A selected list of publications:
Cinkornpumin Jessica, Roos Martina, Nguyen L, Liu Xiaoguang, Gaeta Xavier, Lin S, Chan David N, Liu A, Gregory Richard I, Jung Michael E, Chute John, Zhu Hao, Lowry William E
A small molecule screen to identify regulators of let-7 targets
Scientific Reports,
2017; 7(1):
15973.
Micewicz Ewa D, Kim Kwanghee, Iwamoto Keisuke S, Ratikan Josephine A, Cheng Genhong, Boxx Gayle M, Damoiseaux Robert D, Whitelegge Julian P, Ruchala Piotr, Nguyen Christine, Purbey Prabhat, Loo Joseph, Deng Gang, Jung Michael E, Sayre James W, Norris Andrew J, Schaue Dörthe, McBride William H
4-(Nitrophenylsulfonyl)piperazines mitigate radiation damage to
multiple tissues
PloS one,
2017; 12(7):
e0181577.
Chan Albert H, Yi Sung Wook, Weiner Ethan M, Amer Brendan R, Sue Christopher K, Wereszczynski Jeff, Dillen Carly A, Senese Silvia, Torres Jorge Z, McCammon J Andrew, Miller Lloyd S, Jung Michael E, Clubb Robert T
NMR structure-based optimization of Staphylococcus aureus sortase A
pyridazinone inhibitors
Chemical biology & drug design,
2017; 90(3):
327-344.
Balmer Bethany F, Powers Rachel L, Zhang Ting-Hu, Lee Jihye, Vigant Frederic, Lee Benhur, Jung Michael E, Purcell Maureen K, Snekvik Kevin, Aguilar Hector C
Inhibition of an Aquatic Rhabdovirus Demonstrates Promise of a
Broad-Spectrum Antiviral for Use in Aquaculture
Journal of virology,
2017; 91(4):
301-306.
Shi Yuan, Daniels-Wells Tracy R, Frost Patrick, Lee Jihye, Finn Richard S, Bardeleben Carolyne, Penichet Manuel L, Jung Michael E, Gera Joseph, LIchtenstein Alan
Cytotoxic Properties of a DEPTOR-mTOR Inhibitor in Multiple Myeloma Cells
Cancer Research,
2016; 76(19):
5822-5831.
Fu Xudong, Chin Randall M, Vergnes Laurent, Hwang Heejun, Deng Gang, Xing Yanpeng, Pai Melody Y, Li Sichen, Ta Lisa, Fazlollahi Farbod, Chen Chuo, Prins Robert M, Teitell Michael A, Nathanson David A, Lai Albert, Faull Kym F, Jiang Meisheng, Clarke Steven G, Cloughesy Timothy F, Graeber Thomas G, Braas Daniel, Christofk Heather R, Jung Michael E, Reue Karen, Huang Jing
2-Hydroxyglutarate Inhibits ATP Synthase and mTOR Signaling
Cell metabolism,
2015; 22(3):
508-15.
Escamilla Jemima, Schokrpur Shiruyeh, Liu Connie, Priceman Saul J, Moughon Diana, Jiang Ziyue, Pouliot Frederic, Magyar Clara, Sung James L, Xu Jingying, Deng Gang, West Brian L, Bollag Gideon, Fradet Yves, Lacombe Louis, Jung Michael E, Huang Jiaoti, Wu Lily
CSF1 receptor targeting in prostate cancer reverses
macrophage-mediated resistance to androgen blockade therapy
Cancer research,
2015; 75(6):
950-62.
Nair Jayaprakash K, Willoughby Jennifer L S, Chan Amy, Charisse Klaus, Alam Md Rowshon, Wang Qianfan, Hoekstra Menno, Kandasamy Pachamuthu, Kel'in Alexander V, Milstein Stuart, Taneja Nate, O'Shea Jonathan, Shaikh Sarfraz, Zhang Ligang, van der Sluis Ronald J, Jung Michael E, Akinc Akin, Hutabarat Renta, Kuchimanchi Satya, Fitzgerald Kevin, Zimmermann Tracy, van Berkel Theo J C, Maier Martin A, Rajeev Kallanthottathil G, Manoharan Muthiah
Multivalent N-acetylgalactosamine-conjugated siRNA localizes in
hepatocytes and elicits robust RNAi-mediated gene silencing
Journal of the American Chemical Society,
2014; 136(49):
16958-61.
