Roxana A. Radu, M.D.

Mailing Address:
UCLA JSEI-Oph
BOX 957000, A-222A JSEI Bldg
Los Angeles, CA 90095

Affiliations
Affiliations
Assistant Professor, Ophthalmology
Member, Molecular, Cellular & Integrative Physiology GPB Home Area
Biography:

Dr. Radu is an Assistant Professor of Ophthalmology at the UCLA Stein Eye Institute. Roxana Radu received her MD from University of Medicine and Pharmacy of Craiova, Romania and completed a postdoctoral fellowship in retinoid biochemistry at UCLA studying the metabolism of vitamin A in the eye.

Publications

A selected list of publications:

McClements Michelle E, Barnard Alun R, Singh Mandeep S, Charbel Issa Peter, Jiang Zhichun, Radu Roxana A, MacLaren Robert E   An AAV Dual Vector Strategy Ameliorates the Stargardt Phenotype in Adult Abca4 Human gene therapy, 2018; .
Lenis Tamara L, Hu Jane, Ng Sze Yin, Jiang Zhichun, Sarfare Shanta, Lloyd Marcia B, Esposito Nicholas J, Samuel William, Jaworski Cynthia, Bok Dean, Finnemann Silvia C, Radeke Monte J, Redmond T Michael, Travis Gabriel H, Radu Roxana A   Expression of ABCA4 in the retinal pigment epithelium and its implications for Stargardt macular degeneration Proceedings of the National Academy of Sciences of the United States of America, 2018; 115(47): E11120-E11127.
Cook Jeremy D, Ng Sze Yin, Lloyd Marcia, Eddington Shannan, Sun Hui, Nathans Jeremy, Bok Dean, Radu Roxana A, Travis Gabriel H   Peropsin modulates transit of vitamin A from retina to retinal pigment epithelium The Journal of biological chemistry, 2017; 292(52): 21407-21416.
Lenis Tamara L, Sarfare Shanta, Jiang Zhichun, Lloyd Marcia B, Bok Dean, Radu Roxana A   Complement modulation in the retinal pigment epithelium rescues photoreceptor degeneration in a mouse model of Stargardt disease Proceedings of the National Academy of Sciences of the United States of America, 2017; 114(15): 3987-3992.
Müller Philipp L, Gliem Martin, Mangold Elisabeth, Bolz Hanno J, Finger Robert P, McGuinness Myra, Betz Christian, Jiang Zhichun, Weber Bernhard H F, MacLaren Robert E, Holz Frank G, Radu Roxana A, Charbel Issa Peter   Monoallelic ABCA4 Mutations Appear Insufficient to Cause Retinopathy: A Quantitative Autofluorescence Study Investigative ophthalmology & visual science, 2015; 56(13): 8179-86.
Kaylor Joanna J, Radu Roxana A, Bischoff Nicholas, Makshanoff Jacob, Hu Jane, Lloyd Marcia, Eddington Shannan, Bianconi Tran, Bok Dean, Travis Gabriel H   Diacylglycerol O-acyltransferase type-1 synthesizes retinyl esters in the retina and retinal pigment epithelium PloS one, 2015; 10(5): e0125921.
Smit-McBride Zeljka, Oltjen Sharon L, Radu Roxana A, Estep Jason, Nguyen Anthony T, Gong Qizhi, Hjelmeland Leonard M   Localization of complement factor H gene expression and protein distribution in the mouse outer retina Molecular vision, 2015; 21(5): 110-23.
Toops Kimberly A, Tan Li Xuan, Jiang Zhichun, Radu Roxana A, Lakkaraju Aparna   Cholesterol-mediated activation of acid sphingomyelinase disrupts autophagy in the retinal pigment epithelium Molecular biology of the cell, 2015; 26(1): 1-14.
Nociari Marcelo M, Lehmann Guillermo L, Perez Bay Andres E, Radu Roxana A, Jiang Zhichun, Goicochea Shelby, Schreiner Ryan, Warren J David, Shan Jufang, Adam de Beaumais Ségolène, Ménand Mickaël, Sollogoub Matthieu, Maxfield Frederick R, Rodriguez-Boulan Enrique   Beta cyclodextrins bind, stabilize, and remove lipofuscin bisretinoids from retinal pigment epithelium Proceedings of the National Academy of Sciences of the United States of America, 2014; 111(14): E1402-8.
