Paul C. Boutros, Ph.D.
Email Address:
pboutros@mednet.ucla.edu
Work Phone Number:
310 794-7160
Mailing Address:
UCLA Department of Human Genetics
BOX 957088, 57200A South Tower CHS
Los Angeles, CA 90095
Affiliations
Biography:
Dr. Paul Boutros pursued his undergraduate education at the University of Waterloo in Chemistry. During the co-op portion of his degree he worked for a wide range of organizations, including the Federal Government, a water-purification company and Petro-Canada. But he found his true calling during a work-term spent at Michigan State University developing computer models of how cells respond to drugs and toxins. Dr. Boutros’ undergraduate thesis extended this work to focus on modeling DNA damage, and was awarded First Place in the National Undergraduate Chemistry Conference.In 2004, Paul started his PhD at the Ontario Cancer Institute,in Toronto. During his studies he received several awards, including the CIHR/Next Generation First Prize and the Invitrogen Canada Young Investigator Silver Award. After publishing 27 peer-reviewed papers over four years,Paul was awarded his PhD in 2008 for his development of novel biomarkers for predicting cancer severity.
In 2008,Paul started his independent research career at the Ontario Institute for Cancer Research, as Principal Investigator in Informatics & Biocomputing, and Assistant Professor in the Departments of Pharmacology & Toxicology and Medical Biophysics at the University of Toronto. He is a Prostate Cancer Canada Rising Star in Prostate Cancer Research, a Terry Fox New Investigator Award recipient, a University of Waterloo Young Alumni Award winner and recipient of the Early Career Graduate Student Teaching Award. In 2016 he received his MBA from the University of Toronto, and in 2018 Paul was awarded the Dorval Prize by the Canadian Cancer Society, recognizing the best early career investigator nationally.
In 2018, Paul relocated to join the University of California, Los Angeles, taking on leadership roles at the Jonsson Comprehensive Cancer Centre and the Institute for Precision Health. As a Professor in the Departments of Human Genetics and Urology, his research focuses on personalizing therapy for cancer by developing novel statistical methodologies. He leads the ICGC-TCGA DREAM Somatic Mutation Calling Challenge that is setting global standards for analyzing cancer genomic data, and drives programs in cancer genomics, data science and biomarker translation.
Publications
A selected list of publications:
McGillivray Patrick D, Ueno Daiki, Pooli Aydin, Mendhiratta Neil, Syed Jamil S, Nguyen Kevin A, Schulam Peter G, Humphrey Peter A, Adeniran Adebowale J, Boutros Paul C, Shuch Brian
Distinguishing Benign Renal Tumors with an Oncocytic Gene Expression
(ONEX) Classifier
European urology,
2020; 15(9):
e0239315.
Haider Syed, Tyekucheva Svitlana, Prandi Davide, Fox Natalie S, Ahn Jaeil, Xu Andrew Wei, Pantazi Angeliki, Park Peter J, Laird Peter W, Sander Chris, Wang Wenyi, Demichelis Francesca, Loda Massimo, Boutros Paul C, Boutros Paul C
Systematic Assessment of Tumor Purity and Its Clinical Implications
JCO precision oncology,
2020; 4(9):
e0239315.
Kishan Amar U, Romero Tahmineh, Alshalalfa Mohammed, Liu Yang, Tran Phuoc T, Nickols Nicholas G, Ye Huihui, Sajed Dipti, Rettig Matthew B, Reiter Robert E, Garraway Isla P, Spratt Daniel E, Freedland Steven J, Zhao Xin, Li Ziwen, Deek Matthew, Livingstone Julie, Mahal Brandon A, Nguyen Paul L, Feng Felix Y, Den Robert B, Schaeffer Edward M, Lotan Tamara L, Karnes R Jeffrey, Klein Eric A, Ross Ashley E, Grogan Tristan, Davicioni Elai, Elashoff David, Boutros Paul C, Weidhaas Joanne B
Transcriptomic Heterogeneity of Gleason Grade Group 5 Prostate Cancer
European urology,
2020; 78(3):
327-332.
Li Constance H, Prokopec Stephenie D, Sun Ren X, Yousif Fouad, Schmitz Nathaniel, Schmitz Nathaniel, Boutros Paul C, Boutros Paul C
Sex differences in oncogenic mutational processes
Nature communications,
2020; 11(1):
4330.
Jeon Jouhyun, Olkhov-Mitsel Ekaterina, Xie Honglei, Yao Cindy Q, Zhao Fang, Jahangiri Sahar, Cuizon Carmelle, Scarcello Seville, Jeyapala Renu, Watson John D, Fraser Michael, Ray Jessica, Commisso Kristina, Loblaw Andrew, Fleshner Neil E, Bristow Robert G, Downes Michelle, Vesprini Danny, Liu Stanley, Bapat Bharati, Boutros Paul C
Temporal Stability and Prognostic Biomarker Potential of the Prostate
Cancer Urine miRNA Transcriptome
Journal of the National Cancer Institute,
2020; 112(3):
247-255.
Bhandari Vinayak, Li Constance H, Bristow Robert G, Boutros Paul C, Boutros Paul C
Divergent mutational processes distinguish hypoxic and normoxic
tumours
Nature communications,
2020; 11(1):
737.
