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Stephen David Cederbaum, M.D.

Mailing Address:
Department of Psychiatry and Biobehavioral Sciences/Pediatrics/Medical Genetics
635 Charles E. Young Dr. South
347 NRB
Mail Code 733222
Los Angeles, CA 90095

Affiliations
Affiliations
Director, Medical Genetics Clinic, Metabolic Clinic
Professor, Pediatrics
Chief Emeritus, Pediatric Genetics
Professor, Human Genetics
Biography

Stephen Cederbaum was born in Brooklyn, NY. After graduating from Midwood High School, he attended Amherst College and received a BA degree with honors in Chemistry. He graduated from NYU School of Medicine in 1964 with honors in Biochemistry and was elected to Alpha Omega Alpha. He was an intern and resident in Internal Medicine at Barnes Hospital and Washington University School of Medicine. After two years at the National Heart Institute in Bethesda, he received medical genetics training at the University of Washington. He has been at UCLA since 1971. He sees patients with genetic and metabolic disorders, has a research laboratory and is active in teaching and training. He is married, has two grown children and lives in Santa Monica, CA.

Publications

A selected list of publications:

Arnold, G.L., Koeberl, D.W., Matern, D., Barshop, B., Braverman, N., Burton, B., Cederbaum, S., Fiegenbaum, A., Garganta, C, Gibson, J., Goodman S.I., Harding, C., Kahler S., Kronn, D., Longo, N. A   Delphi-based consensus clinical practice protocol, for the diagnosis and management of 3-methylcrotonyl CoA carboxylase deficiency. , Mol. Genet. Metab, 2008; 92: 363-370.
Mumenthaler, S.M., Yu, H., Tze, S., Cederbaum, S.D., Pegg, A.E., Seligson, D.B. and Grody W.W.   Differential expression of arginase II in human prostate cancer and its involvement in polyamine synthesis. , Int. J. Oncol, 2008; 32: 357-365.
Crombez, E.A., Cederbaum, S.D., Spector, E., Chan, E., Salazar, D., Neidich, J. and Goodman, S.   Maternal glutaric academia, type I identified by newborn screening, Mol. Genet. Metab, 2008; 94: 132-134.
Deignan, J.L., Livesay, J.C., Pegg, A.E., O’Brien, W.E., Iyer, R.K., Cederbaum, S.D. and Grody, W.W.   Arginase II deficiency alters polyamine homeostasis through the balance of ODC and OAT expression, Amer. J. Physiol, 2007; . 293: C1296-C1301.
Deignan, J.L., Marescau, B., Livesay, J.C., Iyer, R.K., Cederbaum, S.D. and Grody, W.W.   Increased guanidino compounds in brain in a mouse model of hyperargininemia, Mol. Genet. Metab, 2007; .
Levy, H., Burton, B., Cederbaum, S. and Scriver C.   Recommendations for evaluation of responsiveness to tetrahydrobiopterin (BH4) in phenylketonuria and its use in treatment. , Mol. Genet. Metab, 2007; 92: 287-291.
Burton, B.K., Grange, D.K., Milanowski, A., Vockley, G., Feillet, F., Crombez, E.A., Abadie, V., Harding, C.O., Cederbaum, S., Dobbelaere, D., Smith, A. and Dorenbaum, A.   The response of patients with phenylketonuria and elevated serum phenylalanine tp treatment with oral sapropterin (6R-tetrahydrobiopterin): a phase II, multicentre, open-label, screening study, J. Inher. Metab.Dis. , 2007; 30: 700-707.
Deignan J.L., Yoo, P.K., Livesay J.C., Goodman S.I., O'Brien, W.E., Iyer, R.K., Cederbaum, S.D. and Grody, W.W.   "Amino acids in arginase double knockout mice demonstrate ornithine auxotrophy", Mol. Genet. Metab, 2006; 89: 87-96.
Becker-Catania, S.G., Gregory, T.L., Yang, Y., Gau, C-L., de Vellis, J., Cederbaum, S.D. and Iyer, R.K.   "Loss of arginase I results in increased proliferation of neural progenitor cells", J. Neurosci.Res, 2006; 84: 735-746.
Kern, R.M., Yang, Z., Kim, P.S., Grody, W.W., Iyer, R.K. and Cederbaum, S.D.   Arginase induction by sodium phenylbutyrate in mouse tissues and human cell lines. , Mol. Gen. Metab, 2006; 90: 37-41.
