A selected list of publications:
Seet Christopher S, He Chongbin, Bethune Michael T, Li Suwen, Chick Brent, Gschweng Eric H, Zhu Yuhua, Kim Kenneth, Kohn Donald B, Baltimore David, Crooks Gay M, Montel-Hagen Amélie
Generation of mature T cells from human hematopoietic stem and
progenitor cells in artificial thymic organoids
Nature methods,
2017; 14(5):
521-530.
Mahadeo Kris Michael, Weinberg Kenneth I, Abdel-Azim Hisham, Miklos David B, Killen Renna, Kohn Donald, Crooks Gay M, Shah Ami J, Kharbanda Sandhya, Agarwal Rajni, Kapoor Neena
A reduced-toxicity regimen is associated with durable engraftment and
clinical cure of nonmalignant genetic diseases among children
undergoing blood and marrow transplantation with an HLA-matched
related donor
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation,
2015; 21(3):
440-4.
Kim Sanggu, Kim Namshin, Presson Angela P, Metzger Mark E, Bonifacino Aylin C, Sehl Mary, Chow Samson A, Crooks Gay M, Dunbar Cynthia E, An Dong Sung, Donahue Robert E, Chen Irvin S Y
Dynamics of HSPC repopulation in nonhuman primates revealed by a
decade-long clonal-tracking study
Cell stem cell,
2014; 14(4):
473-85.
Chung Brile, Montel-Hagen Amélie, Ge Shundi, Blumberg Garrett, Kim Kenneth, Klein Sam, Zhu Yuhua, Parekh Chintan, Balamurugan Arumugam, Yang Otto O, Crooks Gay M
Engineering the human thymic microenvironment to support thymopoiesis
in vivo
Stem cells (Dayton, Ohio),
2014; 32(9):
2386-96.
Kim William S, Zhu Yuhua, Deng Qiming, Chin Chee Jia, He Chong Bin, Grieco Amanda J, Dravid Gautam G, Parekh Chintan, Hollis Roger P, Lane Timothy F, Bouhassira Eric E, Kohn Donald B, Crooks Gay M
Erythropoiesis from human embryonic stem cells through
erythropoietin-independent AKT signaling
Stem cells (Dayton, Ohio),
2014; 32(6):
1503-14.
Kohn Lisa A, Seet Christopher S, Scholes Jessica, Codrea Felicia, Chan Rebecca, Zaidi-Merchant Sania, Zhu Yuhua, De Oliveira Satiro, Kapoor Neena, Shah Ami, Abdel-Azim Hisham, Kohn Donald B, Crooks Gay M
Human lymphoid development in the absence of common γ-chain receptor
signaling
Journal of immunology (Baltimore, Md. : 1950),
2014; 192(11):
5050-8.
Wu Ling, Bluguermann Carolina, Kyupelyan Levon, Latour Brooke, Gonzalez Stephanie, Shah Saumya, Galic Zoran, Ge Sundi, Zhu Yuhua, Petrigliano Frank A, Nsair Ali, Miriuka Santiago G, Li Xinmin, Lyons Karen M, Crooks Gay M, McAllister David R, Van Handel Ben, Adams John S, Evseenko Denis
Human developmental chondrogenesis as a basis for engineering
chondrocytes from pluripotent stem cells
Stem cell reports,
2013; 1(6):
575-89.
Hsieh Yao-Te, Gang Eun Ji, Geng Huimin, Park Eugene, Huantes Sandra, Chudziak Doreen, Dauber Katrin, Schaefer Paul, Scharman Carlton, Shimada Hiroyuki, Shojaee Seyedmehdi, Klemm Lars, Parameswaran Reshmi, Loh Mignon, Kang Eun-Suk, Koo Hong Hoe, Hofmann Wolf-Karsten, Andrade Jacob, Crooks Gay M, Willman Cheryl L, Müschen Markus, Papayannopoulou Thalia, Heisterkamp Nora, Bönig Halvard, Kim Yong-Mi
Integrin alpha4 blockade sensitizes drug resistant pre-B acute
lymphoblastic leukemia to chemotherapy
Blood,
2013; 121(10):
1814-8.
