Affiliations

Professor, Pathology and Laboratory Medicine, Pediatrics

Co-Director, Eli & Edythe Broad Center of Regenerative Medicine & Stem Cell Research

Director, JCCC Cancer and Stem Cell Biology Program Area

Dr. Crooks has long been interested in the way blood stem cells in the bone marrow are able to generate the billions of diverse cell types in the blood. As a pediatric bone marrow transplant physician, Dr. Crooks cares for children with a wide range of diseases that affect the blood and the immune system. Although stem cell transplantation is the only cure for many of these diseases, too many children and adults who undergo this treatment suffer severe side effects from slow recovery of the immune system because of damage to the thymus, a small gland which sits just behind the sternum in front of the heart. A healthy immune system is critical for the control of infections, cancer, and a vast array of autoimmune diseases. Like other components of the blood, the immune system is generated from stem cells (called hematopoietic, or blood, stem cells) which reside mostly in the bone marrow but circulate to other parts of the body when needed. To form the T-cells of the immune system, stem cells in the bone marrow travel to the thymus. A healthy thymus produces T-cells that are both “tolerant” of normal cells while reacting and protecting us against infection and cancer. Dr Crooks's research aims to tackle all parts of this critical and fascinating process: how the immune system is created from stem cells, how we can regenerate healthy thymus to improve immune function and how an inexhaustible supply of matched blood stem cells might be produced from pluripotent stem cells.

Seet Christopher S, He Chongbin, Bethune Michael T, Li Suwen, Chick Brent, Gschweng Eric H, Zhu Yuhua, Kim Kenneth, Kohn Donald B, Baltimore David, Crooks Gay M, Montel-Hagen Amélie Generation of mature T cells from human hematopoietic stem and progenitor cells in artificial thymic organoids. Nature methods. 2017; 14(5): 521-530. Ha V L, Luong A, Li F, Casero D, Malvar J, Kim Y M, Bhatia R, Crooks G M, Parekh C The T-ALL related gene BCL11B regulates the initial stages of human T-cell differentiation. Leukemia. 2017; 14(5): 521-530. Mahadeo Kris Michael, Weinberg Kenneth I, Abdel-Azim Hisham, Miklos David B, Killen Renna, Kohn Donald, Crooks Gay M, Shah Ami J, Kharbanda Sandhya, Agarwal Rajni, Kapoor Neena A reduced-toxicity regimen is associated with durable engraftment and clinical cure of nonmalignant genetic diseases among children undergoing blood and marrow transplantation with an HLA-matched related donor. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 2015; 21(3): 440-4. Prashad Sacha Leandra, Calvanese Vincenzo, Yao Catherine Yao, Kaiser Joshua, Wang Yanling, Sasidharan Rajkumar, Crooks Gay, Magnusson Mattias, Mikkola Hanna Katri Annikki GPI-80 defines self-renewal ability in hematopoietic stem cells during human development. Cell stem cell. 2015; 16(1): 80-7. Casero David, Sandoval Salemiz, Seet Christopher S, Scholes Jessica, Zhu Yuhua, Ha Vi Luan, Luong Annie, Parekh Chintan, Crooks Gay M Long non-coding RNA profiling of human lymphoid progenitor cells reveals transcriptional divergence of B cell and T cell lineages. Nature immunology. 