Jae Hoon Sul

Work Address:
Gonda Building, Room 3558
695 Charles E. Young Drive South
Los Angeles, CA 90095

Affiliations
Affiliations
Assistant Professor, Psychiatry and Biobehavioral Sciences
Member, Bioinformatics GPB Home Area, Genetics & Genomics GPB Home Area
Research Interests

Our lab is interested in developing computational and statistical approaches to analyze large-scale genomics data, and identifying the genetic basis of neurobehavioral disorders such as bipolar disorder, Tourette Syndrome, and schizophrenia. We use a multidisciplinary approach to achieve these goals by combining statistics, genetics, computer science, bioinformatics, and psychiatry. We extensively collaborate with researchers in UCLA and in other institutions such as Harvard Medical School, Broad Institute, and Asan Medical Center in Korea. More information on our lab can be found in our homepage (http://jaehoonsullab.semel.ucla.edu/).

Publications

A selected list of publications:

Hormozdiari Farhad, van de Bunt Martijn, Segrè Ayellet V, Li Xiao, Joo Jong Wha J, Bilow Michael, Sul Jae Hoon, Sankararaman Sriram, Pasaniuc Bogdan, Eskin Eleazar   Colocalization of GWAS and eQTL Signals Detects Target Genes American journal of human genetics, 2016; 99(6): 1245-1260.
Bae Joon Seol, Koh InSong, Cheong Hyun Sub, Seo Jeong-Meen, Kim Dae-Yeon, Oh Jung-Tak, Kim Hyun-Young, Jung Kyuwhan, Sul Jae Hoon, Park Woong-Yang, Kim Jeong-Hyun, Shin Hyoung Doo   A genome-wide association analysis of chromosomal aberrations and Hirschsprung disease Translational research : the journal of laboratory and clinical medicine, 2016; 177(6): 31-40.e6.
Sul Jae Hoon, Cade Brian E, Cho Michael H, Qiao Dandi, Silverman Edwin K, Redline Susan, Sunyaev Shamil   Increasing Generality and Power of Rare-Variant Tests by Utilizing Extended Pedigrees American journal of human genetics, 2016; 99(4): 846-859.
Duong Dat, Zou Jennifer, Hormozdiari Farhad, Sul Jae Hoon, Ernst Jason, Han Buhm, Eskin Eleazar   Using genomic annotations increases statistical power to detect eGenes Bioinformatics (Oxford, England), 2016; 32(12): i156-i163.
Han Buhm, Duong Dat, Sul Jae Hoon, de Bakker Paul I W, Eskin Eleazar, Raychaudhuri Soumya   A general framework for meta-analyzing dependent studies with overlapping subjects in association mapping Human molecular genetics, 2016; 25(9): 1857-66.
Sul Jae Hoon, Bilow Michael, Yang Wen-Yun, Kostem Emrah, Furlotte Nick, He Dan, Eskin Eleazar   Accounting for Population Structure in Gene-by-Environment Interactions in Genome-Wide Association Studies Using Mixed Models PLoS genetics, 2016; 12(3): e1005849.
Luykx J J, Bakker S C, Visser W F, Verhoeven-Duif N, Buizer-Voskamp J E, den Heijer J M, Boks M P M, Sul J H, Eskin E, Ori A P, Cantor R M, Vorstman J, Strengman E, DeYoung J, Kappen T H, Pariama E, van Dongen E P A, Borgdorff P, Bruins P, de Koning T J, Kahn R S, Ophoff R A   Genome-wide association study of NMDA receptor coagonists in human cerebrospinal fluid and plasma Molecular psychiatry, 2015; 20(12): 1557-64.
Sul Jae Hoon, Raj Towfique, de Jong Simone, de Bakker Paul I W, Raychaudhuri Soumya, Ophoff Roel A, Stranger Barbara E, Eskin Eleazar, Han Buhm   Accurate and fast multiple-testing correction in eQTL studies American journal of human genetics, 2015; 96(6): 857-68.
Wang Zhanyong, Sul Jae Hoon, Snir Sagi, Lozano Jose A, Eskin Eleazar   Gene-Gene Interactions Detection Using a Two-stage Model Journal of computational biology : a journal of computational molecular cell biology, 2015; 22(6): 563-76.
