Holly Ruth Middlekauff, M.D.

Mailing Address:
47-123 CHS

Office Address:
42-237 CHS
Los Angeles, CA

Affiliations
Affiliations
Professor, Medicine
Member, Adult Cardiac Catheterization Laboratory, Molecular, Cellular & Integrative Physiology GPB Home Area
Faculty, Cardiology
Publications

A selected list of publications:

Park Jeanie, Middlekauff Holly R, Campese Vito M   Abnormal sympathetic reactivity to the cold pressor test in overweight humans American journal of hypertension, 2012; 25(12): 1236-41.
Park Jeanie, Quyyumi Arshed A, Middlekauff Holly R   Exercise Pressor Response and Arterial Baroreflex Unloading During Exercise in Chronic Kidney Disease Journal of applied physiology (Bethesda, Md. : 1985), 2012; .
Middlekauff Holly R, Vigna Chris, Verity M Anthony, Fonarow Gregg C, Horwich Tamara B, Hamilton Michele A, Shieh Perry, Tupling A Russell   Abnormalities of calcium handling proteins in skeletal muscle mirror those of the heart in humans with heart failure: a shared mechanism? Journal of cardiac failure, 2012; 18(9): 724-33.
Alves M J N N, dos Santos Marcelo Rodrigues, Nobre Thais Simões, Martinez D G, Pereira Barretto Antonio Carlos, Brum Patricia Chakur, Rondon Maria Urbana P B, Middlekauff Holly R, Negrão Carlos Eduardo   Mechanisms of blunted muscle vasodilation during peripheral chemoreceptor stimulation in heart failure patients Hypertension, 2012; 60(3): 669-76.
Antunes-Correa Ligia M, Kanamura Bianca Y, Melo Ruth C, Nobre Thais S, Ueno Linda M, Franco Fabio G M, Roveda Fabiana, Braga Ana Maria, Rondon Maria U P B, Brum Patricia C, Barretto Antonio C P, Middlekauff Holly R, Negrao Carlos E   Exercise training improves neurovascular control and functional capacity in heart failure patients regardless of age European journal of preventive cardiology, 2012; 19(4): 822-9.
Middlekauff Holly R, Park Jeanie, Gornbein Jeffrey A   Lack of effect of ovarian cycle and oral contraceptives on baroreceptor and nonbaroreceptor control of sympathetic nerve activity in healthy women American journal of physiology. Heart and circulatory physiology, 2012; 302(12): H2560-6.
Martinez Daniel G, Nicolau José C, Lage Rony L, Toschi-Dias Edgar, de Matos Luciana D N J, Alves Maria Janieire N N, Trombetta Ivani C, Dias da Silva Valdo J, Middlekauff Holly R, Negrão Carlos E, Rondon Maria U P B   Effects of long-term exercise training on autonomic control in myocardial infarction patients Hypertension, 2011; 58(6): 1049-56.
Horwich Tamara B, Middlekauff Holly R, Maclellan W Robb, Fonarow Gregg C   Statins do not significantly affect muscle sympathetic nerve activity in humans with nonischemic heart failure: a double-blind placebo-controlled trial Journal of cardiac failure, 2011; 17(11): 879-86.
Soares-Miranda Luisa, Franco Fabio G M, Roveda Fabiana, Martinez Daniel G, Rondon Maria U P B, Mota Jorge, Brum Patricia C, Antunes-Correa Ligia M, Nobre Thais S, Barretto Antonio C P, Middlekauff Holly R, Negrao Carlos E   Effects of exercise training on neurovascular responses during handgrip exercise in heart failure patients International journal of cardiology, 2011; 146(1): 122-5.
Middlekauff Holly R   Making the case for skeletal myopathy as the major limitation of exercise capacity in heart failure Circulation. Heart failure, 2010; 3(4): 537-46.
Antunes-Correa Ligia M, Melo Ruth C, Nobre Thais S, Ueno Linda M, Franco Fabio G M, Braga Ana M W, Rondon Maria U P B, Brum Patricia C, Barretto Antonio C P, Middlekauff Holly R, Negrao Carlos E   Impact of gender on benefits of exercise training on sympathetic nerve activity and muscle blood flow in heart failure European journal of heart failure, 2010; 12(1): 58-65.