2015; . Berent-Maoz Beata, Montecino-Rodriguez Encarnacion, Fice Michael, Casero David, Seet Christopher S, Crooks Gay M, Lowry William, Dorshkind Kenneth The expansion of thymopoiesis in neonatal mice is dependent on expression of high mobility group a 2 protein (Hmga2). PloS one. 2015; 10(5): e0125414. Abdel-Azim Hisham, Mahadeo Kris Michael, Zhao Quan, Khazal Sajad, Kohn Donald B, Crooks Gay M, Shah Ami J, Kapoor Neena Unrelated donor Hematopoietic Stem Cell Transplantation for the treatment of non-malignant genetic diseases: An alemtuzumab based regimen is associated with cure of clinical disease; earlier clearance of alemtuzumab may be associated with graft rejection. American journal of hematology. 2015; . Kim Sanggu, Kim Namshin, Presson Angela P, Metzger Mark E, Bonifacino Aylin C, Sehl Mary, Chow Samson A, Crooks Gay M, Dunbar Cynthia E, An Dong Sung, Donahue Robert E, Chen Irvin S Y Dynamics of HSPC repopulation in nonhuman primates revealed by a decade-long clonal-tracking study. Cell stem cell. 2014; 14(4): 473-85. Chung Brile, Montel-Hagen Amélie, Ge Shundi, Blumberg Garrett, Kim Kenneth, Klein Sam, Zhu Yuhua, Parekh Chintan, Balamurugan Arumugam, Yang Otto O, Crooks Gay M Engineering the human thymic microenvironment to support thymopoiesis in vivo. Stem cells (Dayton, Ohio). 2014; 32(9): 2386-96. Kim William S, Zhu Yuhua, Deng Qiming, Chin Chee Jia, He Chong Bin, Grieco Amanda J, Dravid Gautam G, Parekh Chintan, Hollis Roger P, Lane Timothy F, Bouhassira Eric E, Kohn Donald B, Crooks Gay M Erythropoiesis from human embryonic stem cells through erythropoietin-independent AKT signaling. Stem cells (Dayton, Ohio). 2014; 32(6): 1503-14. Kohn Lisa A, Seet Christopher S, Scholes Jessica, Codrea Felicia, Chan Rebecca, Zaidi-Merchant Sania, Zhu Yuhua, De Oliveira Satiro, Kapoor Neena, Shah Ami, Abdel-Azim Hisham, Kohn Donald B, Crooks Gay M Human lymphoid development in the absence of common γ-chain receptor signaling. Journal of immunology (Baltimore, Md. : 1950). 2014; 192(11): 5050-8. Parekh Chintan, Crooks Gay M Critical Differences in Hematopoiesis and Lymphoid Development between Humans and Mice. Journal of clinical immunology. 2013; 33(4): 711-5. Wu Ling, Bluguermann Carolina, Kyupelyan Levon, Latour Brooke, Gonzalez Stephanie, Shah Saumya, Galic Zoran, Ge Sundi, Zhu Yuhua, Petrigliano Frank A, Nsair Ali, Miriuka Santiago G, Li Xinmin, Lyons Karen M, Crooks Gay M, McAllister David R, Van Handel Ben, Adams John S, Evseenko Denis Human developmental chondrogenesis as a basis for engineering chondrocytes from pluripotent stem cells. Stem cell reports. 2013; 1(6): 575-89. Hsieh Yao-Te, Gang Eun Ji, Geng Huimin, Park Eugene, Huantes Sandra, Chudziak Doreen, Dauber Katrin, Schaefer Paul, Scharman Carlton, Shimada Hiroyuki, Shojaee Seyedmehdi, Klemm Lars, Parameswaran Reshmi, Loh Mignon, Kang Eun-Suk, Koo Hong Hoe, Hofmann Wolf-Karsten, Andrade Jacob, Crooks Gay M, Willman Cheryl L, Müschen Markus, Papayannopoulou Thalia, Heisterkamp Nora, Bönig Halvard, Kim Yong-Mi Integrin alpha4 blockade sensitizes drug resistant pre-B acute lymphoblastic leukemia to chemotherapy. Blood. 2013; 121(10): 1814-8. Evseenko Denis, Latour Brooke, Richardson Wade, Corselli Mirko, Sahaghian Arineh, Cardinal Sofie, Zhu Yuhua, Chan Rebecca, Dunn Bruce, Crooks Gay M Lysophosphatidic acid mediates myeloid differentiation within the human bone marrow microenvironment. PloS one. 2013; 8(5): e63718. Corselli Mirko, Chin Chee Jia, Parekh Chintan, Sahaghian Arineh, Wang Wenyuan, Ge Shundi, Evseenko Denis, Wang Xiaoyan, Montelatici Elisa, Lazzari Lorenza, Crooks Gay M, Péault Bruno Perivascular support of human hematopoietic stem/progenitor cells. Blood. 