Steven M. Dubinett, M.D.

Laboratory Address:
10-240 Factor

Office Address:
10833 Le Conte Ave.
CHS 37-131
Los Angeles, CA 90095

Affiliations
Affiliations
Associate Vice Chancellor for Research, UCLA
Senior Associate Dean, Translational Research, David Geffen School of Medicine at UCLA
Professor, Medicine, Molecular & Medical Pharmacology
Director, CTSI
Chief, Pulmonary and Critical Care Medicine
Division Chief, Clinical Immunology and Allergy
Research Interests
Dr. Dubinett conducts translational research in the immunobiology of lung cancer. Building on original discoveries regarding inflammation in human non-small cell lung cancer (NSCLC), he has developed a translational research program, which now utilizes these laboratory-based studies in the laboratory and clinical setting. His laboratory has identified inflammation-dependent genes and proteins mediating angiogenesis, apoptosis resistance, invasion and immune suppression in NSCLC. His studies focus on the microenvironment, inflammation and epithelial mesenchymal transition in the pathogenesis of lung cancer.
Publications
Gomperts Brigitte N, Walser Tonya C, Spira Avrum, Dubinett Steven M Enriching the molecular definition of the airway "field of cancerization:" establishing new paradigms for the patient at risk for lung cancer. Cancer prevention research (Philadelphia, Pa.). 2013; 6(1): 4-7.
Sharma Sherven, Zhu Li, Davoodi Michael, Harris-White Marni, Lee Jay M, St John Maie, Salgia Ravi, Dubinett Steven TLR3 agonists and proinflammatory antitumor activities. Expert opinion on therapeutic targets. 2013; 17(5): 481-3.
Andersson Asa, Srivastava Minu K, Harris-White Marni, Huang Min, Zhu Li, Elashoff David, Strieter Robert M, Dubinett Steven M, Sharma Sherven Role of CXCR3 ligands in IL-7/IL-7R alpha-Fc-mediated antitumor activity in lung cancer. Clinical cancer research : an official journal of the American Association for Cancer Research. 2011; 17(11): 3660-72.
Garon Edward B, Finn Richard S, Hamidi Habib, Dering Judy, Pitts Sharon, Kamranpour Naeimeh, Desai Amrita J, Hosmer Wylie, Ide Susan, Avsar Emin, Rugaard Jensen Michael, Quadt Cornelia, Liu Manway, Dubinett Steven M, Slamon Dennis J The HSP90 inhibitor NVP-AUY922 potently inhibits non-small cell lung cancer growth. Molecular cancer therapeutics. 2013; 17(5): .
Srivastava Minu K, Dubinett Steven, Sharma Sherven Targeting MDSCs enhance therapeutic vaccination responses against lung cancer. Oncoimmunology. 2012; 1(9): 1650-1651.
Sharma Sherven, Dubinett Steven, Salgia Ravi CD14(+)S100A9(+) myeloid-derived suppressor cells portend decreased survival in patients with advanced lung cancer. American journal of respiratory and critical care medicine. 2012; 186(10): 940-1.
Lu Qing-Yi, Jin Yusheng, Mao Jenny T, Zhang Zuo-Feng, Heber David, Dubinett Steven M, Rao Jianyu Green tea inhibits cycolooxygenase-2 in non-small cell lung cancer cells through the induction of Annexin-1. Biochemical and biophysical research communications. 2012; 427(4): 725-30.
Dennis Miranda, Wang Guanyu, Luo Jie, Lin Yuan, Dohadwala Mariam, Abemayor Elliot, Elashoff David A, Sharma Sherven, Dubinett Steven M, St John Maie A Snail controls the mesenchymal phenotype and drives erlotinib resistance in oral epithelial and head and neck squamous cell carcinoma cells. Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery. 2012; 147(4): 726-32.
Huynh Thu P, Mah Vei, Sampson Valerie B, Chia David, Fishbein Michael C, Horvath Steve, Alavi Mohammad, Wu Debbie C, Harper Jeffrey, Sarafian Ted, Dubinett Steven M, Langhans Sigrid A, Goodglick Lee, Rajasekaran Ayyappan K Na,K-ATPase is a target of cigarette smoke and reduced expression predicts poor patient outcome of smokers with lung cancer. American journal of physiology. Lung cellular and molecular physiology. 2012; 302(11): L1150-8.
Hu David, Lau Ontario D, Wang Linda, Wang Guanyu, Schaue Dorthe, Zhu Li, Huang Min, Lin Yuan, Dennis Miranda, Abemayor Elliot, Elashoff David A, Dubinett Steven M, McBride William H, Sharma Sherven, Wu Ben, St John Maie A A novel modular polymer platform for the treatment of head and neck squamous cell carcinoma in an animal model. Archives of otolaryngology--head & neck surgery. 2012; 138(4): 412-7.
Heinrich Eileen L, Walser Tonya C, Krysan Kostyantyn, Liclican Elvira L, Grant Jeanette L, Rodriguez Nicole L, Dubinett Steven M The inflammatory tumor microenvironment, epithelial mesenchymal transition and lung carcinogenesis. Cancer microenvironment : official journal of the International Cancer Microenvironment Society. 2012; 5(1): 5-18.
