Ben James Glasgow, M.D.

Work Address:
Jules Stein B-279

Affiliations
Affiliations
Chief, Ophthalmic Pathology
Professor, Pathology and Laboratory Medicine, Surgical Pathology
Member, Biochemistry, Biophysics & Structural Biology GPB Home Area, Molecular Pharmacology GPB Home Area, Stein Eye Institute
Faculty, Cellular and Molecular Pathology PhD Program
Research Interests
The laboratory is focused in the structure and function of tear proteins as related to dry eye diseases. Tears contain a variety of proteins that protect the ocular surface. The overall goal is to learn the role of proteins in the molecular mechanisms of tear film function. Current efforts are focused on understanding the molecular basis of selectivity, for a group of lipid binding proteins in tears.
Publications

A selected list of publications:

Yeh Po-Ting, Casey Richard, Glasgow Ben J   A novel fluorescent lipid probe for dry eye: retrieval by tear lipocalin in humans Investigative ophthalmology & visual science, 2013; 54(2): 1398-410.
Gasymov Oktay K, Abduragimov Adil R, Glasgow Ben J   Cation-π interactions in lipocalins: structural and functional implications Biochemistry, 2012; 51(14): 2991-3002.
Dean Austin W, Glasgow Ben J   Mass spectrometric identification of phospholipids in human tears and tear lipocalin Investigative ophthalmology & visual science, 2012; 53(4): 1773-82.
Younger Jared R, Johnson R Duncan, Holland Gary N, Page Jon P, Nepomuceno Richard L, Glasgow Ben J, Aldave Anthony J, Yu Fei, Litak Jason, Mondino Bartly J, Mondino Bartly J   Microbiologic and histopathologic assessment of corneal biopsies in the evaluation of microbial keratitis American journal of ophthalmology, 2012; 154(3): 512-519.e2.
Vira Darshni, Pesce Julianna, Glasgow Ben J, Lai Chi, Elashoff David, Abemayor Elliot, John Maie St   Parotidectomy and neck dissection in the management of conjunctival melanoma: are they necessary? The Laryngoscope, 2012; 122(11): 2436-41.
Gasymov Oktay K, Abduragimov Adil R, Glasgow Ben J   Tryptophan rotamer distribution revealed for the α-helix in tear lipocalin by site-directed tryptophan fluorescence The journal of physical chemistry. B, 2012; 116(45): 13381-8.
Mokhtarzadeh M, Casey R, Glasgow BJ.   Fluorescein punctate staining traced to superficial corneal epithelial cells by impression cytology and confocal microscopy, Invest Ophthalmol Vis Sci. , 2011; 52(5): 2127-35.
Mokhtarzadeh Maryam, Casey Richard, Glasgow Ben J   Fluorescein punctate staining traced to superficial corneal epithelial cells by impression cytology and confocal microscopy Investigative ophthalmology & visual science, 2011; 52(5): 2127-35.
Glasgow Ben J, Gasymov Oktay K   Focus on molecules: tear lipocalin Experimental eye research, 2011; 92(4): 242-3.
Gasymov OK, Abduragimov AR, Glasgow BJ.   The conserved disulfide bond of human tear lipocalin modulates conformation and lipid binding in a ligand selective manner, Biochim Biophys Acta. , 2011; 1814(5): 671-83.
Gasymov Oktay K, Abduragimov Adil R, Glasgow Ben J   The conserved disulfide bond of human tear lipocalin modulates conformation and lipid binding in a ligand selective manner Biochimica et biophysica acta, 2011; 1814(5): 671-83.
Nichols Kelly K, Foulks Gary N, Bron Anthony J, Glasgow Ben J, Dogru Murat, Tsubota Kazuo, Lemp Michael A, Sullivan David A   The international workshop on meibomian gland dysfunction: executive summary Investigative ophthalmology & visual science, 2011; 52(4): 1922-9.
Green-Church Kari B, Butovich Igor, Willcox Mark, Borchman Douglas, Paulsen Friedrich, Barabino Stefano, Glasgow Ben J   The international workshop on meibomian gland dysfunction: report of the subcommittee on tear film lipids and lipid-protein interactions in health and disease Investigative ophthalmology & visual science, 2011; 52(4): 1979-93.
Gasymov OK, Abduragimov AR, Glasgow BJ.   Excited protein states of human tear lipocalin for low- and high-affinity ligand binding revealed by functional AB loop motion, Biophys Chem, 2010; 149(1-2): 47-57.