Evseenko Denis, Latour Brooke, Richardson Wade, Corselli Mirko, Sahaghian Arineh, Cardinal Sofie, Zhu Yuhua, Chan Rebecca, Dunn Bruce, Crooks Gay M
Lysophosphatidic acid mediates myeloid differentiation within the
human bone marrow microenvironment
PloS one,
2013; 8(5):
e63718.
Corselli Mirko, Chin Chee Jia, Parekh Chintan, Sahaghian Arineh, Wang Wenyuan, Ge Shundi, Evseenko Denis, Wang Xiaoyan, Montelatici Elisa, Lazzari Lorenza, Crooks Gay M, Péault Bruno
Perivascular support of human hematopoietic stem/progenitor cells
Blood,
2013; 121(15):
2891-901.
Nsair Ali, Schenke-Layland Katja, Van Handel Ben, Evseenko Denis, Kahn Michael, Zhao Peng, Mendelis Joseph, Heydarkhan Sanaz, Awaji Obina, Vottler Miriam, Geist Susanne, Chyu Jennifer, Gago-Lopez Nuria, Crooks Gay M, Plath Kathrin, Goldhaber Josh, Mikkola Hanna K A, MacLellan W Robb
Characterization and therapeutic potential of induced pluripotent stem
cell-derived cardiovascular progenitor cells
PloS one,
2012; 7(10):
e45603.
Hacke Katrin, Szakmary Akos, Cuddihy Andrew R, Rozengurt Nora, Lemp Nathan A, Aubrecht Jiri, Lawson Gregory W, Rao Nagesh P, Crooks Gay M, Schiestl Robert H, Kasahara Noriyuki
Combined preconditioning and in vivo chemoselection with
6-thioguanine alone achieves highly efficient reconstitution of normal
hematopoiesis with HPRT-deficient bone marrow
Experimental hematology,
2012; 40(1):
3-13.e3.
Candotti Fabio, Shaw Kit L, Muul Linda, Carbonaro Denise, Sokolic Robert, Choi Christopher, Schurman Shepherd H, Garabedian Elizabeth, Kesserwan Chimene, Jagadeesh G Jayashree, Fu Pei-Yu, Gschweng Eric, Cooper Aaron, Tisdale John F, Weinberg Kenneth I, Crooks Gay M, Kapoor Neena, Shah Ami, Abdel-Azim Hisham, Yu Xiao-Jin, Smogorzewska Monika, Wayne Alan S, Rosenblatt Howard M, Davis Carla M, Hanson Celine, Rishi Radha G, Wang Xiaoyan, Gjertson David, Yang Otto O, Balamurugan Arumugam, Bauer Gerhard, Ireland Joanna A, Engel Barbara C, Podsakoff Gregory M, Hershfield Michael S, Blaese R Michael, Parkman Robertson, Kohn Donald B
Gene therapy for adenosine deaminase-deficient severe combined immune
deficiency: clinical comparison of retroviral vectors and treatment
plans
Blood,
2012; 13(10):
.
Parekh Chintan, Sahaghian Arineh, Kim William, Scholes Jessica, Ge Shundi, Zhu Yuhua, Asgharzadeh Shahab, Hollis Roger, Kohn Donald, Ji Lingyun, Malvar Jemily, Wang Xiaoyan, Crooks Gay
Novel pathways to erythropoiesis induced by dimerization of
intracellular C-Mpl in human hematopoietic progenitors
Stem cells (Dayton, Ohio),
2012; 30(4):
697-708.
Dravid G, Zhu Y, Scholes J, Evseenko D, Crooks GM
Dysregulated Gene Expression During Hematopoietic Differentiation From Human Embryonic Stem Cells ,
Molecular Therapy,
2010;
.
Holt Nathalia, Wang Jianbin, Kim Kenneth, Friedman Geoffrey, Wang Xingchao, Taupin Vanessa, Crooks Gay M, Kohn Donald B, Gregory Philip D, Holmes Michael C, Cannon Paula M
Human hematopoietic stem/progenitor cells modified by zinc-finger
nucleases targeted to CCR5 control HIV-1 in vivo
Nature biotechnology,
2010; 28(8):
839-47.