Dubinett Steven M, Shamoon Harry, Center David, Davis Pamela, Tuchman Mendel, Ginsberg Henry, Califf Robert, Stephens David, Mellman Thomas, Verbalis Joseph, Nadler Lee, Shekhar Anantha, Ford Daniel, Rizza Robert, Shaker Reza, Brady Kathleen, Murphy Barbara, Cronstein Bruce, Hochman Judith, Greenland Philip, Orwoll Eric, Sinoway Lawrence, Greenberg Harry, Jackson Rebecca, Coller Barry, Topol Eric, Guay-Woodford Lisa, Runge Marschall, Clark Robert, McClain Don, Selker Harry, Lowery Curtis, Dubinett Steven, Berglund Lars, Cooper Dan, Firestein Gary, Johnston S Clay, Solway Julian, Heubi James, Sokol Ronald, Nelson David, Tobacman Larry, Rosenthal Gary, Aaronson Lauren, Barohn Richard, Kern Philip, Sullivan John, Shanley Thomas, Blazar Bruce, Larson Richard, FitzGerald Garret, Reis Steven, Pearson Thomas, Buchanan Thomas, McPherson David, Brasier Allan, Toto Robert, Disis Mary, Drezner Marc, Bernard Gordon, Clore John, Evanoff Bradley, Imperato-McGinley Julianne, Sherwin Robert, Pulley Jill Preparedness of the CTSA's structural and scientific assets to support the mission of the National Center for Advancing Translational Sciences (NCATS). Clinical and translational science. 2012; 5(2): 121-9.
Srivastava Minu K, Andersson Åsa, Zhu Li, Harris-White Marni, Lee Jay M, Dubinett Steven, Sharma Sherven Myeloid suppressor cells and immune modulation in lung cancer. Immunotherapy. 2012; 4(3): 291-304.
Mendelsohn Abie H, Lai Chi K, Shintaku I Peter, Fishbein Michael C, Brugman Katherine, Elashoff David A, Abemayor Elliot, Dubinett Steven M, St John Maie A Snail as a novel marker for regional metastasis in head and neck squamous cell carcinoma. American journal of otolaryngology. 2012; 33(1): 6-13.
Srivastava Minu K, Zhu Li, Harris-White Marni, Kar Upendra K, Kar Upendra, Huang Min, Johnson Ming F, Lee Jay M, Elashoff David, Strieter Robert, Dubinett Steven, Sharma Sherven Myeloid suppressor cell depletion augments antitumor activity in lung cancer. PloS one. 2012; 7(7): e40677.
Dubinett Steven M, Aberle Denise R, Tashkin Donald P, Mao Jenny T The partners--airflow obstruction, emphysema, and lung cancer. American journal of respiratory and critical care medicine. 2008; 178(7): 665-6.
Dubinett Steven M, Mao Jenny T, Hazra Saswati Focusing downstream in lung cancer prevention: 15-hydroxyprostaglandin dehydrogenase. Cancer prevention research (Philadelphia, Pa.). 2008; 1(4): 223-5.
Baratelli Felicita, Takedatsu Hiroko, Hazra Saswati, Peebles Katherine, Luo Jie, Kurimoto Pam S, Zeng Gang, Batra Raj K, Sharma Sherven, Dubinett Steven M, Lee Jay M Pre-clinical characterization of GMP grade CCL21-gene modified dendritic cells for application in a phase I trial in non-small cell lung cancer. Journal of translational medicine. 2008; 6(4): 38.
Lee Jay M, Yanagawa Jane, Peebles Katherine A, Sharma Sherven, Mao Jenny T, Dubinett Steven M Inflammation in lung carcinogenesis: new targets for lung cancer chemoprevention and treatment. Critical reviews in oncology/hematology. 2008; 66(3): 208-17.
Su Helen, Seimbille Yann, Ferl Gregory Z, Bodenstein Claudia, Fueger Barbara, Kim Kevin J, Hsu Yu-Tien, Dubinett Steven M, Phelps Michael E, Czernin Johannes, Weber Wolfgang A Evaluation of [(18)F]gefitinib as a molecular imaging probe for the assessment of the epidermal growth factor receptor status in malignant tumors. European journal of nuclear medicine and molecular imaging. 2008; 35(6): 1089-99.
Einhorn Lawrence H, Bonomi Philip, Bunn Paul A, Camidge D Ross, Carbone David Paul, Choy Hak, Dubinett Steven M, Gandara David R, Gaspar Laurie E, Govindan Ramaswamy, Johnson David H, Minna John D, Scagliotti Giorgio, West Howard J, Herbst Roy S Summary report 7th Annual Targeted Therapies of the Treatment of Lung Cancer. Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer. 2008; 3(5): 545-55.
Reckamp Karen L, Gardner Brian K, Figlin Robert A, Elashoff David, Krysan Kostyantyn, Dohadwala Mariam, Mao Jenny, Sharma Sherven, Inge Landon, Rajasekaran Ayyappan, Dubinett Steven M Tumor response to combination celecoxib and erlotinib therapy in non-small cell lung cancer is associated with a low baseline matrix metalloproteinase-9 and a decline in serum-soluble E-cadherin. Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer. 2008; 3(2): 117-24.
Krysan Kostyantyn, Lee Jay M, Dohadwala Mariam, Gardner Brian K, Reckamp Karen L, Garon Edward, St John Maie, Sharma Sherven, Dubinett Steven M Inflammation, epithelial to mesenchymal transition, and epidermal growth factor receptor tyrosine kinase inhibitor resistance. Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer. 2008; 3(2): 107-10.
Hazra Saswati, Peebles Katherine A, Sharma Sherven, Mao Jenny T, Dubinett Steven M The Role of PPARgamma in the Cyclooxygenase Pathway in Lung Cancer. PPAR research. 2008; 2008(2): 790568.
Hazra Saswati, Dubinett Steven M Ciglitazone mediates COX-2 dependent suppression of PGE2 in human non-small cell lung cancer cells. Prostaglandins, leukotrienes, and essential fatty acids. 2007; 77(1): 51-8.
Lu Qing-Yi, Jin Yu Sheng, Zhang Zuo-Feng, Le Anh D, Heber David, Li Frederick P, Dubinett Steven M, Rao Jian Yu Green tea induces annexin-I expression in human lung adenocarcinoma A549 cells: involvement of annexin-I in actin remodeling. Laboratory investigation; a journal of technical methods and pathology. 2007; 87(5): 456-65.
Lee Jay M, Mao Jenny T, Krysan Kostyantyn, Dubinett Steven M Significance of cyclooxygenase-2 in prognosis, targeted therapy and chemoprevention of NSCLC. Future oncology (London, England). 2007; 3(2): 149-53.
