Michael E. Jung, Ph.D.

Laboratory Address:
Mol Sci Bldg 3210

Work Address:
Mol Sci Bldg 3505A

Affiliations
Affiliations
Director, Bioscience Synthetic Chemistry
Distinguished Professor, Chemistry and Biochemistry, Organic Chemistry
Member, Basic/Translational Research, Jonsson Comprehensive Cancer Center, California NanoSystems Institute, Molecular Biology Institute
Adjunct Faculty, Molecular & Medical Pharmacology
Researcher, Chemical Biology, Organic, Synthesis
Hospital Affiliations:
Medicinal Chemistry
Biography

Mike Jung received his Bachelor of Arts in 1969 from Rice University, doing research with Richard Turner, and then his PhD in 1973 from Columbia, where he worked with Gilbert Stork. After a one-year NATO postdoctoral fellowship with Albert Eschenmoser at the ETH in Zurich, he joined the faculty at UCLA in 1974. He has risen through the ranks at UCLA and is now a Distinguished Professor of Chemistry. He has served as a reviewer of proposals for various organizations, e.g., NSF, PRF, NIH Medicinal Chemistry Study Section, Research Corporation and others. He is on the Scientific Advisory Boards of several pharmaceutical firms and consults currently for more than 20 industrial laboratories in both the biotech and big pharma settings. Professor Jung is an authority on synthetic organic and medicinal chemistry and has more than 25 patents arising from both his consulting activities and his own research. His current interests include the easy preparation of hindered systems via both Diels-Alder reactions using a new mixed Lewis acid catalyst and via an unusual formal [3,3]-sigmatropic rearrangement. He has also pioneered the use of epoxide rearrangements in synthesis (e.g., the non-aldol aldol) and has investigated new types of gem-disubstituent effects in synthesis. He has published more than 250 articles in refereed journals and has given over 470 lectures on his research, including lectures in German and French. Finally one of his recent compounds is in Phase 1/2a clinical trials for the treatment of hormone refractory prostate cancer.

Publications
Xing Yanpeng, Zuo Jun, Krogstad Paul, Jung Michael E Synthesis and Structure-Activity Relationship (SAR) Studies of Novel Pyrazolopyridine Derivatives as Inhibitors of Enterovirus Replication. Journal of medicinal chemistry. 2018; 61(4): 1688-1703.
Cinkornpumin Jessica, Roos Martina, Nguyen L, Liu Xiaoguang, Gaeta Xavier, Lin S, Chan David N, Liu A, Gregory Richard I, Jung Michael E, Chute John, Zhu Hao, Lowry William E A small molecule screen to identify regulators of let-7 targets. Scientific Reports. 2017; 7(1): 15973.
Micewicz Ewa D, Kim Kwanghee, Iwamoto Keisuke S, Ratikan Josephine A, Cheng Genhong, Boxx Gayle M, Damoiseaux Robert D, Whitelegge Julian P, Ruchala Piotr, Nguyen Christine, Purbey Prabhat, Loo Joseph, Deng Gang, Jung Michael E, Sayre James W, Norris Andrew J, Schaue Dörthe, McBride William H 4-(Nitrophenylsulfonyl)piperazines mitigate radiation damage to multiple tissues. PloS one. 2017; 12(7): e0181577.
Lee Jihye, Shi Yijiang, Vega Mario, Yang Yonghui, Gera Joseph, Jung Michael E, Lichtenstein Alan Structure-activity relationship study of small molecule inhibitors of the DEPTOR-mTOR interaction. Bioorganic & medicinal chemistry letters. 2017; 27(20): 4714-4724.
Chan Albert H, Yi Sung Wook, Weiner Ethan M, Amer Brendan R, Sue Christopher K, Wereszczynski Jeff, Dillen Carly A, Senese Silvia, Torres Jorge Z, McCammon J Andrew, Miller Lloyd S, Jung Michael E, Clubb Robert T NMR structure-based optimization of Staphylococcus aureus sortase A pyridazinone inhibitors. Chemical biology & drug design. 2017; 90(3): 327-344.
