Tamer Sallam, M.D., Ph.D.
Affiliations
Affiliations
Assistant Professor, Cardiology
Research Interests
My research investigates the contributions of long non-coding RNAs in cardiometabolic disease.
Biography:

Dr. Sallam is an Assistant Professor of Medicine at the David Geffen School of Medicine at UCLA and a clinical cardiologist at Ronald Reagan UCLA Medical Center. He is a member of the Atherosclerosis Research Unit and Cardiovascular Theme Initiative at UCLA. Dr. Sallam graduated from the University of California, Irvine School of Medicine. He completed residency and chief residency training in Internal Medicine at Yale, followed by Cardiology fellowship training at UCLA. Dr. Sallam graduated from the STAR program at UCLA earning a PhD in Molecular, Cellular and Integrative Physiology in the HHMI Lab of Peter Tontonoz. He joined the UCLA faculty after fellowship, where his research investigates the role of novel transcription factor regulatory circuits in cardiometabolic disease. In 2015, Dr. Sallam has been awarded the Lauren B. Leichtman and Arthur E. Levine Cardiovascular Discovery Fund investigatorship at UCLA. Dr. Sallam is the recipient of an NIH K Award, American College of Cardiology Presidential Career Development Award, American Heart Association Early Career Investigator recognition, and American Society for Clinical Investigation Young Investigator Award. Dr. Sallam currently serves as co-director of the UCLA center for Cholesterol Management and Assistant Director of the UCLA Specialty Training and Advanced Research (STAR) Program.

Publications
Beceiro Susana, Pap Attila, Czimmerer Zsolt, Sallam Tamer, Guillén Jose A, Gallardo Germán, Hong Cynthia, A-Gonzalez Noelia, Tabraue Carlos, Diaz Mercedes, Lopez Felix, Matalonga Jonathan, Valledor Annabel F, Dominguez Pilar, Ardavin Carlos, Delgado-Martin Cristina, Partida-Sanchez Santiago, Rodriguez-Fernandez Jose Luis, Nagy Laszlo, Tontonoz Peter, Castrillo Antonio LXR nuclear receptors are transcriptional regulators of dendritic cell chemotaxis. Molecular and cellular biology. 2018; .
Sallam Tamer, Jones Marius, Thomas Brandon J, Wu Xiaohui, Gilliland Thomas, Qian Kevin, Eskin Ascia, Casero David, Zhang Zhengyi, Sandhu Jaspreet, Salisbury David, Rajbhandari Prashant, Civelek Mete, Hong Cynthia, Ito Ayaka, Liu Xin, Daniel Bence, Lusis Aldons J, Whitelegge Julian, Nagy Laszlo, Castrillo Antonio, Smale Stephen, Tontonoz Peter Transcriptional regulation of macrophage cholesterol efflux and atherogenesis by a long noncoding RNA. Nature medicine. 2018; 24(3): 304-312.
Rajbhandari Prashant, Thomas Brandon J, Feng An-Chieh, Hong Cynthia, Wang Jiexin, Vergnes Laurent, Sallam Tamer, Wang Bo, Sandhu Jaspreet, Seldin Marcus M, Lusis Aldons J, Fong Loren G, Katz Melanie, Lee Richard, Young Stephen G, Reue Karen, Smale Stephen T, Tontonoz Peter IL-10 Signaling Remodels Adipose Chromatin Architecture to Limit Thermogenesis and Energy Expenditure. Cell. 2018; 172(1-2): 218-233.e17.
Sallam Tamer, Sandhu Jaspreet, Tontonoz Peter Long Noncoding RNA Discovery in Cardiovascular Disease: Decoding Form to Function. Circulation research. 2018; 122(1): 155-166.
Zhang Li, Rajbhandari Prashant, Priest Christina, Sandhu Jaspreet, Wu Xiaohui, Temel Ryan, Castrillo Antonio, de Aguiar Vallim Thomas Q, Sallam Tamer, Tontonoz Peter Inhibition of cholesterol biosynthesis through RNF145-dependent ubiquitination of SCAP. eLife. 2017; 6(1): 155-166.
Tarling Elizabeth J, Clifford Bethan L, Cheng Joan, Morand Pauline, Cheng Angela, Lester Ellen, Sallam Tamer, Turner Martin, de Aguiar Vallim Thomas Q RNA-binding protein ZFP36L1 maintains posttranscriptional regulation of bile acid metabolism. The Journal of clinical investigation. 2017; 127(10): 3741-3754.
Tontonoz Peter, Wu Xiaohui, Jones Marius, Zhang Zhengyi, Salisbury David, Sallam Tamer Long Noncoding RNA Facilitated Gene Therapy Reduces Atherosclerosis in a Murine Model of Familial Hypercholesterolemia. Circulation. 2017; 136(8): 776-778.
