Charalabos Pothoulakis, M.D.

Mailing Address:
675 Charles E. Young Dr. South
MRL 1240, Box 957019
Los Angeles, CA 90095

Eli and Edythe Broad Chair, Medicine
Director of Research, UCLA Center for Inflammatory Bowel Diseases
Director, Research Integration
Professor, Pathology and Laboratory Medicine, Vatche and Tamar Manoukian Division of Digestive Diseases
Member, CTSI, I3T Theme, Immunity, Microbes & Molecular Pathogenesis GPB Home Area, Molecular, Cellular & Integrative Physiology GPB Home Area, Tumor Immunology Program at the Jonsson Comprehensive Cancer Center (JCCC)

Dr. Pothoulakis’ research program is primarily focused on the role of neuropeptides and hormones in several disease states, including inflammatory bowel disease, Clostridium difficile infection, and irritable bowel syndrome. His recent projects also involve characterization of neuropeptide-microRNA dependent signaling mechanisms that modulate development of colitis and inflammatory bowel disease. In 2005, Dr. Pothoulakis received an honorary degree from Harvard University and he is the recipient of the “Janssen Award in Basic Research in Gastrointestinal Motility” by the American Gastroenterological Association for his discoveries and insights into the function of gastrointestinal neuropeptides. In 2017 he also received the Mentor Award from the Cellular and Molecular Gastroenterology Section of the American Gastroenterological Association. Dr. Pothoulakis’ research projects have been supported by grants from the National Institutes of Health, the Broad Foundation, The Martin Blinder Foundation for Crohn’s Disease, and the Knapp Foundation.


A selected list of publications:

Koukos Georgios, Polytarchou Christos, Kaplan Jess L, Morley-Fletcher Alessio, Gras-Miralles Beatriz, Kokkotou Efi, Baril-Dore Mariah, Pothoulakis Charalabos, Winter Harland S, Iliopoulos Dimitrios   MicroRNA-124 Regulates STAT3 Expression and Is Down-regulated in Colon Tissues of Pediatric Patients With Ulcerative Colitis Gastroenterology, 2013; 145(4): 842-852.e2.
Hing Tressia C, Ho Samantha, Shih David Q, Ichikawa Ryan, Cheng Michelle, Chen Jeremy, Chen Xinhua, Law Ivy, Najarian Robert, Kelly Ciaran P, Gallo Richard L, Targan Stephan R, Pothoulakis Charalabos, Koon Hon Wai   The antimicrobial peptide cathelicidin modulates Clostridium difficile-associated colitis and toxin A-mediated enteritis in mice Gut, 2013; 62(9): 1295-305.
Koon Hon Wai, Shih David Q, Hing Tressia C, Yoo Jun Hwan, Ho Samantha, Chen Xinhua, Kelly Ciarán P, Targan Stephan R, Pothoulakis Charalabos   Human monoclonal antibodies against Clostridium difficile toxins A and B inhibit inflammatory and histologic responses to the toxins in human colon and peripheral blood monocytes Antimicrobial agents and chemotherapy, 2013; 57(7): 3214-23.
Ho Samantha, Pothoulakis Charalabos, Koon Hon Wai   Antimicrobial peptides and colitis Current pharmaceutical design, 2013; 19(1): 40-7.
Tuominen Iina, Al-Rabadi Leina, Stavrakis Dimitris, Karagiannides Iordanis, Pothoulakis Charalabos, Bugni James M   Diet-induced obesity promotes colon tumor development in azoxymethane-treated mice PloS one, 2013; 8(4): e60939.