Østergaard Michael E, Nichols Josh, Dwight Timothy A, Lima Walt, Jung Michael E, Swayze Eric E, Seth Punit P Fluorinated Nucleotide Modifications Modulate Allele Selectivity of SNP-Targeting Antisense Oligonucleotides. Molecular therapy. Nucleic acids. 2017; 7(7): 20-30.
Benavides-Serrato Angelica, Lee Jihye, Holmes Brent, Landon Kenna A, Bashir Tariq, Jung Michael E, Lichtenstein Alan, Gera Joseph Specific blockade of Rictor-mTOR association inhibits mTORC2 activity and is cytotoxic in glioblastoma. PloS one. 2017; 12(4): e0176599.
Balmer Bethany F, Powers Rachel L, Zhang Ting-Hu, Lee Jihye, Vigant Frederic, Lee Benhur, Jung Michael E, Purcell Maureen K, Snekvik Kevin, Aguilar Hector C Inhibition of an Aquatic Rhabdovirus Demonstrates Promise of a Broad-Spectrum Antiviral for Use in Aquaculture. Journal of virology. 2017; 91(4): 301-306.
Jung Michael E, Sun Daniel L, Dwight Timothy A, Yu Peiyuan, Li Wei, Houk K N Synthesis of 2-Ethenylcyclopropyl Aryl Ketones via Intramolecular SN2-like Displacement of an Ester. Organic letters. 2016; 18(19): 5138-5141.
Shi Yuan, Daniels-Wells Tracy R, Frost Patrick, Lee Jihye, Finn Richard S, Bardeleben Carolyne, Penichet Manuel L, Jung Michael E, Gera Joseph, LIchtenstein Alan Cytotoxic Properties of a DEPTOR-mTOR Inhibitor in Multiple Myeloma Cells. Cancer Research. 2016; 76(19): 5822-5831.
Jacobitz Alex W, Naziga Emmanuel B, Yi Sung Wook, McConnell Scott A, Peterson Robert, Jung Michael E, Clubb Robert T, Wereszczynski Jeff The "Lid" in the Streptococcus pneumoniae SrtC1 Sortase Adopts a Rigid Structure that Regulates Substrate Access to the Active Site. The journal of physical chemistry. B. 2016; 120(33): 8302-12.
Holmes Brent, Lee Jihye, Landon Kenna A, Benavides-Serrato Angelica, Bashir Tariq, Jung Michael E, Lichtenstein Alan, Gera Joseph Mechanistic Target of Rapamycin (mTOR) Inhibition Synergizes with Reduced Internal Ribosome Entry Site (IRES)-mediated Translation of Cyclin D1 and c-MYC mRNAs to Treat Glioblastoma. The Journal of biological chemistry. 2016; 291(27): 14146-59.
Chen Jane Y, Tran Conny, Hwang Lin, Deng Gang, Jung Michael E, Faull Kym F, Levine Michael S, Cepeda Carlos Partial Amelioration of Peripheral and Central Symptoms of Huntington's Disease via Modulation of Lipid Metabolism. Journal of Huntington's disease. 2016; 5(1): 65-81.
Jung Michael E, Roberts Courtney A, Perez Felix, Pham Hung V, Zou Lufeng, Houk K N Thermodynamic Control of Isomerizations of Bicyclic Radicals: Interplay of Ring Strain and Radical Stabilization. Organic letters. 2016; 18(1): 32-5.
Chan Albert H, Yi Sung Wook, Terwilliger Austen L, Maresso Anthony W, Jung Michael E, Clubb Robert T Structure of the Bacillus anthracis Sortase A Enzyme Bound to Its Sorting Signal: A FLEXIBLE AMINO-TERMINAL APPENDAGE MODULATES SUBSTRATE ACCESS. The Journal of biological chemistry. 2015; 290(42): 25461-74.