Salcedo Adriana, Tarabichi Maxime, Espiritu Shadrielle Melijah G, Deshwar Amit G, David Matei, Wilson Nathan M, Dentro Stefan, Wintersinger Jeff A, Liu Lydia Y, Ko Minjeong, Sivanandan Srinivasan, Zhang Hongjiu, Zhu Kaiyi, Ou Yang Tai-Hsien, Chilton John M, Buchanan Alex, Lalansingh Christopher M, P'ng Christine, Anghel Catalina V, Umar Imaad, Lo Bryan, Zou William, Zou William, Simpson Jared T, Stuart Joshua M, Anastassiou Dimitris, Guan Yuanfang, Ewing Adam D, Ellrott Kyle, Wedge David C, Morris Quaid, Van Loo Peter, Boutros Paul C
A community effort to create standards for evaluating tumor subclonal
reconstruction
Nature biotechnology,
2020; 38(1):
97-107.
Lin Xihui, Boutros Paul C
Optimization and expansion of non-negative matrix factorization
BMC bioinformatics,
2020; 21(1):
7.
Prokopec Stephenie D, Lu Aileen, Lee Sandy Che-Eun S, Yao Cindy Q, Sun Ren X, Watson John D, Soliymani Rabah, de Borja Richard, Wong Ada, Sam Michelle, Zuzarte Philip, McPherson John D, Okey Allan B, Pohjanvirta Raimo, Boutros Paul C
Comparative toxicoproteogenomics of mouse and rat liver identifies
TCDD-resistance genes
Archives of toxicology,
2019; 93(10):
2961-2978.
Houlahan Kathleen E, Shiah Yu-Jia, Gusev Alexander, Yuan Jiapei, Ahmed Musaddeque, Shetty Anamay, Ramanand Susmita G, Yao Cindy Q, Bell Connor, O'Connor Edward, Huang Vincent, Fraser Michael, Heisler Lawrence E, Livingstone Julie, Yamaguchi Takafumi N, Rouette Alexandre, Foucal Adrien, Espiritu Shadrielle Melijah G, Sinha Ankit, Sam Michelle, Timms Lee, Johns Jeremy, Wong Ada, Murison Alex, Orain Michèle, Picard Valérie, Hovington Hélène, Bergeron Alain, Lacombe Louis, Lupien Mathieu, Fradet Yves, Têtu Bernard, McPherson John D, Pasaniuc Bogdan, Kislinger Thomas, Chua Melvin L K, Pomerantz Mark M, van der Kwast Theodorus, Freedman Matthew L, Mani Ram S, He Housheng H, Bristow Robert G, Boutros Paul C
Genome-wide germline correlates of the epigenetic landscape of
prostate cancer
Nature medicine,
2019; 25(10):
1615-1626.
Ellrott Kyle, Buchanan Alex, Creason Allison, Mason Michael, Schaffter Thomas, Hoff Bruce, Eddy James, Chilton John M, Yu Thomas, Stuart Joshua M, Saez-Rodriguez Julio, Stolovitzky Gustavo, Boutros Paul C, Guinney Justin
Reproducible biomedical benchmarking in the cloud: lessons from
crowd-sourced data challenges
Genome biology,
2019; 20(1):
195.
Fox Natalie S, Haider Syed, Harris Adrian L, Boutros Paul C
Landscape of transcriptomic interactions between breast cancer and its
microenvironment
Nature communications,
2019; 10(1):
3116.
Houlahan Kathleen E, Salmasi Amirali, Sadun Taylor Y, Pooli Aydin, Felker Ely R, Livingstone Julie, Huang Vincent, Raman Steven S, Ahuja Preeti, Sisk Anthony E, Boutros Paul C, Reiter Robert E
Molecular Hallmarks of Multiparametric Magnetic Resonance Imaging
Visibility in Prostate Cancer
European urology,
2019; 76(1):
18-23.
Sinha Ankit, Huang Vincent, Livingstone Julie, Wang Jenny, Fox Natalie S, Kurganovs Natalie, Ignatchenko Vladimir, Fritsch Katharina, Donmez Nilgun, Heisler Lawrence E, Shiah Yu-Jia, Yao Cindy Q, Alfaro Javier A, Volik Stas, Lapuk Anna, Fraser Michael, Kron Ken, Murison Alex, Lupien Mathieu, Sahinalp Cenk, Collins Colin C, Tetu Bernard, Masoomian Mehdi, Berman David M, van der Kwast Theodorus, Bristow Robert G, Kislinger Thomas, Boutros Paul C
The Proteogenomic Landscape of Curable Prostate Cancer
Cancer cell,
2019; 35(3):
414-427.e6.
Bhandari Vinayak, Hoey Christianne, Liu Lydia Y, Lalonde Emilie, Ray Jessica, Livingstone Julie, Lesurf Robert, Shiah Yu-Jia, Vujcic Tina, Huang Xiaoyong, Espiritu Shadrielle M G, Heisler Lawrence E, Yousif Fouad, Huang Vincent, Yamaguchi Takafumi N, Yao Cindy Q, Sabelnykova Veronica Y, Fraser Michael, Chua Melvin L K, van der Kwast Theodorus, Liu Stanley K, Boutros Paul C, Bristow Robert G
Molecular landmarks of tumor hypoxia across cancer types
Nature genetics,
2019; 51(2):
308-318.
