Maureen A. Su, M.D.
Affiliations
Affiliations
Professor, Pediatric Endocrinology, Microbiology, Immunology & Molecular Genetics
Member, Immunity, Microbes & Molecular Pathogenesis GPB Home Area
Biography:

Maureen A. Su, MD, is a Professor of Microbiology/Immunology and Medical Genetics at University of California, Los Angeles (UCLA). Dr. Su received her combined bachelor’s and master’s degrees from Harvard College and her M.D. degree from Harvard Medical School. She completed her pediatrics residency and fellowship in endocrinology at the University of California, San Francisco (UCSF). After 8 years on faculty in the Department of Pediatrics and Microbiology/Immunology at University of North Carolina at Chapel Hill (UNC-CH), she moved to UCLA in 2018.

As a physician-scientist, her long-term goal is to understand what causes autoimmune diseases with the goal of developing therapeutics to prevent and treat the underlying immune condition. Her work has focused on understanding Autoimmune Polyendocrinopathy Syndrome (APS1), autoimmunity against the peripheral nervous system (GBS/CIDP), and Type 1 Diabetes (T1D). Using knowledge gained from studying autoimmunity, she is developing ways to harness the autoimmune response to fight off cancer. She was elected to the Council of the Society for Pediatric Research (SPR) and is a member of the American Society of Clinical Investigation (ASCI).

Publications

A selected list of publications:

