Joshua I Goldhaber, M.D.
Affiliations
Affiliations
Professor, Medicine
Member, Molecular, Cellular & Integrative Physiology GPB Home Area
Faculty, Cardiovascular Research Laboratory, Cardiology
Publications

A selected list of publications:

Nicoll Debora A, Ottolia Michela, Goldhaber Joshua I, Philipson Kenneth D   20 years from NCX purification and cloning: milestones Advances in experimental medicine and biology, 2013; 961: 17-23.
Goldhaber Joshua I, Philipson Kenneth D   Cardiac sodium-calcium exchange and efficient excitation-contraction coupling: implications for heart disease Advances in experimental medicine and biology, 2013; 961: 355-64.
Ottolia Michela, Torres Natalia, Bridge John H B, Philipson Kenneth D, Goldhaber Joshua I   Na/Ca exchange and contraction of the heart Journal of molecular and cellular cardiology, 2013; 61: 28-33.
Angelis Ekaterini, Zhao Peng, Zhang Rui, Goldhaber Joshua I, Maclellan W Robb   The role of E2F-1 and downstream target genes in mediating ischemia/reperfusion injury in vivo Journal of molecular and cellular cardiology, 2011; 51(6): 919-26.
Larbig Robert, Torres Natalia, Bridge John H B, Goldhaber Joshua I, Philipson Kenneth D   Activation of reverse Na+-Ca2+ exchange by the Na+ current augments the cardiac Ca2+ transient: evidence from NCX knockout mice The Journal of physiology, 2010; 588(Pt 17): 3267-76.
Torres Natalia S, Larbig Robert, Rock Alex, Goldhaber Joshua I, Bridge John H B   Na+ currents are required for efficient excitation-contraction coupling in rabbit ventricular myocytes: a possible contribution of neuronal Na+ channels The Journal of physiology, 2010; 588(Pt 21): 4249-60.
Goldhaber Joshua I, Hamilton Michele A   Role of inotropic agents in the treatment of heart failure Circulation, 2010; 121(14): 1655-60.
Neco Patricia, Rose Beth, Huynh Nhi, Zhang Rui, Bridge John H B, Philipson Kenneth D, Goldhaber Joshua I   Sodium-calcium exchange is essential for effective triggering of calcium release in mouse heart Biophysical journal, 2010; 99(3): 755-64.
Jumabay Medet, Zhang Rui, Yao Yucheng, Goldhaber Joshua I, Boström Kristina I   Spontaneously beating cardiomyocytes derived from white mature adipocytes Cardiovascular research, 2010; 85(1): 17-27.
Goldhaber Joshua I, Bridge John H B   Loss of intracellular and intercellular synchrony of calcium release in systolic heart failure Circulation. Heart failure, 2009; 2(3): 157-9.
Chantawansri Chana, Huynh Nhi, Yamanaka Jun, Garfinkel Alan, Lamp Scott T, Inoue Masashi, Bridge John H B, Goldhaber Joshua I   Effect of metabolic inhibition on couplon behavior in rabbit ventricular myocytes Biophysical journal, 2008; 94(5): 1656-66.
Schenke-Layland Katja, Rhodes Katrin E, Angelis Ekaterini, Butylkova Yekaterina, Heydarkhan-Hagvall Sepideh, Gekas Christos, Zhang Rui, Goldhaber Joshua I, Mikkola Hanna K, Plath Kathrin, MacLellan W Robb   Reprogrammed mouse fibroblasts differentiate into cells of the cardiovascular and hematopoietic lineages Stem cells (Dayton, Ohio), 2008; 26(6): 1537-46.
Sachse Frank B, Savio-Galimberti Eleonora, Goldhaber Joshua I, Bridge John H B   Sub-micrometer anatomical models of the sarcolemma of cardiac myocytes based on confocal imaging Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing, 2008; 94(5): 390-401.
