Paul C. Boutros, Ph.D.

Mailing Address:
UCLA Department of Human Genetics
BOX 957088, 57200A South Tower CHS
Los Angeles, CA 90095

Affiliations
Affiliations
Professor, Human Genetics
Member, Bioinformatics GPB Home Area, Cell & Developmental Biology GPB Home Area, Gene Regulation GPB Home Area, Genetics & Genomics GPB Home Area
Biography:

Dr. Paul Boutros pursued his undergraduate education at the University of Waterloo in Chemistry. During the co-op portion of his degree he worked for a wide range of organizations, including the Federal Government, a water-purification company and Petro-Canada. But he found his true calling during a work-term spent at Michigan State University developing computer models of how cells respond to drugs and toxins. Dr. Boutros’ undergraduate thesis extended this work to focus on modeling DNA damage, and was awarded First Place in the National Undergraduate Chemistry Conference.In 2004, Paul started his PhD at the Ontario Cancer Institute,in Toronto. During his studies he received several awards, including the CIHR/Next Generation First Prize and the Invitrogen Canada Young Investigator Silver Award. After publishing 27 peer-reviewed papers over four years,Paul was awarded his PhD in 2008 for his development of novel biomarkers for predicting cancer severity.

In 2008,Paul started his independent research career at the Ontario Institute for Cancer Research, as Principal Investigator in Informatics & Biocomputing, and Assistant Professor in the Departments of Pharmacology & Toxicology and Medical Biophysics at the University of Toronto. He is a Prostate Cancer Canada Rising Star in Prostate Cancer Research, a Terry Fox New Investigator Award recipient, a University of Waterloo Young Alumni Award winner and recipient of the Early Career Graduate Student Teaching Award. In 2016 he received his MBA from the University of Toronto, and in 2018 Paul was awarded the Dorval Prize by the Canadian Cancer Society, recognizing the best early career investigator nationally.

In 2018, Paul relocated to join the University of California, Los Angeles, taking on leadership roles at the Jonsson Comprehensive Cancer Centre and the Institute for Precision Health. As a Professor in the Departments of Human Genetics and Urology, his research focuses on personalizing therapy for cancer by developing novel statistical methodologies. He leads the ICGC-TCGA DREAM Somatic Mutation Calling Challenge that is setting global standards for analyzing cancer genomic data, and drives programs in cancer genomics, data science and biomarker translation.

Publications

A selected list of publications:

Grzadkowski Michal R, Sendorek Dorota H, P'ng Christine, Huang Vincent, Boutros Paul C   A comparative study of survival models for breast cancer prognostication revisited: the benefits of multi-gene models BMC bioinformatics, 2018; 19(1): 400.
Ruicci Kara M, Meens Jalna, Sun Ren X, Rizzo Giananthony, Pinto Nicole, Yoo John, Fung Kevin, MacNeil Danielle, Mymryk Joe S, Barrett John W, Boutros Paul C, Ailles Laurie, Nichols Anthony C   A controlled trial of HNSCC patient-derived xenografts reveals broad efficacy of PI3Kα inhibition in controlling tumor growth International journal of cancer, 2018; .
Lee Anna Y, Ewing Adam D, Ellrott Kyle, Hu Yin, Houlahan Kathleen E, Bare J Christopher, Espiritu Shadrielle Melijah G, Huang Vincent, Dang Kristen, Chong Zechen, Caloian Cristian, Yamaguchi Takafumi N, Yamaguchi Takafumi N, Kellen Michael R, Chen Ken, Norman Thea C, Friend Stephen H, Guinney Justin, Stolovitzky Gustavo, Haussler David, Margolin Adam A, Stuart Joshua M, Boutros Paul C   Combining accurate tumor genome simulation with crowdsourcing to benchmark somatic structural variant detection Genome biology, 2018; 19(1): 188.
Pinto Nicole, Prokopec Stephenie D, Vizeacoumar Frederick, Searle Karlee, Lowerison Matthew, Ruicci Kara M, Yoo John, Fung Kevin, MacNeil Danielle, Lacefield Jim C, Leong Hon S, Mymryk Joe S, Barrett John W, Datti Alessandro, Boutros Paul C, Nichols Anthony C   Lestaurtinib is a potent inhibitor of anaplastic thyroid cancer cell line models PloS one, 2018; 13(11): e0207152.
Haider Syed, Yao Cindy Q, Sabine Vicky S, Grzadkowski Michal, Stimper Vincent, Starmans Maud H W, Wang Jianxin, Nguyen Francis, Moon Nathalie C, Lin Xihui, Drake Camilla, Crozier Cheryl A, Brookes Cassandra L, van de Velde Cornelis J H, Hasenburg Annette, Kieback Dirk G, Markopoulos Christos J, Dirix Luc Y, Seynaeve Caroline, Rea Daniel W, Kasprzyk Arek, Lambin Philippe, Lio' Pietro, Bartlett John M S, Boutros Paul C   Pathway-based subnetworks enable cross-disease biomarker discovery Nature communications, 2018; 9(1): 4746.
Boutros Paul C   The Promise and Perils of Sequencing Individual Prostate Cancer Nuclei European urology, 2018; 74(5): 560-561.
Tu William B, Shiah Yu-Jia, Lourenco Corey, Mullen Peter J, Dingar Dharmendra, Redel Cornelia, Tamachi Aaliya, Ba-Alawi Wail, Aman Ahmed, Al-Awar Rima, Cescon David W, Haibe-Kains Benjamin, Arrowsmith Cheryl H, Raught Brian, Boutros Paul C, Penn Linda Z   MYC Interacts with the G9a Histone Methyltransferase to Drive Transcriptional Repression and Tumorigenesis Cancer cell, 2018; 34(4): 579-595.e8.
Kalkat Manpreet, Resetca Diana, Lourenco Corey, Chan Pak-Kei, Wei Yong, Shiah Yu-Jia, Vitkin Natasha, Tong Yufeng, Sunnerhagen Maria, Done Susan J, Boutros Paul C, Raught Brian, Penn Linda Z   MYC Protein Interactome Profiling Reveals Functionally Distinct Regions that Cooperate to Drive Tumorigenesis Molecular cell, 2018; 74(5): 560-561.
Li Constance H, Haider Syed, Shiah Yu-Jia, Thai Kevin, Boutros Paul C   Sex Differences in Cancer Driver Genes and Biomarkers Cancer research, 2018; 78(19): 5527-5537.
Gong Inna Y, Fox Natalie S, Huang Vincent, Boutros Paul C   Prediction of early breast cancer patient survival using ensembles of hypoxia signatures PloS one, 2018; 13(9): e0204123.
Cooper Christopher I, Yao Delia, Sendorek Dorota H, Yamaguchi Takafumi N, P'ng Christine, Houlahan Kathleen E, Caloian Cristian, Fraser Michael, Fraser Michael, Ellrott Kyle, Margolin Adam A, Bristow Robert G, Stuart Joshua M, Boutros Paul C   Valection: design optimization for validation and verification studies BMC bioinformatics, 2018; 19(1): 339.