Chen Sujun, Huang Vincent, Xu Xin, Livingstone Julie, Soares Fraser, Jeon Jouhyun, Zeng Yong, Hua Junjie Tony, Petricca Jessica, Guo Haiyang, Wang Miranda, Yousif Fouad, Zhang Yuzhe, Donmez Nilgun, Ahmed Musaddeque, Volik Stas, Lapuk Anna, Chua Melvin L K, Heisler Lawrence E, Foucal Adrien, Fox Natalie S, Fraser Michael, Bhandari Vinayak, Shiah Yu-Jia, Guan Jiansheng, Li Jixi, Orain Michèle, Picard Valérie, Hovington Hélène, Bergeron Alain, Lacombe Louis, Fradet Yves, Têtu Bernard, Liu Stanley, Feng Felix, Wu Xue, Shao Yang W, Komor Malgorzata A, Sahinalp Cenk, Collins Colin, Hoogstrate Youri, de Jong Mark, Fijneman Remond J A, Fei Teng, Jenster Guido, van der Kwast Theodorus, Bristow Robert G, Boutros Paul C, He Housheng Hansen
Widespread and Functional RNA Circularization in Localized Prostate
Cancer
Cell,
2019; 176(4):
831-843.e22.
P'ng Christine, Green Jeffrey, Chong Lauren C, Waggott Daryl, Prokopec Stephenie D, Shamsi Mehrdad, Nguyen Francis, Mak Denise Y F, Lam Felix, Albuquerque Marco A, Wu Ying, Jung Esther H, Starmans Maud H W, Chan-Seng-Yue Michelle A, Yao Cindy Q, Liang Bianca, Lalonde Emilie, Haider Syed, Simone Nicole A, Sendorek Dorota, Chu Kenneth C, Moon Nathalie C, Fox Natalie S, Grzadkowski Michal R, Harding Nicholas J, Fung Clement, Murdoch Amanda R, Houlahan Kathleen E, Wang Jianxin, Garcia David R, de Borja Richard, Sun Ren X, Lin Xihui, Chen Gregory M, Lu Aileen, Shiah Yu-Jia, Zia Amin, Kearns Ryan, Boutros Paul C
BPG: Seamless, automated and interactive visualization of scientific
data
BMC bioinformatics,
2019; 20(1):
42.
Grzadkowski Michal R, Sendorek Dorota H, P'ng Christine, Huang Vincent, Boutros Paul C
A comparative study of survival models for breast cancer
prognostication revisited: the benefits of multi-gene models
BMC bioinformatics,
2018; 19(1):
400.
Ruicci Kara M, Meens Jalna, Sun Ren X, Rizzo Giananthony, Pinto Nicole, Yoo John, Fung Kevin, MacNeil Danielle, Mymryk Joe S, Barrett John W, Boutros Paul C, Ailles Laurie, Nichols Anthony C
A controlled trial of HNSCC patient-derived xenografts reveals broad
efficacy of PI3Kα inhibition in controlling tumor growth
International journal of cancer,
2018;
.
Lee Anna Y, Ewing Adam D, Ellrott Kyle, Hu Yin, Houlahan Kathleen E, Bare J Christopher, Espiritu Shadrielle Melijah G, Huang Vincent, Dang Kristen, Chong Zechen, Caloian Cristian, Yamaguchi Takafumi N, Yamaguchi Takafumi N, Kellen Michael R, Chen Ken, Norman Thea C, Friend Stephen H, Guinney Justin, Stolovitzky Gustavo, Haussler David, Margolin Adam A, Stuart Joshua M, Boutros Paul C
Combining accurate tumor genome simulation with crowdsourcing to
benchmark somatic structural variant detection
Genome biology,
2018; 19(1):
188.
Pinto Nicole, Prokopec Stephenie D, Vizeacoumar Frederick, Searle Karlee, Lowerison Matthew, Ruicci Kara M, Yoo John, Fung Kevin, MacNeil Danielle, Lacefield Jim C, Leong Hon S, Mymryk Joe S, Barrett John W, Datti Alessandro, Boutros Paul C, Nichols Anthony C
Lestaurtinib is a potent inhibitor of anaplastic thyroid cancer cell
line models
PloS one,
2018; 13(11):
e0207152.
Haider Syed, Yao Cindy Q, Sabine Vicky S, Grzadkowski Michal, Stimper Vincent, Starmans Maud H W, Wang Jianxin, Nguyen Francis, Moon Nathalie C, Lin Xihui, Drake Camilla, Crozier Cheryl A, Brookes Cassandra L, van de Velde Cornelis J H, Hasenburg Annette, Kieback Dirk G, Markopoulos Christos J, Dirix Luc Y, Seynaeve Caroline, Rea Daniel W, Kasprzyk Arek, Lambin Philippe, Lio' Pietro, Bartlett John M S, Boutros Paul C
Pathway-based subnetworks enable cross-disease biomarker discovery
Nature communications,
2018; 9(1):
4746.
Boutros Paul C
The Promise and Perils of Sequencing Individual Prostate Cancer
Nuclei
European urology,
2018; 74(5):
560-561.