Ruan Hongmei, Mitchell Scherise, Vainoriene Monika, Lou Qing, Xie Lai-Hua, Ren Shuxun, Goldhaber Joshua I, Wang Yibin   Gi alpha 1-mediated cardiac electrophysiological remodeling and arrhythmia in hypertrophic cardiomyopathy Circulation, 2007; 116(6): 596-605.
Pott Christian, Goldhaber Joshua I, Philipson Kenneth D   Homozygous overexpression of the Na+-Ca2+ exchanger in mice: evidence for increased transsarcolemmal Ca2+ fluxes Annals of the New York Academy of Sciences, 2007; 1099(6): 310-4.
Pott Christian, Ren Xiaoyan, Tran Diana X, Yang Ming-Jim, Henderson Scott, Jordan Maria C, Roos Kenneth P, Garfinkel Alan, Philipson Kenneth D, Goldhaber Joshua I   Mechanism of shortened action potential duration in Na+-Ca2+ exchanger knockout mice American journal of physiology. Cell physiology, 2007; 292(2): C968-73.
Pott Christian, Henderson Scott A, Goldhaber Joshua I, Philipson Kenneth D   Na+/Ca2+ exchanger knockout mice: plasticity of cardiac excitation-contraction coupling Annals of the New York Academy of Sciences, 2007; 1099(6): 270-5.
Pott Christian, Yip Mey, Goldhaber Joshua I, Philipson Kenneth D   Regulation of cardiac L-type Ca2+ current in Na+-Ca2+ exchanger knockout mice: functional coupling of the Ca2+ channel and the Na+-Ca2+ exchanger Biophysical journal, 2007; 92(4): 1431-7.
Pott Christian, Goldhaber Joshua I   Is the ryanodine receptor a target for antiarrhythmic therapy? Circulation research, 2006; 98(10): 1232-3.
Slesina M, Inman EM, Moore AE, Goldhaber JI, Rome LH, Volknandt W   Movement of vault particles visualized by GFP-tagged major vault protein, Cell Tissue Res, 2006; 324: 403-410.
Goldhaber, J.I., Xie, L., T. Duong, C. Motter, K. Khuu, and J.N. Weiss   Action Potential Duration Restitution and Alternans in Rabbit Ventricular Myocytes: The Key Role of Intracellular Calcium Cycling, Circ. Res, 2005; 96:459-466.
Imahashi K., C. Pott, J.I. Goldhaber, C. Steenbergen, K.D. Philipson, E. Murphy   Cardiac-specific ablation of the Na+/Ca2+ exchanger confers protection against ischemia/reperfusion injury, Cir. Res, 2005; 97: 916-921.
Fukumoto, G.H., S.T. Lamp, C. Motter, J. H. B. Bridge, A. Garfinkel and J.I. Goldhaber   Metabolic inhibition alters subcellular calcium release patterns in rat ventricular myocytes: implications for defective excitation-contraction coupling during ischemia and reperfusion, Cir. Res, 2005; 96: 551-557.
Langenbacher AD, Dong Y, Shu XD, Choi JY, Nicoll DA, Goldhaber JI, Philipson KD, Chen JN   Mutation in sodium-calcium exchanger 1 (NCX1) causes cardiac fibrillation in zebrafish Proc, Natl. Acad. Sci, 2005; 102: 17699-17704.
Pott, C., K. D. Philipson, and J. I. Goldhaber   Reduced transarcolemmal calcium flux with increased E-C coupling gain explains survival in Na+-Ca2+ exchange knockout mice, Cir. Res, 2005; 97: 1288-95.
Honda H M, Wakamatsu B K, Goldhaber J I, Berliner J A, Navab M, Weiss J N   High-density lipoprotein increases intracellular calcium levels by releasing calcium from internal stores in human endothelial cells Atherosclerosis, 1999; 143(2): 299-306.
Honda H M, Leitinger N, Frankel M, Goldhaber J I, Natarajan R, Nadler J L, Weiss J N, Berliner J A   Induction of monocyte binding to endothelial cells by MM-LDL: role of lipoxygenase metabolites Arteriosclerosis, thrombosis, and vascular biology, 1999; 19(3): 680-6.