Su Helen, Bodenstein Claudia, Dumont Rebecca A, Seimbille Yann, Dubinett Steven, Phelps Michael E, Herschman Harvey, Czernin Johannes, Weber Wolfgang Monitoring tumor glucose utilization by positron emission tomography for the prediction of treatment response to epidermal growth factor receptor kinase inhibitors. Clinical cancer research : an official journal of the American Association for Cancer Research. 2006; 12(19): 5659-67.
Zeng Gang, Aldridge Michael E, Tian Xiaoli, Seiler Daniel, Zhang Xiaolong, Jin Yusheng, Rao Jianyu, Li Weidong, Chen Dequan, Langford Marlyn P, Duggan Chris, Belldegrun Arie S, Dubinett Steven M Dendritic cell surface calreticulin is a receptor for NY-ESO-1: direct interactions between tumor-associated antigen and the innate immune system. Journal of immunology (Baltimore, Md. : 1950). 2006; 177(6): 3582-9.
Hoang Bao, Zhu Li, Shi Yijiang, Frost Patrick, Yan Huajun, Sharma Sanjai, Sharma Sherven, Goodglick Lee, Dubinett Steven, Lichtenstein Alan Oncogenic RAS mutations in myeloma cells selectively induce cox-2 expression, which participates in enhanced adhesion to fibronectin and chemoresistance. Blood. 2006; 107(11): 4484-90.
Kelloff Gary J, Lippman Scott M, Dannenberg Andrew J, Sigman Caroline C, Pearce Homer L, Reid Brian J, Szabo Eva, Jordan V Craig, Spitz Margaret R, Mills Gordon B, Papadimitrakopoulou Vali A, Lotan Reuben, Aggarwal Bharat B, Bresalier Robert S, Kim Jeri, Arun Banu, Lu Karen H, Thomas Melanie E, Rhodes Helen E, Brewer Molly A, Follen Michele, Shin Dong M, Parnes Howard L, Siegfried Jill M, Evans Alison A, Blot William J, Chow Wong-Ho, Blount Patricia L, Maley Carlo C, Wang Kenneth K, Lam Stephen, Lee J Jack, Dubinett Steven M, Engstrom Paul F, Meyskens Frank L, O'Shaughnessy Joyce, Hawk Ernest T, Levin Bernard, Nelson William G, Hong Waun Ki, Hong Waun Ki Progress in chemoprevention drug development: the promise of molecular biomarkers for prevention of intraepithelial neoplasia and cancer--a plan to move forward. Clinical cancer research : an official journal of the American Association for Cancer Research. 2006; 12(12): 3661-97.
Reckamp Karen L, Krysan Kostyantyn, Morrow Jason D, Milne Ginger L, Newman Robert A, Tucker Christopher, Elashoff Robert M, Dubinett Steven M, Figlin Robert A A phase I trial to determine the optimal biological dose of celecoxib when combined with erlotinib in advanced non-small cell lung cancer. Clinical cancer research : an official journal of the American Association for Cancer Research. 2006; 12(11 Pt 1): 3381-8.
Cui Xiaoyan, Yang Seok-Chul, Sharma Sherven, Heuze-Vourc'h Nathalie, Dubinett Steven M IL-4 regulates COX-2 and PGE2 production in human non-small cell lung cancer. Biochemical and biophysical research communications. 2006; 343(4): 995-1001.
Dohadwala Mariam, Yang Seok-Chul, Luo Jie, Sharma Sherven, Batra Raj K, Huang Min, Lin Ying, Goodglick Lee, Krysan Kostyantyn, Fishbein Michael C, Hong Longsheng, Lai Chi, Cameron Robert B, Gemmill Robert M, Drabkin Harry A, Dubinett Steven M Cyclooxygenase-2-dependent regulation of E-cadherin: prostaglandin E(2) induces transcriptional repressors ZEB1 and snail in non-small cell lung cancer. Cancer research. 2006; 66(10): 5338-45.
Krysan Kostyantyn, Reckamp Karen L, Sharma Sherven, Dubinett Steven M The potential and rationale for COX-2 inhibitors in lung cancer. Anti-cancer agents in medicinal chemistry. 2006; 6(3): 209-20.
Yang Seok-Chul, Batra Raj K, Hillinger Sven, Reckamp Karen L, Strieter Robert M, Dubinett Steven M, Sharma Sherven Intrapulmonary administration of CCL21 gene-modified dendritic cells reduces tumor burden in spontaneous murine bronchoalveolar cell carcinoma. Cancer research. 2006; 66(6): 3205-13.
Pan Judong, Burdick Marie D, Belperio John A, Xue Ying Ying, Gerard Craig, Sharma Sherven, Dubinett Steven M, Strieter Robert M CXCR3/CXCR3 ligand biological axis impairs RENCA tumor growth by a mechanism of immunoangiostasis. Journal of immunology (Baltimore, Md. : 1950). 2006; 176(3): 1456-64.
Liu Wei, Dubinett Steven, Patterson Simie Lavern A, Kelly Kathleen A COX-2 inhibition affects growth rate of Chlamydia muridarum within epithelial cells. Microbes and infection / Institut Pasteur. 2006; 8(2): 478-86.
Mao Jenny T, Fishbein Michael C, Adams Bradley, Roth Michael D, Goodglick Lee, Hong Longsheng, Burdick Marie, Strieter E Robert M, Holmes Carmack, Tashkin Donald P, Dubinett Steven M Celecoxib decreases Ki-67 proliferative index in active smokers. Clinical cancer research : an official journal of the American Association for Cancer Research. 2006; 12(1): 314-20.
Dalwadi Harnisha, Krysan Kostyantyn, Heuze-Vourc'h Nathalie, Dohadwala Mariam, Elashoff David, Sharma Sherven, Cacalano Nicholas, Lichtenstein Alan, Dubinett Steven Cyclooxygenase-2-dependent activation of signal transducer and activator of transcription 3 by interleukin-6 in non-small cell lung cancer. Clinical cancer research : an official journal of the American Association for Cancer Research. 2005; 11(21): 7674-82.