Berlin Alejandro, Murgic Jure, Hosni Ali, Pintilie Melania, Salcedo Adriana, Fraser Michael, Kamel-Reid Suzanne, Zhang Jingbin, Wang Qiqi, Ch'ng Carolyn, Deheshi Samineh, Davicioni Elai, van der Kwast Theodorus, Boutros Paul C, Bristow Robert G, Chua Melvin L K   Genomic classifier for guiding treatment of intermediate-risk prostate cancers to dose-escalated image-guided radiotherapy without hormone therapy International journal of radiation oncology, biology, physics, 2018; 9(1): 3502.
Dingar Dharmendra, Tu William B, Resetca Diana, Lourenco Corey, Tamachi Aaliya, De Melo Jason, Houlahan Kathleen E, Kalkat Manpreet, Chan Pak-Kei, Boutros Paul C, Raught Brian, Penn Linda Z   MYC dephosphorylation by the PP1/PNUTS phosphatase complex regulates chromatin binding and protein stability Nature communications, 2018; 9(1): 3502.
Casey Alison E, Sinha Ankit, Singhania Rajat, Livingstone Julie, Waterhouse Paul, Tharmapalan Pirashaanthy, Cruickshank Jennifer, Shehata Mona, Drysdale Erik, Fang Hui, Kim Hyeyeon, Isserlin Ruth, Bailey Swneke, Medina Tiago, Deblois Genevieve, Shiah Yu-Jia, Barsyte-Lovejoy Dalia, Hofer Stefan, Bader Gary, Lupien Mathieu, Arrowsmith Cheryl, Knapp Stefan, De Carvalho Daniel, Berman Hal, Boutros Paul C, Kislinger Thomas, Khokha Rama   Mammary molecular portraits reveal lineage-specific features and progenitor cell vulnerabilities The Journal of cell biology, 2018; 217(8): 2951-2974.
Hoey Christianne, Ray Jessica, Jeon Jouhyun, Huang Xiaoyong, Taeb Samira, Ylanko Jarkko, Andrews David W, Boutros Paul C, Liu Stanley K   miRNA-106a and prostate cancer radioresistance: a novel role for LITAF in ATM regulation Molecular oncology, 2018; 12(8): 1324-1341.
Hua Junjie Tony, Ahmed Musaddeque, Guo Haiyang, Zhang Yuzhe, Chen Sujun, Soares Fraser, Lu Jennifer, Zhou Stanley, Wang Miranda, Li Hui, Larson Nicholas B, McDonnell Shannon K, Patel Parasvi S, Liang Yi, Yao Cindy Q, van der Kwast Theodorus, Lupien Mathieu, Feng Felix Y, Zoubeidi Amina, Tsao Ming-Sound, Thibodeau Stephen N, Boutros Paul C, He Housheng Hansen   Risk SNP-Mediated Promoter-Enhancer Switching Drives Prostate Cancer through lncRNA PCAT19 Cell, 2018; 174(3): 564-575.e18.
Yang Lingjian, Roberts Darren, Takhar Mandeep, Erho Nicholas, Bibby Becky A S, Thiruthaneeswaran Niluja, Bhandari Vinayak, Cheng Wei-Chen, Haider Syed, McCorry Amy M B, McArt Darragh, Jain Suneil, Alshalalfa Mohammed, Ross Ashley, Schaffer Edward, Den Robert B, Jeffrey Karnes R, Klein Eric, Hoskin Peter J, Freedland Stephen J, Lamb Alastair D, Neal David E, Buffa Francesca M, Bristow Robert G, Boutros Paul C, Davicioni Elai, Choudhury Ananya, West Catharine M L   Development and Validation of a 28-gene Hypoxia-related Prognostic Signature for Localized Prostate Cancer EBioMedicine, 2018; 31(4): 182-189.
Ghasemi Farhad, Black Morgan, Sun Ren X, Vizeacoumar Frederick, Pinto Nicole, Ruicci Kara M, Yoo John, Fung Kevin, MacNeil Danielle, Palma David A, Winquist Eric, Mymryk Joe S, Ailles Laurie A, Datti Alessandro, Barrett John W, Boutros Paul C, Nichols Anthony C   High-throughput testing in head and neck squamous cell carcinoma identifies agents with preferential activity in human papillomavirus-positive or negative cell lines Oncotarget, 2018; 9(40): 26064-26071.
Wither Joan E, Prokopec Stephenie D, Noamani Babak, Chang Nan-Hua, Bonilla Dennisse, Touma Zahi, Avila-Casado Carmen, Reich Heather N, Scholey James, Fortin Paul R, Boutros Paul C, Landolt-Marticorena Carolina   Identification of a neutrophil-related gene expression signature that is enriched in adult systemic lupus erythematosus patients with active nephritis: Clinical/pathologic associations and etiologic mechanisms PloS one, 2018; 13(5): e0196117.
Hopkins Julia F, Denroche Robert E, Aguiar Jennifer A, Notta Faiyaz, Connor Ashton A, Wilson Julie M, Stein Lincoln D, Gallinger Steven, Boutros Paul C   Mutations in Mitochondrial DNA From Pancreatic Ductal Adenocarcinomas Associate With Survival Times of Patients and Accumulate as Tumors Progress Gastroenterology, 2018; 154(6): 1620-1624.e5.
Wedge David C, Gundem Gunes, Mitchell Thomas, Woodcock Dan J, Martincorena Inigo, Ghori Mohammed, Zamora Jorge, Butler Adam, Whitaker Hayley, Kote-Jarai Zsofia, Alexandrov Ludmil B, Van Loo Peter, Massie Charlie E, Dentro Stefan, Warren Anne Y, Verrill Clare, Berney Dan M, Dennis Nening, Merson Sue, Hawkins Steve, Howat William, Lu Yong-Jie, Lambert Adam, Kay Jonathan, Kremeyer Barbara, Karaszi Katalin, Luxton Hayley, Camacho Niedzica, Marsden Luke, Edwards Sandra, Matthews Lucy, Bo Valeria, Leongamornlert Daniel, McLaren Stuart, Ng Anthony, Yu Yongwei, Zhang Hongwei, Dadaev Tokhir, Thomas Sarah, Easton Douglas F, Ahmed Mahbubl, Bancroft Elizabeth, Fisher Cyril, Livni Naomi, Nicol David, Tavaré Simon, Gill Pelvender, Greenman Christopher, Khoo Vincent, Van As Nicholas, Kumar Pardeep, Ogden Christopher, Cahill Declan, Thompson Alan, Mayer Erik, Rowe Edward, Dudderidge Tim, Gnanapragasam Vincent, Shah Nimish C, Raine Keiran, Jones David, Menzies Andrew, Stebbings Lucy, Teague Jon, Hazell Steven, Corbishley Cathy, Corbishley Cathy, de Bono Johann, Attard Gerhardt, Isaacs William, Visakorpi Tapio, Fraser Michael, Boutros Paul C, Bristow Robert G, Workman Paul, Sander Chris, Sander Chris, Hamdy Freddie C, Futreal Andrew, McDermott Ultan, Al-Lazikani Bissan, Lynch Andrew G, Bova G Steven, Foster Christopher S, Brewer Daniel S, Neal David E, Cooper Colin S, Eeles Rosalind A   Sequencing of prostate cancers identifies new cancer genes, routes of progression and drug targets Nature genetics, 2018; 50(5): 682-692.