John S A, Kondo R, Wang S Y, Goldhaber J I, Weiss J N   Connexin-43 hemichannels opened by metabolic inhibition The Journal of biological chemistry, 1999; 274(1): 236-40.
Ross R S, Pham C, Shai S Y, Goldhaber J I, Fenczik C, Glembotski C C, Ginsberg M H, Loftus J C   Beta1 integrins participate in the hypertrophic response of rat ventricular myocytes Circulation research, 1998; 82(11): 1160-72.
Hamilton M A, Stevenson L W, Fonarow G C, Steimle A, Goldhaber J I, Child J S, Chopra I J, Moriguchi J D, Hage A   Safety and hemodynamic effects of intravenous triiodothyronine in advanced congestive heart failure The American journal of cardiology, 1998; 81(4): 443-7.
Middlekauff H R, Rivkees S A, Raybould H E, Bitticaca M, Goldhaber J I, Weiss J N   Localization and functional effects of adenosine A1 receptors on cardiac vagal afferents in adult rats The American journal of physiology, 1998; 274(2 Pt 2): H441-7.
Goldhaber J N, Deutsch J N, Alexander J N, Weiss J N   Lysophosphatidylcholine and Cellular Potassium Loss in Isolated Rabbit Ventricle Journal of cardiovascular pharmacology and therapeutics, 1998; 3(1): 37-42.
Shivkumar K, Deutsch N A, Lamp S T, Khuu K, Goldhaber J I, Weiss J N   Mechanism of hypoxic K loss in rabbit ventricle The Journal of clinical investigation, 1997; 100(7): 1782-8.
Goldhaber J I, Kim K H, Natterson P D, Lawrence T, Yang P, Weiss J N   Effects of TNF-alpha on [Ca2+]i and contractility in isolated adult rabbit ventricular myocytes The American journal of physiology, 1996; 271(4 Pt 2): H1449-55.
Goldhaber J I   Free radicals enhance Na+/Ca2+ exchange in ventricular myocytes The American journal of physiology, 1996; 271(3 Pt 2): H823-33.
Honda H M, Goldhaber J I, Demer L L, Weiss J N   Endothelium-dependent vasodilators do not cause propagated intercellular Ca2+ waves in vascular endothelial monolayers Cell calcium, 1996; 19(2): 97-104.
Goldhaber J I, Liu E   Excitation-contraction coupling in single guinea-pig ventricular myocytes exposed to hydrogen peroxide The Journal of physiology, 1994; 477 ( Pt 1)(2): 135-47.
Shieh R C, Goldhaber J I, Stuart J S, Weiss J N   Lactate transport in mammalian ventricle. General properties and relation to K+ fluxes Circulation research, 1994; 74(5): 829-38.
Leaf D A, Goldhaber J   Effects of physical exercise training in syndrome X Clinical cardiology, 1993; 16(1): 65-6.
Liu E, Goldhaber J I, Weiss J N   Effects of lysophosphatidylcholine on electrophysiological properties and excitation-contraction coupling in isolated guinea pig ventricular myocytes The Journal of clinical investigation, 1991; 88(6): 1819-32.
Goldhaber J I, Weiss J N   Oxygen free radicals and cardiac reperfusion abnormalities Hypertension, 1992; 20(1): 118-27.
Goldhaber J I, Parker J M, Weiss J N   Mechanisms of excitation-contraction coupling failure during metabolic inhibition in guinea-pig ventricular myocytes The Journal of physiology, 1991; 443(6): 371-86.
Goldhaber J I, Ji S, Lamp S T, Weiss J N   Effects of exogenous free radicals on electromechanical function and metabolism in isolated rabbit and guinea pig ventricle. Implications for ischemia and reperfusion injury The Journal of clinical investigation, 1989; 83(6): 1800-9.