Nomme Julian, Li Zheng, Gipson Raymond M, Wang Jue, Armijo Amanda L, Le Thuc, Poddar Soumya, Smith Tony, Santarsiero Bernard D, Nguyen Hien-Anh, Czernin Johannes, Alexandrova Anastassia N, Jung Michael E, Radu Caius G, Lavie Arnon
Structure-guided development of deoxycytidine kinase inhibitors with
nanomolar affinity and improved metabolic stability
Journal of medicinal chemistry,
2014; 57(22):
9480-94.
Hong Cynthia, Marshall Stephanie M, McDaniel Allison L, Graham Mark, Layne Joseph D, Cai Lei, Scotti Elena, Boyadjian Rima, Kim Jason, Chamberlain Brian T, Tangirala Rajendra K, Jung Michael E, Fong Loren, Lee Richard, Young Stephen G, Temel Ryan E, Tontonoz Peter
The LXR-Idol axis differentially regulates plasma LDL levels in
primates and mice
Cell metabolism,
2014; 20(5):
910-918.
Montgomery Scott R, Nargizyan Taya, Meliton Vicente, Nachtergaele Sigrid, Rohatgi Rajat, Stappenbeck Frank, Jung Michael E, Johnson Jared S, Aghdasi Bayan, Tian Haijun, Weintraub Gil, Inoue Hirokazu, Atti Elisa, Tetradis Sotirios, Pereira Renata C, Hokugo Akishige, Alobaidaan Raed, Tan Yanlin, Hahn Theodor J, Wang Jeffrey C, Parhami Farhad
A novel osteogenic oxysterol compound for therapeutic development to
promote bone growth: activation of hedgehog signaling and osteogenesis
through smoothened binding
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research,
2014; 29(8):
1872-85.
Clark Peter M, Flores Graciela, Evdokimov Nikolai M, McCracken Melissa N, Chai Timothy, Nair-Gill Evan, O'Mahony Fiona, Beaven Simon W, Faull Kym F, Phelps Michael E, Jung Michael E, Witte Owen N
Positron emission tomography probe demonstrates a striking
concentration of ribose salvage in the liver
Proceedings of the National Academy of Sciences of the United States of America,
2014; 111(28):
E2866-74.
Sallam Tamer, Ito Ayaka, Rong Xin, Kim Jason, van Stijn Caroline, Chamberlain Brian T, Jung Michael E, Chao Lily C, Jones Marius, Gilliland Thomas, Wu XiaoHui, Su Grace L, Tangirala Rajendra K, Tontonoz Peter, Hong Cynthia
The macrophage LBP gene is an LXR target that promotes macrophage
survival and atherosclerosis
Journal of lipid research,
2014; 55(6):
1120-30.
Nathanson David A, Armijo Amanda L, Tom Michelle, Li Zheng, Dimitrova Elizabeth, Austin Wayne R, Nomme Julian, Campbell Dean O, Ta Lisa, Le Thuc M, Lee Jason T, Darvish Ryan, Gordin Ari, Wei Liu, Liao Hsiang-I, Wilks Moses, Martin Colette, Sadeghi Saman, Murphy Jennifer M, Boulos Nidal, Phelps Michael E, Faull Kym F, Herschman Harvey R, Jung Michael E, Czernin Johannes, Lavie Arnon, Radu Caius G
Co-targeting of convergent nucleotide biosynthetic pathways for
leukemia eradication
The Journal of experimental medicine,
2014; 211(3):
473-86.
Jacobitz Alex W, Wereszczynski Jeff, Yi Sung Wook, Amer Brendan R, Huang Grace L, Nguyen Angelyn V, Sawaya Michael R, Jung Michael E, McCammon J Andrew, Clubb Robert T
Structural and computational studies of the Staphylococcus aureus
sortase B-substrate complex reveal a substrate-stabilized oxyanion
hole
The Journal of biological chemistry,
2014; 289(13):
8891-902.
Kim Kyun-Do, Srikanth Sonal, Tan Yossan-Var, Yee Ma-Khin, Jew Marcus, Damoiseaux Robert, Jung Michael E, Shimizu Saki, An Dong Sung, Ribalet Bernard, Waschek James A, Gwack Yousang
Calcium signaling via Orai1 is essential for induction of the nuclear
orphan receptor pathway to drive Th17 differentiation
Journal of immunology (Baltimore, Md. : 1950),
2014; 192(1):
110-22.