Espiritu Shadrielle Melijah G, Liu Lydia Y, Rubanova Yulia, Bhandari Vinayak, Holgersen Erle M, Szyca Lesia M, Fox Natalie S, Chua Melvin L K, Yamaguchi Takafumi N, Heisler Lawrence E, Livingstone Julie, Wintersinger Jeff, Yousif Fouad, Lalonde Emilie, Rouette Alexandre, Salcedo Adriana, Houlahan Kathleen E, Li Constance H, Huang Vincent, Fraser Michael, van der Kwast Theodorus, Morris Quaid D, Bristow Robert G, Boutros Paul C   The Evolutionary Landscape of Localized Prostate Cancers Drives Clinical Aggression Cell, 2018; 173(4): 1003-1013.e15.
Fraser Michael, Boutros Paul C, Bristow Robert G   A Partner in Crime: Tumor-associated Stroma and Metastatic Prostate Cancer European urology, 2018; 73(4): 533-534.
Chong Taryne, Sarac Amila, Yao Cindy Q, Liao Linda, Lyttle Nicola, Boutros Paul C, Bartlett John M S, Spears Melanie   Deregulation of the spindle assembly checkpoint is associated with paclitaxel resistance in ovarian cancer Journal of ovarian research, 2018; 11(1): 27.
Huang Kuan-Lin, Mashl R Jay, Wu Yige, Ritter Deborah I, Wang Jiayin, Oh Clara, Paczkowska Marta, Reynolds Sheila, Wyczalkowski Matthew A, Oak Ninad, Scott Adam D, Krassowski Michal, Cherniack Andrew D, Houlahan Kathleen E, Jayasinghe Reyka, Wang Liang-Bo, Zhou Daniel Cui, Liu Di, Cao Song, Kim Young Won, Koire Amanda, McMichael Joshua F, Hucthagowder Vishwanathan, Kim Tae-Beom, Hahn Abigail, Wang Chen, McLellan Michael D, Al-Mulla Fahd, Johnson Kimberly J, Johnson Kimberly J, Lichtarge Olivier, Boutros Paul C, Raphael Benjamin, Lazar Alexander J, Zhang Wei, Wendl Michael C, Govindan Ramaswamy, Jain Sanjay, Wheeler David, Kulkarni Shashikant, Dipersio John F, Reimand Jüri, Meric-Bernstam Funda, Chen Ken, Shmulevich Ilya, Plon Sharon E, Chen Feng, Ding Li   Pathogenic Germline Variants in 10,389 Adult Cancers Cell, 2018; 173(2): 355-370.e14.
Encinas Giselly, Sabelnykova Veronica Y, de Lyra Eduardo Carneiro, Hirata Katayama Maria Lucia, Maistro Simone, de Vasconcellos Valle Pedro Wilson Mompean, de Lima Pereira Gláucia Fernanda, Rodrigues Lívia Munhoz, de Menezes Pacheco Serio Pedro Adolpho, de Gouvêa Ana Carolina Ribeiro Chaves, Geyer Felipe Correa, Basso Ricardo Alves, Pasini Fátima Solange, Del Pilar Esteves Diz Maria, Brentani Maria Mitzi, Guedes Sampaio Góes João Carlos, Chammas Roger, Boutros Paul C, Koike Folgueira Maria Aparecida Azevedo   Somatic mutations in early onset luminal breast cancer Oncotarget, 2018; 9(32): 22460-22479.
Sendorek Dorota H, Lalonde Emilie, Yao Cindy Q, Sabelnykova Veronica Y, Bristow Robert G, Boutros Paul C   NanoStringNormCNV: pre-processing of NanoString CNV data Bioinformatics (Oxford, England), 2018; 34(6): 1034-1036.
Böttcher René, Kweldam Charlotte F, Livingstone Julie, Lalonde Emilie, Yamaguchi Takafumi N, Huang Vincent, Yousif Fouad, Fraser Michael, Bristow Robert G, van der Kwast Theodorus, Boutros Paul C, Jenster Guido, van Leenders Geert J L H   Cribriform and intraductal prostate cancer are associated with increased genomic instability and distinct genomic alterations BMC cancer, 2018; 18(1): 8.
Sendorek Dorota H, Caloian Cristian, Ellrott Kyle, Bare J Christopher, Yamaguchi Takafumi N, Ewing Adam D, Houlahan Kathleen E, Norman Thea C, Margolin Adam A, Stuart Joshua M, Boutros Paul C   Germline contamination and leakage in whole genome somatic single nucleotide variant detection BMC bioinformatics, 2018; 19(1): 28.
Li Madeline, Kouzmina Ekaterina, McCusker Megan, Rodin Danielle, Boutros Paul C, Paige Christopher J, Rodin Gary   Cytokines and depression in cancer patients and caregivers Neuropsychiatric disease and treatment, 2017; 13(12): 2903-2911.
Li Madeline, Kouzmina Ekaterina, McCusker Megan, Rodin Danielle, Boutros Paul C, Paige Christopher J, Rodin Gary   Pro- and anti-inflammatory cytokine associations with major depression in cancer patients Psycho-oncology, 2017; 26(12): 2149-2156.
Briollais Laurent, Bristow Robert G, Boutros Paul C, Boutros Paul C, Zlotta Alexandre R   Response Journal of the National Cancer Institute, 2017; 109(12): 8.
Chua Melvin L K, Lo Winnie, Pintilie Melania, Murgic Jure, Lalonde Emilie, Bhandari Vinayak, Mahamud Osman, Gopalan Anuradha, Kweldam Charlotte F, van Leenders Geert J L H, Verhoef Esther I, Hoogland Agnes Marije, Livingstone Julie, Berlin Alejandro, Dal Pra Alan, Meng Alice, Zhang Junyan, Orain Michèle, Picard Valérie, Hovington Hélène, Bergeron Alain, Lacombe Louis, Fradet Yves, Têtu Bernard, Reuter Victor E, Fleshner Neil, Fraser Michael, Boutros Paul C, van der Kwast Theodorus H, Bristow Robert G   A Prostate Cancer "Nimbosus": Genomic Instability and SChLAP1 Dysregulation Underpin Aggression of Intraductal and Cribriform Subpathologies European urology, 2017; 72(5): 665-674.
Abdalla Moustafa, Tran-Thanh Danh, Moreno Juan, Iakovlev Vladimir, Nair Ranju, Kanwar Nisha, Abdalla Mohamed, Lee Jennifer P Y, Kwan Jennifer Yin Yee, Cawthorn Thomas R, Warren Keisha, Arneson Nona, Wang Dong-Yu, Fox Natalie S, Youngson Bruce J, Miller Naomi A, Easson Alexandra M, McCready David, Leong Wey L, Boutros Paul C, Done Susan J   Mapping genomic and transcriptomic alterations spatially in epithelial cells adjacent to human breast carcinoma Nature communications, 2017; 8(1): 1245.
Shiah Yu-Jia, Fraser Michael, Bristow Robert G, Boutros Paul C   Comparison of pre-processing methods for Infinium HumanMethylation450 BeadChip array Bioinformatics (Oxford, England), 2017; 33(20): 3151-3157.
Liang Yi, Ahmed Musaddeque, Guo Haiyang, Soares Fraser, Hua Junjie T, Gao Shuai, Lu Catherine, Poon Christine, Han Wanting, Langstein Jens, Ekram Muhammad B, Li Brian, Davicioni Elai, Takhar Mandeep, Erho Nicholas, Karnes R Jeffrey, Chadwick Dianne, van der Kwast Theodorus, Boutros Paul C, Arrowsmith Cheryl H, Feng Felix Y, Joshua Anthony M, Zoubeidi Amina, Cai Changmeng, He Housheng H   LSD1-Mediated Epigenetic Reprogramming Drives CENPE Expression and Prostate Cancer Progression Cancer research, 2017; 77(20): 5479-5490.