Fu Xudong, Chin Randall M, Vergnes Laurent, Hwang Heejun, Deng Gang, Xing Yanpeng, Pai Melody Y, Li Sichen, Ta Lisa, Fazlollahi Farbod, Chen Chuo, Prins Robert M, Teitell Michael A, Nathanson David A, Lai Albert, Faull Kym F, Jiang Meisheng, Clarke Steven G, Cloughesy Timothy F, Graeber Thomas G, Braas Daniel, Christofk Heather R, Jung Michael E, Reue Karen, Huang Jing 2-Hydroxyglutarate Inhibits ATP Synthase and mTOR Signaling. Cell metabolism. 2015; 22(3): 508-15.
Jung Michael E, Chamberlain Brian T, Koch Pierre, Niazi Kayvan R Synthesis and Bioactivity of a Brasilicardin A Analogue Featuring a Simplified Core. Organic letters. 2015; 17(14): 3608-11.
Evdokimov Nikolai M, Clark Peter M, Flores Graciela, Chai Timothy, Faull Kym F, Phelps Michael E, Witte Owen N, Jung Michael E Development of 2-Deoxy-2-[18F]fluororibose for Positron Emission Tomography Imaging Liver Function in Vivo. The Journal of Medicinal Chemistry. 2015; 58(14): 5538-5547.
Escamilla Jemima, Schokrpur Shiruyeh, Liu Connie, Priceman Saul J, Moughon Diana, Jiang Ziyue, Pouliot Frederic, Magyar Clara, Sung James L, Xu Jingying, Deng Gang, West Brian L, Bollag Gideon, Fradet Yves, Lacombe Louis, Jung Michael E, Huang Jiaoti, Wu Lily CSF1 receptor targeting in prostate cancer reverses macrophage-mediated resistance to androgen blockade therapy. Cancer research. 2015; 75(6): 950-62.
Nair Jayaprakash K, Willoughby Jennifer L S, Chan Amy, Charisse Klaus, Alam Md Rowshon, Wang Qianfan, Hoekstra Menno, Kandasamy Pachamuthu, Kel'in Alexander V, Milstein Stuart, Taneja Nate, O'Shea Jonathan, Shaikh Sarfraz, Zhang Ligang, van der Sluis Ronald J, Jung Michael E, Akinc Akin, Hutabarat Renta, Kuchimanchi Satya, Fitzgerald Kevin, Zimmermann Tracy, van Berkel Theo J C, Maier Martin A, Rajeev Kallanthottathil G, Manoharan Muthiah Multivalent N-acetylgalactosamine-conjugated siRNA localizes in hepatocytes and elicits robust RNAi-mediated gene silencing. Journal of the American Chemical Society. 2014; 136(49): 16958-61.
Nomme Julian, Li Zheng, Gipson Raymond M, Wang Jue, Armijo Amanda L, Le Thuc, Poddar Soumya, Smith Tony, Santarsiero Bernard D, Nguyen Hien-Anh, Czernin Johannes, Alexandrova Anastassia N, Jung Michael E, Radu Caius G, Lavie Arnon Structure-guided development of deoxycytidine kinase inhibitors with nanomolar affinity and improved metabolic stability. Journal of medicinal chemistry. 2014; 57(22): 9480-94.
Hong Cynthia, Marshall Stephanie M, McDaniel Allison L, Graham Mark, Layne Joseph D, Cai Lei, Scotti Elena, Boyadjian Rima, Kim Jason, Chamberlain Brian T, Tangirala Rajendra K, Jung Michael E, Fong Loren, Lee Richard, Young Stephen G, Temel Ryan E, Tontonoz Peter The LXR-Idol axis differentially regulates plasma LDL levels in primates and mice. Cell metabolism. 2014; 20(5): 910-918.
Jung Michael E, Lee Gloria S Synthesis of Highly Substituted Adamantanones from Bicyclo[3.3.1]nonanes. The Journal of Organic Chemistry. 2014; 79(21): 10547-10552.
