Ketema Paul, Ph.D.
Professor, Integrative Biology and Physiology
Member, Molecular, Cellular & Integrative Physiology GPB Home Area

Dr. Paul studies the genetic, molecular, and neural underpinnings of sleep. His primary interests are comprised of uncovering the mechanisms responsible for the negative effects of sleep deprivation. He also probes the origins of gender/sex differences in the ability to recover from sleep loss in order to develop therapeutic targets for sleep disorders that disproportionately affect women. His work has shown that sex differences in daily sleep amount are dependent on circulating reproductive hormones while sex differences in the ability to recover from sleep loss are relatively insensitive to them. Dr. Paul’s current research involves applying a forward genetics approach to uncover the core genes responsible for sleep-wake regulation and the impairing effects of sleep loss. Effective treatments for common sleep-wake disorders are elusive. Dr. Paul conducts a forward genetics approach to facilitate gene identification that takes advantage of natural variation occurring in sleep-replete and sleep-deprived mice. This approach applies the most cutting edge genome mapping, positional cloning, and DNA sequencing techniques to identifying the genetic origins of unique sleep phenotypes in transgenic mouse models. These studies are expected to identify novel sleep regulatory genes and lead to the development of new therapeutic targets and improved treatments for sleep disorders.


A selected list of publications:

Brager Allison J, Heemstra Lydia, Bhambra Raman, Ehlen J Christopher, Esser Karyn A, Paul Ketema N, Novak Colleen M   Homeostatic effects of exercise and sleep on metabolic processes in mice with an overexpressed skeletal muscle clock Biochimie, 2017; 132(11): 161-165.
Ehlen J Christopher, Jones Kelly A, Pinckney Lennisha, Gray Cloe L, Burette Susan, Weinberg Richard J, Evans Jennifer A, Brager Allison J, Zylka Mark J, Paul Ketema N, Philpot Benjamin D, DeBruyne Jason P   Maternal Ube3a Loss Disrupts Sleep Homeostasis But Leaves Circadian Rhythmicity Largely Intact The Journal of neuroscience : the official journal of the Society for Neuroscience, 2015; 35(40): 13587-98.
Evans Jennifer A, Suen Ting-Chung, Callif Ben L, Mitchell Andrew S, Castanon-Cervantes Oscar, Baker Kimberly M, Kloehn Ian, Baba Kenkichi, Teubner Brett J W, Ehlen J Christopher, Paul Ketema N, Bartness Timothy J, Tosini Gianluca, Leise Tanya, Davidson Alec J   Shell neurons of the master circadian clock coordinate the phase of tissue clocks throughout the brain and body BMC biology, 2015; 13(40): 43.
Jefferson F, Ehlen J C, Williams N S, Montemarano J J, Paul K N   A dopamine receptor d2-type agonist attenuates the ability of stress to alter sleep in mice Endocrinology, 2014; 155(11): 4411-21.
Ehlen J Christopher, Jefferson Felicia, Brager Allison J, Benveniste Morris, Paul Ketema N   Period-amplitude analysis reveals wake-dependent changes in the electroencephalogram during sleep deprivation Sleep, 2013; 36(11): 1723-35.