Hopkins Julia F, Sabelnykova Veronica Y, Weischenfeldt Joachim, Simon Ronald, Aguiar Jennifer A, Alkallas Rached, Heisler Lawrence E, Zhang Junyan, Watson John D, Chua Melvin L K, Fraser Michael, Favero Francesco, Lawerenz Chris, Plass Christoph, Sauter Guido, McPherson John D, van der Kwast Theodorus, Korbel Jan, Schlomm Thorsten, Bristow Robert G, Boutros Paul C   Mitochondrial mutations drive prostate cancer aggression Nature communications, 2017; 8(1): 656.
Chüeh Anderly C, Liew Mun-Sem, Russell Prudence A, Walkiewicz Marzena, Jayachandran Aparna, Starmans Maud H W, Boutros Paul C, Wright Gavin, Barnett Stephen A, Mariadason John M, John Thomas   Promoter hypomethylation of NY-ESO-1, association with clinicopathological features and PD-L1 expression in non-small cell lung cancer Oncotarget, 2017; 8(43): 74036-74048.
Ghasemi Farhad, Black Morgan, Vizeacoumar Frederick, Pinto Nicole, Ruicci Kara M, Le Carson Cao Son Huu, Lowerison Matthew R, Leong Hon Sing, Yoo John, Fung Kevin, MacNeil Danielle, Palma David A, Winquist Eric, Mymryk Joe S, Boutros Paul C, Datti Alessandro, Barrett John W, Nichols Anthony C   Repurposing Albendazole: new potential as a chemotherapeutic agent with preferential activity against HPV-negative head and neck squamous cell cancer Oncotarget, 2017; 8(42): 71512-71519.
Kron Ken J, Murison Alexander, Zhou Stanley, Huang Vincent, Yamaguchi Takafumi N, Shiah Yu-Jia, Fraser Michael, van der Kwast Theodorus, Boutros Paul C, Bristow Robert G, Lupien Mathieu   TMPRSS2-ERG fusion co-opts master transcription factors and activates NOTCH signaling in primary prostate cancer Nature genetics, 2017; 49(9): 1336-1345.
Alfaro Javier A, Ignatchenko Alexandr, Ignatchenko Vladimir, Sinha Ankit, Boutros Paul C, Kislinger Thomas   Detecting protein variants by mass spectrometry: a comprehensive study in cancer cell-lines Genome medicine, 2017; 9(1): 62.
Taghiyar M Jafar, Rosner Jamie, Grewal Diljot, Grande Bruno M, Aniba Radhouane, Grewal Jasleen, Boutros Paul C, Morin Ryan D, Bashashati Ali, Shah Sohrab P   Kronos: a workflow assembler for genome analytics and informatics GigaScience, 2017; 6(7): 1-10.
Lalonde Emilie, Alkallas Rached, Chua Melvin Lee Kiang, Fraser Michael, Haider Syed, Meng Alice, Zheng Junyan, Yao Cindy Q, Picard Valerie, Orain Michele, Hovington Helène, Murgic Jure, Berlin Alejandro, Lacombe Louis, Bergeron Alain, Fradet Yves, Têtu Bernard, Lindberg Johan, Egevad Lars, Grönberg Henrik, Ross-Adams Helen, Lamb Alastair D, Halim Silvia, Dunning Mark J, Neal David E, Pintilie Melania, van der Kwast Theodorus, Bristow Robert G, Boutros Paul C   Translating a Prognostic DNA Genomic Classifier into the Clinic: Retrospective Validation in 563 Localized Prostate Tumors European urology, 2017; 72(1): 22-31.
Albuquerque Marco A, Grande Bruno M, Ritch Elie J, Pararajalingam Prasath, Jessa Selin, Krzywinski Martin, Grewal Jasleen K, Shah Sohrab P, Boutros Paul C, Morin Ryan D   Enhancing knowledge discovery from cancer genomics data with Galaxy GigaScience, 2017; 6(5): 1-13.
Thapa Bibhusal, Salcedo Adriana, Lin Xihui, Walkiewicz Marzena, Murone Carmel, Ameratunga Malaka, Asadi Khashyar, Deb Siddhartha, Barnett Stephen Arthur, Knight Simon, Mitchell Paul, Watkins D Neil, Boutros Paul C, John Thomas   The Immune Microenvironment, Genome-wide Copy Number Aberrations, and Survival in Mesothelioma Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, 2017; 12(5): 850-859.
Briollais Laurent, Ozcelik Hilmi, Xu Jingxiong, Kwiatkowski Maciej, Lalonde Emilie, Sendorek Dorota H, Fleshner Neil E, Recker Franz, Kuk Cynthia, Olkhov-Mitsel Ekaterina, Savas Sevtap, Hanna Sally, Juvet Tristan, Hunter Geoffrey A, Friedlander Matt, Li Hong, Chadwick Karen, Prassas Ioannis, Soosaipillai Antoninus, Randazzo Marco, Trachtenberg John, Toi Ants, Shiah Yu-Jia, Fraser Michael, van der Kwast Theodorus, Bristow Robert G, Bapat Bharati, Diamandis Eleftherios P, Boutros Paul C, Zlotta Alexandre R   Germline Mutations in the Kallikrein 6 Region and Predisposition for Aggressive Prostate Cancer Journal of the National Cancer Institute, 2017; 109(4): 71512-71519.
Dunning Mark J, Vowler Sarah L, Lalonde Emilie, Ross-Adams Helen, Boutros Paul, Mills Ian G, Lynch Andy G, Lamb Alastair D   Mining Human Prostate Cancer Datasets: The "camcAPP" Shiny App EBioMedicine, 2017; 17(4): 5-6.
Bayani Jane, Yao Cindy Q, Quintayo Mary Anne, Yan Fu, Haider Syed, D'Costa Alister, Brookes Cassandra L, van de Velde Cornelis J H, Hasenburg Annette, Kieback Dirk G, Markopoulos Christos, Dirix Luc, Seynaeve Caroline, Rea Daniel, Boutros Paul C, Bartlett John M S   Molecular stratification of early breast cancer identifies drug targets to drive stratified medicine NPJ breast cancer, 2017; 3(4): 3.
Wang Dennis, Pham Nhu-An, Tong Jiefei, Sakashita Shingo, Allo Ghassan, Kim Lucia, Yanagawa Naoki, Raghavan Vibha, Wei Yuhong, To Christine, Trinh Quang M, Starmans Maud H W, Chan-Seng-Yue Michelle A, Chadwick Dianne, Li Lei, Zhu Chang-Qi, Liu Ni, Li Ming, Lee Sharon, Ignatchenko Vladimir, Strumpf Dan, Taylor Paul, Moghal Nadeem, Liu Geoffrey, Boutros Paul C, Kislinger Thomas, Pintilie Melania, Jurisica Igor, Shepherd Frances A, McPherson John D, Muthuswamy Lakshmi, Moran Michael F, Tsao Ming-Sound   Molecular heterogeneity of non-small cell lung carcinoma patient-derived xenografts closely reflect their primary tumors International journal of cancer, 2017; 140(3): 662-673.