Weinberg Olga K, Marquez-Garban Diana C, Fishbein Michael C, Goodglick Lee, Garban Hermes J, Dubinett Steven M, Pietras Richard J Aromatase inhibitors in human lung cancer therapy. Cancer research. 2005; 65(24): 11287-91.
Rodriguez Paulo C, Hernandez Claudia P, Quiceno David, Dubinett Steven M, Zabaleta Jovanny, Ochoa Juan B, Gilbert Jill, Ochoa Augusto C Arginase I in myeloid suppressor cells is induced by COX-2 in lung carcinoma. The Journal of experimental medicine. 2005; 202(7): 931-9.
Baratelli Felicita, Lin Ying, Zhu Li, Yang Seok-Chul, Heuzé-Vourc'h Nathalie, Zeng Gang, Reckamp Karen, Dohadwala Mariam, Sharma Sherven, Dubinett Steven M Prostaglandin E2 induces FOXP3 gene expression and T regulatory cell function in human CD4+ T cells. Journal of immunology (Baltimore, Md. : 1950). 2005; 175(3): 1483-90.
Baratelli Felicita, Krysan Kostyantyn, Heuzé-Vourc'h Nathalie, Zhu Li, Escuadro Brian, Sharma Sherven, Reckamp Karen, Dohadwala Mariam, Dubinett Steven M PGE2 confers survivin-dependent apoptosis resistance in human monocyte-derived dendritic cells. Journal of leukocyte biology. 2005; 78(2): 555-64.
Heuzé-Vourc'h Nathalie, Liu Ming, Dalwadi Harnisha, Baratelli Felicita E, Zhu Li, Goodglick Lee, Põld Mehis, Sharma Sherven, Ramirez Ruben D, Shay Jerry W, Minna John D, Strieter Robert M, Dubinett Steven M IL-20, an anti-angiogenic cytokine that inhibits COX-2 expression. Biochemical and biophysical research communications. 2005; 333(2): 470-5.
Krysan Kostyantyn, Reckamp Karen L, Dalwadi Harnisha, Sharma Sherven, Rozengurt Enrique, Dohadwala Mariam, Dubinett Steven M Prostaglandin E2 activates mitogen-activated protein kinase/Erk pathway signaling and cell proliferation in non-small cell lung cancer cells in an epidermal growth factor receptor-independent manner. Cancer research. 2005; 65(14): 6275-81.
Sharma Sherven, Zhu Li, Yang Seok Chul, Zhang Ling, Lin Jeff, Hillinger Sven, Gardner Brian, Reckamp Karen, Strieter Robert M, Huang Min, Batra Raj K, Dubinett Steven M Cyclooxygenase 2 inhibition promotes IFN-gamma-dependent enhancement of antitumor responses. Journal of immunology (Baltimore, Md. : 1950). 2005; 175(2): 813-9.
Mao Jenny T, Cui Xiaoyan, Reckamp Karen, Liu Ming, Krysan Kostyantyn, Dalwadi Harnisha, Sharma Sherven, Hazra Saswati, Strieter Robert, Gardner Brian, Dubinett Steven M Chemoprevention strategies with cyclooxygenase-2 inhibitors for lung cancer. Clinical lung cancer. 2005; 7(1): 30-9.
Sharma Sherven, Yang Seok-Chul, Zhu Li, Reckamp Karen, Gardner Brian, Baratelli Felicita, Huang Min, Batra Raj K, Dubinett Steven M Tumor cyclooxygenase-2/prostaglandin E2-dependent promotion of FOXP3 expression and CD4+ CD25+ T regulatory cell activities in lung cancer. Cancer research. 2005; 65(12): 5211-20.
Gamradt Seth C, Feeley Brian T, Liu Nancy Q, Roostaeian Jason, Lin Ying Q, Zhu Li X, Sharma Sherven, Dubinett Steven M, Lieberman Jay R The effect of cyclooxygenase-2 (COX-2) inhibition on human prostate cancer induced osteoblastic and osteolytic lesions in bone. Anticancer research. 2005; 25(1A): 107-15.
Zeng Gang, Aldridge Michael E, Wang Yu, Pantuck Allan J, Wang Allen Y, Liu Yue-xiang, Han Yan, Yuan Yan-hua, Robbins Paul F, Dubinett Steven M, deKernion Jean B, Belldegrun Arie S Dominant B cell epitope from NY-ESO-1 recognized by sera from a wide spectrum of cancer patients: implications as a potential biomarker. International journal of cancer. Journal international du cancer. 2005; 114(2): 268-73.
Strieter Robert M, Belperio John A, Burdick Marie D, Sharma Sherven, Dubinett Steven M, Keane Michael P CXC chemokines: angiogenesis, immunoangiostasis, and metastases in lung cancer. Annals of the New York Academy of Sciences. 2004; 1028(1A): 351-60.
Baratelli Felicita E, Heuzé-Vourc'h Nathalie, Krysan Kostyantyn, Dohadwala Mariam, Riedl Karen, Sharma Sherven, Dubinett Steven M Prostaglandin E2-dependent enhancement of tissue inhibitors of metalloproteinases-1 production limits dendritic cell migration through extracellular matrix. Journal of immunology (Baltimore, Md. : 1950). 2004; 173(9): 5458-66.
Mao Jenny T, Tsu I-Hsien, Dubinett Steven M, Adams Bradley, Sarafian Theodore, Baratelli Felicita, Roth Michael D, Serio Kenneth J Modulation of pulmonary leukotriene B4 production by cyclooxygenase-2 inhibitors and lipopolysaccharide. Clinical cancer research : an official journal of the American Association for Cancer Research. 2004; 10(20): 6872-8.