Schenke-Layland Katja, Nsair Ali, Van Handel Ben, Angelis Ekaterini, Gluck Jessica M, Votteler Miriam, Goldhaber Joshua I, Mikkola Hanna K, Kahn Michael, Maclellan William R   Recapitulation of the embryonic cardiovascular progenitor cell niche Biomaterials, 2011; 32(11): 2748-56.
Barwe Sonali P, Jordan Maria C, Skay Anna, Inge Landon, Rajasekaran Sigrid A, Wolle Daniel, Johnson Christina L, Neco Patricia, Fang Kun, Rozengurt Nora, Goldhaber Joshua I, Roos Kenneth P, Rajasekaran Ayyappan K   Dysfunction of ouabain-induced cardiac contractility in mice with heart-specific ablation of Na,K-ATPase beta1-subunit Journal of molecular and cellular cardiology, 2009; 47(4): 552-60.
Sachse Frank B, Savio-Galimberti Eleonora, Goldhaber Joshua I, Bridge John H B   Towards computational modeling of excitation-contraction coupling in cardiac myocytes: reconstruction of structures and proteins from confocal imaging Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing, 2009; 47(4): 328-39.
Savio-Galimberti Eleonora, Frank Joy, Inoue Masashi, Goldhaber Joshua I, Cannell Mark B, Bridge John H B, Sachse Frank B   Novel features of the rabbit transverse tubular system revealed by quantitative analysis of three-dimensional reconstructions from confocal images Biophysical journal, 2008; 95(4): 2053-62.
Pott Christian, Philipson Kenneth D, Goldhaber Joshua I   Excitation-contraction coupling in Na+-Ca2+ exchanger knockout mice: reduced transsarcolemmal Ca2+ flux Circulation research, 2005; 97(12): 1288-95.
Langenbacher Adam D, Dong Yuan, Shu Xiaodong, Choi Jayoung, Nicoll Debora A, Goldhaber Joshua I, Philipson Kenneth D, Chen Jau-Nian   Mutation in sodium-calcium exchanger 1 (NCX1) causes cardiac fibrillation in zebrafish Proceedings of the National Academy of Sciences of the United States of America, 2005; 102(49): 17699-704.
Imahashi Kenichi, Pott Christian, Goldhaber Joshua I, Steenbergen Charles, Philipson Kenneth D, Murphy Elizabeth   Cardiac-specific ablation of the Na+-Ca2+ exchanger confers protection against ischemia/reperfusion injury Circulation research, 2005; 97(9): 916-21.
Reuter Hannes, Pott Christian, Goldhaber Joshua I, Henderson Scott A, Philipson Kenneth D, Schwinger Robert H G   Na(+)--Ca2+ exchange in the regulation of cardiac excitation-contraction coupling Cardiovascular research, 2005; 67(2): 198-207.
Shimizu Hirohito, Schredelseker Johann, Huang Jie, Lu Kui, Naghdi Shamim, Lu Fei, Franklin Sarah, Fiji Hannah Dg, Wang Kevin, Zhu Huanqi, Tian Cheng, Lin Billy, Nakano Haruko, Ehrlich Amy, Nakai Junichi, Stieg Adam Z, Gimzewski James K, Nakano Atsushi, Goldhaber Joshua I, Vondriska Thomas M, Hajnóczky György, Kwon Ohyun, Chen Jau-Nian   Mitochondrial Ca(2+) uptake by the voltage-dependent anion channel 2 regulates cardiac rhythmicity eLife, 2015; 4: .
Goldhaber Joshua I, Henderson Scott A, Reuter Hannes, Pott Christian, Philipson Kenneth D   Effects of Na+-Ca2+ exchange expression on excitation-contraction coupling in genetically modified mice Annals of the New York Academy of Sciences, 2005; 1047(2): 122-6.
Anderson Mark E, Goldhaber Joshua, Houser Steven R, Puceat Michel, Sussman Mark A   Embryonic stem cell-derived cardiac myocytes are not ready for human trials Circulation research, 2014; 115(3): 335-8.