Watson John D, Prokopec Stephenie D, Smith Ashley B, Okey Allan B, Pohjanvirta Raimo, Boutros Paul C   2,3,7,8 Tetrachlorodibenzo-p-dioxin-induced RNA abundance changes identify Ackr3, Col18a1, Cyb5a and Glud1 as candidate mediators of toxicity Archives of toxicology, 2017; 91(1): 325-338.
Prokopec Stephenie D, Houlahan Kathleen E, Sun Ren X, Watson John D, Yao Cindy Q, Lee Jamie, P'ng Christine, Pang Renee, Wu Alexander H, Chong Lauren C, Smith Ashley B, Harding Nicholas J, Moffat Ivy D, Lindén Jere, Lensu Sanna, Okey Allan B, Pohjanvirta Raimo, Boutros Paul C   Compendium of TCDD-mediated transcriptomic response datasets in mammalian model systems BMC genomics, 2017; 18(1): 78.
Haider Syed, Waggott Daryl, Lalonde Emilie, Fung Clement, Liu Fei-Fei, Boutros Paul C   Erratum to: A bedr way of genomic interval processing Source code for biology and medicine, 2017; 12(1): 1.
Fraser Michael, Sabelnykova Veronica Y, Yamaguchi Takafumi N, Heisler Lawrence E, Livingstone Julie, Huang Vincent, Shiah Yu-Jia, Yousif Fouad, Lin Xihui, Masella Andre P, Fox Natalie S, Xie Michael, Prokopec Stephenie D, Berlin Alejandro, Lalonde Emilie, Ahmed Musaddeque, Trudel Dominique, Luo Xuemei, Beck Timothy A, Meng Alice, Zhang Junyan, D'Costa Alister, Denroche Robert E, Kong Haiying, Espiritu Shadrielle Melijah G, Chua Melvin L K, Wong Ada, Chong Taryne, Sam Michelle, Johns Jeremy, Timms Lee, Buchner Nicholas B, Orain Michèle, Picard Valérie, Hovington Helène, Murison Alexander, Kron Ken, Harding Nicholas J, P'ng Christine, Houlahan Kathleen E, Chu Kenneth C, Lo Bryan, Nguyen Francis, Li Constance H, Sun Ren X, de Borja Richard, Cooper Christopher I, Hopkins Julia F, Govind Shaylan K, Fung Clement, Waggott Daryl, Green Jeffrey, Haider Syed, Chan-Seng-Yue Michelle A, Jung Esther, Wang Zhiyuan, Bergeron Alain, Dal Pra Alan, Lacombe Louis, Collins Colin C, Sahinalp Cenk, Lupien Mathieu, Fleshner Neil E, He Housheng H, Fradet Yves, Tetu Bernard, van der Kwast Theodorus, McPherson John D, Bristow Robert G, Boutros Paul C   Genomic hallmarks of localized, non-indolent prostate cancer Nature, 2017; 541(7637): 359-364.
Taylor Renea A, Fraser Michael, Livingstone Julie, Espiritu Shadrielle Melijah G, Thorne Heather, Huang Vincent, Lo Winnie, Shiah Yu-Jia, Yamaguchi Takafumi N, Sliwinski Ania, Horsburgh Sheri, Meng Alice, Heisler Lawrence E, Yu Nancy, Yousif Fouad, Papargiris Melissa, Lawrence Mitchell G, Timms Lee, Murphy Declan G, Frydenberg Mark, Hopkins Julia F, Bolton Damien, Clouston David, McPherson John D, van der Kwast Theodorus, Boutros Paul C, Risbridger Gail P, Bristow Robert G   Germline BRCA2 mutations drive prostate cancers with distinct evolutionary trajectories Nature communications, 2017; 8(1): 13671.
Fotouhi Ghiam Alireza, Taeb Samira, Huang Xiaoyong, Huang Vincent, Ray Jessica, Scarcello Seville, Hoey Christianne, Jahangiri Sahar, Fokas Emmanouil, Loblaw Andrew, Bristow Robert G, Vesprini Danny, Boutros Paul, Liu Stanley K   Long non-coding RNA urothelial carcinoma associated 1 (UCA1) mediates radiation response in prostate cancer Oncotarget, 2017; 8(3): 4668-4689.
David Matei, Dursi L J, Yao Delia, Boutros Paul C, Simpson Jared T   Nanocall: an open source basecaller for Oxford Nanopore sequencing data Bioinformatics (Oxford, England), 2017; 33(1): 49-55.
Chong Zechen, Ruan Jue, Gao Min, Zhou Wanding, Chen Tenghui, Fan Xian, Ding Li, Lee Anna Y, Boutros Paul, Chen Junjie, Chen Ken   novoBreak: local assembly for breakpoint detection in cancer genomes Nature methods, 2017; 14(1): 65-67.
Landolt-Marticorena Carolina, Prokopec Stephenie D, Morrison Stacey, Noamani Babak, Bonilla Dennisse, Reich Heather, Scholey James, Avila-Casado Carmen, Fortin Paul R, Boutros Paul C, Wither Joan   A discrete cluster of urinary biomarkers discriminates between active systemic lupus erythematosus patients with and without glomerulonephritis Arthritis research & therapy, 2016; 18(1): 218.
Guo Haiyang, Ahmed Musaddeque, Zhang Fan, Yao Cindy Q, Li SiDe, Liang Yi, Hua Junjie, Soares Fraser, Sun Yifei, Langstein Jens, Li Yuchen, Poon Christine, Bailey Swneke D, Desai Kinjal, Fei Teng, Li Qiyuan, Sendorek Dorota H, Fraser Michael, Prensner John R, Pugh Trevor J, Pomerantz Mark, Bristow Robert G, Lupien Mathieu, Feng Felix Y, Boutros Paul C, Freedman Matthew L, Walsh Martin J, He Housheng Hansen   Modulation of long noncoding RNAs by risk SNPs underlying genetic predispositions to prostate cancer Nature genetics, 2016; 48(10): 1142-50.
Lam Felix, Lalansingh Christopher M, Babaran Holly E, Wang Zhiyuan, Prokopec Stephenie D, Fox Natalie S, Boutros Paul C   VennDiagramWeb: a web application for the generation of highly customizable Venn and Euler diagrams BMC bioinformatics, 2016; 17(1): 401.
Huang Barbara F F, Boutros Paul C   The parameter sensitivity of random forests BMC bioinformatics, 2016; 17(1): 331.
Spears Melanie, Lyttle Nicola, D'Costa Alister, Chen Bingshu E, Yao Cindy Q, Boutros Paul C, Burnell Margot, Levine Mark N, O'Brien Patti, Shepherd Lois, Bartlett John M S   A four gene signature of chromosome instability (CIN4) predicts for benefit from taxanes in the NCIC-CTG MA21 clinical trial Oncotarget, 2016; 7(31): 49099-49106.
Masella Andre P, Lalansingh Christopher M, Sivasundaram Pragash, Fraser Michael, Bristow Robert G, Boutros Paul C   BAMQL: a query language for extracting reads from BAM files BMC bioinformatics, 2016; 17(1): 305.
Bhandari Vinayak, Boutros Paul C   Comparing continuous and discrete analyses of breast cancer survival information Genomics, 2016; 108(2): 78-83.
Chia Puey Ling, Gedye Craig, Boutros Paul C, Wheatley-Price Paul, John Thomas   Current and Evolving Methods to Visualize Biological Data in Cancer Research Journal of the National Cancer Institute, 2016; 108(8): 173-80.