Radu Roxana A, Hu Jane, Jiang Zhichun, Bok Dean   Bisretinoid-mediated complement activation on retinal pigment epithelial cells is dependent on complement factor H haplotype The Journal of biological chemistry, 2014; 289(13): 9113-20.
Charbel Issa Peter, Barnard Alun R, Singh Mandeep S, Carter Emma, Jiang Zhichun, Radu Roxana A, Schraermeyer Ulrich, MacLaren Robert E   Fundus autofluorescence in the Abca4(-/-) mouse model of Stargardt disease--correlation with accumulation of A2E, retinal function, and histology Investigative ophthalmology & visual science, 2013; 54(8): 5602-12.
Ruiz Alberto, Mark Manuel, Jacobs Hugues, Klopfenstein Muriel, Hu Jane, Lloyd Marcia, Habib Samer, Tosha Chinatsu, Radu Roxana A, Ghyselinck Norbert B, Nusinowitz Steven, Bok Dean   Retinoid content, visual responses, and ocular morphology are compromised in the retinas of mice lacking the retinol-binding protein receptor, STRA6 Investigative ophthalmology & visual science, 2012; 53(6): 3027-39.
Mullins Robert F, Kuehn Markus H, Radu Roxana A, Enriquez G Stephanie, East Jade S, Schindler Emily I, Travis Gabriel H, Stone Edwin M   Autosomal recessive retinitis pigmentosa due to ABCA4 mutations: clinical, pathologic, and molecular characterization Investigative ophthalmology & visual science, 2012; 53(4): 1883-94.
Lopes Vanda S, Gibbs Daniel, Libby Richard T, Aleman Tomas S, Welch Darcy L, Lillo Concepción, Jacobson Samuel G, Radu Roxana A, Steel Karen P, Williams David S   The Usher 1B protein, MYO7A, is required for normal localization and function of the visual retinoid cycle enzyme, RPE65 Human molecular genetics, 2011; 20(13): 2560-70.
Radu Roxana A, Hu Jane, Yuan Quan, Welch Darcy L, Makshanoff Jacob, Lloyd Marcia, McMullen Stephen, Travis Gabriel H, Bok Dean   Complement system dysregulation and inflammation in the retinal pigment epithelium of a mouse model for Stargardt macular degeneration The Journal of biological chemistry, 2011; 286(21): 18593-601.
Linton Jonathan D, Holzhausen Lars C, Babai Norbert, Song Hongman, Miyagishima Kiyoharu J, Stearns George W, Lindsay Ken, Wei Junhua, Chertov Andrei O, Peters Theo A, Caffe Romeo, Pluk Helma, Seeliger Mathias W, Tanimoto Naoyuki, Fong Kimberly, Bolton Laura, Kuok Denise L T, Sweet Ian R, Bartoletti Theodore M, Radu Roxana A, Travis Gabriel H, Zagotta Willam N, Townes-Anderson Ellen, Parker Ed, Van der Zee Catharina E E M, Sampath Alapakkam P, Sokolov Maxim, Thoreson Wallace B, Hurley James B   Flow of energy in the outer retina in darkness and in light Proceedings of the National Academy of Sciences of the United States of America, 2010; 107(19): 8599-604.
Jin Minghao, Li Songhua, Nusinowitz Steven, Lloyd Marcia, Hu Jane, Radu Roxana A, Bok Dean, Travis Gabriel H   The role of interphotoreceptor retinoid-binding protein on the translocation of visual retinoids and function of cone photoreceptors The Journal of neuroscience : the official journal of the Society for Neuroscience, 2009; 29(5): 1486-95.
Radu Roxana A, Yuan Quan, Hu Jane, Peng Jennifer H, Lloyd Marcia, Nusinowitz Steven, Bok Dean, Travis Gabriel H   Accelerated accumulation of lipofuscin pigments in the RPE of a mouse model for ABCA4-mediated retinal dystrophies following Vitamin A supplementation Investigative ophthalmology & visual science, 2008; 49(9): 3821-9.