Camacho, J.A., Mardach, M.R., Rioseco-Camacho, N.,Ruiz-Pesini, E., Derbeneva, O., Andrade, D., Zaldivar, F., Qu, Y. and Cederbaum, S.D.   Clinical and functional characterization of a human ORNT1mutation (T32R) in the hyperornithinemia-hyperammonemia-homocitrullinuria (HHH) syndrome, Pediatr. Res. , 2006; 60: 423-429.
Schimmenti, L.A., Crombez, E., Schwahn, B.C., Heese, B.A., Wood, T.C., Schroer, R.J., Bentler K., Cederbaum, S., Sarafoglou, K., McCann, M., Rinaldo, P., Matern, D., di San Filippo, C.A., Pasquali, M., Berry, S.A. and Longo, N.   Expanded newborn screening identifies maternal primary carnitine deficiency, Mol. Genet. Metab, 2006; 90: 441-445.
Cederbaum, SD   New frontiers in hereditary metabolic disease: An historical perspective Mol. Genet. Metab, 2006; In press: .
Mardach, M.R., Verity, M.A. and Cederbaum, S.D.   Myocardial carnitine deficiency associated with cardiomyopathy in a child with propionic acidemia, Mol Genet Metab, 2005; 85: 286-290.
Crombez, EA Cederbaum, SD   Hyperargininemia due to liver arginase deficiency Molecular genetics and metabolism. , 2005; 84(3): 243-51.
Cederbaum, SD Yu, H Grody, WW Kern, RM Yoo, P Iyer, RK   Arginases I and II: do their functions overlap? Molecular genetics and metabolism. , 2004; 81 Suppl 1: S38-44.
Yu, H Yoo, PK Aguirre, CC Tsoa, RW Kern, RM Grody, WW Cederbaum, SD Iyer, RK   Widespread expression of arginase I in mouse tissues. Biochemical and physiological implications The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society. , 2003; 51(9): 1151-60.
Svitanovic Sojat, L., Tein, I, Lamhonwah, A-M., De Meirleir, L., Cederbaum, S.D., Jurcic, Z, Mucic-Pucic, B. and Lukanovic-Novak, T.   "Fourteen-year follow up of a girl with primary systemic carnitine due to a carnitine transporter defect and OCTN2 mutation", Paediatr. Croat. 47, 2003; 83-86.
Hewson, S Clarke, JT Cederbaum, S   Prenatal diagnosis for arginase deficiency: a case study Journal of inherited metabolic disease. , 2003; 26(6): 607-10.
Gobin, S Bonnefont, JP Prip-Buus, C Mugnier, C Ferrec, M Demaugre, F Saudubray, JM Rostane, H Djouadi, F Wilcox, W Cederbaum, S Haas, R Nyhan, WL Green, A Gray, G Girard, J Thuillier, L   Organization of the human liver carnitine palmitoyltransferase 1 gene ( CPT1A) and identification of novel mutations in hypoketotic hypoglycaemia Human genetics. , 2002; 111(2): 179-89.
Yu, H Iyer, RK Yoo, PK Kern, RM Grody, WW Cederbaum, SD   Arginase expression in mouse embryonic development Mechanisms of development. , 2002; 115(1-2): 151-5.
Iyer, RK Yoo, PK Kern, RM Rozengurt, N Tsoa, R O'Brien, WE Yu, H Grody, WW Cederbaum, SD   Mouse model for human arginase deficiency Molecular and cellular biology. , 2002; 22(13): 4491-8.
Mardach, R., Zempleni, J., Wolf, B., Cannon, M.J., Jennings, M.L., Cress, S., Boylan, J., Roth, S., Cederbaum, S. and Mock, D.   "Biotin dependency due to a defect in biotin transport", J. Clin. Invest. 109, 2002; 1617-1623.
Nguyen, TV Andresen, BS Corydon, TJ Ghisla, S Abd-El Razik, N Mohsen, AW Cederbaum, SD Roe, DS Roe, CR Lench, NJ Vockley, J   Identification of isobutyryl-CoA dehydrogenase and its deficiency in humans Molecular genetics and metabolism. , 2002; 77(1-2): 68-79.
Kim, PS Iyer, RK Lu, KV Yu, H Karimi, A Kern, RM Tai, DK Cederbaum, SD Grody, WW   Expression of the liver form of arginase in erythrocytes Molecular genetics and metabolism. , 2002; 76(2): 100-10.
Gobert, AP Cheng, Y Wang, JY Boucher, JL Iyer, RK Cederbaum, SD Casero, RA Newton, JC Wilson, KT   Helicobacter pylori induces macrophage apoptosis by activation of arginase II Journal of immunology (Baltimore, Md. : 1950) , 2002; 168(9): 4692-700.
Iyer, RK Kim, HK Tsoa, RW Grody, WW Cederbaum, SD   Cloning and characterization of human agmatinase Molecular genetics and metabolism. , 2002; 75(3): 209-18.