Wang Jiexin, Rajbhandari Prashant, Damianov Andrey, Han Areum, Sallam Tamer, Waki Hironori, Villanueva Claudio J, Lee Stephen D, Nielsen Ronni, Mandrup Susanne, Reue Karen, Young Stephen G, Whitelegge Julian, Saez Enrique, Black Douglas L, Tontonoz Peter RNA-binding protein PSPC1 promotes the differentiation-dependent nuclear export of adipocyte RNAs. The Journal of clinical investigation. 2017; 127(3): 987-1004.
Watson Karol E, Sallam Tamer MY APPROACH to the Patient With Memory Loss Who Needs a Statin. Trends in cardiovascular medicine. 2017; 27(2): 158-159.
Sallam Tamer, Jones Marius C, Gilliland Thomas, Zhang Li, Wu Xiaohui, Eskin Ascia, Sandhu Jaspreet, Casero David, Vallim Thomas Q de Aguiar, Hong Cynthia, Katz Melanie, Lee Richard, Whitelegge Julian, Tontonoz Peter Feedback modulation of cholesterol metabolism by the lipid-responsive non-coding RNA LeXis. Nature. 2016; 534(7605): 124-8.
Wong Mitchell D, Guerrero Lourdes, Sallam Tamer, Frank Joy S, Fogelman Alan M, Demer Linda L Outcomes of a Novel Training Program for Physician-Scientists: Integrating Graduate Degree Training With Specialty Fellowship. Journal of graduate medical education. 2016; 8(1): 85-90.
Edris Ahmad, Gordin Jonathan, Sallam Tamer, Wachsner Robin, Meymandi Sheba, Traina Mahmoud Facilitated patent haemostasis after transradial catheterisation to reduce radial artery occlusion. EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology. 2015; 11(7): 765-71.
Mitchell Adam, Misialek Jeffrey R, Folsom Aaron R, Duprez Daniel, Alonso Alvaro, Jerosch-Herold Michael, Sanchez Otto A, Watson Karol E, Sallam Tamer, Konety Suma H Usefulness of N-terminal Pro-brain Natriuretic Peptide and Myocardial Perfusion in Asymptomatic Adults (from the Multi-Ethnic Study of Atherosclerosis). The American journal of cardiology. 2015; 115(10): 1341-5.
Lee Changhan, Zeng Jennifer, Drew Brian G, Sallam Tamer, Martin-Montalvo Alejandro, Wan Junxiang, Kim Su-Jeong, Mehta Hemal, Hevener Andrea L, de Cabo Rafael, Cohen Pinchas The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance. Cell metabolism. 2015; 21(3): 443-54.
Parks Brian W, Sallam Tamer, Mehrabian Margarete, Psychogios Nikolas, Hui Simon T, Norheim Frode, Castellani Lawrence W, Rau Christoph D, Pan Calvin, Phun Jennifer, Zhou Zhenqi, Yang Wen-Pin, Neuhaus Isaac, Gargalovic Peter S, Kirchgessner Todd G, Graham Mark, Lee Richard, Tontonoz Peter, Gerszten Robert E, Hevener Andrea L, Lusis Aldons J Genetic architecture of insulin resistance in the mouse. Cell metabolism. 2015; 21(2): 334-46.
Sallam Tamer, Ito Ayaka, Rong Xin, Kim Jason, van Stijn Caroline, Chamberlain Brian T, Jung Michael E, Chao Lily C, Jones Marius, Gilliland Thomas, Wu XiaoHui, Su Grace L, Tangirala Rajendra K, Tontonoz Peter, Hong Cynthia The macrophage LBP gene is an LXR target that promotes macrophage survival and atherosclerosis. Journal of lipid research. 2014; 55(6): 1120-30.
Edris Ahmad, Sallam Tamer, Traina Mahmoud Idris A wrong turn in embryologic development: a case of a primary right ventricular intracardiac tumor. Journal of the American College of Cardiology. 2014; 63(13): e29.
Sallam Tamer, Watson Karol E Predictors of cardiovascular risk in women. Women's health (London, England). 2013; 9(5): 491-8.
Sallam Tamer, Cheng Henry, Demer Linda L, Tintut Yin Regulatory circuits controlling vascular cell calcification. Cellular and molecular life sciences : CMLS. 2013; 70(17): 3187-97.
Sallam Tamer, Levi Daniel, Tobis Jonathan Coil embolization of left coronary artery pseudoaneurysms arising as a complication of percutaneous coronary intervention. Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions. 2012; 80(7): 1228-31.
Kashani Amir, Sallam Tamer, Bheemreddy Swarna, Mann Douglas L, Wang Yun, Foody JoAnne M Review of side-effect profile of combination ezetimibe and statin therapy in randomized clinical trials. The American journal of cardiology. 2008; 101(11): 1606-13.