Evseenko Denis, Zhu Yuhua, Schenke-Layland Katja, Kuo Jeffrey, Latour Brooke, Ge Shundi, Scholes Jessica, Dravid Gautam, Li Xinmin, MacLellan W Robb, Crooks Gay M
Mapping the first stages of mesoderm commitment during differentiation
of human embryonic stem cells
Proceedings of the National Academy of Sciences of the United States of America,
2010; 107(31):
13742-7.
Pais Eszter, Park Jean, Alexy Tamas, Nikolian Vahagn, Ge Shundi, Shaw Kit, Senadheera Shantha, Hardee Cinnamon L, Skelton Dianne, Hollis Roger, Crooks Gay M, Kohn Donald B
Regulated expansion of human pancreatic beta-cells
Molecular therapy : the journal of the American Society of Gene Therapy,
2010; 18(7):
1389-96.
Gruber Tanja A, Shah Ami J, Hernandez Michelle, Crooks Gay M, Abdel-Azim Hisham, Gupta Sudhir, McKnight Sean, White Drew, Kapoor Neena, Kohn Donald B
Clinical and genetic heterogeneity in Omenn syndrome and severe
combined immune deficiency
Pediatric transplantation,
2009; 13(2):
244-50.
Shah Ami J, Kapoor Neena, Cooper Robert M, Crooks Gay M, Lenarsky Carl, Abdel-Azim Hisham, Wu Shi Qi, Wilson Kathy, Weinberg Kenneth I, Parkman Robertson, Kohn Donald B
Pre- and post-natal treatment of hemophagocytic lymphohistiocytosis
Pediatric blood & cancer,
2009; 52(1):
139-42.
Abdel-Azim Hisham, Zhu Yuhua, Hollis Roger, Wang Xiuli, Ge Shundi, Hao Qian-Lin, Smbatyan Goar, Kohn Donald B, Rosol Michael, Crooks Gay M
Expansion of multipotent and lymphoid-committed human progenitors
through intracellular dimerization of Mpl
Blood,
2008; 111(8):
4064-74.
Evseenko D, Schenke-Layland K, Dravid G, Zhu Y, Hao QL, Scholes J, Wan XC, MacLellan R, Crooks GM
Identification of the critical extracellular matrix proteins that promote human embryonic stem cell assembly,
Stem Cells and Development,
2008; 18(6):
919-928.
Shah Ami J, Epport Karen, Azen Colleen, Killen Renna, Wilson Kathy, De Clerck Dominique, Crooks Gay, Kapoor Neena, Kohn Donald B, Parkman Robertson, Weinberg Kenneth I
Progressive declines in neurocognitive function among survivors of
hematopoietic stem cell transplantation for pediatric hematologic
malignancies
Journal of pediatric hematology/oncology,
2008; 30(6):
411-8.
Berg Tove, Rountree C Bart, Lee Lily, Estrada Joaquin, Sala Fréderic G, Choe Andrea, Veltmaat Jacqueline M, De Langhe Stijn, Lee Rene, Tsukamoto Hide, Crooks Gay M, Bellusci Saverio, Wang Kasper S
Fibroblast growth factor 10 is critical for liver growth during
embryogenesis and controls hepatoblast survival via beta-catenin
activation
Hepatology (Baltimore, Md.),
2007; 46(4):
1187-97.
Engel Barbara C, Podsakoff Greg M, Ireland Joanna L, Smogorzewska E Monika, Carbonaro Denise A, Wilson Kathy, Shah Ami, Kapoor Neena, Sweeney Mirna, Borchert Mark, Crooks Gay M, Weinberg Kenneth I, Parkman Robertson, Rosenblatt Howard M, Wu Shi-Qi, Hershfield Michael S, Candotti Fabio, Kohn Donald B
Prolonged pancytopenia in a gene therapy patient with ADA-deficient
SCID and trisomy 8 mosaicism: a case report
Blood,
2007; 109(2):
503-6.
Shah Ami J, Kapoor Neena, Crooks Gay M, Weinberg Kenneth I, Azim Hisham Abdel, Killen Renna, Kuo Lily, Rushing Teresa, Kohn Donald B, Parkman Robertson
The effects of Campath 1H upon graft-versus-host disease, infection,
relapse, and immune reconstitution in recipients of pediatric
unrelated transplants
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation,
2007; 13(5):
584-93.