2013; 121(15): 2891-901. Nsair Ali, Schenke-Layland Katja, Van Handel Ben, Evseenko Denis, Kahn Michael, Zhao Peng, Mendelis Joseph, Heydarkhan Sanaz, Awaji Obina, Vottler Miriam, Geist Susanne, Chyu Jennifer, Gago-Lopez Nuria, Crooks Gay M, Plath Kathrin, Goldhaber Josh, Mikkola Hanna K A, MacLellan W Robb Characterization and therapeutic potential of induced pluripotent stem cell-derived cardiovascular progenitor cells. PloS one. 2012; 7(10): e45603. Hacke Katrin, Szakmary Akos, Cuddihy Andrew R, Rozengurt Nora, Lemp Nathan A, Aubrecht Jiri, Lawson Gregory W, Rao Nagesh P, Crooks Gay M, Schiestl Robert H, Kasahara Noriyuki Combined preconditioning and in vivo chemoselection with 6-thioguanine alone achieves highly efficient reconstitution of normal hematopoiesis with HPRT-deficient bone marrow. Experimental hematology. 2012; 40(1): 3-13.e3. Candotti Fabio, Shaw Kit L, Muul Linda, Carbonaro Denise, Sokolic Robert, Choi Christopher, Schurman Shepherd H, Garabedian Elizabeth, Kesserwan Chimene, Jagadeesh G Jayashree, Fu Pei-Yu, Gschweng Eric, Cooper Aaron, Tisdale John F, Weinberg Kenneth I, Crooks Gay M, Kapoor Neena, Shah Ami, Abdel-Azim Hisham, Yu Xiao-Jin, Smogorzewska Monika, Wayne Alan S, Rosenblatt Howard M, Davis Carla M, Hanson Celine, Rishi Radha G, Wang Xiaoyan, Gjertson David, Yang Otto O, Balamurugan Arumugam, Bauer Gerhard, Ireland Joanna A, Engel Barbara C, Podsakoff Gregory M, Hershfield Michael S, Blaese R Michael, Parkman Robertson, Kohn Donald B Gene therapy for adenosine deaminase-deficient severe combined immune deficiency: clinical comparison of retroviral vectors and treatment plans. Blood. 2012; 13(10): . Kohn Lisa A, Hao Qian-Lin, Sasidharan Rajkumar, Parekh Chintan, Ge Shundi, Zhu Yuhua, Mikkola Hanna K A, Crooks Gay M Lymphoid priming in human bone marrow begins before expression of CD10 with upregulation of L-selectin. Nature immunology. 2012; 13(10): 963-71. Parekh Chintan, Sahaghian Arineh, Kim William, Scholes Jessica, Ge Shundi, Zhu Yuhua, Asgharzadeh Shahab, Hollis Roger, Kohn Donald, Ji Lingyun, Malvar Jemily, Wang Xiaoyan, Crooks Gay Novel pathways to erythropoiesis induced by dimerization of intracellular C-Mpl in human hematopoietic progenitors. Stem cells (Dayton, Ohio). 2012; 30(4): 697-708. Cuddihy Andrew R, Suterwala Batul T, Ge Shundi, Kohn Lisa A, Jang Julie, Andrade Jacob, Wang Xiaoyan, Crooks Gay M Rapid Thymic Reconstitution Following Bone Marrow Transplantation in Neonatal Mice is VEGF-Dependent. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 2012; 18(5): 683-9. Reiff Andreas, Shaham Bracha, Weinberg Kenneth I, Crooks Gay M, Parkman Robertson Anti-CD52 antibody-mediated immune ablation with autologous immune recovery for the treatment of refractory juvenile polymyositis. Journal of clinical immunology. 2011; 31(4): 615-22. Dravid Gautam, Zhu Yuhua, Scholes Jessica, Evseenko Denis, Crooks Gay M Dysregulated gene expression during hematopoietic differentiation from human embryonic stem cells. Molecular therapy : the journal of the American Society of Gene Therapy. 2011; 19(4): 768-81. Andrade Jacob, Ge Shundi, Symbatyan Goar, Rosol Michael S, Olch Arthur J, Crooks Gay M Effects of sublethal irradiation on patterns of engraftment after murine bone marrow transplantation. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 2011; 17(5): 608-19. Rountree C Bart, Ding Wei, Dang Hein, Vankirk Colleen, Crooks Gay M Isolation of CD133+ liver stem cells for clonal expansion. Journal of visualized experiments : JoVE. 2011; (56): . Crooks Gay M Lineage assays: which pathway to take?. Blood. 2011; 117(9): 2560. Dravid Gautam G, Crooks Gay M The challenges and promises of blood engineered from human pluripotent stem cells. Advanced drug delivery reviews. 2011; 63(4-5): 331-41. Dravid G, Zhu Y, Scholes J, Evseenko D, Crooks GM Dysregulated Gene Expression During Hematopoietic Differentiation From Human Embryonic Stem Cells . Molecular Therapy 2010; . Holt Nathalia, Wang Jianbin, Kim Kenneth, Friedman Geoffrey, Wang Xingchao, Taupin Vanessa, Crooks Gay M, Kohn Donald B, Gregory Philip D, Holmes Michael C, Cannon Paula M Human hematopoietic stem/progenitor cells modified by zinc-finger nucleases targeted to CCR5 control HIV-1 in vivo. Nature biotechnology. 2010; 28(8): 839-47. Akagi Tadayuki, Thoennissen Nils H, George Ann, Crooks Gay, Song Jee Hoon, Okamoto Ryoko, Nowak Daniel, Gombart Adrian F, Koeffler H Phillip In vivo deficiency of both C/EBPβ and C/EBPε results in highly defective myeloid differentiation and lack of cytokine response. PloS one. 2010; 5(11): e15419. Evseenko Denis, Zhu Yuhua, Schenke-Layland Katja, Kuo Jeffrey, Latour Brooke, Ge Shundi, Scholes Jessica, Dravid Gautam, Li Xinmin, MacLellan W Robb, Crooks Gay M Mapping the first stages of mesoderm commitment during differentiation of human embryonic stem cells. Proceedings of the National Academy of Sciences of the United States of America. 2010; 107(31): 13742-7. Pais Eszter, Park Jean, Alexy Tamas, Nikolian Vahagn, Ge Shundi, Shaw Kit, Senadheera Shantha, Hardee Cinnamon L, Skelton Dianne, Hollis Roger, Crooks Gay M, Kohn Donald B Regulated expansion of human pancreatic beta-cells. Molecular therapy : the journal of the American Society of Gene Therapy. 2010; 18(7): 1389-96. Crooks Gay M Uncertainty plagues US stem cell research. Pediatric research. 2010; 68(5): 373. Gruber Tanja A, Shah Ami J, Hernandez Michelle, Crooks Gay M, Abdel-Azim Hisham, Gupta Sudhir, McKnight Sean, White Drew, Kapoor Neena, Kohn Donald B Clinical and genetic heterogeneity in Omenn syndrome and severe combined immune deficiency. Pediatric transplantation. 2009; 13(2): 244-50. Wang Xiuli, Ge Shundi, Crooks Gay M Fluorescent immunohistochemistry and in situ hybridization analysis of pancreas. Methods in molecular biology (Clifton, N.J.). 2009; 560(10): 191-201. Evseenko Denis, Schenke-Layland Katja, Dravid Gautam, Zhu Yuhua, Hao Qian-Lin, Scholes Jessica, Wang Xing Chao, Maclellan W Robb, Crooks Gay M Identification of the critical extracellular matrix proteins that promote human embryonic stem cell assembly. Stem cells and development. 2009; 18(6): 919-28. Shah Ami J, Kapoor Neena, Cooper Robert M, Crooks Gay M, Lenarsky Carl, Abdel-Azim Hisham, Wu Shi Qi, Wilson Kathy, Weinberg Kenneth I, Parkman Robertson, Kohn Donald B Pre- and post-natal treatment of hemophagocytic lymphohistiocytosis. Pediatric blood & cancer. 2009; 52(1): 139-42. Sumiyoshi Teiko, Holt Nathalia G, Hollis Roger P, Ge Shundi, Cannon Paula M, Crooks Gay M, Kohn Donald B Stable transgene expression in primitive human CD34+ hematopoietic stem/progenitor cells, using the Sleeping Beauty transposon system. Human gene therapy. 