Tu William B, Shiah Yu-Jia, Lourenco Corey, Mullen Peter J, Dingar Dharmendra, Redel Cornelia, Tamachi Aaliya, Ba-Alawi Wail, Aman Ahmed, Al-Awar Rima, Cescon David W, Haibe-Kains Benjamin, Arrowsmith Cheryl H, Raught Brian, Boutros Paul C, Penn Linda Z
MYC Interacts with the G9a Histone Methyltransferase to Drive
Transcriptional Repression and Tumorigenesis
Cancer cell,
2018; 34(4):
579-595.e8.
Kalkat Manpreet, Resetca Diana, Lourenco Corey, Chan Pak-Kei, Wei Yong, Shiah Yu-Jia, Vitkin Natasha, Tong Yufeng, Sunnerhagen Maria, Done Susan J, Boutros Paul C, Raught Brian, Penn Linda Z
MYC Protein Interactome Profiling Reveals Functionally Distinct
Regions that Cooperate to Drive Tumorigenesis
Molecular cell,
2018; 74(5):
560-561.
Li Constance H, Haider Syed, Shiah Yu-Jia, Thai Kevin, Boutros Paul C
Sex Differences in Cancer Driver Genes and Biomarkers
Cancer research,
2018; 78(19):
5527-5537.
Gong Inna Y, Fox Natalie S, Huang Vincent, Boutros Paul C
Prediction of early breast cancer patient survival using ensembles of
hypoxia signatures
PloS one,
2018; 13(9):
e0204123.
Cooper Christopher I, Yao Delia, Sendorek Dorota H, Yamaguchi Takafumi N, P'ng Christine, Houlahan Kathleen E, Caloian Cristian, Fraser Michael, Fraser Michael, Ellrott Kyle, Margolin Adam A, Bristow Robert G, Stuart Joshua M, Boutros Paul C
Valection: design optimization for validation and verification
studies
BMC bioinformatics,
2018; 19(1):
339.
Berlin Alejandro, Murgic Jure, Hosni Ali, Pintilie Melania, Salcedo Adriana, Fraser Michael, Kamel-Reid Suzanne, Zhang Jingbin, Wang Qiqi, Ch'ng Carolyn, Deheshi Samineh, Davicioni Elai, van der Kwast Theodorus, Boutros Paul C, Bristow Robert G, Chua Melvin L K
Genomic classifier for guiding treatment of intermediate-risk prostate
cancers to dose-escalated image-guided radiotherapy without hormone
therapy
International journal of radiation oncology, biology, physics,
2018; 9(1):
3502.
Dingar Dharmendra, Tu William B, Resetca Diana, Lourenco Corey, Tamachi Aaliya, De Melo Jason, Houlahan Kathleen E, Kalkat Manpreet, Chan Pak-Kei, Boutros Paul C, Raught Brian, Penn Linda Z
MYC dephosphorylation by the PP1/PNUTS phosphatase complex regulates
chromatin binding and protein stability
Nature communications,
2018; 9(1):
3502.
Casey Alison E, Sinha Ankit, Singhania Rajat, Livingstone Julie, Waterhouse Paul, Tharmapalan Pirashaanthy, Cruickshank Jennifer, Shehata Mona, Drysdale Erik, Fang Hui, Kim Hyeyeon, Isserlin Ruth, Bailey Swneke, Medina Tiago, Deblois Genevieve, Shiah Yu-Jia, Barsyte-Lovejoy Dalia, Hofer Stefan, Bader Gary, Lupien Mathieu, Arrowsmith Cheryl, Knapp Stefan, De Carvalho Daniel, Berman Hal, Boutros Paul C, Kislinger Thomas, Khokha Rama
Mammary molecular portraits reveal lineage-specific features and
progenitor cell vulnerabilities
The Journal of cell biology,
2018; 217(8):
2951-2974.
Hoey Christianne, Ray Jessica, Jeon Jouhyun, Huang Xiaoyong, Taeb Samira, Ylanko Jarkko, Andrews David W, Boutros Paul C, Liu Stanley K
miRNA-106a and prostate cancer radioresistance: a novel role for LITAF
in ATM regulation
Molecular oncology,
2018; 12(8):
1324-1341.
Hua Junjie Tony, Ahmed Musaddeque, Guo Haiyang, Zhang Yuzhe, Chen Sujun, Soares Fraser, Lu Jennifer, Zhou Stanley, Wang Miranda, Li Hui, Larson Nicholas B, McDonnell Shannon K, Patel Parasvi S, Liang Yi, Yao Cindy Q, van der Kwast Theodorus, Lupien Mathieu, Feng Felix Y, Zoubeidi Amina, Tsao Ming-Sound, Thibodeau Stephen N, Boutros Paul C, He Housheng Hansen
Risk SNP-Mediated Promoter-Enhancer Switching Drives Prostate Cancer
through lncRNA PCAT19
Cell,
2018; 174(3):
564-575.e18.
Yang Lingjian, Roberts Darren, Takhar Mandeep, Erho Nicholas, Bibby Becky A S, Thiruthaneeswaran Niluja, Bhandari Vinayak, Cheng Wei-Chen, Haider Syed, McCorry Amy M B, McArt Darragh, Jain Suneil, Alshalalfa Mohammed, Ross Ashley, Schaffer Edward, Den Robert B, Jeffrey Karnes R, Klein Eric, Hoskin Peter J, Freedland Stephen J, Lamb Alastair D, Neal David E, Buffa Francesca M, Bristow Robert G, Boutros Paul C, Davicioni Elai, Choudhury Ananya, West Catharine M L
Development and Validation of a 28-gene Hypoxia-related Prognostic
Signature for Localized Prostate Cancer
EBioMedicine,
2018; 31(4):
182-189.
