Affiliations

Professor, Anesthesiology

Member, Molecular Medicine, CTSI, Cell & Developmental Biology GPB Home Area, Center for Duchenne Muscular Dystrophy, Genetics & Genomics GPB Home Area, Molecular, Cellular & Integrative Physiology GPB Home Area

Faculty, Cardiovascular Research Laboratory, Cardiology

The Vondriska Lab at UCLA investigates epigenomic mechanisms of cardiovascular disease. Our systems biology approach marshals genomic, epigenomic and proteomic discovery tools to examine animal models and human populations. Data science and network biology play important roles in our holistic studies of cardiovascular health. Our mission is to discover the basic principles of chromatin biology as well as to understand the causes of cardiovascular disease--to aid in the development of new therapies and cures.

Monte Emma, Rosa-Garrido Manuel, Karbassi Elaheh, Chen Haodong, Lopez Rachel, Rau Christoph D, Wang Jessica, Nelson Stanley F, Wu Yong, Stefani Enrico, Lusis Aldons J, Wang Yibin, Kurdistani Siavash K, Franklin Sarah, Vondriska Thomas M Reciprocal Regulation of the Cardiac Epigenome by Chromatin Structural Proteins Hmgb and Ctcf: IMPLICATIONS FOR TRANSCRIPTIONAL REGULATION. The Journal of biological chemistry. 2016; 291(30): 15428-46. Karbassi Elaheh, Monte Emma, Chapski Douglas J, Lopez Rachel, Rosa Garrido Manuel, Kim Joseph, Wisniewski Nicholas, Rau Christoph D, Wang Jessica J, Weiss James N, Wang Yibin, Lusis Aldons J, Vondriska Thomas M Relationship of Disease-Associated Gene Expression to Cardiac Phenotype is Buffered by Genetic Diversity and Chromatin Regulation. Physiological genomics. 2016; 291(30): physiolgenomics.00035.2016. Chen Haodong, Orozco Luz D, Wang Jessica, Rau Christoph D, Rubbi Liudmilla, Ren Shuxun, Wang Yibin, Pellegrini Matteo, Lusis Aldons J, Vondriska Thomas M DNA Methylation Indicates Susceptibility to Isoproterenol-Induced Cardiac Pathology and Is Associated With Chromatin States. Circulation research. 2016; 118(5): 786-97. Monte Emma, Lopez Rachel, Vondriska Thomas M Not low hanging but still sweet: Metabolic proteomes in cardiovascular disease. Journal of molecular and cellular cardiology. 2016; 90(1): 70-3. Monte Emma, Vondriska Thomas M Epigenomes: the missing heritability in human cardiovascular disease?. Proteomics. Clinical applications. 2014; 8(7-8): 480-7.