Jose Alfonso Rodriguez, Ph.D.
Assistant Professor, Chemistry and Biochemistry
Member, Biochemistry, Biophysics & Structural Biology GPB Home Area, California NanoSystems Institute

Prof. Rodriguez studies the complex architecture of biological systems - from single biomolecules to cellular assemblies - at high resolution. His work is largely based on diffraction phenomena and combines computational, biochemical and biophysical experiments. The development of new methods is central to this work, particularly using emerging technologies in cryo-electron microscopy, nano and coherent x-ray diffraction, and macromolecular design. Combined, these tools can reveal undiscovered structures that broadly influence chemistry, biology, and medicine.


A selected list of publications:

Xu Rui, Jiang Huaidong, Song Changyong, Rodriguez Jose A, Huang Zhifeng, Chen Chien-Chun, Nam Daewoong, Park Jaehyun, Gallagher-Jones Marcus, Kim Sangsoo, Kim Sunam, Suzuki Akihiro, Takayama Yuki, Oroguchi Tomotaka, Takahashi Yukio, Fan Jiadong, Zou Yunfei, Hatsui Takaki, Inubushi Yuichi, Kameshima Takashi, Yonekura Koji, Tono Kensuke, Togashi Tadashi, Sato Takahiro, Yamamoto Masaki, Nakasako Masayoshi, Yabashi Makina, Ishikawa Tetsuya, Miao Jianwei   Single-shot three-dimensional structure determination of nanocrystals with femtosecond X-ray free-electron laser pulses Nature communications, 2014; 5(3): 4061.
Ding Hui, Helguera Gustavo, Rodríguez José A, Markman Janet, Luria-Pérez Rosendo, Gangalum Pallavi, Portilla-Arias Jose, Inoue Satoshi, Daniels-Wells Tracy R, Black Keith, Holler Eggehard, Penichet Manuel L, Ljubimova Julia Y   Polymalic acid nanobioconjugate for simultaneous immunostimulation and inhibition of tumor growth in HER2/neu-positive breast cancer Journal of controlled release : official journal of the Controlled Release Society, 2013; 171(3): 322-9.
Rodriguez Jose A, Xu Rui, Chen Chien-Chun, Zou Yunfei, Miao Jianwei   Oversampling smoothness: an effective algorithm for phase retrieval of noisy diffraction intensities Journal of applied crystallography, 2013; 46(Pt 2): 312-318.
Daniels-Wells Tracy R, Helguera Gustavo, Rodríguez José A, Leoh Lai Sum, Erb Michael A, Diamante Graciel, Casero David, Pellegrini Matteo, Martínez-Maza Otoniel, Penichet Manuel L   Insights into the mechanism of cell death induced by saporin delivered into cancer cells by an antibody fusion protein targeting the transferrin receptor 1 Toxicology in vitro : an international journal published in association with BIBRA, 2013; 27(1): 220-31.
Daniels Tracy R, Leuchter Richard K, Quintero Rafaela, Helguera Gustavo, Rodríguez José A, Martínez-Maza Otoniel, Schultes Birgit C, Nicodemus Christopher F, Penichet Manuel L   Targeting HER2/neu with a fully human IgE to harness the allergic reaction against cancer cells Cancer immunology, immunotherapy : CII, 2012; 61(7): 991-1003.
Helguera Gustavo, Jemielity Stephanie, Abraham Jonathan, Cordo Sandra M, Martinez M Guadalupe, Rodríguez José A, Bregni Carlos, Wang Jinyize J, Farzan Michael, Penichet Manuel L, Candurra Nélida A, Choe Hyeryun   An antibody recognizing the apical domain of human transferrin receptor 1 efficiently inhibits the entry of all new world hemorrhagic Fever arenaviruses Journal of virology, 2012; 86(7): 4024-8.
Daniels Tracy R, Bernabeu Ezequiel, Rodríguez José A, Patel Shabnum, Kozman Maggie, Chiappetta Diego A, Holler Eggehard, Ljubimova Julia Y, Helguera Gustavo, Penichet Manuel L   The transferrin receptor and the targeted delivery of therapeutic agents against cancer Biochimica et biophysica acta, 2012; 1820(3): 291-317.
Rodríguez José A, Luria-Pérez Rosendo, López-Valdés Héctor E, Casero David, Daniels Tracy R, Patel Shabnum, Avila David, Leuchter Richard, So Sokuntheavy, Ortiz-Sánchez Elizabeth, Bonavida Benjamin, Martínez-Maza Otoniel, Charles Andrew C, Pellegrini Matteo, Helguera Gustavo, Penichet Manuel L   Lethal iron deprivation induced by non-neutralizing antibodies targeting transferrin receptor 1 in malignant B cells Leukemia & lymphoma, 2011; 52(11): 2169-78.
Helguera Gustavo, Rodríguez José A, Luria-Pérez Rosendo, Henery Shannon, Catterton Paul, Bregni Carlos, George Thaddeus C, Martínez-Maza Otoniel, Penichet Manuel L   Visualization and quantification of cytotoxicity mediated by antibodies using imaging flow cytometry Journal of immunological methods, 2011; 368(1-2): 54-63.
Jensen-Jarolim E, Achatz G, Turner M C, Karagiannis S, Legrand F, Capron M, Penichet M L, Rodríguez J A, Siccardi A G, Vangelista L, Riemer A B, Gould H   AllergoOncology: the role of IgE-mediated allergy in cancer Allergy, 2008; 63(10): 1255-66.
Rodríguez José A, Helguera Gustavo, Daniels Tracy R, Neacato Isabel I, López-Valdés Héctor E, Charles Andrew C, Penichet Manuel L   Binding specificity and internalization properties of an antibody-avidin fusion protein targeting the human transferrin receptor Journal of controlled release : official journal of the Controlled Release Society, 2007; 124(1-2): 35-42.
Helguera Gustavo, Rodríguez José A, Daniels Tracy R, Penichet Manuel L   Long-term immunity elicited by antibody-cytokine fusion proteins protects against sequential challenge with murine mammary and colon malignancies Cancer immunology, immunotherapy : CII, 2007; 56(9): 1507-12.
Daniels Tracy R, Delgado Tracie, Rodriguez Jose A, Helguera Gustavo, Penichet Manuel L   The transferrin receptor part I: Biology and targeting with cytotoxic antibodies for the treatment of cancer Clinical immunology (Orlando, Fla.), 2006; 121(2): 144-58.
Ng Patrick P, Helguera Gustavo, Daniels Tracy R, Lomas Simon Z, Rodriguez Jose A, Schiller Gary, Bonavida Benjamin, Morrison Sherie L, Penichet Manuel L   Molecular events contributing to cell death in malignant human hematopoietic cells elicited by an IgG3-avidin fusion protein targeting the transferrin receptor Blood, 2006; 108(8): 2745-54.
Helguera Gustavo, Rodríguez José A, Penichet Manuel L   Cytokines fused to antibodies and their combinations as therapeutic agents against different peritoneal HER2/neu expressing tumors Molecular cancer therapeutics, 2006; 5(4): 1029-40.