Ghasemi Farhad, Black Morgan, Sun Ren X, Vizeacoumar Frederick, Pinto Nicole, Ruicci Kara M, Yoo John, Fung Kevin, MacNeil Danielle, Palma David A, Winquist Eric, Mymryk Joe S, Ailles Laurie A, Datti Alessandro, Barrett John W, Boutros Paul C, Nichols Anthony C
High-throughput testing in head and neck squamous cell carcinoma
identifies agents with preferential activity in human
papillomavirus-positive or negative cell lines
Oncotarget,
2018; 9(40):
26064-26071.
Wither Joan E, Prokopec Stephenie D, Noamani Babak, Chang Nan-Hua, Bonilla Dennisse, Touma Zahi, Avila-Casado Carmen, Reich Heather N, Scholey James, Fortin Paul R, Boutros Paul C, Landolt-Marticorena Carolina
Identification of a neutrophil-related gene expression signature that
is enriched in adult systemic lupus erythematosus patients with active
nephritis: Clinical/pathologic associations and etiologic mechanisms
PloS one,
2018; 13(5):
e0196117.
Hopkins Julia F, Denroche Robert E, Aguiar Jennifer A, Notta Faiyaz, Connor Ashton A, Wilson Julie M, Stein Lincoln D, Gallinger Steven, Boutros Paul C
Mutations in Mitochondrial DNA From Pancreatic Ductal Adenocarcinomas
Associate With Survival Times of Patients and Accumulate as Tumors
Progress
Gastroenterology,
2018; 154(6):
1620-1624.e5.
Wedge David C, Gundem Gunes, Mitchell Thomas, Woodcock Dan J, Martincorena Inigo, Ghori Mohammed, Zamora Jorge, Butler Adam, Whitaker Hayley, Kote-Jarai Zsofia, Alexandrov Ludmil B, Van Loo Peter, Massie Charlie E, Dentro Stefan, Warren Anne Y, Verrill Clare, Berney Dan M, Dennis Nening, Merson Sue, Hawkins Steve, Howat William, Lu Yong-Jie, Lambert Adam, Kay Jonathan, Kremeyer Barbara, Karaszi Katalin, Luxton Hayley, Camacho Niedzica, Marsden Luke, Edwards Sandra, Matthews Lucy, Bo Valeria, Leongamornlert Daniel, McLaren Stuart, Ng Anthony, Yu Yongwei, Zhang Hongwei, Dadaev Tokhir, Thomas Sarah, Easton Douglas F, Ahmed Mahbubl, Bancroft Elizabeth, Fisher Cyril, Livni Naomi, Nicol David, Tavaré Simon, Gill Pelvender, Greenman Christopher, Khoo Vincent, Van As Nicholas, Kumar Pardeep, Ogden Christopher, Cahill Declan, Thompson Alan, Mayer Erik, Rowe Edward, Dudderidge Tim, Gnanapragasam Vincent, Shah Nimish C, Raine Keiran, Jones David, Menzies Andrew, Stebbings Lucy, Teague Jon, Hazell Steven, Corbishley Cathy, Corbishley Cathy, de Bono Johann, Attard Gerhardt, Isaacs William, Visakorpi Tapio, Fraser Michael, Boutros Paul C, Bristow Robert G, Workman Paul, Sander Chris, Sander Chris, Hamdy Freddie C, Futreal Andrew, McDermott Ultan, Al-Lazikani Bissan, Lynch Andrew G, Bova G Steven, Foster Christopher S, Brewer Daniel S, Neal David E, Cooper Colin S, Eeles Rosalind A
Sequencing of prostate cancers identifies new cancer genes, routes of
progression and drug targets
Nature genetics,
2018; 50(5):
682-692.
Espiritu Shadrielle Melijah G, Liu Lydia Y, Rubanova Yulia, Bhandari Vinayak, Holgersen Erle M, Szyca Lesia M, Fox Natalie S, Chua Melvin L K, Yamaguchi Takafumi N, Heisler Lawrence E, Livingstone Julie, Wintersinger Jeff, Yousif Fouad, Lalonde Emilie, Rouette Alexandre, Salcedo Adriana, Houlahan Kathleen E, Li Constance H, Huang Vincent, Fraser Michael, van der Kwast Theodorus, Morris Quaid D, Bristow Robert G, Boutros Paul C
The Evolutionary Landscape of Localized Prostate Cancers Drives
Clinical Aggression
Cell,
2018; 173(4):
1003-1013.e15.
Fraser Michael, Boutros Paul C, Bristow Robert G
A Partner in Crime: Tumor-associated Stroma and Metastatic Prostate
Cancer
European urology,
2018; 73(4):
533-534.
Chong Taryne, Sarac Amila, Yao Cindy Q, Liao Linda, Lyttle Nicola, Boutros Paul C, Bartlett John M S, Spears Melanie
Deregulation of the spindle assembly checkpoint is associated with
paclitaxel resistance in ovarian cancer
Journal of ovarian research,
2018; 11(1):
27.