Põld Mehis, Krysan Kostyantyn, Põld Anu, Dohadwala Mariam, Heuze-Vourc'h Nathalie, Mao Jenny T, Riedl Karen L, Sharma Sherven, Dubinett Steven M Cyclooxygenase-2 modulates the insulin-like growth factor axis in non-small-cell lung cancer. Cancer research. 2004; 64(18): 6549-55.
Krysan Kostyantyn, Dalwadi Harnisha, Sharma Sherven, Põld Mehis, Dubinett Steven Cyclooxygenase 2-dependent expression of survivin is critical for apoptosis resistance in non-small cell lung cancer. Cancer research. 2004; 64(18): 6359-62.
Dubinett Steven M, Elashoff David, Meyerson Matthew Assessing prognosis in non-small-cell lung cancer: avenues to a more complete picture?. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2004; 22(16): 3209-11.
Zhang Ling, Keane Michael P, Zhu Li X, Sharma Sherven, Rozengurt Enrique, Strieter Robert M, Dubinett Steven M, Huang Min Interleukin-7 and transforming growth factor-beta play counter-regulatory roles in protein kinase C-delta-dependent control of fibroblast collagen synthesis in pulmonary fibrosis. The Journal of biological chemistry. 2004; 279(27): 28315-9.
Riedl Karen, Krysan Kostyantyn, Põld Mehis, Dalwadi Harnisha, Heuze-Vourc'h Nathalie, Dohadwala Mariam, Liu Ming, Cui Xiaoyan, Figlin Robert, Mao Jenny T, Strieter Robert, Sharma Sherven, Dubinett Steven M Multifaceted roles of cyclooxygenase-2 in lung cancer. Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy. 2004; 7(3): 169-84.
Yang Seok-Chul, Hillinger Sven, Riedl Karen, Zhang Ling, Zhu Li, Huang Min, Atianzar Kimberly, Kuo Brian Y, Gardner Brian, Batra Raj K, Strieter Robert M, Dubinett Steven M, Sharma Sherven Intratumoral administration of dendritic cells overexpressing CCL21 generates systemic antitumor responses and confers tumor immunity. Clinical cancer research : an official journal of the American Association for Cancer Research. 2004; 10(8): 2891-901.
Krysan Kostyantyn, Dohadwala Mariam, Luo Jie, Lin Ying, Zhu Li, Heuze-Vourc'h Nathalie, Goodglick Lee, Merchant Farrukh, Seligson David, Pold Mehis, Strieter Robert, Sharma Sherven, Dubinett Steven Cyclooxygenase-2-dependent expression of survivin in non-small cell lung cancer. Chest. 2004; 125(5 Suppl): 140S.
Mortazavi Fariborz, Dubinett Steven, Rettig Matthew c-Crk proto-oncogene contributes to transcriptional repression of p120-catenin in non-small cell lung cancer cells. Clinical & experimental metastasis. 2011; 28(4): 391-404.
Gomperts Brigitte N, Spira Avrum, Massion Pierre P, Walser Tonya C, Wistuba Ignacio I, Minna John D, Dubinett Steven M Evolving concepts in lung carcinogenesis. Seminars in respiratory and critical care medicine. 2011; 32(1): 32-43.
Hosmer Wylie D, Dubinett Steven M, Garon Edward B Novel drugs--miscellaneous category. Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer. 2010; 5(12 Suppl 6): S468-9.
Garon Edward B, Dubinett Steven M Poly(ADP-ribose) polymerase inhibitors. Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer. 2010; 5(12 Suppl 6): S455-6.
Patz Edward F, Caporaso Neil E, Dubinett Steven M, Massion Pierre P, Hirsch Fred R, Minna John D, Gatsonis Constantine, Duan Fenghai, Adams Amanda, Apgar Charles, Medina Rosa M, Aberle Denise R National Lung Cancer Screening Trial American College of Radiology Imaging Network Specimen Biorepository originating from the Contemporary Screening for the Detection of Lung Cancer Trial (NLST, ACRIN 6654): design, intent, and availability of specimens for validation of lung cancer biomarkers. Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer. 2010; 5(10): 1502-6.
Mendelsohn Abie H, Lai Chi K, Shintaku I Peter, Elashoff David A, Dubinett Steven M, Abemayor Elliot, St John Maie A Histopathologic findings of HPV and p16 positive HNSCC. The Laryngoscope. 2010; 120(9): 1788-94.
Ooi Aik T, Mah Vei, Nickerson Derek W, Gilbert Jennifer L, Ha Vi Luan, Hegab Ahmed E, Horvath Steve, Alavi Mohammad, Maresh Erin L, Chia David, Gower Adam C, Lenburg Marc E, Spira Avrum, Solis Luisa M, Wistuba Ignacio I, Walser Tonya C, Wallace William D, Dubinett Steven M, Goodglick Lee, Gomperts Brigitte N Presence of a putative tumor-initiating progenitor cell population predicts poor prognosis in smokers with non-small cell lung cancer. Cancer research. 2010; 70(16): 6639-48.
Lee Wen-Hwa, Hung Mien-Chie, Iczkowski Kenneth A, Languino Lucia R, Dubinett Steven M, Wang Dengshun Editorial Board 2010 American Journal of Translational Research (ISSN 1943-8141): www.ajtr.org Publisher: e-Century Publishing Corporation (www.e-Century.org). American journal of translational research. 2010; 2(4): 458-62.
Ohashi Kadoaki, Sequist Lecia V, Arcila Maria E, Lovly Christine M, Chen Xi, Rudin Charles M, Moran Teresa, Camidge David Ross, Vnencak-Jones Cindy L, Berry Lynne, Pan Yumei, Sasaki Hidefumi, Engelman Jeffrey A, Garon Edward B, Dubinett Steven M, Franklin Wilbur A, Riely Gregory J, Sos Martin L, Kris Mark G, Dias-Santagata Dora, Ladanyi Marc, Bunn Paul A, Pao William Characteristics of Lung Cancers Harboring NRAS Mutations. Clinical cancer research : an official journal of the American Association for Cancer Research. 2013; 19(9): 2584-2591.