Negrão Carlos E, Santos Amilton C, Rondon Maria U, Franco Fabio G, Ianni Barbara, Rochitte Carlos E, Braga Ana M F W, Oliveira Múcio T, Mady Charles, Barretto Antonio C P, Middlekauff Holly R   Muscle sympathetic nerve activity in patients with Chagas' disease International journal of cardiology, 2009; 137(3): 252-9.
Park Jeanie, Middlekauff Holly R   Altered pattern of sympathetic activity with the ovarian cycle in female smokers American journal of physiology. Heart and circulatory physiology, 2009; 297(2): H564-8.
Barretto Antonio C P, Santos Amilton C, Munhoz Robinson, Rondon Maria U P B, Franco Fábio G, Trombetta Ivani C, Roveda Fabiana, de Matos Luciana N J, Braga Ana M W, Middlekauff Holly R, Negrão Carlos E   Increased muscle sympathetic nerve activity predicts mortality in heart failure patients International journal of cardiology, 2009; 135(3): 302-7.
Ueno Linda M, Drager Luciano F, Rodrigues Ana C T, Rondon Maria U P B, Braga Ana M F W, Mathias Wilson, Krieger Eduardo M, Barretto Antonio C P, Middlekauff Holly R, Lorenzi-Filho Geraldo, Negrão Carlos E   Effects of exercise training in patients with chronic heart failure and sleep apnea Sleep, 2009; 32(5): 637-47.
Park Jeanie, Campese Vito M, Nobakht Niloofar, Middlekauff Holly R   Differential distribution of muscle and skin sympathetic nerve activity in patients with end-stage renal disease Journal of applied physiology (Bethesda, Md. : 1985), 2008; 105(6): 1873-6.
Park Jeanie, Campese Vito M, Middlekauff Holly R   Exercise pressor reflex in humans with end-stage renal disease American journal of physiology. Regulatory, integrative and comparative physiology, 2008; 295(4): R1188-94.
Middlekauff Holly R, Chiu Josephine, Hamilton Michele A, Fonarow Gregg C, Maclellan W Robb, Hage Antoine, Moriguchi Jaime, Patel Jignesh   Cyclooxygenase products sensitize muscle mechanoreceptors in humans with heart failure American journal of physiology. Heart and circulatory physiology, 2008; 294(4): H1956-62.
Horwich Tamara B, Middlekauff Holly R   Potential autonomic nervous system effects of statins in heart failure Heart failure clinics, 2008; 4(2): 163-70.
Negrão Carlos E, Middlekauff Holly R   Exercise training in heart failure: reduction in angiotensin II, sympathetic nerve activity, and baroreflex control Journal of applied physiology (Bethesda, Md. : 1985), 2008; 104(3): 577-8.
Negrao Carlos Eduardo, Middlekauff Holly R   Adaptations in autonomic function during exercise training in heart failure Heart failure reviews, 2008; 13(1): 51-60.
Alves Maria Janieire N N, Rondon Maria Urbana P B, Santos Amilton C, Dias Rodrigo G, Barretto Antonio Carlos P, Krieger Eduardo M, Middlekauff Holly R, Negrão Carlos Eduardo   Sympathetic nerve activity restrains reflex vasodilatation in heart failure Clinical autonomic research : official journal of the Clinical Autonomic Research Society, 2007; 17(6): 364-9.
Di Vanna Andrea, Braga Ana Maria F W, Laterza Mateus C, Ueno Linda M, Rondon Maria Urbana P B, Barretto Antonio C P, Middlekauff Holly R, Negrão Carlos E   Blunted muscle vasodilatation during chemoreceptor stimulation in patients with heart failure American journal of physiology. Heart and circulatory physiology, 2007; 293(1): H846-52.
Fraga Raffael, Franco Fábio G, Roveda Fabiana, de Matos Luciana N J, Braga Ana M F W, Rondon Maria U P B, Rotta Daniel R, Brum Patricia C, Barretto Antonio C P, Middlekauff Holly R, Negrão Carlos E   Exercise training reduces sympathetic nerve activity in heart failure patients treated with carvedilol European journal of heart failure, 2007; 9(6-7): 630-6.
Middlekauff Holly R, Sinoway Lawrence I   Increased mechanoreceptor stimulation explains the exaggerated exercise pressor reflex seen in heart failure Journal of applied physiology (Bethesda, Md. : 1985), 2007; 102(1): 492-4; discussion 496.