Fukumoto Gary H, Lamp Scott T, Motter Christi, Bridge John H B, Garfinkel Alan, Goldhaber Joshua I   Metabolic inhibition alters subcellular calcium release patterns in rat ventricular myocytes: implications for defective excitation-contraction coupling during cardiac ischemia and failure Circulation research, 2005; 96(5): 551-7.
Goldhaber Joshua I, Xie Lai-Hua, Duong Tan, Motter Christi, Khuu Kien, Weiss James N   Action potential duration restitution and alternans in rabbit ventricular myocytes: the key role of intracellular calcium cycling Circulation research, 2005; 96(4): 459-66.
Torres Natalia S, Sachse Frank B, Izu Leighton T, Goldhaber Joshua I, Spitzer Kenneth W, Bridge John H   A modified local control model for Ca2+ transients in cardiomyocytes: junctional flux is accompanied by release from adjacent non-junctional RyRs Journal of molecular and cellular cardiology, 2014; 68(3): 1-11.
Pott Christian, Goldhaber Joshua I, Philipson Kenneth D   Genetic manipulation of cardiac Na+/Ca2+ exchange expression Biochemical and biophysical research communications, 2004; 322(4): 1336-40.
Myerburg Robert J, Halperin Henry, Egan Debra A, Boineau Robin, Chugh Sumeet S, Gillis Anne M, Goldhaber Joshua I, Lathrop David A, Liu Peter, Niemann James T, Ornato Joseph P, Sopko George, Van Eyk Jennifer E, Walcott Gregory P, Weisfeldt Myron L, Wright Jacqueline D, Zipes Douglas P   Pulseless electric activity: definition, causes, mechanisms, management, and research priorities for the next decade: report from a National Heart, Lung, and Blood Institute workshop Circulation, 2013; 128(23): 2532-41.
Henderson Scott A, Goldhaber Joshua I, So Jessica M, Han Tieyan, Motter Christi, Ngo An, Chantawansri Chana, Ritter Matthew R, Friedlander Martin, Nicoll Debora A, Frank Joy S, Jordan Maria C, Roos Kenneth P, Ross Robert S, Philipson Kenneth D   Functional adult myocardium in the absence of Na+-Ca2+ exchange: cardiac-specific knockout of NCX1 Circulation research, 2004; 95(6): 604-11.
Okada Hideshi, Lai N Chin, Kawaraguchi Yoshitaka, Liao Peter, Copps Jeffrey, Sugano Yasuo, Okada-Maeda Sunaho, Banerjee Indroneal, Schilling Jan M, Gingras Alexandre R, Asfaw Elizabeth K, Suarez Jorge, Kang Seok-Min, Perkins Guy A, Au Carol G, Israeli-Rosenberg Sharon, Manso Ana Maria, Liu Zheng, Milner Derek J, Kaufman Stephen J, Patel Hemal H, Roth David M, Hammond H Kirk, Taylor Susan S, Dillmann Wolfgang H, Goldhaber Joshua I, Ross Robert S   Integrins protect cardiomyocytes from ischemia/reperfusion injury The Journal of clinical investigation, 2013; 123(10): 4294-308.
Wang Yibin, Goldhaber Joshua I   Return of calcium: manipulating intracellular calcium to prevent cardiac pathologies Proceedings of the National Academy of Sciences of the United States of America, 2004; 101(16): 5697-8.
Groenke Sabine, Larson Eric D, Alber Sarah, Zhang Rui, Lamp Scott T, Ren Xiaoyan, Nakano Haruko, Jordan Maria C, Karagueuzian Hrayr S, Roos Kenneth P, Nakano Atsushi, Proenza Catherine, Philipson Kenneth D, Goldhaber Joshua I   Complete atrial-specific knockout of sodium-calcium exchange eliminates sinoatrial node pacemaker activity PloS one, 2013; 8(11): e81633.
Reuter Hannes, Han Tieyan, Motter Christi, Philipson Kenneth D, Goldhaber Joshua I   Mice overexpressing the cardiac sodium-calcium exchanger: defects in excitation-contraction coupling The Journal of physiology, 2004; 554(Pt 3): 779-89.