Gasymov Oktay K, Abduragimov Adil R, Glasgow Ben J   Excited protein states of human tear lipocalin for low- and high-affinity ligand binding revealed by functional AB loop motion Biophysical chemistry, 2010; 149(1-2): 47-57.
Pai VC, Glasgow BJ.   MUC16 as a sensitive and specific marker for epithelial downgrowth, Arch Ophthalmol, 2010; 128(11): 1407-12.
Pai Vicky C, Glasgow Ben J   MUC16 as a sensitive and specific marker for epithelial downgrowth Archives of ophthalmology, 2010; 128(11): 1407-12.
Thinda Sumeer, Sikh Puneeta K, Hopp Lawrence M, Glasgow Ben J   Polycarbonate membrane impression cytology: evidence for fluorescein staining in normal and dry eye corneas The British journal of ophthalmology, 2010; 94(4): 406-9.
Glasgow BJ, Gasymov OK, Abduragimov AR, Engle JJ, Casey RC.   Tear lipocalin captures exogenous lipid from abnormal corneal surfaces, Invest Ophthalmol Vis Sci. , 2010; 51(4): 1981-7.
Glasgow Ben J, Gasymov Oktay K, Abduragimov Adil R, Engle Jamison J, Casey Richard C   Tear lipocalin captures exogenous lipid from abnormal corneal surfaces Investigative ophthalmology & visual science, 2010; 51(4): 1981-7.
Gasymov OK, Abduragimov AR, Glasgow BJ.   pH-Dependent conformational changes in tear lipocalin by site-directed tryptophan fluorescence, Biochemistry, 2010; 49(3): 582-90.
Gasymov Oktay K, Abduragimov Adil R, Glasgow Ben J   pH-Dependent conformational changes in tear lipocalin by site-directed tryptophan fluorescence Biochemistry, 2010; 49(3): 582-90.
Yu Le, Aldave Anthony J, Glasgow Ben J   Epstein-Barr virus-associated smooth muscle tumor of the iris in a patient with transplant: a case report and review of the literature Archives of pathology & laboratory medicine, 2009; 133(8): 1238-41.
Chang Heather S, Glasgow Ben J   Evidence that anterior episcleral nerve sheath tumors arise from the Axenfeld nerve loop Archives of ophthalmology, 2009; 127(8): 1060-2.
Glasgow Ben J, Gasymov Oktay K, Casey Richard C   Exfoliative epitheliopathy of bullous keratopathy with breaches in the MUC16 Glycocalyx Investigative ophthalmology & visual science, 2009; 50(9): 4060-4.
Gasymov Oktay K, Abduragimov Adil R, Glasgow Ben J   Intracavitary ligand distribution in tear lipocalin by site-directed tryptophan fluorescence Biochemistry, 2009; 48(30): 7219-28.
Ralli Monica, Goldman Jonathan W, Lee Eric, Pinter-Brown Lauren C, Glasgow Ben J, Sarraf David   Intraocular involvement of mycosis fungoides Archives of ophthalmology, 2009; 127(3): 343-5.
Tai Tak Yee Tania, Damani Mausam R, Vo Rosalind, Rayner Sylvia A, Glasgow Ben J, Hofbauer John D, Casey Richard, Aldave Anthony J   Keratoconus associated with corneal stromal amyloid deposition containing TGFBIp Cornea, 2009; 28(5): 589-93.
Aldave Anthony J, Yellore Vivek S, Sonmez Baris, Bourla Nirit, Salem Andrew K, Khan M Ali, Rayner Sylvia A, Glasgow Ben J   A novel variant of combined granular-lattice corneal dystrophy associated with the Met619Lys mutation in the TGFBI gene Archives of ophthalmology, 2008; 126(3): 371-7.
Tai Tak Yee Tania, Glasgow Ben J   Illuminating the invisible specimen: Descemet membrane endothelial keratoplasty Archives of pathology & laboratory medicine, 2008; 132(3): 322.
Gasymov Oktay K, Abduragimov Adil R, Glasgow Ben J   Ligand binding site of tear lipocalin: contribution of a trigonal cluster of charged residues probed by 8-anilino-1-naphthalenesulfonic acid Biochemistry, 2008; 47(5): 1414-24.
Gasymov Oktay K, Abduragimov Adil R, Glasgow Ben J   Site-directed circular dichroism of proteins: 1Lb bands of Trp resolve position-specific features in tear lipocalin Analytical biochemistry, 2008; 374(2): 386-95.
Yusifov Taleh N, Abduragimov Adil R, Narsinh Kiran, Gasymov Oktay K, Glasgow Ben J   Tear lipocalin is the major endonuclease in tears Molecular vision, 2008; 14(2): 180-8.
Young Tara A, Burgess Barry L, Rao Nagesh P, Glasgow Ben J, Straatsma Bradley R   Transscleral fine-needle aspiration biopsy of macular choroidal melanoma American journal of ophthalmology, 2008; 145(2): 297-302.
Gasymov Oktay K, Abduragimov Adil R, Glasgow Ben J   Evidence for internal and external binding sites on human tear lipocalin Archives of biochemistry and biophysics, 2007; 468(1): 15-21.