Huang Kuan-Lin, Mashl R Jay, Wu Yige, Ritter Deborah I, Wang Jiayin, Oh Clara, Paczkowska Marta, Reynolds Sheila, Wyczalkowski Matthew A, Oak Ninad, Scott Adam D, Krassowski Michal, Cherniack Andrew D, Houlahan Kathleen E, Jayasinghe Reyka, Wang Liang-Bo, Zhou Daniel Cui, Liu Di, Cao Song, Kim Young Won, Koire Amanda, McMichael Joshua F, Hucthagowder Vishwanathan, Kim Tae-Beom, Hahn Abigail, Wang Chen, McLellan Michael D, Al-Mulla Fahd, Johnson Kimberly J, Johnson Kimberly J, Lichtarge Olivier, Boutros Paul C, Raphael Benjamin, Lazar Alexander J, Zhang Wei, Wendl Michael C, Govindan Ramaswamy, Jain Sanjay, Wheeler David, Kulkarni Shashikant, Dipersio John F, Reimand Jüri, Meric-Bernstam Funda, Chen Ken, Shmulevich Ilya, Plon Sharon E, Chen Feng, Ding Li
Pathogenic Germline Variants in 10,389 Adult Cancers
Cell,
2018; 173(2):
355-370.e14.
Encinas Giselly, Sabelnykova Veronica Y, de Lyra Eduardo Carneiro, Hirata Katayama Maria Lucia, Maistro Simone, de Vasconcellos Valle Pedro Wilson Mompean, de Lima Pereira Gláucia Fernanda, Rodrigues Lívia Munhoz, de Menezes Pacheco Serio Pedro Adolpho, de Gouvêa Ana Carolina Ribeiro Chaves, Geyer Felipe Correa, Basso Ricardo Alves, Pasini Fátima Solange, Del Pilar Esteves Diz Maria, Brentani Maria Mitzi, Guedes Sampaio Góes João Carlos, Chammas Roger, Boutros Paul C, Koike Folgueira Maria Aparecida Azevedo
Somatic mutations in early onset luminal breast cancer
Oncotarget,
2018; 9(32):
22460-22479.
Sendorek Dorota H, Lalonde Emilie, Yao Cindy Q, Sabelnykova Veronica Y, Bristow Robert G, Boutros Paul C
NanoStringNormCNV: pre-processing of NanoString CNV data
Bioinformatics (Oxford, England),
2018; 34(6):
1034-1036.
Böttcher René, Kweldam Charlotte F, Livingstone Julie, Lalonde Emilie, Yamaguchi Takafumi N, Huang Vincent, Yousif Fouad, Fraser Michael, Bristow Robert G, van der Kwast Theodorus, Boutros Paul C, Jenster Guido, van Leenders Geert J L H
Cribriform and intraductal prostate cancer are associated with
increased genomic instability and distinct genomic alterations
BMC cancer,
2018; 18(1):
8.
Sendorek Dorota H, Caloian Cristian, Ellrott Kyle, Bare J Christopher, Yamaguchi Takafumi N, Ewing Adam D, Houlahan Kathleen E, Norman Thea C, Margolin Adam A, Stuart Joshua M, Boutros Paul C
Germline contamination and leakage in whole genome somatic single
nucleotide variant detection
BMC bioinformatics,
2018; 19(1):
28.
Li Madeline, Kouzmina Ekaterina, McCusker Megan, Rodin Danielle, Boutros Paul C, Paige Christopher J, Rodin Gary
Cytokines and depression in cancer patients and caregivers
Neuropsychiatric disease and treatment,
2017; 13(12):
2903-2911.
Li Madeline, Kouzmina Ekaterina, McCusker Megan, Rodin Danielle, Boutros Paul C, Paige Christopher J, Rodin Gary
Pro- and anti-inflammatory cytokine associations with major depression
in cancer patients
Psycho-oncology,
2017; 26(12):
2149-2156.
Briollais Laurent, Bristow Robert G, Boutros Paul C, Boutros Paul C, Zlotta Alexandre R
Response
Journal of the National Cancer Institute,
2017; 109(12):
8.
Chua Melvin L K, Lo Winnie, Pintilie Melania, Murgic Jure, Lalonde Emilie, Bhandari Vinayak, Mahamud Osman, Gopalan Anuradha, Kweldam Charlotte F, van Leenders Geert J L H, Verhoef Esther I, Hoogland Agnes Marije, Livingstone Julie, Berlin Alejandro, Dal Pra Alan, Meng Alice, Zhang Junyan, Orain Michèle, Picard Valérie, Hovington Hélène, Bergeron Alain, Lacombe Louis, Fradet Yves, Têtu Bernard, Reuter Victor E, Fleshner Neil, Fraser Michael, Boutros Paul C, van der Kwast Theodorus H, Bristow Robert G
A Prostate Cancer "Nimbosus": Genomic Instability and SChLAP1
Dysregulation Underpin Aggression of Intraductal and Cribriform
Subpathologies
European urology,
2017; 72(5):
665-674.
Abdalla Moustafa, Tran-Thanh Danh, Moreno Juan, Iakovlev Vladimir, Nair Ranju, Kanwar Nisha, Abdalla Mohamed, Lee Jennifer P Y, Kwan Jennifer Yin Yee, Cawthorn Thomas R, Warren Keisha, Arneson Nona, Wang Dong-Yu, Fox Natalie S, Youngson Bruce J, Miller Naomi A, Easson Alexandra M, McCready David, Leong Wey L, Boutros Paul C, Done Susan J
Mapping genomic and transcriptomic alterations spatially in epithelial
cells adjacent to human breast carcinoma
Nature communications,
2017; 8(1):
1245.