Liu Can, He Hua, Li Xiaobing, Su Maureen A, Cao Yanguang   Dynamic metrics-based biomarkers to predict responders to anti-PD-1 immunotherapy British journal of cancer, 2018; .
Allard Denise E, Wang Yan, Li Jian Joel, Conley Bridget, Xu Erin W, Sailer David, Kimpston Caellaigh, Notini Rebecca, Smith Collin-Jamal, Koseoglu Emel, Starmer Joshua, Zeng Xiaopei L, Howard James F, Hoke Ahmet, Scherer Steven S, Su Maureen A   Schwann cell-derived periostin promotes autoimmune peripheral polyneuropathy via macrophage recruitment The Journal of clinical investigation, 2018; .
Zhang Yang, Hwang Bin-Jin, Liu Zhen, Li Ning, Lough Kendall, Williams Scott E, Chen Jinbo, Burette Susan W, Diaz Luis A, Su Maureen A, Xiao Shengxiang, Liu Zhi   BP180 dysfunction triggers spontaneous skin inflammation in mice Proceedings of the National Academy of Sciences of the United States of America, 2018; 115(25): 6434-6439.
Smith Collin-Jamal, Allard Denise E, Wang Yan, Howard James F, Montgomery Stephanie A, Su Maureen A   IL-10 Paradoxically Promotes Autoimmune Neuropathy through S1PR1-Dependent CD4 Journal of immunology (Baltimore, Md. : 1950), 2018; 200(5): 1580-1592.
Bakhru Pearl, Zhu Meng-Lei, Wang Hsing-Hui, Hong Lee K, Khan Imran, Mouchess Maria, Gulati Ajay S, Starmer Joshua, Hou Yafei, Sailer David, Lee Sandra, Zhao Fengmin, Kirkwood John M, Moschos Stergios, Fong Lawrence, Anderson Mark S, Su Maureen A   Combination central tolerance and peripheral checkpoint blockade unleashes antimelanoma immunity JCI insight, 2017; 2(18): 1580-1592.
Thrasher Bradly J, Hong Lee Kyung, Whitmire Jason K, Su Maureen A   Epigenetic Dysfunction in Turner Syndrome Immune Cells Current allergy and asthma reports, 2016; 16(5): 36.
Anderson Mark S, Su Maureen A   AIRE expands: new roles in immune tolerance and beyond Nature reviews immunology, 2016; 16(4): 247-58.
Bakhru Pearl, Su Maureen A   Estrogen turns down "the AIRE" Journal of clinical investigation, 2016; 126(4): 1239-41.
Zhu Meng-Lei, Bakhru Pearl, Conley Bridget, Nelson Jennifer S, Free Meghan, Martin Aaron, Starmer Joshua, Wilson Elizabeth M, Su Maureen A   Sex bias in CNS autoimmune disease mediated by androgen control of autoimmune regulator Nature communications, 2016; 7(5): 11350.
Su Maureen A, Anderson Mark S   Breaking through the central tolerance ceiling to unleash anticancer immune responses Oncoimmunology, 2015; 3(8): e950169.
Cook Kevin D, Shpargel Karl B, Starmer Joshua, Whitfield-Larry Fatima, Conley Bridget, Allard Denise E, Rager Julia E, Fry Rebecca C, Davenport Marsha L, Magnuson Terry, Whitmire Jason K, Su Maureen A   T Follicular Helper Cell-Dependent Clearance of a Persistent Virus Infection Requires T Cell Expression of the Histone Demethylase UTX Immunity, 2015; 43(4): 703-14.
Whitfield-Larry Fatima, Felton Jamie, Buse John, Su Maureen A   Myeloid-derived suppressor cells are increased in frequency but not maximally suppressive in peripheral blood of Type 1 Diabetes Mellitus patients Clinical immunology (Orlando, Fla.), 2014; 153(1): 156-64.
Khan Imran S, Mouchess Maria L, Zhu Meng-Lei, Conley Bridget, Fasano Kayla J, Hou Yafei, Fong Lawrence, Su Maureen A, Anderson Mark S   Enhancement of an anti-tumor immune response by transient blockade of central T cell tolerance The Journal of experimental medicine, 2014; 211(5): 761-8.
Waterfield Michael, Khan Imran S, Cortez Jessica T, Fan Una, Metzger Todd, Greer Alexandra, Fasano Kayla, Martinez-Llordella Marc, Pollack Joshua L, Erle David J, Su Maureen, Anderson Mark S   The transcriptional regulator Aire coopts the repressive ATF7ip-MBD1 complex for the induction of immunotolerance Nature immunology, 2014; 15(3): 258-65.
Sarantopoulos Stefanie, Su Maureen A   BAFF-ling autoantibodies The Journal of clinical investigation, 2013; 123(12): 5006-8.
Misumi Ichiro, Alirezaei Mehrdad, Eam Boreth, Su Maureen A, Whitton J Lindsay, Whitmire Jason K   Differential T cell responses to residual viral antigen prolong CD4+ T cell contraction following the resolution of infection Journal of immunology (Baltimore, Md. : 1950), 2013; 191(11): 5655-68.
Free Meghan E, Su Maureen A   Reply: To PMID 23553415 Arthritis and rheumatism, 2013; 65(12): 3316-8.