de Mello Franco Fábio Gazelato, Santos Amilton C, Rondon Maria Urbana P, Trombetta Ivani C, Strunz Célia, Braga Ana Maria W, Middlekauff Holly, Negrão Carlos E, Pereira Barretto Antônio C   Effects of home-based exercise training on neurovascular control in patients with heart failure European journal of heart failure, 2006; 8(8): 851-5.
Rondon Eduardo, Brasileiro-Santos Maria S, Moreira Edson D, Rondon Maria U P B, Mattos Katt C, Coelho Marcele A, Silva Gustavo J J, Brum Patricia C, Fiorino Patricia, Irigoyen Maria C, Krieger Eduardo M, Middlekauff Holly R, Negrão Carlos E   Exercise training improves aortic depressor nerve sensitivity in rats with ischemia-induced heart failure American journal of physiology. Heart and circulatory physiology, 2006; 291(6): H2801-6.
Middlekauff Holly R   How does cardiac resynchronization therapy improve exercise capacity in chronic heart failure? Journal of cardiac failure, 2005; 11(7): 534-41.
Santos Amilton C, Alves Maria J N N, Rondon Maria U P B, Barretto Antonio C P, Middlekauff Holly R, Negrão Carlos E   Sympathetic activation restrains endothelium-mediated muscle vasodilatation in heart failure patients American journal of physiology. Heart and circulatory physiology, 2005; 289(2): H593-9.
Thomas M Albert, Chung Hyun-Kyung, Middlekauff Holly   Localized two-dimensional 1H magnetic resonance exchange spectroscopy: a preliminary evaluation in human muscle Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine, 2005; 53(3): 495-502.
De Matos Luciana D N J, Gardenghi Giulliano, Rondon Maria Urbana P B, Soufen Helena N, Tirone Adriana P, Barretto Antonio C P, Brum Patrcia C, Middlekauff Holly R, Negrão Carlos E   Impact of 6 months of therapy with carvedilol on muscle sympathetic nerve activity in heart failure patients Journal of cardiac failure, 2004; 10(6): 496-502.
Middlekauff Holly R   Acupuncture in the treatment of heart failure Cardiology in review, 2004; 12(3): 171-3.
Middlekauff Holly R, Chiu Josephine   Cyclooxygenase products sensitize muscle mechanoreceptors in healthy humans American journal of physiology. Heart and circulatory physiology, 2004; 287(5): H1944-9.
Middlekauff Holly R, Chiu Josephine, Hamilton Michele A, Fonarow Gregg C, Maclellan W Robb, Hage Antoine, Moriguchi Jaime, Patel Jignash   Muscle mechanoreceptor sensitivity in heart failure American journal of physiology. Heart and circulatory physiology, 2004; 287(5): H1937-43.
Middlekauff Holly R, Shah Janki B, Yu Jun Liang, Hui Kakit   Acupuncture effects on autonomic responses to cold pressor and handgrip exercise in healthy humans Clinical autonomic research : official journal of the Clinical Autonomic Research Society, 2004; 14(2): 113-8.
Tede Nikola H, Shivkumar Kalyanam, Perloff Joseph K, Middlekauff Holly R, Fishbein Michael C, Child John S, Laks Hillel   Signal-averaged electrocardiogram in Ebstein's anomaly The American journal of cardiology, 2004; 93(4): 432-6.
Roveda Fabiana, Middlekauff Holly R, Rondon Maria Urbana P B, Reis Soraya F, Souza Márcio, Nastari Luciano, Barretto Antonio Carlos P, Krieger Eduardo M, Negrão Carlos Eduardo   The effects of exercise training on sympathetic neural activation in advanced heart failure: a randomized controlled trial Journal of the American College of Cardiology, 2003; 42(5): 854-60.
Middlekauff Holly R, Hui Kakit, Yu Jun Liang, Hamilton Michele A, Fonarow Gregg C, Moriguchi Jaime, Maclellan W Robb, Hage Antoine   Acupuncture inhibits sympathetic activation during mental stress in advanced heart failure patients Journal of cardiac failure, 2002; 8(6): 399-406.