Stojanova Angelina, Tu William B, Ponzielli Romina, Kotlyar Max, Chan Pak-Kei, Boutros Paul C, Khosravi Fereshteh, Jurisica Igor, Raught Brian, Penn Linda Z   MYC interaction with the tumor suppressive SWI/SNF complex member INI1 regulates transcription and cellular transformation Cell cycle (Georgetown, Tex.), 2016; 15(13): 1693-705.
Noren David P, Long Byron L, Norel Raquel, Rrhissorrakrai Kahn, Hess Kenneth, Hu Chenyue Wendy, Bisberg Alex J, Schultz Andre, Engquist Erik, Liu Li, Lin Xihui, Chen Gregory M, Xie Honglei, Hunter Geoffrey A M, Boutros Paul C, Stepanov Oleg, Stepanov Oleg, Norman Thea, Friend Stephen H, Stolovitzky Gustavo, Kornblau Steven, Qutub Amina A   A Crowdsourcing Approach to Developing and Assessing Prediction Algorithms for AML Prognosis PLoS computational biology, 2016; 12(6): e1004890.
Azad Abul Kalam, Bairati Isabelle, Qiu Xin, Girgis Hala, Cheng Lu, Waggott Daryl, Cheng Dangxiao, Mirshams Maryam, Ho James, Fortin André, Vigneault Eric, Huang Shao-Hui, O'Sullivan Brian, Waldron John, Boutros Paul C, Goldstein David, Meyer Francois, Xu Wei, Liu Geoffrey   A genome-wide association study of non-HPV-related head and neck squamous cell carcinoma identifies prognostic genetic sequence variants in the MAP-kinase and hormone pathways Cancer epidemiology, 2016; 42(6): 173-80.
Allen Genevera I, Amoroso Nicola, Anghel Catalina, Balagurusamy Venkat, Bare Christopher J, Beaton Derek, Bellotti Roberto, Bennett David A, Boehme Kevin L, Boutros Paul C, Caberlotto Laura, Caloian Cristian, Campbell Frederick, Chaibub Neto Elias, Chang Yu-Chuan, Chen Beibei, Chen Chien-Yu, Chien Ting-Ying, Clark Tim, Das Sudeshna, Davatzikos Christos, Deng Jieyao, Dillenberger Donna, Dobson Richard J B, Dong Qilin, Doshi Jimit, Duma Denise, Errico Rosangela, Erus Guray, Everett Evan, Fardo David W, Friend Stephen H, Fröhlich Holger, Gan Jessica, St George-Hyslop Peter, Ghosh Satrajit S, Glaab Enrico, Green Robert C, Guan Yuanfang, Hong Ming-Yi, Huang Chao, Hwang Jinseub, Ibrahim Joseph, Inglese Paolo, Iyappan Anandhi, Jiang Qijia, Katsumata Yuriko, Kauwe John S K, Klein Arno, Kong Dehan, Krause Roland, Lalonde Emilie, Lauria Mario, Lee Eunjee, Lin Xihui, Liu Zhandong, Livingstone Julie, Logsdon Benjamin A, Lovestone Simon, Ma Tsung-Wei, Malhotra Ashutosh, Mangravite Lara M, Maxwell Taylor J, Merrill Emily, Nagorski John, Namasivayam Aishwarya, Narayan Manjari, Naz Mufassra, Newhouse Stephen J, Norman Thea C, Nurtdinov Ramil N, Oyang Yen-Jen, Pawitan Yudi, Peng Shengwen, Peters Mette A, Piccolo Stephen R, Praveen Paurush, Priami Corrado, Sabelnykova Veronica Y, Senger Philipp, Shen Xia, Simmons Andrew, Sotiras Aristeidis, Stolovitzky Gustavo, Tangaro Sabina, Tateo Andrea, Tung Yi-An, Tustison Nicholas J, Varol Erdem, Vradenburg George, Weiner Michael W, Xiao Guanghua, Xie Lei, Xie Yang, Xu Jia, Yang Hojin, Zhan Xiaowei, Zhou Yunyun, Zhu Fan, Zhu Hongtu, Zhu Shanfeng, Zhu Shanfeng   Crowdsourced estimation of cognitive decline and resilience in Alzheimer's disease Alzheimer's & dementia : the journal of the Alzheimer's Association, 2016; 12(6): 645-53.
Macdonald John M, Boutros Paul C   Log::ProgramInfo: A Perl module to collect and log data for bioinformatics pipelines Source code for biology and medicine, 2016; 11(6): 9.
Kim Yunee, Jeon Jouhyun, Mejia Salvador, Yao Cindy Q, Ignatchenko Vladimir, Nyalwidhe Julius O, Gramolini Anthony O, Lance Raymond S, Troyer Dean A, Drake Richard R, Boutros Paul C, Semmes O John, Kislinger Thomas   Targeted proteomics identifies liquid-biopsy signatures for extracapsular prostate cancer Nature communications, 2016; 7(13): 11906.
Gagliano Sarah A, Ptak Carolyn, Mak Denise Y F, Shamsi Mehrdad, Oh Gabriel, Knight Joanne, Boutros Paul C, Petronis Arturas   Allele-Skewed DNA Modification in the Brain: Relevance to a Schizophrenia GWAS American journal of human genetics, 2016; 98(5): 956-962.
Boutros Paul C, Fraser Michael, van der Kwast Theodorus, Bristow Robert G   Clonality of localized and metastatic prostate cancer Current opinion in urology, 2016; 26(3): 219-24.
Ameratunga Malaka, Asadi Khashayar, Lin Xihui, Walkiewicz Marzena, Murone Carmel, Knight Simon, Mitchell Paul, Boutros Paul, John Thomas   PD-L1 and Tumor Infiltrating Lymphocytes as Prognostic Markers in Resected NSCLC PloS one, 2016; 11(4): e0153954.
Babichev Yael, Kabaroff Leah, Datti Alessandro, Uehling David, Isaac Methvin, Al-Awar Rima, Prakesch Michael, Sun Ren X, Boutros Paul C, Venier Rosemarie, Dickson Brendan C, Gladdy Rebecca A   PI3K/AKT/mTOR inhibition in combination with doxorubicin is an effective therapy for leiomyosarcoma Journal of translational medicine, 2016; 14(4): 67.
Braunstein Marsela, Liao Linda, Lyttle Nicola, Lobo Nazleen, Taylor Karen J, Krzyzanowski Paul M, Kalatskaya Irina, Yao Cindy Q, Stein Lincoln D, Boutros Paul C, Twelves Christopher J, Marcellus Richard, Bartlett John M S, Spears Melanie   Downregulation of histone H2A and H2B pathways is associated with anthracycline sensitivity in breast cancer Breast cancer research : BCR, 2016; 18(1): 16.
Haider Syed, Waggott Daryl, Lalonde Emilie, Fung Clement, Liu Fei-Fei, Boutros Paul C   A bedr way of genomic interval processing Source code for biology and medicine, 2016; 11(1): 14.