Shiah Yu-Jia, Fraser Michael, Bristow Robert G, Boutros Paul C
Comparison of pre-processing methods for Infinium HumanMethylation450
BeadChip array
Bioinformatics (Oxford, England),
2017; 33(20):
3151-3157.
Liang Yi, Ahmed Musaddeque, Guo Haiyang, Soares Fraser, Hua Junjie T, Gao Shuai, Lu Catherine, Poon Christine, Han Wanting, Langstein Jens, Ekram Muhammad B, Li Brian, Davicioni Elai, Takhar Mandeep, Erho Nicholas, Karnes R Jeffrey, Chadwick Dianne, van der Kwast Theodorus, Boutros Paul C, Arrowsmith Cheryl H, Feng Felix Y, Joshua Anthony M, Zoubeidi Amina, Cai Changmeng, He Housheng H
LSD1-Mediated Epigenetic Reprogramming Drives CENPE Expression and
Prostate Cancer Progression
Cancer research,
2017; 77(20):
5479-5490.
Hopkins Julia F, Sabelnykova Veronica Y, Weischenfeldt Joachim, Simon Ronald, Aguiar Jennifer A, Alkallas Rached, Heisler Lawrence E, Zhang Junyan, Watson John D, Chua Melvin L K, Fraser Michael, Favero Francesco, Lawerenz Chris, Plass Christoph, Sauter Guido, McPherson John D, van der Kwast Theodorus, Korbel Jan, Schlomm Thorsten, Bristow Robert G, Boutros Paul C
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Chüeh Anderly C, Liew Mun-Sem, Russell Prudence A, Walkiewicz Marzena, Jayachandran Aparna, Starmans Maud H W, Boutros Paul C, Wright Gavin, Barnett Stephen A, Mariadason John M, John Thomas
Promoter hypomethylation of NY-ESO-1, association with
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Oncotarget,
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Ghasemi Farhad, Black Morgan, Vizeacoumar Frederick, Pinto Nicole, Ruicci Kara M, Le Carson Cao Son Huu, Lowerison Matthew R, Leong Hon Sing, Yoo John, Fung Kevin, MacNeil Danielle, Palma David A, Winquist Eric, Mymryk Joe S, Boutros Paul C, Datti Alessandro, Barrett John W, Nichols Anthony C
Repurposing Albendazole: new potential as a chemotherapeutic agent
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Kron Ken J, Murison Alexander, Zhou Stanley, Huang Vincent, Yamaguchi Takafumi N, Shiah Yu-Jia, Fraser Michael, van der Kwast Theodorus, Boutros Paul C, Bristow Robert G, Lupien Mathieu
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Nature genetics,
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Alfaro Javier A, Ignatchenko Alexandr, Ignatchenko Vladimir, Sinha Ankit, Boutros Paul C, Kislinger Thomas
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Taghiyar M Jafar, Rosner Jamie, Grewal Diljot, Grande Bruno M, Aniba Radhouane, Grewal Jasleen, Boutros Paul C, Morin Ryan D, Bashashati Ali, Shah Sohrab P
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Translating a Prognostic DNA Genomic Classifier into the Clinic:
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Albuquerque Marco A, Grande Bruno M, Ritch Elie J, Pararajalingam Prasath, Jessa Selin, Krzywinski Martin, Grewal Jasleen K, Shah Sohrab P, Boutros Paul C, Morin Ryan D
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2017; 6(5):
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Thapa Bibhusal, Salcedo Adriana, Lin Xihui, Walkiewicz Marzena, Murone Carmel, Ameratunga Malaka, Asadi Khashyar, Deb Siddhartha, Barnett Stephen Arthur, Knight Simon, Mitchell Paul, Watkins D Neil, Boutros Paul C, John Thomas
The Immune Microenvironment, Genome-wide Copy Number Aberrations, and
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Briollais Laurent, Ozcelik Hilmi, Xu Jingxiong, Kwiatkowski Maciej, Lalonde Emilie, Sendorek Dorota H, Fleshner Neil E, Recker Franz, Kuk Cynthia, Olkhov-Mitsel Ekaterina, Savas Sevtap, Hanna Sally, Juvet Tristan, Hunter Geoffrey A, Friedlander Matt, Li Hong, Chadwick Karen, Prassas Ioannis, Soosaipillai Antoninus, Randazzo Marco, Trachtenberg John, Toi Ants, Shiah Yu-Jia, Fraser Michael, van der Kwast Theodorus, Bristow Robert G, Bapat Bharati, Diamandis Eleftherios P, Boutros Paul C, Zlotta Alexandre R
Germline Mutations in the Kallikrein 6 Region and Predisposition for
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Journal of the National Cancer Institute,
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Dunning Mark J, Vowler Sarah L, Lalonde Emilie, Ross-Adams Helen, Boutros Paul, Mills Ian G, Lynch Andy G, Lamb Alastair D
Mining Human Prostate Cancer Datasets: The "camcAPP" Shiny App
EBioMedicine,
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Bayani Jane, Yao Cindy Q, Quintayo Mary Anne, Yan Fu, Haider Syed, D'Costa Alister, Brookes Cassandra L, van de Velde Cornelis J H, Hasenburg Annette, Kieback Dirk G, Markopoulos Christos, Dirix Luc, Seynaeve Caroline, Rea Daniel, Boutros Paul C, Bartlett John M S
Molecular stratification of early breast cancer identifies drug