2009; 20(12): 1607-26. Cuddihy Andrew R, Ge Shundi, Zhu Judy, Jang Julie, Chidgey Ann, Thurston Gavin, Boyd Richard, Crooks Gay M VEGF-mediated cross-talk within the neonatal murine thymus. Blood. 2009; 113(12): 2723-31. Rountree C Bart, Senadheera Shantha, Mato Jose M, Crooks Gay M, Lu Shelly C Expansion of liver cancer stem cells during aging in methionine adenosyltransferase 1A-deficient mice. Hepatology (Baltimore, Md.). 2008; 47(4): 1288-97. Abdel-Azim Hisham, Zhu Yuhua, Hollis Roger, Wang Xiuli, Ge Shundi, Hao Qian-Lin, Smbatyan Goar, Kohn Donald B, Rosol Michael, Crooks Gay M Expansion of multipotent and lymphoid-committed human progenitors through intracellular dimerization of Mpl. Blood. 2008; 111(8): 4064-74. Hao Qian-Lin, George Aswathi A, Zhu Judy, Barsky Lora, Zielinska Ewa, Wang Xiuli, Price Mary, Ge Shundi, Crooks Gay M Human intrathymic lineage commitment is marked by differential CD7 expression: identification of CD7- lympho-myeloid thymic progenitors. Blood. 2008; 111(3): 1318-26. Evseenko D, Schenke-Layland K, Dravid G, Zhu Y, Hao QL, Scholes J, Wan XC, MacLellan R, Crooks GM Identification of the critical extracellular matrix proteins that promote human embryonic stem cell assembly. Stem Cells and Development 2008; 18(6): 919-928. Chu Michelle, Siegmund Kimberly D, Hao Qian-Lin, Crooks Gay M, Tavaré Simon, Shibata Darryl Inferring relative numbers of human leucocyte genome replications. British journal of haematology. 2008; 141(6): 862-71. Shah Ami J, Epport Karen, Azen Colleen, Killen Renna, Wilson Kathy, De Clerck Dominique, Crooks Gay, Kapoor Neena, Kohn Donald B, Parkman Robertson, Weinberg Kenneth I Progressive declines in neurocognitive function among survivors of hematopoietic stem cell transplantation for pediatric hematologic malignancies. Journal of pediatric hematology/oncology. 2008; 30(6): 411-8. Rountree C Bart, Barsky Lora, Ge Shundi, Zhu Judy, Senadheera Shantha, Crooks Gay M A CD133-expressing murine liver oval cell population with bilineage potential. Stem cells (Dayton, Ohio). 2007; 25(10): 2419-29. Rountree C Bart, Wang Xuli, Ge Shundi, Barsky Lora, Zhu Judy, Gonzales Ignacio, Crooks Gay M Bone marrow fails to differentiate into liver epithelium during murine development and regeneration. Hepatology (Baltimore, Md.). 2007; 45(5): 1250-60. Berg Tove, Rountree C Bart, Lee Lily, Estrada Joaquin, Sala Fréderic G, Choe Andrea, Veltmaat Jacqueline M, De Langhe Stijn, Lee Rene, Tsukamoto Hide, Crooks Gay M, Bellusci Saverio, Wang Kasper S Fibroblast growth factor 10 is critical for liver growth during embryogenesis and controls hepatoblast survival via beta-catenin activation. Hepatology (Baltimore, Md.). 2007; 46(4): 1187-97. Payne Kimberly J, Crooks Gay M Immune-cell lineage commitment: translation from mice to humans. Immunity. 2007; 26(6): 674-7. Engel Barbara C, Podsakoff Greg M, Ireland Joanna L, Smogorzewska E Monika, Carbonaro Denise A, Wilson Kathy, Shah Ami, Kapoor Neena, Sweeney Mirna, Borchert Mark, Crooks Gay M, Weinberg Kenneth I, Parkman Robertson, Rosenblatt Howard M, Wu Shi-Qi, Hershfield Michael S, Candotti Fabio, Kohn Donald B Prolonged pancytopenia in a gene therapy patient with ADA-deficient SCID and trisomy 8 mosaicism: a case report. Blood. 