Alioto Tyler S, Buchhalter Ivo, Derdak Sophia, Hutter Barbara, Eldridge Matthew D, Hovig Eivind, Heisler Lawrence E, Beck Timothy A, Simpson Jared T, Tonon Laurie, Sertier Anne-Sophie, Patch Ann-Marie, Jäger Natalie, Ginsbach Philip, Drews Ruben, Paramasivam Nagarajan, Kabbe Rolf, Chotewutmontri Sasithorn, Diessl Nicolle, Previti Christopher, Schmidt Sabine, Brors Benedikt, Feuerbach Lars, Heinold Michael, Gröbner Susanne, Korshunov Andrey, Tarpey Patrick S, Butler Adam P, Hinton Jonathan, Jones David, Menzies Andrew, Raine Keiran, Shepherd Rebecca, Stebbings Lucy, Teague Jon W, Ribeca Paolo, Giner Francesc Castro, Beltran Sergi, Raineri Emanuele, Dabad Marc, Heath Simon C, Gut Marta, Denroche Robert E, Harding Nicholas J, Yamaguchi Takafumi N, Fujimoto Akihiro, Nakagawa Hidewaki, Quesada Víctor, Valdés-Mas Rafael, Nakken Sigve, Vodák Daniel, Bower Lawrence, Lynch Andrew G, Anderson Charlotte L, Waddell Nicola, Pearson John V, Grimmond Sean M, Peto Myron, Spellman Paul, He Minghui, Kandoth Cyriac, Lee Semin, Zhang John, Létourneau Louis, Ma Singer, Seth Sahil, Torrents David, Xi Liu, Wheeler David A, López-Otín Carlos, Campo Elías, Campbell Peter J, Boutros Paul C, Puente Xose S, Gerhard Daniela S, Pfister Stefan M, McPherson John D, Hudson Thomas J, Schlesner Matthias, Lichter Peter, Eils Roland, Jones David T W, Gut Ivo G   A comprehensive assessment of somatic mutation detection in cancer using whole-genome sequencing Nature communications, 2015; 6(1): 10001.
Spears Melanie, Yousif Fouad, Lyttle Nicola, Boutros Paul C, Munro Alison F, Twelves Chris, Pritchard Kathleen I, Levine Mark N, Shepherd Lois, Bartlett John M S   A four gene signature predicts benefit from anthracyclines: evidence from the BR9601 and MA.5 clinical trials Oncotarget, 2015; 6(31): 31693-701.
Boutros Paul C   The path to routine use of genomic biomarkers in the cancer clinic Genome research, 2015; 25(10): 1508-13.
Houlahan Kathleen E, Prokopec Stephenie D, Sun Ren X, Moffat Ivy D, Lindén Jere, Lensu Sanna, Okey Allan B, Pohjanvirta Raimo, Boutros Paul C   Transcriptional profiling of rat white adipose tissue response to 2,3,7,8-tetrachlorodibenzo-ρ-dioxin Toxicology and applied pharmacology, 2015; 288(2): 223-31.
Huang Xiaoyong, Taeb Samira, Jahangiri Sahar, Korpela Elina, Cadonic Ivan, Yu Nancy, Krylov Sergey N, Fokas Emmanouil, Boutros Paul C, Liu Stanley K   miR-620 promotes tumor radioresistance by targeting 15-hydroxyprostaglandin dehydrogenase (HPGD) Oncotarget, 2015; 6(26): 22439-51.
Lee Jamie, Prokopec Stephenie D, Watson John D, Sun Ren X, Pohjanvirta Raimo, Boutros Paul C   Male and female mice show significant differences in hepatic transcriptomic response to 2,3,7,8-tetrachlorodibenzo-p-dioxin BMC genomics, 2015; 16(26): 625.
Ewing Adam D, Houlahan Kathleen E, Hu Yin, Ellrott Kyle, Caloian Cristian, Yamaguchi Takafumi N, Bare J Christopher, P'ng Christine, Waggott Daryl, Sabelnykova Veronica Y, Sabelnykova Veronica Y, Kellen Michael R, Norman Thea C, Haussler David, Friend Stephen H, Stolovitzky Gustavo, Margolin Adam A, Stuart Joshua M, Boutros Paul C   Combining tumor genome simulation with crowdsourcing to benchmark somatic single-nucleotide-variant detection Nature methods, 2015; 12(7): 623-30.
Creixell Pau, Reimand Jüri, Haider Syed, Wu Guanming, Shibata Tatsuhiro, Vazquez Miguel, Mustonen Ville, Gonzalez-Perez Abel, Pearson John, Sander Chris, Raphael Benjamin J, Marks Debora S, Ouellette B F Francis, Valencia Alfonso, Bader Gary D, Boutros Paul C, Stuart Joshua M, Linding Rune, Lopez-Bigas Nuria, Stein Lincoln D, Stein Lincoln D   Pathway and network analysis of cancer genomes Nature methods, 2015; 12(7): 615-621.
Boutros Paul C, Fraser Michael, Harding Nicholas J, de Borja Richard, Trudel Dominique, Lalonde Emilie, Meng Alice, Hennings-Yeomans Pablo H, McPherson Andrew, Sabelnykova Veronica Y, Zia Amin, Fox Natalie S, Livingstone Julie, Shiah Yu-Jia, Wang Jianxin, Beck Timothy A, Have Cherry L, Chong Taryne, Sam Michelle, Johns Jeremy, Timms Lee, Buchner Nicholas, Wong Ada, Watson John D, Simmons Trent T, P'ng Christine, Zafarana Gaetano, Nguyen Francis, Luo Xuemei, Chu Kenneth C, Prokopec Stephenie D, Sykes Jenna, Dal Pra Alan, Berlin Alejandro, Brown Andrew, Chan-Seng-Yue Michelle A, Yousif Fouad, Denroche Robert E, Chong Lauren C, Chen Gregory M, Jung Esther, Fung Clement, Starmans Maud H W, Chen Hanbo, Govind Shaylan K, Hawley James, D'Costa Alister, Pintilie Melania, Waggott Daryl, Hach Faraz, Lambin Philippe, Muthuswamy Lakshmi B, Cooper Colin, Eeles Rosalind, Neal David, Tetu Bernard, Sahinalp Cenk, Stein Lincoln D, Fleshner Neil, Shah Sohrab P, Collins Colin C, Hudson Thomas J, McPherson John D, van der Kwast Theodorus, Bristow Robert G   Spatial genomic heterogeneity within localized, multifocal prostate cancer Nature genetics, 2015; 47(7): 736-45.
Cooper Colin S, Eeles Rosalind, Wedge David C, Van Loo Peter, Gundem Gunes, Alexandrov Ludmil B, Kremeyer Barbara, Butler Adam, Lynch Andrew G, Camacho Niedzica, Massie Charlie E, Kay Jonathan, Luxton Hayley J, Edwards Sandra, Kote-Jarai Zsofia, Dennis Nening, Merson Sue, Leongamornlert Daniel, Zamora Jorge, Corbishley Cathy, Thomas Sarah, Nik-Zainal Serena, Ramakrishna Manasa, O'Meara Sarah, Matthews Lucy, Clark Jeremy, Hurst Rachel, Mithen Richard, Bristow Robert G, Boutros Paul C, Fraser Michael, Cooke Susanna, Raine Keiran, Jones David, Menzies Andrew, Stebbings Lucy, Hinton Jon, Teague Jon, McLaren Stuart, Mudie Laura, Hardy Claire, Anderson Elizabeth, Joseph Olivia, Goody Victoria, Robinson Ben, Maddison Mark, Gamble Stephen, Greenman Christopher, Berney Dan, Hazell Steven, Livni Naomi, Livni Naomi, Fisher Cyril, Ogden Christopher, Kumar Pardeep, Thompson Alan, Woodhouse Christopher, Nicol David, Mayer Erik, Dudderidge Tim, Shah Nimish C, Gnanapragasam Vincent, Voet Thierry, Campbell Peter, Futreal Andrew, Easton Douglas, Warren Anne Y, Foster Christopher S, Stratton Michael R, Whitaker Hayley C, McDermott Ultan, Brewer Daniel S, Neal David E   Corrigendum: analysis of the genetic phylogeny of multifocal prostate cancer identifies multiple independent clonal expansions in neoplastic and morphologically normal prostate tissue Nature genetics, 2015; 47(6): 689.