Janzen Deanna M, Paik Daniel Y, Rosales Miguel A, Yep Brian, Cheng Donghui, Witte Owen N, Kayadibi Huseyin, Ryan Christopher M, Jung Michael E, Faull Kym, Memarzadeh Sanaz
Low levels of circulating estrogen sensitize PTEN-null endometrial
tumors to PARP inhibition in vivo
Molecular cancer therapeutics,
2013; 12(12):
2917-28.
Gillespie Eugene J, Ho Chi-Lee C, Balaji Kavitha, Clemens Daniel L, Deng Gang, Wang Yao E, Elsaesser Heidi J, Tamilselvam Batcha, Gargi Amandeep, Dixon Shandee D, France Bryan, Chamberlain Brian T, Blanke Steven R, Cheng Genhong, de la Torre Juan Carlos, Brooks David G, Jung Michael E, Colicelli John, Damoiseaux Robert, Bradley Kenneth A
Selective inhibitor of endosomal trafficking pathways exploited by
multiple toxins and viruses
Proceedings of the National Academy of Sciences of the United States of America,
2013; 110(50):
E4904-12.
Rong Xin, Albert Carolyn J, Hong Cynthia, Duerr Mark A, Chamberlain Brian T, Tarling Elizabeth J, Ito Ayaka, Gao Jie, Wang Bo, Edwards Peter A, Jung Michael E, Ford David A, Tontonoz Peter
LXRs regulate ER stress and inflammation through dynamic modulation of
membrane phospholipid composition
Cell metabolism,
2013; 18(5):
685-97.
Du Liutao, Jung Michael E, Damoiseaux Robert, Completo Gladys, Fike Francesca, Ku Jin-Mo, Nahas Shareef, Piao Cijing, Hu Hailiang, Gatti Richard A
A new series of small molecular weight compounds induce read through
of all three types of nonsense mutations in the ATM gene
Molecular therapy : the journal of the American Society of Gene Therapy,
2013; 21(9):
1653-60.
Murphy Jennifer M, Armijo Amanda L, Nomme Julian, Lee Chi Hang, Smith Quentin A, Li Zheng, Campbell Dean O, Liao Hsiang-I, Nathanson David A, Austin Wayne R, Lee Jason T, Darvish Ryan, Wei Liu, Wang Jue, Su Ying, Damoiseaux Robert, Sadeghi Saman, Phelps Michael E, Herschman Harvey R, Czernin Johannes, Alexandrova Anastassia N, Jung Michael E, Lavie Arnon, Radu Caius G
Development of new deoxycytidine kinase inhibitors and noninvasive in
vivo evaluation using positron emission tomography
Journal of medicinal chemistry,
2013; 56(17):
6696-708.
Williams Kevin J, Argus Joseph P, Zhu Yue, Wilks Moses Q, Marbois Beth N, York Autumn G, Kidani Yoko, Pourzia Alexandra L, Akhavan David, Lisiero Dominique N, Komisopoulou Evangelia, Henkin Amy H, Soto Horacio, Chamberlain Brian T, Vergnes Laurent, Jung Michael E, Torres Jorge Z, Liau Linda M, Christofk Heather R, Prins Robert M, Mischel Paul S, Reue Karen, Graeber Thomas G, Bensinger Steven J
An essential requirement for the SCAP/SREBP signaling axis to protect
cancer cells from lipotoxicity
Cancer research,
2013; 73(9):
2850-62.
Vigant Frederic, Lee Jihye, Hollmann Axel, Tanner Lukas B, Akyol Ataman Zeynep, Yun Tatyana, Shui Guanghou, Aguilar Hector C, Zhang Dong, Meriwether David, Roman-Sosa Gleyder, Robinson Lindsey R, Juelich Terry L, Buczkowski Hubert, Chou Sunwen, Castanho Miguel A R B, Wolf Mike C, Smith Jennifer K, Banyard Ashley, Kielian Margaret, Reddy Srinivasa, Wenk Markus R, Selke Matthias, Santos Nuno C, Freiberg Alexander N, Jung Michael E, Lee Benhur
A mechanistic paradigm for broad-spectrum antivirals that target
virus-cell fusion
PLoS pathogens,
2013; 9(4):
e1003297.