Østergaard Michael E, Dwight Timothy, Berdeja Andres, Swayze Eric E, Jung Michael E, Seth Punit P Comparison of duplex stabilizing properties of 2'-fluorinated nucleic acid analogues with furanose and non-furanose sugar rings. The Journal of organic chemistry. 2014; 79(18): 8877-81.
Jung Michael E, Dwight Timothy A, Vigant Frederic, Østergaard Michael E, Swayze Eric E, Seth Punit P Synthesis and duplex-stabilizing properties of fluorinated N-methanocarbathymidine analogues locked in the C3'-endo conformation. Angewandte Chemie (International ed. in English). 2014; 53(37): 9893-7.
Montgomery Scott R, Nargizyan Taya, Meliton Vicente, Nachtergaele Sigrid, Rohatgi Rajat, Stappenbeck Frank, Jung Michael E, Johnson Jared S, Aghdasi Bayan, Tian Haijun, Weintraub Gil, Inoue Hirokazu, Atti Elisa, Tetradis Sotirios, Pereira Renata C, Hokugo Akishige, Alobaidaan Raed, Tan Yanlin, Hahn Theodor J, Wang Jeffrey C, Parhami Farhad A novel osteogenic oxysterol compound for therapeutic development to promote bone growth: activation of hedgehog signaling and osteogenesis through smoothened binding. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 2014; 29(8): 1872-85.
Clark Peter M, Flores Graciela, Evdokimov Nikolai M, McCracken Melissa N, Chai Timothy, Nair-Gill Evan, O'Mahony Fiona, Beaven Simon W, Faull Kym F, Phelps Michael E, Jung Michael E, Witte Owen N Positron emission tomography probe demonstrates a striking concentration of ribose salvage in the liver. Proceedings of the National Academy of Sciences of the United States of America. 2014; 111(28): E2866-74.
Chin Randall M, Pai Melody Y, Fu Xudong, Diep Simon, Jung Gwanghyun, Clarke Catherine F, Frand Alison R, Jung Michael E, Huang Jing The metabolite alpha-ketoglutarate extends lifespan by inhibiting the ATP synthase and TOR. Nature. 2014; 510(7505): 397-401.
Sallam Tamer, Ito Ayaka, Rong Xin, Kim Jason, van Stijn Caroline, Chamberlain Brian T, Jung Michael E, Chao Lily C, Jones Marius, Gilliland Thomas, Wu XiaoHui, Su Grace L, Tangirala Rajendra K, Tontonoz Peter, Hong Cynthia The macrophage LBP gene is an LXR target that promotes macrophage survival and atherosclerosis. Journal of lipid research. 2014; 55(6): 1120-30.
Evdokimov Nikolai M, Flores Graciela, Clark Peter M, Phelps Michael E, Witte Owen N, Jung Michael E 5-(2-[18 F]Fluoroethyl)-4-Methylthiazole Probe For Positron Emission Tomography Of The Central Nervous System. Chemistry of Heterocyclic Compounds. 2014; 50(2): 303-307.
Jung Michael E, Lee Gloria S, Pham Hung V, Houk K N Palladium hydride promoted stereoselective isomerization of unactivated di(exo)methylenes to endocyclic dienes. Organic letters. 2014; 16(9): 2382-5.
Jung Michael E, Deng Gang Synthesis of α-diketones from alkylaryl- and diarylalkynes using mercuric salts. Organic letters. 2014; 16(8): 2142-5.
Nathanson David A, Armijo Amanda L, Tom Michelle, Li Zheng, Dimitrova Elizabeth, Austin Wayne R, Nomme Julian, Campbell Dean O, Ta Lisa, Le Thuc M, Lee Jason T, Darvish Ryan, Gordin Ari, Wei Liu, Liao Hsiang-I, Wilks Moses, Martin Colette, Sadeghi Saman, Murphy Jennifer M, Boulos Nidal, Phelps Michael E, Faull Kym F, Herschman Harvey R, Jung Michael E, Czernin Johannes, Lavie Arnon, Radu Caius G Co-targeting of convergent nucleotide biosynthetic pathways for leukemia eradication. The Journal of experimental medicine. 2014; 211(3): 473-86.
