A selected list of publications:
Senturia, R., Laganowsky, A., Barr, I., Brooke D. Scheidemantle, B.D., and Guo, F.
Dimerization and heme binding are conserved in amphibian and starfish homologues of the microRNA processing protein DGCR8
PLoS ONE,
2012; 7(7):
e39688.
Download
Gong, M., Chen, Y., Senturia, R., Ulgherait, M., Faller, M., and Guo, F.
Caspases cleave and inhibit the microRNA processing protein DiGeorge Critical Region 8.
Protein Sci,
2012; 21:
797-808.
Barr, I., Smith, A.T., Chen, Y., Senturia, R., Burstyn, J.N., and Guo, F.
Ferric, not ferrous, heme activates RNA-binding protein DGCR8 for primary microRNA processing
Proc. Natl. Acad. Sci. USA,
2012; 109:
1919-1924.
Meer, E.J., Wang, D.O., Kim, S.M., Barr, I., Guo, F., and Martin, K.C.
Identification of a cis-acting element that localizes mRNA to synapses,
Proc. Natl. Acad. Sci. USA,
2012; 109:
4639-4644.
Barr, I., Smith, A.T., Senturia, R., Chen, Y., Scheidemantle, B.D., Burstyn, J.N., and Guo, F.
DiGeorge Critical Region 8 (DGCR8) is a double-cysteine-ligated heme protein
J. Biol. Chem,
2011; 286:
16716-25.
Faller, M., Toso, D., Matsunaga, M., Atanasov, I., Senturia, R., Chen, Y., Zhou, Z.H., and Guo, F.
DGCR8 recognizes primary transcripts of microRNAs through highly cooperative binding and formation of higher-order structures
RNA,
2010; 16:
1570-1583.
Senturia, R., Faller, M., Yin, S., Loo, J.A., Cascio, D., Sawaya, M.R., Hwang, D., Clubb, R.T., and Guo, F.
Structure of the dimerization domain of DiGeorge Critical Region 8
Protein Sci,
2010; 19:
1354-1365.
Faller, M., Matsunaga, M., Yin, S., Loo, J., and Guo, F.
Heme is involved in microRNA processing,
Nat. Struct. Mol. Biol,
2007; 14(1):
23-29.
Download
Guo, F., Gooding, A.R. and Cech, T.R.
Comparison of crystal structure interactions and thermodynamics for stabilizing mutations in the Tetrahymena ribozyme,
RNA,
2006; 12:
387-395.
Download
Weitz, S. H., Gong, M., Barr, I., Weiss, S., and Guo, F.
Processing of microRNA primary transcripts requires heme in mammalian cells
Proc. Natl. Acad. Sci. USA,
2014; 111:
1861-1866.
Quick-Cleveland, J., Jacob, J.P., Weitz, S.H., Shoffner, G., Senturia, R., and Guo, F.
The DGCR8 RNA-binding heme domain recognizes primary microRNAs by clamping the hairpin
Cell Rep,
2014; 7(6):
1994-2005.
Chin, R.M., Fu, X., Pai, M.Y., Vergnes, L., Hwang, H., Deng, G., Diep, S., Lomenick, B., Meli, V.S., Monsalve, G.C., Hu, E., Whelan, S.A., Wang, J.X., Jung, G., Solis, G.M., Fazlollahi, F., Kaweeteerawat, C., Quach, A., Nili, M., Krall, A.S., Godwin, H.A., Chang, H.R., Faull, K.F., Guo, F., Jiang, M., Trauger, S.A., Saghatelian, A., Braas, D., Christofk, H.R., Clarke, C.F., Teitell, M.A., Petrascheck, M., Reue, K., Jung, M.E., Frand, A.R., and Huang, J.
The metabolite α-ketoglutarate extends lifespan by inhibiting ATP synthase and TOR
Nature,
2014; 510:
397-410.
Lal Sneha, Comer Jonathan M, Konduri Purna C, Shah Ajit, Wang Tianyuan, Lewis Anthony, Shoffner Grant, Guo Feng, Zhang Li
Heme promotes transcriptional and demethylase activities of Gis1, a member of the histone demethylase JMJD2/KDM4 family
Nucleic Acids Res,
2018; 46(1):
215-228.
Tayeb-Fligelman Einav, Cheng Xinyi, Tai Christen, Bowler Jeannette T, Griner Sarah, Sawaya Michael R, Seidler Paul M, Jiang Yi Xiao, Lu Jiahui, Rosenberg Gregory M, Salwinski Lukasz, Abskharon Romany, Zee Chih-Te, Hou Ke, Li Yan, Boyer David R, Murray Kevin A, Falcon Genesis, Anderson Daniel H, Cascio Duilio, Saelices Lorena, Damoiseaux Robert, Guo Feng, Eisenberg David S
Inhibition of amyloid formation of the Nucleoprotein of SARS-CoV-2
bioRxiv : the preprint server for biology,
2021; 21(1):
155.
Weitz, S.H., Quick-Cleveland, J., Jacob, J.P., Barr, I., Senturia, R., Koyano, K., Xiao, X., Weiss, S., and Guo, F.
Fe(III) heme sets an activation threshold for processing distinct groups of pri-miRNAs in mammalian cells
bioRxiv,
2020;
.
Download