Radu Roxana A, Hu Jane, Peng Jennifer, Bok Dean, Mata Nathan L, Travis Gabriel H   Retinal pigment epithelium-retinal G protein receptor-opsin mediates light-dependent translocation of all-trans-retinyl esters for synthesis of visual chromophore in retinal pigment epithelial cells The Journal of biological chemistry, 2008; 283(28): 19730-8.
Brill Elliott, Malanson Katherine M, Radu Roxana A, Boukharov Natalia V, Wang Zhongyan, Chung Hae-Yun, Lloyd Marcia B, Bok Dean, Travis Gabriel H, Obin Martin, Lem Janis   A novel form of transducin-dependent retinal degeneration: accelerated retinal degeneration in the absence of rod transducin Investigative ophthalmology & visual science, 2007; 48(12): 5445-53.
Bakall B, Radu R A, Stanton J B, Burke J M, McKay B S, Wadelius C, Mullins R F, Stone E M, Travis G H, Marmorstein A D   Enhanced accumulation of A2E in individuals homozygous or heterozygous for mutations in BEST1 (VMD2) Experimental eye research, 2007; 85(1): 34-43.
Bui Tam V, Han Yun, Radu Roxana A, Travis Gabriel H, Mata Nathan L   Characterization of native retinal fluorophores involved in biosynthesis of A2E and lipofuscin-associated retinopathies The Journal of biological chemistry, 2006; 281(26): 18112-9.
Radu Roxana A, Han Yun, Bui Tam V, Nusinowitz Steven, Bok Dean, Lichter Jay, Widder Ken, Travis Gabriel H, Mata Nathan L   Reductions in serum vitamin A arrest accumulation of toxic retinal fluorophores: a potential therapy for treatment of lipofuscin-based retinal diseases Investigative ophthalmology & visual science, 2005; 46(12): 4393-401.
Mata Nathan L, Ruiz Alberto, Radu Roxana A, Bui Tam V, Travis Gabriel H   Chicken retinas contain a retinoid isomerase activity that catalyzes the direct conversion of all-trans-retinol to 11-cis-retinol Biochemistry, 2005; 44(35): 11715-21.
Radu Roxana A, Mata Nathan L, Nusinowitz Steven, Liu Xinran, Travis Gabriel H   Isotretinoin treatment inhibits lipofuscin accumulation in a mouse model of recessive Stargardt's macular degeneration Novartis Foundation symposium, 2004; 255(16): 51-63; discussion 63-7, 177-8.
Radu Roxana A, Mata Nathan L, Bagla Aarti, Travis Gabriel H   Light exposure stimulates formation of A2E oxiranes in a mouse model of Stargardt's macular degeneration Proceedings of the National Academy of Sciences of the United States of America, 2004; 101(16): 5928-33.
Mata Nathan L, Moghrabi Walid N, Lee Jung S, Bui Tam V, Radu Roxana A, Horwitz Joseph, Travis Gabriel H   Rpe65 is a retinyl ester binding protein that presents insoluble substrate to the isomerase in retinal pigment epithelial cells The Journal of biological chemistry, 2004; 279(1): 635-43.
Nusinowitz Steven, Nguyen Lina, Radu Roxanna, Kashani Zahra, Farber Debora, Danciger Michael   Electroretinographic evidence for altered phototransduction gain and slowed recovery from photobleaches in albino mice with a MET450 variant in RPE65 Experimental eye research, 2003; 77(5): 627-38.
Radu Roxana A, Mata Nathan L, Nusinowitz Steven, Liu Xinran, Sieving Paul A, Travis Gabriel H   Treatment with isotretinoin inhibits lipofuscin accumulation in a mouse model of recessive Stargardt's macular degeneration Proceedings of the National Academy of Sciences of the United States of America, 2003; 100(8): 4742-7.
Mata Nathan L, Radu Roxana A, Clemmons Richard C, Travis Gabriel H   Isomerization and oxidation of vitamin a in cone-dominant retinas: a novel pathway for visual-pigment regeneration in daylight Neuron, 2002; 36(1): 69-80.