Pott Christian, Muszynski Adam, Ruhe Matthias, Bögeholz N, Schulte Jan S, Milberg Peter, Mönnig Gerold, Fabritz Larissa, Goldhaber Joshua I, Breithardt Günter, Schmitz Wilhelm, Philipson Kenneth D, Eckardt Lars, Kirchhof Paulus, Müller Frank U   Proarrhythmia in a non-failing murine model of cardiac-specific Na+/Ca 2+ exchanger overexpression: whole heart and cellular mechanisms Basic research in cardiology, 2012; 107(2): 247.
Reuter Hannes, Henderson Scott A, Han Tieyan, Mottino Giuliano A, Frank Joy S, Ross Robert S, Goldhaber Joshua I, Philipson Kenneth D   Cardiac excitation-contraction coupling in the absence of Na(+) - Ca2+ exchange Cell calcium, 2003; 34(1): 19-26.
Nsair Ali, Schenke-Layland Katja, Van Handel Ben, Evseenko Denis, Kahn Michael, Zhao Peng, Mendelis Joseph, Heydarkhan Sanaz, Awaji Obina, Vottler Miriam, Geist Susanne, Chyu Jennifer, Gago-Lopez Nuria, Crooks Gay M, Plath Kathrin, Goldhaber Josh, Mikkola Hanna K A, MacLellan W Robb   Characterization and therapeutic potential of induced pluripotent stem cell-derived cardiovascular progenitor cells PloS one, 2012; 7(10): e45603.
Reuter Hannes, Henderson Scott A, Han Tieyan, Matsuda Toshio, Baba Akemichi, Ross Robert S, Goldhaber Joshua I, Philipson Kenneth D   Knockout mice for pharmacological screening: testing the specificity of Na+-Ca2+ exchange inhibitors Circulation research, 2002; 91(2): 90-2.
Pott Christian, Eckardt Lars, Goldhaber Joshua I   Triple threat: the Na+/Ca2+ exchanger in the pathophysiology of cardiac arrhythmia, ischemia and heart failure Current drug targets, 2011; 12(5): 737-47.
Reuter Hannes, Henderson Scott A, Han Tieyan, Ross Robert S, Goldhaber Joshua I, Philipson Kenneth D   The Na+-Ca2+ exchanger is essential for the action of cardiac glycosides Circulation research, 2002; 90(3): 305-8.
Korge P, Goldhaber J I, Weiss J N   Phenylarsine oxide induces mitochondrial permeability transition, hypercontracture, and cardiac cell death American journal of physiology. Heart and circulatory physiology, 2001; 280(5): H2203-13.
Kondo R P, Wang S Y, John S A, Weiss J N, Goldhaber J I   Metabolic inhibition activates a non-selective current through connexin hemichannels in isolated ventricular myocytes Journal of molecular and cellular cardiology, 2000; 32(10): 1859-72.
Kondo R P, Weiss J N, Goldhaber J I   Putative ryanodine receptors in the sarcolemma of ventricular myocytes Pflügers Archiv : European journal of physiology, 2000; 440(1): 125-31.
Goldhaber J I, Qayyum M S   Oxygen free radicals and excitation-contraction coupling Antioxidants & redox signaling, 2000; 2(1): 55-64.
Chudin E, Goldhaber J, Garfinkel A, Weiss J, Kogan B   Intracellular Ca(2+) dynamics and the stability of ventricular tachycardia Biophysical journal, 1999; 77(6): 2930-41.
Goldhaber J I   Sodium-calcium exchange: the phantom menace Circulation research, 1999; 85(11): 982-4.
Goldhaber J I, Lamp S T, Walter D O, Garfinkel A, Fukumoto G H, Weiss J N   Local regulation of the threshold for calcium sparks in rat ventricular myocytes: role of sodium-calcium exchange The Journal of physiology, 1999; 520 Pt 2(11): 431-8.