Dubinett Steven M, Lee Jay M, Sharma Sherven, Mulé James J Chemokines: can effector cells be redirected to the site of the tumor?. Cancer journal (Sudbury, Mass.). 2010; 16(4): 325-35.
Garon Edward B, Pietras Richard J, Finn Richard S, Kamranpour Naeimeh, Pitts Sharon, Márquez-Garbán Diana C, Desai Amrita J, Dering Judy, Hosmer Wylie, von Euw Erika M, Dubinett Steven M, Slamon Dennis J Antiestrogen fulvestrant enhances the antiproliferative effects of epidermal growth factor receptor inhibitors in human non-small-cell lung cancer. Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer. 2013; 8(3): 270-8.
Baratelli Felicita, Lee Jay M, Hazra Saswati, Lin Ying, Walser Tonya C, Schaue Dorthe, Pak Peter S, Elashoff David, Reckamp Karen, Zhang Ling, Fishbein Michael C, Sharma Sherven, Dubinett Steven M PGE(2) contributes to TGF-beta induced T regulatory cell function in human non-small cell lung cancer. American journal of translational research. 2010; 2(4): 356-67.
Demaria Sandra, Pikarsky Eli, Karin Michael, Coussens Lisa M, Chen Yen-Ching, El-Omar Emad M, Trinchieri Giorgio, Dubinett Steven M, Mao Jenny T, Szabo Eva, Krieg Arthur, Weiner George J, Fox Bernard A, Coukos George, Wang Ena, Abraham Robert T, Carbone Michele, Lotze Michael T Cancer and inflammation: promise for biologic therapy. Journal of immunotherapy (Hagerstown, Md. : 1997). 2010; 33(4): 335-51.
Stoyanov Evgeniy, Uddin Mohib, Mankuta David, Dubinett Steven M, Levi-Schaffer Francesca Mast cells and histamine enhance the proliferation of non-small cell lung cancer cells. Lung cancer (Amsterdam, Netherlands). 2012; 75(1): 38-44.
Mortazavi Fariborz, An Jiabin, Dubinett Steven, Rettig Matthew p120-catenin is transcriptionally downregulated by FOXC2 in non-small cell lung cancer cells. Molecular cancer research : MCR. 2010; 8(5): 762-74.
Garon Edward B, Dubinett Steven M Mitotic inhibitors. Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer. 2011; 6(11 Suppl 4): S1791-2.
Yanagawa Jane, Walser Tonya C, Zhu Li X, Hong Longsheng, Fishbein Michael C, Mah Vei, Chia David, Goodglick Lee, Elashoff David A, Luo Jie, Magyar Clara E, Dohadwala Mariam, Lee Jay M, St John Maie A, Strieter Robert M, Sharma Sherven, Dubinett Steven M Snail promotes CXCR2 ligand-dependent tumor progression in non-small cell lung carcinoma. Clinical cancer research : an official journal of the American Association for Cancer Research. 2009; 15(22): 6820-9.
Sharma Sherven, Srivastava Minu K, Harris-White Marni, Lee Jay Moon, Dubinett Steven MUC1 peptide vaccine mediated antitumor activity in non-small cell lung cancer. Expert opinion on biological therapy. 2011; 11(8): 987-90.
Garon Edward B, Dubinett Steven M Intracellular signaling molecules. Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer. 2009; 4(11 Suppl 3): S1057-8.
Mao Jenny T, Roth Michael D, Fishbein Michael C, Aberle Denise R, Zhang Zuo-Feng, Rao Jian Yu, Tashkin Donald P, Goodglick Lee, Holmes E Carmack, Cameron Robert B, Dubinett Steven M, Elashoff Robert, Szabo Eva, Elashoff David Lung cancer chemoprevention with celecoxib in former smokers. Cancer prevention research (Philadelphia, Pa.). 2011; 4(7): 984-93.
Lee Wen-Hwa, Hung Mien-Chie, Iczkowski Kenneth A, Languino Lucia R, Dubinett Steven M, Wang Dengshun Editorial Board 2009: American Journal of Translational Research (ISSN 1943-8141) www.ajtr.orgPublisher: e-Century Publishing Corporation (www.e-Century.org). American journal of translational research. 2009; 1(4): 412-4.
Al-Shyoukh Ibrahim, Yu Fuqu, Feng Jiaying, Yan Karen, Dubinett Steven, Ho Chih-Ming, Shamma Jeff S, Sun Ren Systematic quantitative characterization of cellular responses induced by multiple signals. BMC systems biology. 2011; 5(7): 88.
St John Maie A, Dohadwala Mariam, Luo Jie, Wang Guanyu, Lee Gina, Shih Hubert, Heinrich Eileen, Krysan Kostantyn, Walser Tonya, Hazra Saswati, Zhu Li, Lai Chi, Abemayor Elliot, Fishbein Michael, Elashoff David A, Sharma Sherven, Dubinett Steven M Proinflammatory mediators upregulate snail in head and neck squamous cell carcinoma. Clinical cancer research : an official journal of the American Association for Cancer Research. 2009; 15(19): 6018-27.
Lee Gina, Gardner Brian K, Elashoff David A, Purcell Colleen M, Sandha Harpavan S, Mao Jenny T, Krysan Kostyantyn, Lee Jay M, Dubinett Steven M Elevated levels of CXC chemokine connective tissue activating peptide (CTAP)-III in lung cancer patients. American journal of translational research. 2011; 3(3): 226-33.
Lee Wen-Hwa, Hung Mien-Chie, Iczkowski Kenneth A, Languino Lucia R, Dubinett Steven M, Wang Dengshun The launch of the american journal of translational research. American journal of translational research. 2009; 1(1): i.
Kar Upendra K, Srivastava Minu K, Andersson Asa, Baratelli Felicita, Huang Min, Kickhoefer Valerie A, Dubinett Steven M, Rome Leonard H, Sharma Sherven Novel CCL21-vault nanocapsule intratumoral delivery inhibits lung cancer growth. PloS one. 2011; 6(5): e18758.