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Wang Dennis, Pham Nhu-An, Tong Jiefei, Sakashita Shingo, Allo Ghassan, Kim Lucia, Yanagawa Naoki, Raghavan Vibha, Wei Yuhong, To Christine, Trinh Quang M, Starmans Maud H W, Chan-Seng-Yue Michelle A, Chadwick Dianne, Li Lei, Zhu Chang-Qi, Liu Ni, Li Ming, Lee Sharon, Ignatchenko Vladimir, Strumpf Dan, Taylor Paul, Moghal Nadeem, Liu Geoffrey, Boutros Paul C, Kislinger Thomas, Pintilie Melania, Jurisica Igor, Shepherd Frances A, McPherson John D, Muthuswamy Lakshmi, Moran Michael F, Tsao Ming-Sound
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International journal of cancer,
2017; 140(3):
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Watson John D, Prokopec Stephenie D, Smith Ashley B, Okey Allan B, Pohjanvirta Raimo, Boutros Paul C
2,3,7,8 Tetrachlorodibenzo-p-dioxin-induced RNA abundance changes
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Archives of toxicology,
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Prokopec Stephenie D, Houlahan Kathleen E, Sun Ren X, Watson John D, Yao Cindy Q, Lee Jamie, P'ng Christine, Pang Renee, Wu Alexander H, Chong Lauren C, Smith Ashley B, Harding Nicholas J, Moffat Ivy D, Lindén Jere, Lensu Sanna, Okey Allan B, Pohjanvirta Raimo, Boutros Paul C
Compendium of TCDD-mediated transcriptomic response datasets in
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Fotouhi Ghiam Alireza, Taeb Samira, Huang Xiaoyong, Huang Vincent, Ray Jessica, Scarcello Seville, Hoey Christianne, Jahangiri Sahar, Fokas Emmanouil, Loblaw Andrew, Bristow Robert G, Vesprini Danny, Boutros Paul, Liu Stanley K
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Oncotarget,
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Landolt-Marticorena Carolina, Prokopec Stephenie D, Morrison Stacey, Noamani Babak, Bonilla Dennisse, Reich Heather, Scholey James, Avila-Casado Carmen, Fortin Paul R, Boutros Paul C, Wither Joan
A discrete cluster of urinary biomarkers discriminates between active
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Lam Felix, Lalansingh Christopher M, Babaran Holly E, Wang Zhiyuan, Prokopec Stephenie D, Fox Natalie S, Boutros Paul C
VennDiagramWeb: a web application for the generation of highly
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BMC bioinformatics,
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Huang Barbara F F, Boutros Paul C
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Spears Melanie, Lyttle Nicola, D'Costa Alister, Chen Bingshu E, Yao Cindy Q, Boutros Paul C, Burnell Margot, Levine Mark N, O'Brien Patti, Shepherd Lois, Bartlett John M S
A four gene signature of chromosome instability (CIN4) predicts for
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Masella Andre P, Lalansingh Christopher M, Sivasundaram Pragash, Fraser Michael, Bristow Robert G, Boutros Paul C
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Bhandari Vinayak, Boutros Paul C
Comparing continuous and discrete analyses of breast cancer survival
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Current and Evolving Methods to Visualize Biological Data in Cancer
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Stojanova Angelina, Tu William B, Ponzielli Romina, Kotlyar Max, Chan Pak-Kei, Boutros Paul C, Khosravi Fereshteh, Jurisica Igor, Raught Brian, Penn Linda Z
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Cell cycle (Georgetown, Tex.),
2016; 15(13):
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A Crowdsourcing Approach to Developing and Assessing Prediction
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A genome-wide association study of non-HPV-related head and neck
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Crowdsourced estimation of cognitive decline and resilience in
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Nature communications,
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Gagliano Sarah A, Ptak Carolyn, Mak Denise Y F, Shamsi Mehrdad, Oh Gabriel, Knight Joanne, Boutros Paul C, Petronis Arturas
Allele-Skewed DNA Modification in the Brain: Relevance to a
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Ameratunga Malaka, Asadi Khashayar, Lin Xihui, Walkiewicz Marzena, Murone Carmel, Knight Simon, Mitchell Paul, Boutros Paul, John Thomas
PD-L1 and Tumor Infiltrating Lymphocytes as Prognostic Markers in
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PloS one,
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Babichev Yael, Kabaroff Leah, Datti Alessandro, Uehling David, Isaac Methvin, Al-Awar Rima, Prakesch Michael, Sun Ren X, Boutros Paul C, Venier Rosemarie, Dickson Brendan C, Gladdy Rebecca A
PI3K/AKT/mTOR inhibition in combination with doxorubicin is an
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A comprehensive assessment of somatic mutation detection in cancer
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Huang Xiaoyong, Taeb Samira, Jahangiri Sahar, Korpela Elina, Cadonic Ivan, Yu Nancy, Krylov Sergey N, Fokas Emmanouil, Boutros Paul C, Liu Stanley K
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