Kim Jeong-Hyun, Cheong Hyun Sub, Sul Jae Hoon, Seo Jeong-Meen, Kim Dae-Yeon, Oh Jung-Tak, Park Kwi-Won, Kim Hyun-Young, Jung Soo-Min, Jung Kyuwhan, Cho Min Jeng, Bae Joon Seol, Shin Hyoung Doo   A genome-wide association study identifies potential susceptibility loci for Hirschsprung disease PloS one, 2014; 9(10): e110292.
Plongthongkum Nongluk, van Eijk Kristel R, de Jong Simone, Wang Tina, Sul Jae Hoon, Boks Marco P M, Kahn René S, Fung Ho-Lim, Ophoff Roel A, Zhang Kun   Characterization of genome-methylome interactions in 22 nuclear pedigrees PloS one, 2014; 9(7): e99313.
Joo Jong Wha J, Sul Jae Hoon, Han Buhm, Ye Chun, Eskin Eleazar   Effectively identifying regulatory hotspots while capturing expression heterogeneity in gene expression studies Genome biology, 2014; 15(4): r61.
Luykx J J, Bakker S C, Lentjes E, Neeleman M, Strengman E, Mentink L, DeYoung J, de Jong S, Sul J H, Eskin E, van Eijk K, van Setten J, Buizer-Voskamp J E, Cantor R M, Lu A, van Amerongen M, van Dongen E P A, Keijzers P, Kappen T, Borgdorff P, Bruins P, Derks E M, Kahn R S, Ophoff R A   Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid Molecular psychiatry, 2014; 19(2): 228-34.
Navon Oron, Sul Jae Hoon, Han Buhm, Conde Lucia, Bracci Paige M, Riby Jacques, Skibola Christine F, Eskin Eleazar, Halperin Eran   Rare variant association testing under low-coverage sequencing Genetics, 2013; 194(3): 769-79.
Sul Jae Hoon, Han Buhm, Ye Chun, Choi Ted, Eskin Eleazar   Effectively identifying eQTLs from multiple tissues by combining mixed model and meta-analytic approaches PLoS genetics, 2013; 9(6): e1003491.
Rietveld Cornelius A, Medland Sarah E, Derringer Jaime, Yang Jian, Esko Tõnu, Martin Nicolas W, Westra Harm-Jan, Shakhbazov Konstantin, Abdellaoui Abdel, Agrawal Arpana, Albrecht Eva, Alizadeh Behrooz Z, Amin Najaf, Barnard John, Baumeister Sebastian E, Benke Kelly S, Bielak Lawrence F, Boatman Jeffrey A, Boyle Patricia A, Davies Gail, de Leeuw Christiaan, Eklund Niina, Evans Daniel S, Ferhmann Rudolf, Fischer Krista, Gieger Christian, Gjessing HÃ¥kon K, Hägg Sara, Harris Jennifer R, Hayward Caroline, Holzapfel Christina, Ibrahim-Verbaas Carla A, Ingelsson Erik, Jacobsson Bo, Joshi Peter K, Jugessur Astanand, Kaakinen Marika, Kanoni Stavroula, Karjalainen Juha, Kolcic Ivana, Kristiansson Kati, Kutalik Zoltán, Lahti Jari, Lee Sang H, Lin Peng, Lind Penelope A, Liu Yongmei, Lohman Kurt, Loitfelder Marisa, McMahon George, Vidal Pedro Marques, Meirelles Osorio, Milani Lili, Myhre Ronny, Nuotio Marja-Liisa, Oldmeadow Christopher J, Petrovic Katja E, Peyrot Wouter J, Polasek Ozren, Quaye Lydia, Reinmaa Eva, Rice John P, Rizzi Thais S, Schmidt Helena, Schmidt Reinhold, Smith Albert V, Smith Jennifer A, Tanaka Toshiko, Terracciano Antonio, van der Loos Matthijs J H M, Vitart Veronique, Völzke Henry, Wellmann Jürgen, Yu Lei, Zhao Wei, Allik Jüri, Attia John R, Bandinelli Stefania, Bastardot François, Beauchamp Jonathan, Bennett David A, Berger Klaus, Bierut Laura J, Boomsma Dorret I, Bültmann Ute, Campbell Harry, Chabris Christopher F, Cherkas Lynn, Chung Mina K, Cucca Francesco, de Andrade Mariza, De Jager Philip L, De Neve Jan-Emmanuel, Deary Ian J, Dedoussis George V, Deloukas Panos, Dimitriou Maria, Eiríksdóttir Guðny, Elderson Martin F, Eriksson Johan G, Evans David M, Faul Jessica D, Ferrucci Luigi, Garcia Melissa E, Grönberg Henrik, Guðnason Vilmundur, Hall Per, Harris Juliette M, Harris Tamara B, Hastie Nicholas D, Heath Andrew C, Hernandez Dena G, Hoffmann Wolfgang, Hofman Adriaan, Holle Rolf, Holliday Elizabeth G, Hottenga Jouke-Jan, Iacono William G, Illig Thomas, Järvelin Marjo-Riitta, Kähönen