Limsukon Atikun, Susanto Irawan, Hoo Guy W Soo, Dubinett Steven M, Batra Raj K Regression of recurrent respiratory papillomatosis with celecoxib and erlotinib combination therapy. Chest. 2009; 136(3): 924-6.
Dubinett Steven, Sharma Sherven Towards effective immunotherapy for lung cancer: simultaneous targeting of tumor-initiating cells and immune pathways in the tumor microenvironment. Immunotherapy. 2009; 1(5): 721-5.
Lee Gina, Walser Tonya C, Dubinett Steven M Chronic inflammation, chronic obstructive pulmonary disease, and lung cancer. Current opinion in pulmonary medicine. 2009; 15(4): 303-7.
Reckamp Karen L, Figlin Robert A, Burdick Marie D, Dubinett Steven M, Elashoff Robert M, Strieter Robert M CXCR4 expression on circulating pan-cytokeratin positive cells is associated with survival in patients with advanced non-small cell lung cancer. BMC cancer. 2009; 9(4): 213.
Andersson Asa, Yang Seok-Chul, Huang Min, Zhu Li, Kar Upendra K, Batra Raj K, Elashoff David, Strieter Robert M, Dubinett Steven M, Sharma Sherven IL-7 promotes CXCR3 ligand-dependent T cell antitumor reactivity in lung cancer. Journal of immunology (Baltimore, Md. : 1950). 2009; 182(11): 6951-8.
Punturieri Antonello, Szabo Eva, Croxton Thomas L, Shapiro Steven D, Dubinett Steven M Lung cancer and chronic obstructive pulmonary disease: needs and opportunities for integrated research. Journal of the National Cancer Institute. 2009; 101(8): 554-9.
Lu Qing-Yi, Yang Yanan, Jin Yu Sheng, Zhang Zuo-Feng, Heber David, Li Frederick P, Dubinett Steven M, Sondej Melissa A, Loo Joseph A, Rao Jian Yu Effects of green tea extract on lung cancer A549 cells: proteomic identification of proteins associated with cell migration. Proteomics. 2009; 9(3): 757-67.
Walser Tonya, Cui Xiaoyan, Yanagawa Jane, Lee Jay M, Heinrich Eileen, Lee Gina, Sharma Sherven, Dubinett Steven M Smoking and lung cancer: the role of inflammation. Proceedings of the American Thoracic Society. 2008; 5(8): 811-5.
Perdomo Catalina, Campbell Joshua D, Gerrein Joseph, Tellez Carmen S, Garrison Carly B, Walser Tonya C, Drizik Eduard, Si Huiqing, Gower Adam C, Vick Jessica, Anderlind Christina, Jackson George R, Mankus Courtney, Schembri Frank, O'Hara Carl, Gomperts Brigitte N, Dubinett Steven M, Hayden Patrick, Belinsky Steven A, Lenburg Marc E, Spira Avrum MicroRNA 4423 is a primate-specific regulator of airway epithelial cell differentiation and lung carcinogenesis. Proceedings of the National Academy of Sciences of the United States of America. 2013; 110(47): 18946-51.
Liao Wei, Jordaan Gwen, Srivastava Minu K, Dubinett Steven, Sharma Sherven, Sharma Sanjai Effect of epigenetic histone modifications on E-cadherin splicing and expression in lung cancer. American journal of cancer research. 2013; 3(4): 374-89.
Hong Candice Sun, Graham Nicholas A, Gu Wen, Espindola Camacho Carolina, Mah Vei, Maresh Erin L, Alavi Mohammed, Bagryanova Lora, Krotee Pascal A L, Gardner Brian K, Behbahan Iman Saramipoor, Horvath Steve, Chia David, Mellinghoff Ingo K, Hurvitz Sara A, Dubinett Steven M, Critchlow Susan E, Kurdistani Siavash K, Goodglick Lee, Braas Daniel, Graeber Thomas G, Christofk Heather R MCT1 Modulates Cancer Cell Pyruvate Export and Growth of Tumors that Co-express MCT1 and MCT4. Cell reports. 2016; 14(7): 1590-601.
Sharma Sherven, Zhu Li, Srivastava Minu K, Harris-White Marni, Huang Min, Lee Jay M, Rosen Fran, Lee Gina, Wang Gerald, Kickhoefer Valerie, Rome Leonard H, Baratelli Felicita, St John Maie, Reckamp Karen, Chul-Yang Seok, Hillinger Sven, Strieter Robert, Dubinett Steven CCL21 Chemokine Therapy for Lung Cancer. International trends in immunity. 2013; 1(1): 10-15.
Krysan Kostyantyn, Cui Xiaoyan, Gardner Brian K, Reckamp Karen L, Wang Xiaoyan, Hong Longsheng, Walser Tonya C, Rodriguez Nicole L, Pagano Paul C, Garon Edward B, Brothers John F, Elashoff David, Lee Jay M, Spira Avrum E, Sharma Sherven, Fishbein Michael C, Dubinett Steven M Elevated neutrophil gelatinase-associated lipocalin contributes to erlotinib resistance in non-small cell lung cancer. American journal of translational research. 2013; 5(5): 481-96.
Momcilovic Milica, McMickle Robert, Abt Evan, Seki Atsuko, Simko Sarah A, Magyar Clara, Stout David B, Fishbein Michael C, Walser Tonya C, Dubinett Steven M, Shackelford David B Heightening Energetic Stress Selectively Targets LKB1-Deficient Non-Small Cell Lung Cancers. Cancer research. 2015; 75(22): 4910-22.
Srivastava Minu K, Zhu Li, Harris-White Marni, Huang Min, St John Maie, Lee Jay M, Salgia Ravi, Cameron Robert B, Strieter Robert, Dubinett Steven, Sharma Sherven Targeting myeloid-derived suppressor cells augments antitumor activity against lung cancer. ImmunoTargets and therapy. 2012; 2012(1): 7-12.