Starmans Maud H, Boutros Paul C   Biomarkers and subtypes of cancer Aging, 2015; 7(5): 280-1.
How Christine, Pintilie Melania, Bruce Jeff P, Hui Angela B Y, Clarke Blaise A, Wong Philip, Yin Shaoming, Yan Rui, Waggott Daryl, Boutros Paul C, Fyles Anthony, Hedley David W, Hill Richard P, Milosevic Michael, Liu Fei-Fei   Developing a prognostic micro-RNA signature for human cervical carcinoma PloS one, 2015; 10(4): e0123946.
Anghel Catalina V, Quon Gerald, Haider Syed, Nguyen Francis, Deshwar Amit G, Morris Quaid D, Boutros Paul C   ISOpureR: an R implementation of a computational purification algorithm of mixed tumour profiles BMC bioinformatics, 2015; 16(6): 156.
Reich Heather N, Sabelnykova Veronica Y, Boutros Paul C   Matching Kidneys and Urines: Establishing Noninvasive Surrogates of Intrarenal Events in Primary Glomerulonephritis Seminars in nephrology, 2015; 35(3): 256-65.
Cooper Colin S, Eeles Rosalind, Wedge David C, Van Loo Peter, Gundem Gunes, Alexandrov Ludmil B, Kremeyer Barbara, Butler Adam, Lynch Andrew G, Camacho Niedzica, Massie Charlie E, Kay Jonathan, Luxton Hayley J, Edwards Sandra, Kote-Jarai ZSofia, Dennis Nening, Merson Sue, Leongamornlert Daniel, Zamora Jorge, Corbishley Cathy, Thomas Sarah, Nik-Zainal Serena, O'Meara Sarah, Matthews Lucy, Clark Jeremy, Hurst Rachel, Mithen Richard, Bristow Robert G, Boutros Paul C, Fraser Michael, Cooke Susanna, Raine Keiran, Jones David, Menzies Andrew, Stebbings Lucy, Hinton Jon, Teague Jon, McLaren Stuart, Mudie Laura, Hardy Claire, Anderson Elizabeth, Joseph Olivia, Goody Victoria, Robinson Ben, Maddison Mark, Gamble Stephen, Greenman Christopher, Berney Dan, Hazell Steven, Livni Naomi, Livni Naomi, Fisher Cyril, Ogden Christopher, Kumar Pardeep, Thompson Alan, Woodhouse Christopher, Nicol David, Mayer Erik, Dudderidge Tim, Shah Nimish C, Gnanapragasam Vincent, Voet Thierry, Campbell Peter, Futreal Andrew, Easton Douglas, Warren Anne Y, Foster Christopher S, Stratton Michael R, Whitaker Hayley C, McDermott Ultan, Brewer Daniel S, Neal David E   Analysis of the genetic phylogeny of multifocal prostate cancer identifies multiple independent clonal expansions in neoplastic and morphologically normal prostate tissue Nature genetics, 2015; 47(4): 367-372.
Dodbiba Lorin, Teichman Jennifer, Fleet Andrew, Thai Henry, Starmans Maud H W, Navab Roya, Chen Zhuo, Girgis Hala, Eng Lawson, Espin-Garcia Osvaldo, Shen Xiaowei, Bandarchi Bizhan, Schwock Joerg, Tsao Ming-Sound, El-Zimaity Hala, Der Sandy D, Xu Wei, Bristow Robert G, Darling Gail E, Boutros Paul C, Ailles Laurie E, Liu Geoffrey   Appropriateness of using patient-derived xenograft models for pharmacologic evaluation of novel therapies for esophageal/gastro-esophageal junction cancers PloS one, 2015; 10(3): e0121872.
Prokopec Stephenie D, Watson John D, Lee Jamie, Pohjanvirta Raimo, Boutros Paul C   Sex-related differences in murine hepatic transcriptional and proteomic responses to TCDD Toxicology and applied pharmacology, 2015; 284(2): 188-96.
Ignatchenko Vladimir, Ignatchenko Alexandr, Sinha Ankit, Boutros Paul C, Kislinger Thomas   VennDIS: a JavaFX-based Venn and Euler diagram software to generate publication quality figures Proteomics, 2015; 15(7): 1239-44.
Shiah Yu-Jia, Tharmapalan Pirashaanthy, Casey Alison E, Joshi Purna A, McKee Trevor D, Jackson Hartland W, Beristain Alexander G, Chan-Seng-Yue Michelle A, Bader Gary D, Lydon John P, Waterhouse Paul D, Boutros Paul C, Khokha Rama   A Progesterone-CXCR4 Axis Controls Mammary Progenitor Cell Fate in the Adult Gland Stem cell reports, 2015; 4(3): 313-322.
Li Timothy, Prokopec Stephenie D, Morrison Stacey, Lou Wendy, Reich Heather, Gladman Dafna, Urowitz Murray, Scholey James, Fortin Paul R, Boutros Paul C, Wither Joan, Landolt-Marticorena Carolina   Anti-nucleosome antibodies outperform traditional biomarkers as longitudinal indicators of disease activity in systemic lupus erythematosus Rheumatology (Oxford, England), 2015; 54(3): 449-57.
Starmans Maud H W, Pintilie Melania, Chan-Seng-Yue Michelle, Moon Nathalie C, Haider Syed, Nguyen Francis, Lau Suzanne K, Liu Ni, Kasprzyk Arek, Wouters Bradly G, Der Sandy D, Shepherd Frances A, Jurisica Igor, Penn Linda Z, Tsao Ming-Sound, Lambin Philippe, Boutros Paul C   Integrating RAS status into prognostic signatures for adenocarcinomas of the lung Clinical cancer research : an official journal of the American Association for Cancer Research, 2015; 21(6): 1477-86.
Bruce Jeff P, Hui Angela B Y, Shi Wei, Perez-Ordonez Bayardo, Weinreb Ilan, Xu Wei, Haibe-Kains Benjamin, Waggott Daryl M, Boutros Paul C, O'Sullivan Brian, Waldron John, Huang Shao Hui, Chen Eric X, Gilbert Ralph, Liu Fei-Fei   Identification of a microRNA signature associated with risk of distant metastasis in nasopharyngeal carcinoma Oncotarget, 2015; 6(6): 4537-50.
Houlahan Kathleen E, Prokopec Stephenie D, Moffat Ivy D, Lindén Jere, Lensu Sanna, Okey Allan B, Pohjanvirta Raimo, Boutros Paul C   Transcriptional profiling of rat hypothalamus response to 2,3,7,8-tetrachlorodibenzo-ρ-dioxin Toxicology, 2015; 328(6): 93-101.