Wang Xiuli, Ge Shundi, Gonzalez Ignacio, McNamara George, Rountree C Barth, Xi Kenny Kezhe, Huang Grace, Bhushan Anil, Crooks Gay M
Formation of pancreatic duct epithelium from bone marrow during
neonatal development
Stem cells (Dayton, Ohio),
2006; 24(2):
307-14.
Price Mary A, Case Scott S, Carbonaro Denise A, Yu Xiao-Jin, Petersen Denise, Sabo Kathleen M, Curran Michael A, Engel Barbara C, Margarian Hovanes, Abkowitz Janis L, Nolan Garry P, Kohn Donald B, Crooks Gay M
Expression from second-generation feline immunodeficiency virus
vectors is impaired in human hematopoietic cells
Molecular therapy : the journal of the American Society of Gene Therapy,
2002; 6(5):
645-52.
Shah Ami J, Kapoor Neena, Weinberg Kenneth I, Crooks Gay M, Kohn Donald B, Lenarsky Carl, Kaufman Francine, Epport Karen, Wilson Kathy, Parkman Robertson
Second hematopoietic stem cell transplantation in pediatric patients:
overall survival and long-term follow-up
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation,
2002; 8(4):
221-8.
Hao QL, Zhu J, Price MA, Payne KJ, Barsky LW, Crooks GM
Identification of a novel, human multi-lymphoid progenitor in cord blood,
Blood,
2001; 97(12):
3683-3690.
Haas DL, Case SS, Crooks GM, Kohn DB
Critical factors influencing stable transduction of human CD34+ cells with HIV 1 derived lentiviral vector,
Molec Therapy,
2000;
.
Crooks GM, Fuller J, Petersen D, Izadi P, Malik P, Pattengale PK, Kohn DB, Gasson JC
Constitutive HOXA5 expression inhibits erythropoiesis and increases myelopoiesis from human hematopoietic progenitors,
BLOOD,
1999;
.
Case SS, Price MA, Jordan CT, Yu XJ, Wang L, Bauer G, Haas DL, Xu D, Stripecke R., Naldini L, Kohn DB, and Crooks GM
Stable transduction of quiescent CD34+CD38-human hematopoietic cells by HIV-1 based lentiviral vectors,
Proceedings of the National Academy of Science ,
1999; 96(6):
2988-2993.
Hao QL, Smogorzewska EM, Barsky LW, Crooks GM
In Vitro Identification of Single CD34+CD38 Cells With Both Lymphoid and Myeloid Potential,
Blood,
1998; 91(11):
4145-4151.
Rawlings DJ, Quan S, Hao Q-L, Thiemann FT, Smogorzewska M, Witte ON, and Crooks GM
Differentiation of human CD34+CD38- cord blood stem cells into B cell progenitors in vitro,
Exp Hematology,
1997;
.
Hao QL, Thiemann FT, Petersen D, Smogorzewska EM, Crooks GM
Extended long term culture reveals a highly quiescent and primitive human hematopoietc progenitor population,
Blood,
1996; 88(9):
3306-3313.
Shah AJ, Smogorzewska EM, Hannum C, Crooks GM
Flt3 Ligand Induces Proliferation of Quiescent Human Bone Marrow CD34+CD38-Cells and Maintains Progenitor Cells In Vitro,
Blood,
1996; 87(9):
3563-3570.
Hao Q-L, Shah AJ, Thiemann FT, Smogorzewska EM, Crooks GM
A Functional Comparison of CD34+CD38- Cells in Cord Blood and Bone Marrow,
BLOOD,
1995;
.
Crooks GM, Sato JK
Ifosfamide and VP16 for Relapsed Childhood Acute Lymphoblastic Leukemia,
J Ped Hematol-Oncol ,
1995;
.
Lill MC, Fuller JF, Crooks GM, Gasson JC
The Role of the Homeobox Gene, HOX B7, in Human Myelomonocytic Differentiation,
BLOOD,
1995;
.
Crooks GM, Kohn DB
Growth Factors Increase Amphotropic Retrovirus Binding to Human CD34 Positive Bone Marrow Progenitor Cells,
Blood,
1993;
.