2007; 109(2): 503-6. Garon Edward B, Marcu Laura, Luong Quang, Tcherniantchouk Oxana, Crooks Gay M, Koeffler H Phillip Quantum dot labeling and tracking of human leukemic, bone marrow and cord blood cells. Leukemia research. 2007; 31(5): 643-51. Shah Ami J, Kapoor Neena, Crooks Gay M, Weinberg Kenneth I, Azim Hisham Abdel, Killen Renna, Kuo Lily, Rushing Teresa, Kohn Donald B, Parkman Robertson The effects of Campath 1H upon graft-versus-host disease, infection, relapse, and immune reconstitution in recipients of pediatric unrelated transplants. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 2007; 13(5): 584-93. Ge Shundi, Crooks Gay M, McNamara George, Wang Xiuli Fluorescent immunohistochemistry and in situ hybridization analysis of mouse pancreas using low-power antigen-retrieval technique. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society. 2006; 54(7): 843-7. Wang Xiuli, Ge Shundi, Gonzalez Ignacio, McNamara George, Rountree C Barth, Xi Kenny Kezhe, Huang Grace, Bhushan Anil, Crooks Gay M Formation of pancreatic duct epithelium from bone marrow during neonatal development. Stem cells (Dayton, Ohio). 2006; 24(2): 307-14. Crooks Gay M, Weinberg Kenneth, Mackall Crystal Immune reconstitution: from stem cells to lymphocytes. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 2006; 12(1 Suppl 1): 42-6. Hollis Roger P, Nightingale Sarah J, Wang Xiuli, Pepper Karen A, Yu Xiao-Jin, Barsky Lora, Crooks Gay M, Kohn Donald B Stable gene transfer to human CD34(+) hematopoietic cells using the Sleeping Beauty transposon. Experimental hematology. 2006; 34(10): 1333-43. Crooks Gay M, Weinberg Kenneth The unpredictable stem cell. Nature immunology. 2006; 7(11): 1129-30. Zhang Yanjia, Payne Kimberly J, Zhu Yuhua, Price Mary A, Parrish Yasmin K, Zielinska Ewa, Barsky Lora W, Crooks Gay M SCL expression at critical points in human hematopoietic lineage commitment. Stem cells (Dayton, Ohio). 2005; 23(6): 852-60. Shah Ami J, Kapoor Neena, Crooks Gay M, Parkman Robertson, Weinberg Kenneth I, Wilson Kathy, Kohn Donald B Successful hematopoietic stem cell transplantation for Niemann-Pick disease type B. Pediatrics. 2005; 116(4): 1022-5. Jodele Sonata, Chantrain Christophe F, Blavier Laurence, Lutzko Carolyn, Crooks Gay M, Shimada Hiroyuki, Coussens Lisa M, Declerck Yves A The contribution of bone marrow-derived cells to the tumor vasculature in neuroblastoma is matrix metalloproteinase-9 dependent. Cancer research. 2005; 65(8): 3200-8. Shah Ami J, Lenarsky Carl, Kapoor Neena, Crooks Gay M, Kohn Donald B, Parkman Robertson, Epport Karen, Wilson Kathy, Weinberg Ken Busulfan and cyclophosphamide as a conditioning regimen for pediatric acute lymphoblastic leukemia patients undergoing bone marrow transplantation. Journal of pediatric hematology/oncology. 2004; 26(2): 91-7. Baev Denis V, Peng Xiao-Hui, Song Liping, Barnhart Jerry R, Crooks Gay M, Weinberg Kenneth I, Metelitsa Leonid S Distinct homeostatic requirements of CD4+ and CD4- subsets of Valpha24-invariant natural killer T cells in humans. Blood. 2004; 104(13): 4150-6. Wang Xiuli, Ge Shundi, McNamara George, Hao Qian-Lin, Crooks Gay M, Nolta Jan A Albumin-expressing hepatocyte-like cells develop in the livers of immune-deficient mice that received transplants of highly purified human hematopoietic stem cells. Blood. 2003; 101(10): 4201-8. Wang Xiuli, Rosol Michael, Ge Shundi, Peterson Denise, McNamara George, Pollack Harvey, Kohn Donald B, Nelson Marvin D, Crooks Gay M Dynamic tracking of human hematopoietic stem cell engraftment using in vivo bioluminescence imaging. Blood. 