Lin Yuan, Mallen-St Clair Jon, Luo Jie, Sharma Sherven, Dubinett Steven, St John Maie p53 modulates NF-κB mediated epithelial-to-mesenchymal transition in head and neck squamous cell carcinoma. Oral oncology. 2015; 51(10): 921-8.
Reckamp Karen L, Koczywas Marianna, Cristea Mihaela C, Dowell Jonathan E, Wang He-Jing, Gardner Brian K, Milne Ginger L, Figlin Robert A, Fishbein Michael C, Elashoff Robert M, Dubinett Steven M Randomized phase 2 trial of erlotinib in combination with high-dose celecoxib or placebo in patients with advanced non-small cell lung cancer. Cancer. 2015; 121(18): 3298-306.
Zhu Li X, Davoodi Michael, Srivastava Minu K, Kachroo Puja, Lee Jay M, St John Maie, Harris-White Marni, Huang Min, Strieter Robert M, Dubinett Steven, Sharma Sherven GITR agonist enhances vaccination responses in lung cancer. Oncoimmunology. 2015; 4(4): e992237.
Lee Mi-Heon, Kachroo Puja, Pagano Paul C, Yanagawa Jane, Wang Gerald, Walser Tonya C, Krysan Kostyantyn, Sharma Sherven, John Maie St, Dubinett Steven M, Lee Jay M Combination Treatment with Apricoxib and IL-27 Enhances Inhibition of Epithelial-Mesenchymal Transition in Human Lung Cancer Cells through a STAT1 Dominant Pathway. Journal of cancer science & therapy. 2014; 6(11): 468-477.
Lin Yuan, Luo Jie, Zhu Weichao Eric, Srivastava Minu, Schaue Dorthe, Elashoff David A, Dubinett Steven M, Sharma Sherven, Wu Benjamin, St John Maie A A cytokine-delivering polymer is effective in reducing tumor burden in a head and neck squamous cell carcinoma murine model. Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery. 2014; 151(3): 447-53.
Liclican Elvira L, Walser Tonya C, Hazra Saswati, Krysan Kostyantyn, Park Stacy J, Pagano Paul C, Gardner Brian K, Larsen Jill E, Minna John D, Dubinett Steven M Loss of miR125a expression in a model of K-ras-dependent pulmonary premalignancy. Cancer prevention research (Philadelphia, Pa.). 2014; 7(8): 845-55.
Hanas Jay S, Peyton Marvin D, Lerner Megan R, Lightfoot Stan A, Deb Subrato J, Hanas Rushie J, Vu Nicole T, Kupiec Thomas C, Stowell Donald E, Brackett Daniel J, Dubinett Steven M, Hocker James R Distinguishing patients with stage I lung cancer versus control individuals using serum mass profiling. Cancer investigation. 2014; 32(4): 136-43.
Ooi Aik T, Gower Adam C, Zhang Kelvin X, Vick Jessica L, Hong Longsheng, Nagao Brian, Wallace W Dean, Elashoff David A, Walser Tonya C, Dubinett Steven M, Pellegrini Matteo, Lenburg Marc E, Spira Avrum, Gomperts Brigitte N Molecular profiling of premalignant lesions in lung squamous cell carcinomas identifies mechanisms involved in stepwise carcinogenesis. Cancer prevention research (Philadelphia, Pa.). 2014; 7(5): 487-95.
Krysan Kostyantyn, Kusko Rebecca, Grogan Tristan, O'Hearn James, Reckamp Karen L, Walser Tonya C, Garon Edward B, Lenburg Marc E, Sharma Sherven, Spira Avrum E, Elashoff David, Dubinett Steven M PGE2-driven expression of c-Myc and oncomiR-17-92 contributes to apoptosis resistance in NSCLC. Molecular cancer research : MCR. 2014; 12(5): 765-74.
Garon Edward B, Christofk Heather R, Hosmer Wylie, Britten Carolyn D, Bahng Agnes, Crabtree Matthew J, Hong Candice Sun, Kamranpour Naeimeh, Pitts Sharon, Kabbinavar Fairooz, Patel Cecil, von Euw Erika, Black Alexander, Michelakis Evangelos D, Dubinett Steven M, Slamon Dennis J Dichloroacetate should be considered with platinum-based chemotherapy in hypoxic tumors rather than as a single agent in advanced non-small cell lung cancer. Journal of cancer research and clinical oncology. 2014; 140(3): 443-52.
Grant Jeanette L, Fishbein Michael C, Hong Long-Sheng, Krysan Kostyantyn, Minna John D, Shay Jerry W, Walser Tonya C, Dubinett Steven M A novel molecular pathway for Snail-dependent, SPARC-mediated invasion in non-small cell lung cancer pathogenesis. Cancer prevention research (Philadelphia, Pa.). 2014; 7(1): 150-60.
Ofili Elizabeth O, Fair Alecia, Norris Keith, Verbalis Joseph G, Poland Russell, Bernard Gordon, Stephens David S, Dubinett Steven M, Imperato-McGinley Julianne, Dottin Robert P, Pulley Jill, West Andrew, Brown Arleen, Mellman Thomas A Models of interinstitutional partnerships between research intensive universities and minority serving institutions (MSI) across the Clinical Translational Science Award (CTSA) consortium. Clinical and translational science. 2013; 6(6): 435-43.
Kachroo Puja, Lee Mi-Heon, Zhang Ling, Baratelli Felicita, Lee Gina, Srivastava Minu K, Wang Gerald, Walser Tonya C, Krysan Kostyantyn, Sharma Sherven, Dubinett Steven M, Lee Jay M IL-27 inhibits epithelial-mesenchymal transition and angiogenic factor production in a STAT1-dominant pathway in human non-small cell lung cancer. Journal of experimental & clinical cancer research : CR. 2013; 32(6): 97.
Dubinett Steven M, Spira Avrum Challenge and opportunity of targeted lung cancer chemoprevention. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2013; 31(33): 4169-71.