, Chu C, Bouchard LS, Pierce KL, Pines A   Spin coherence transfer in chemical transformations monitored by remote detection NMR, Analytical Chemistry , 2007; 79: 2806–2811 .
Bouchard LS, Anwar MS   Synthesis of matched magnetic fields for controlled spin precession, Physical Review B , 2007; 76: 014430 .
Bouchard LS   Unidirectional magnetic-field gradients and geometric-phase errors during Fourier encoding using orthogonal ac fields, Physical Review B , 2006; 74: 054103 .
Bouchard LS, Warren WS   Multiple-quantum vector field imaging by magnetic resonance J. Magn. Reson, 2005; 177(1): 1-13.
Bouchard LS, Wehrli FW, Chin CL, Warren WS   Structural anisotropy and internal magnetic fields in trabecular bone: coupling solution and solid dipolar interactions J. Magn. Reson, 2005; 176(1): 27-36.
Ledbetter MP, Savukov IM, Bouchard LS, Romalis MV,   Numerical and experimental studies of long-range magnetic dipolar interactions J. Chem. Phys. , 2004; 121: 1454-65.
Tang XP, Chin CL, Bouchard LS, Warren WS, Wehlri FW   Observing Bragg-like diffraction via multiple coupled nuclear spins Phys. Lett. A, 2004; 326: 114-25.
Bouchard LS, Warren WS   Reconstruction of porous material geometry by stochastic optimization based on NMR measurements of the dipolar field J. Magn. Reson, 2004; 170: 299-309.
Shannon KL, Branca RT, Galiana G, Cenzano S, Bouchard LS, Soboyejo W, Warren WS   Simultaneous acquisition of multiple orders of intermolecular multiple-quantum coherence images in vivo Magn. Reson. Imaging, 2004; 22: 1407-12.
Bouchard LS, Warren WS   Tensorial character of magnetization diffusion in periodic lattices Phys. Rev. B, 2004; 70(224426): .
Chin CL, Tang XP, Bouchard LS, Saha PK, Warren WS, Wehrli FW   Isolating quantum coherences in structural imaging using intermolecular double-quantum coherence MRI J. Magn. Reson, 2003; 165(2): 309-14.
Bouchard LS, Rizi RR, Warren WS   Magnetization structure contrast based on intermolecular multiple-quantum coherences Magn. Reson. Med. , 2002; 48: 972-9.
Bouchard LS, Bronskill MJ   Magnetic resonance imaging of thermal coagulation effects in a phantom for calibrating thermal therapy devices Med. Phys, 2000; 27: 1141-5.