2003; 102(10): 3478-82. Payne Kimberly J, Huang Grace, Sahakian Eva, Zhu Judy Y, Barteneva Natasha S, Barsky Lora W, Payne Marvin A, Crooks Gay M Ikaros isoform x is selectively expressed in myeloid differentiation. Journal of immunology (Baltimore, Md. : 1950). 2003; 170(6): 3091-8. Price Mary A, Case Scott S, Carbonaro Denise A, Yu Xiao-Jin, Petersen Denise, Sabo Kathleen M, Curran Michael A, Engel Barbara C, Margarian Hovanes, Abkowitz Janis L, Nolan Garry P, Kohn Donald B, Crooks Gay M Expression from second-generation feline immunodeficiency virus vectors is impaired in human hematopoietic cells. Molecular therapy : the journal of the American Society of Gene Therapy. 2002; 6(5): 645-52. Payne Kimberly J, Crooks Gay M Human hematopoietic lineage commitment. Immunological reviews. 2002; 187(5): 48-64. Shah Ami J, Kapoor Neena, Weinberg Kenneth I, Crooks Gay M, Kohn Donald B, Lenarsky Carl, Kaufman Francine, Epport Karen, Wilson Kathy, Parkman Robertson Second hematopoietic stem cell transplantation in pediatric patients: overall survival and long-term follow-up. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 2002; 8(4): 221-8. Hao QL, Zhu J, Price MA, Payne KJ, Barsky LW, Crooks GM Identification of a novel, human multi-lymphoid progenitor in cord blood. Blood 2001; 97(12): 3683-3690. Haas DL, Case SS, Crooks GM, Kohn DB Critical factors influencing stable transduction of human CD34+ cells with HIV –1 derived lentiviral vector. Molec Therapy 2000; . Crooks GM, Fuller J, Petersen D, Izadi P, Malik P, Pattengale PK, Kohn DB, Gasson JC Constitutive HOXA5 expression inhibits erythropoiesis and increases myelopoiesis from human hematopoietic progenitors. BLOOD 1999; . Case SS, Price MA, Jordan CT, Yu XJ, Wang L, Bauer G, Haas DL, Xu D, Stripecke R., Naldini L, Kohn DB, and Crooks GM Stable transduction of quiescent CD34+CD38-human hematopoietic cells by HIV-1 based lentiviral vectors. Proceedings of the National Academy of Science 1999; 96(6): 2988-2993. Hao QL, Smogorzewska EM, Barsky LW, Crooks GM In Vitro Identification of Single CD34+CD38 Cells With Both Lymphoid and Myeloid Potential. Blood 1998; 91(11): 4145-4151. Rawlings DJ, Quan S, Hao Q-L, Thiemann FT, Smogorzewska M, Witte ON, and Crooks GM Differentiation of human CD34+CD38- cord blood stem cells into B cell progenitors in vitro. Exp Hematology 1997; . Hao QL, Thiemann FT, Petersen D, Smogorzewska EM, Crooks GM Extended long term culture reveals a highly quiescent and primitive human hematopoietc progenitor population. Blood 1996; 88(9): 3306-3313. Shah AJ, Smogorzewska EM, Hannum C, Crooks GM Flt3 Ligand Induces Proliferation of Quiescent Human Bone Marrow CD34+CD38-Cells and Maintains Progenitor Cells In Vitro. Blood 1996; 87(9): 3563-3570. Hao Q-L, Shah AJ, Thiemann FT, Smogorzewska EM, Crooks GM A Functional Comparison of CD34+CD38- Cells in Cord Blood and Bone Marrow. BLOOD 1995; . Crooks GM, Sato JK Ifosfamide and VP16 for Relapsed Childhood Acute Lymphoblastic Leukemia. J Ped Hematol-Oncol 1995; . Lill MC, Fuller JF, Crooks GM, Gasson JC The Role of the Homeobox Gene, HOX B7, in Human Myelomonocytic Differentiation. BLOOD 1995; . Crooks GM, Kohn DB Growth Factors Increase Amphotropic Retrovirus Binding to Human CD34 Positive Bone Marrow Progenitor Cells. Blood 1993; .