Jacobitz Alex W, Wereszczynski Jeff, Yi Sung Wook, Amer Brendan R, Huang Grace L, Nguyen Angelyn V, Sawaya Michael R, Jung Michael E, McCammon J Andrew, Clubb Robert T Structural and computational studies of the Staphylococcus aureus sortase B-substrate complex reveal a substrate-stabilized oxyanion hole. The Journal of biological chemistry. 2014; 289(13): 8891-902.
Vigant Frederic, Hollmann Axel, Lee Jihye, Santos Nuno C, Jung Michael E, Lee Benhur The rigid amphipathic fusion inhibitor dUY11 acts through photosensitization of viruses. Journal of virology. 2014; 88(3): 1849-53.
Jung Michael E, Chamberlain Brian T, Ho Chi-Lee C, Gillespie Eugene J, Bradley Kenneth A Structure–Activity Relationship of Semicarbazone EGA Furnishes Photoaffinity Inhibitors of Anthrax Toxin Cellular Entry. ACS Medicinal Chemistry Letters. 2014; 5(4): 363-367.
Kim Kyun-Do, Srikanth Sonal, Tan Yossan-Var, Yee Ma-Khin, Jew Marcus, Damoiseaux Robert, Jung Michael E, Shimizu Saki, An Dong Sung, Ribalet Bernard, Waschek James A, Gwack Yousang Calcium signaling via Orai1 is essential for induction of the nuclear orphan receptor pathway to drive Th17 differentiation. Journal of immunology (Baltimore, Md. : 1950). 2014; 192(1): 110-22.
Yan Xinmin, Lee Sangderk, Gugiu B Gabriel, Koroniak Lukasz, Jung Michael E, Berliner Judith, Cheng Jinluo, Li Rongsong Fatty acid epoxyisoprostane E2 stimulates an oxidative stress response in endothelial cells. Biochemical and biophysical research communications. 2014; 444(1): 69-74.
Janzen Deanna M, Paik Daniel Y, Rosales Miguel A, Yep Brian, Cheng Donghui, Witte Owen N, Kayadibi Huseyin, Ryan Christopher M, Jung Michael E, Faull Kym, Memarzadeh Sanaz Low levels of circulating estrogen sensitize PTEN-null endometrial tumors to PARP inhibition in vivo. Molecular cancer therapeutics. 2013; 12(12): 2917-28.
Gillespie Eugene J, Ho Chi-Lee C, Balaji Kavitha, Clemens Daniel L, Deng Gang, Wang Yao E, Elsaesser Heidi J, Tamilselvam Batcha, Gargi Amandeep, Dixon Shandee D, France Bryan, Chamberlain Brian T, Blanke Steven R, Cheng Genhong, de la Torre Juan Carlos, Brooks David G, Jung Michael E, Colicelli John, Damoiseaux Robert, Bradley Kenneth A Selective inhibitor of endosomal trafficking pathways exploited by multiple toxins and viruses. Proceedings of the National Academy of Sciences of the United States of America. 2013; 110(50): E4904-12.
Zhong Wei, Springstead James R, Al-Mubarak Ramea, Lee Sangderk, Li Rongsong, Emert Benjamin, Berliner Judith A, Jung Michael E An epoxyisoprostane is a major regulator of endothelial cell function. Journal of medicinal chemistry. 2013; 56(21): 8521-32.
Rong Xin, Albert Carolyn J, Hong Cynthia, Duerr Mark A, Chamberlain Brian T, Tarling Elizabeth J, Ito Ayaka, Gao Jie, Wang Bo, Edwards Peter A, Jung Michael E, Ford David A, Tontonoz Peter LXRs regulate ER stress and inflammation through dynamic modulation of membrane phospholipid composition. Cell metabolism. 2013; 18(5): 685-97.