Free Meghan E, Bunch Donna O'Dell, McGregor Julie Anne, Jones Britta E, Berg Elisabeth A, Hogan Susan L, Hu Yichun, Preston Gloria A, Jennette J Charles, Falk Ronald J, Su Maureen A   Patients with antineutrophil cytoplasmic antibody-associated vasculitis have defective Treg cell function exacerbated by the presence of a suppression-resistant effector cell population Arthritis and rheumatism, 2013; 65(7): 1922-33.
Zhu Meng-Lei, Nagavalli Anil, Su Maureen A   Aire deficiency promotes TRP-1-specific immune rejection of melanoma Cancer research, 2013; 73(7): 2104-16.
Zeng Xiaopei L, Nagavalli Anil, Smith Colin-Jamal, Howard James F, Su Maureen A   Divergent effects of T cell costimulation and inflammatory cytokine production on autoimmune peripheral neuropathy provoked by Aire deficiency Journal of immunology (Baltimore, Md. : 1950), 2013; 190(8): 3895-904.
Su Maureen A, Davini Dan, Cheng Philip, Giang Karen, Fan Una, DeVoss Jason J, Johannes Kellsey P A, Taylor Lorelei, Shum Anthony K, Valenzise Mariella, Meloni Antonella, Bour-Jordan Helene, Anderson Mark S   Defective autoimmune regulator-dependent central tolerance to myelin protein zero is linked to autoimmune peripheral neuropathy Journal of immunology (Baltimore, Md. : 1950), 2012; 188(10): 4906-12.
Wang Yunqi, Su Maureen A, Wan Yisong Y   An essential role of the transcription factor GATA-3 for the function of regulatory T cells Immunity, 2011; 35(3): 337-48.
Anderson Mark S, Su Maureen A   Aire and T cell development Current opinion in immunology, 2011; 23(2): 198-206.
Su Maureen A, Anderson Mark S   Monogenic autoimmune diseases: insights into self-tolerance Pediatric research, 2009; 65(5 Pt 2): 20R-25R.
Su Maureen A, Stenerson Matthew, Liu Weihong, Putnam Amy, Conte Felix, Bluestone Jeffrey A, Anderson Mark S   The role of X-linked FOXP3 in the autoimmune susceptibility of Turner Syndrome patients Clinical immunology (Orlando, Fla.), 2009; 131(1): 139-44.
Louvet Cédric, Kabre Beniwende G, Davini Dan W, Martinier Nicolas, Su Maureen A, DeVoss Jason J, Rosenthal Wendy L, Anderson Mark S, Bour-Jordan Hélène, Bluestone Jeffrey A   A novel myelin P0-specific T cell receptor transgenic mouse develops a fulminant autoimmune peripheral neuropathy The Journal of experimental medicine, 2009; 206(3): 507-14.
Gardner James M, Devoss Jason J, Friedman Rachel S, Wong David J, Tan Ying X, Zhou Xuyu, Johannes Kellsey P, Su Maureen A, Chang Howard Y, Krummel Matthew F, Anderson Mark S   Deletional tolerance mediated by extrathymic Aire-expressing cells Science (New York, N.Y.), 2008; 321(5890): 843-7.
Su Maureen A, Giang Karen, Zumer Kristina, Jiang Huimin, Oven Irena, Rinn John L, Devoss Jason J, Johannes Kellsey P A, Lu Wen, Gardner James, Chang Angela, Bubulya Paula, Chang Howard Y, Peterlin B Matija, Anderson Mark S   Mechanisms of an autoimmunity syndrome in mice caused by a dominant mutation in Aire The Journal of clinical investigation, 2008; 118(5): 1712-26.
Zhang Li, Barker Jennifer M, Babu Sunanda, Su Maureen, Stenerson Matthew, Cheng Mickie, Shum Anthony, Zamir Ehud, Badolato Raffaele, Law Adam, Eisenbarth George S, Anderson Mark S   A robust immunoassay for anti-interferon autoantibodies that is highly specific for patients with autoimmune polyglandular syndrome type 1 Clinical immunology (Orlando, Fla.), 2007; 125(2): 131-7.
Sipe Walter E B, Su Maureen, Posselt Andrew, Kim Grace E, Quiros Jose Antonio, Rosenthal Philip   Propylthiouracil-associated liver failure presenting as probable autoimmune hepatitis in a child with Graves' disease Pediatric transplantation, 2006; 10(4): 525-8.
Su Maureen A, Anderson Mark S   Aire: an update Current opinion in immunology, 2004; 16(6): 746-52.
Su M A, Wisotzkey R G, Newfeld S J   A screen for modifiers of decapentaplegic mutant phenotypes identifies lilliputian, the only member of the Fragile-X/Burkitt's Lymphoma family of transcription factors in Drosophila melanogaster Genetics, 2001; 157(2): 717-25.
Su M A, Trenor C C, Fleming J C, Fleming M D, Andrews N C   The G185R mutation disrupts function of the iron transporter Nramp2 Blood, 1998; 92(6): 2157-63.
Fleming M D, Trenor C C, Su M A, Foernzler D, Beier D R, Dietrich W F, Andrews N C   Microcytic anaemia mice have a mutation in Nramp2, a candidate iron transporter gene Nature genetics, 1997; 16(4): 383-6.