Mika, Kaprio Jaakko, Kirkpatrick Robert M, Kowgier Matthew, Latvala Antti, Launer Lenore J, Lawlor Debbie A, Lehtimäki Terho, Li Jingmei, Lichtenstein Paul, Lichtner Peter, Liewald David C, Madden Pamela A, Magnusson Patrik K E, Mäkinen Tomi E, Masala Marco, McGue Matt, Metspalu Andres, Mielck Andreas, Miller Michael B, Montgomery Grant W, Mukherjee Sutapa, Nyholt Dale R, Oostra Ben A, Palmer Lyle J, Palotie Aarno, Penninx Brenda W J H, Perola Markus, Peyser Patricia A, Preisig Martin, Räikkönen Katri, Raitakari Olli T, Realo Anu, Ring Susan M, Ripatti Samuli, Rivadeneira Fernando, Rudan Igor, Rustichini Aldo, Salomaa Veikko, Sarin Antti-Pekka, Schlessinger David, Scott Rodney J, Snieder Harold, St Pourcain Beate, Starr John M, Sul Jae Hoon, Surakka Ida, Svento Rauli, Teumer Alexander, Teumer Alexander, Tiemeier Henning, van Rooij Frank J A, Van Wagoner David R, Vartiainen Erkki, Viikari Jorma, Vollenweider Peter, Vonk Judith M, Waeber Gérard, Weir David R, Wichmann H-Erich, Widen Elisabeth, Willemsen Gonneke, Wilson James F, Wright Alan F, Conley Dalton, Davey-Smith George, Franke Lude, Groenen Patrick J F, Hofman Albert, Johannesson Magnus, Kardia Sharon L R, Krueger Robert F, Laibson David, Martin Nicholas G, Meyer Michelle N, Posthuma Danielle, Thurik A Roy, Timpson Nicholas J, Uitterlinden André G, van Duijn Cornelia M, Visscher Peter M, Benjamin Daniel J, Cesarini David, Koellinger Philipp D   GWAS of 126,559 individuals identifies genetic variants associated with educational attainment Science (New York, N.Y.), 2013; 340(6139): 1467-71.
Sul Jae Hoon, Eskin Eleazar   Mixed models can correct for population structure for genomic regions under selection Nature reviews. Genetics, 2013; 14(4): 300.
Miller Michael B, Basu Saonli, Cunningham Julie, Eskin Eleazar, Malone Steven M, Oetting William S, Schork Nicholas, Sul Jae Hoon, Iacono William G, McGue Matt   The Minnesota Center for Twin and Family Research genome-wide association study Twin research and human genetics : the official journal of the International Society for Twin Studies, 2012; 15(6): 767-74.
Sul Jae Hoon, Han Buhm, Eskin Eleazar   Increasing power of groupwise association test with likelihood ratio test Journal of computational biology : a journal of computational molecular cell biology, 2011; 18(11): 1611-24.
Sul Jae Hoon, Han Buhm, He Dan, Eskin Eleazar   An optimal weighted aggregated association test for identification of rare variants involved in common diseases Genetics, 2011; 188(1): 181-8.
Stein Jason L, Hua Xue, Morra Jonathan H, Lee Suh, Hibar Derrek P, Ho April J, Leow Alex D, Toga Arthur W, Sul Jae Hoon, Kang Hyun Min, Eskin Eleazar, Saykin Andrew J, Shen Li, Foroud Tatiana, Pankratz Nathan, Huentelman Matthew J, Craig David W, Gerber Jill D, Allen April N, Corneveaux Jason J, Stephan Dietrich A, Webster Jennifer, DeChairo Bryan M, Potkin Steven G, Jack Clifford R, Weiner Michael W, Thompson Paul M, Thompson Paul M   Genome-wide analysis reveals novel genes influencing temporal lobe structure with relevance to neurodegeneration in Alzheimer's disease NeuroImage, 2010; 51(2): 542-54.
Kang Hyun Min, Sul Jae Hoon, Service Susan K, Zaitlen Noah A, Kong Sit-Yee, Freimer Nelson B, Sabatti Chiara, Eskin Eleazar   Variance component model to account for sample structure in genome-wide association studies Nature genetics, 2010; 42(4): 348-54.
Ginsparg Paul, Houle Paul, Joachims Thorsten, Sul Jae-Hoon   Mapping subsets of scholarly information Proceedings of the National Academy of Sciences of the United States of America, 2004; 101 Suppl 1(4): 5236-40.