Chan Albert H, Wereszczynski Jeff, Amer Brendan R, Yi Sung Wook, Jung Michael E, McCammon J Andrew, Clubb Robert T Discovery of Staphylococcus aureus sortase A inhibitors using virtual screening and the relaxed complex scheme. Chemical biology & drug design. 2013; 82(4): 418-28.
Majer Jakub, Jurczak Janusz, Kwiatkowski Piotr, Cotarca Livius, Jung Michael E, Caille Jean-Claude Asymmetric synthesis of (−)-bissetone via a highly enantioselective hetero-Diels–Alder reaction. Tetrahedron. 2013; 69(30): 8463-8469.
Jung Michael E, Trzoss Michael, Tsay James M, Weiss Shimon A Bis(phosphine)-Modified Peptide Ligand for Stable and Luminescent Quantum Dots in Aqueous Media. Synthesis. 2013; 45(17): 2426-2430.
Du Liutao, Jung Michael E, Damoiseaux Robert, Completo Gladys, Fike Francesca, Ku Jin-Mo, Nahas Shareef, Piao Cijing, Hu Hailiang, Gatti Richard A A new series of small molecular weight compounds induce read through of all three types of nonsense mutations in the ATM gene. Molecular therapy : the journal of the American Society of Gene Therapy. 2013; 21(9): 1653-60.
Murphy Jennifer M, Armijo Amanda L, Nomme Julian, Lee Chi Hang, Smith Quentin A, Li Zheng, Campbell Dean O, Liao Hsiang-I, Nathanson David A, Austin Wayne R, Lee Jason T, Darvish Ryan, Wei Liu, Wang Jue, Su Ying, Damoiseaux Robert, Sadeghi Saman, Phelps Michael E, Herschman Harvey R, Czernin Johannes, Alexandrova Anastassia N, Jung Michael E, Lavie Arnon, Radu Caius G Development of new deoxycytidine kinase inhibitors and noninvasive in vivo evaluation using positron emission tomography. Journal of medicinal chemistry. 2013; 56(17): 6696-708.
Jung Michael E, Guzaev Mikhail Studies toward the enantiospecific total synthesis of rhodexin A. The Journal of organic chemistry. 2013; 78(15): 7518-26.
Williams Kevin J, Argus Joseph P, Zhu Yue, Wilks Moses Q, Marbois Beth N, York Autumn G, Kidani Yoko, Pourzia Alexandra L, Akhavan David, Lisiero Dominique N, Komisopoulou Evangelia, Henkin Amy H, Soto Horacio, Chamberlain Brian T, Vergnes Laurent, Jung Michael E, Torres Jorge Z, Liau Linda M, Christofk Heather R, Prins Robert M, Mischel Paul S, Reue Karen, Graeber Thomas G, Bensinger Steven J An essential requirement for the SCAP/SREBP signaling axis to protect cancer cells from lipotoxicity. Cancer research. 2013; 73(9): 2850-62.
Vigant Frederic, Lee Jihye, Hollmann Axel, Tanner Lukas B, Akyol Ataman Zeynep, Yun Tatyana, Shui Guanghou, Aguilar Hector C, Zhang Dong, Meriwether David, Roman-Sosa Gleyder, Robinson Lindsey R, Juelich Terry L, Buczkowski Hubert, Chou Sunwen, Castanho Miguel A R B, Wolf Mike C, Smith Jennifer K, Banyard Ashley, Kielian Margaret, Reddy Srinivasa, Wenk Markus R, Selke Matthias, Santos Nuno C, Freiberg Alexander N, Jung Michael E, Lee Benhur A mechanistic paradigm for broad-spectrum antivirals that target virus-cell fusion. PLoS pathogens. 2013; 9(4): e1003297.
Jung Michael E, Perez Felix, Regan Collin F, Yi Sung Wook, Perron Quentin Se-phenyl prop-2-eneselenoate: an ethylene equivalent for Diels-Alder reactions. Angewandte Chemie (International ed. in English). 2013; 52(7): 2060-2.