Affiliations

Director, Epilepsy Telemetry Unit, Seizure Disorder Center

Professor, Neurology, Psychiatry and Biobehavioral Sciences, Jane and Terry Semel Institute for Neuroscience and Human Behavior, Neurobiology

Member, Brain Research Institute, Neuroscience GPB Home Area

Our laboratories are engaged in understanding the fundamental neuronal mechanisms underlying epileptic and nonepileptic functions of the human limbic system. A variety of in vivo noninvasive and invasive studies, including microelectrode recordings and microdialysis of limbic structures, are carried out in patients with temporal lobe epilepsy during the course of their evaluation for surgical treatment. Following surgery, in vitro electrophysiological, microanatomical and molecular biological studies are performed on resected temporal lobe tissue. Parallel animal studies involve rats made epileptic by intrahippocampal injections of kainic acid. The results of this multidisciplinary human and animal research indicate that enhanced inhibitory, as well as excitatory, mechanisms contribute to the generation of some epileptic seizures, and that disturbed inhibition may also mediate postictal, as well as interictal, nonepileptic behavioral disturbances.

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