Michael J Gandal, M.D., Ph.D.
Affiliations
Affiliations
Assistant Professor, Psychiatry and Biobehavioral Sciences
Member, Bioinformatics GPB Home Area, Brain Research Institute, Genetics & Genomics GPB Home Area
Biography:

Michael Gandal, MD PhD, is an Assistant Professor in the Department of Psychiatry and Biobehavioral Sciences at UCLA and the Semel Institute for Neuroscience and Human Behavior. He received his BS in Engineering (biomedical computation) from Stanford University and his MD/PhD in Bioengineering from the University of Pennsylvania, using electrophysiology to investigate neural circuit dysfunction in mouse models of schizophrenia and autism. He completed his residency training in Psychiatry at UCLA and a postdoctoral fellowship in neurogenetics in the lab of Dan Geschwind, characterizing the genetic contributions to shared gene expression alterations in human brain across several major psychiatric disorders. Dr. Gandal joined the faculty at UCLA in 2017. The Gandal laboratory employs systems-level, functional genomic approaches in human brain to understand the neurobiological mechanisms underlying psychiatric disorders, including autism, schizophrenia, and bipolar disorder. Dr. Gandal also conducts proof-of-principle clinical trials to investigate the translational potential of basic research findings, using PET imaging to interrogate the functional significance of microglial activation in autism.

Publications

A selected list of publications:

Gandal Michael J, Haney Jillian R, Parikshak Neelroop N, Leppa Virpi, Ramaswami Gokul, Hartl Chris, Schork Andrew J, Appadurai Vivek, Buil Alfonso, Werge Thomas M, Liu Chunyu, White Kevin P, White Kevin P, White Kevin P, White Kevin P, Horvath Steve, Geschwind Daniel H   Shared molecular neuropathology across major psychiatric disorders parallels polygenic overlap Science (New York, N.Y.), 2018; 359(6376): 693-697.
Gandal Michael J, Leppa Virpi, Won Hyejung, Parikshak Neelroop N, Geschwind Daniel H   The road to precision psychiatry: translating genetics into disease mechanisms Nature neuroscience, 2016; 19(11): 1397-1407.
Parikshak Neelroop N, Swarup Vivek, Belgard T Grant, Irimia Manuel, Ramaswami Gokul, Gandal Michael J, Hartl Christopher, Leppa Virpi, Ubieta Luis de la Torre, Huang Jerry, Lowe Jennifer K, Blencowe Benjamin J, Horvath Steve, Geschwind Daniel H   Genome-wide changes in lncRNA, splicing, and regional gene expression patterns in autism Nature, 2016; 540(7633): 423-427.
Won Hyejung, de la Torre-Ubieta Luis, Stein Jason L, Parikshak Neelroop N, Huang Jerry, Opland Carli K, Gandal Michael J, Sutton Gavin J, Hormozdiari Farhad, Lu Daning, Lee Changhoon, Eskin Eleazar, Voineagu Irina, Ernst Jason, Geschwind Daniel H   Chromosome conformation elucidates regulatory relationships in developing human brain Nature, 2016; 538(7626): 523-527.
Singh Tarjinder, Walters James T R, Johnstone Mandy, Curtis David, Suvisaari Jaana, Torniainen Minna, Rees Elliott, Iyegbe Conrad, Blackwood Douglas, McIntosh Andrew M, Kirov Georg, Geschwind Daniel, Murray Robin M, Di Forti Marta, Bramon Elvira, Gandal Michael, Hultman Christina M, Sklar Pamela, Sklar Pamela, Sklar Pamela, Palotie Aarno, Sullivan Patrick F, O'Donovan Michael C, Owen Michael J, Barrett Jeffrey C   The contribution of rare variants to risk of schizophrenia in individuals with and without intellectual disability Nature genetics, 2017; 49(8): 1167-1173.
Gandal Michael J, Geschwind Daniel H   The Genetics-Driven Revival in Neuropsychiatric Drug Development Biological psychiatry, 2016; 79(8): 628-30.
Parikshak Neelroop N, Gandal Michael J, Geschwind Daniel H   Systems biology and gene networks in neurodevelopmental and neurodegenerative disorders Nature reviews. Genetics, 2015; 16(8): 441-58.
Gandal Michael J, Nesbitt Addie May, McCurdy Richard M, Alter Mark D   Measuring the maturity of the fast-spiking interneuron transcriptional program in autism, schizophrenia, and bipolar disorder PloS one, 2012; 7(8): e41215.
Gandal M J, Sisti J, Klook K, Ortinski P I, Leitman V, Liang Y, Thieu T, Anderson R, Pierce R C, Jonak G, Gur R E, Carlson G, Siegel S J   GABAB-mediated rescue of altered excitatory-inhibitory balance, gamma synchrony and behavioral deficits following constitutive NMDAR-hypofunction Translational psychiatry, 2012; 2(3): e142.
Gandal Michael J, Edgar J Christopher, Klook Kerstin, Siegel Steven J   Gamma synchrony: towards a translational biomarker for the treatment-resistant symptoms of schizophrenia Neuropharmacology, 2012; 62(3): 1504-18.
Gandal Michael J, Edgar J Christopher, Ehrlichman Richard S, Mehta Mili, Roberts Timothy P L, Siegel Steven J   Validating γ oscillations and delayed auditory responses as translational biomarkers of autism Biological psychiatry, 2010; 68(12): 1100-6.