Marmar Vaseghi, M.D., Ph.D., M.M.Sc.

Mailing Address:
UCLA Med-Cardio
BOX 957392, 100 Medical Plaza, Suite 660
Los Angeles, CA 90095

Affiliations
Affiliations
Associate Professor, Medicine
Member, Molecular, Cellular & Integrative Physiology GPB Home Area
Research Interests
autonomic control of atrial and ventricular arrhythmias, autonomic remodeling in setting of cardiac disease, novel technologies to treat cardiac arrhythmias.
Biography:

Dr. Vaseghi is currently Associate Professor of Medicine in the David Geffen School of Medicine at UCLA. She is the Director of Clinical and Translational Research at the UCLA Cardiac Arrhythmias Center, overseeing translational and clinical studies related to cardiac arrhythmias. She is a faculty of the Molecular, Cellular, & Integrative Physiology Interdepartmental Program and Neurcardiology Program of Excellence. She is the winner of the 2015 NIH New Innovator Award and has published over 100 publications in peer-reviewed journals. Dr. Vaseghi received her B.S. in Biomedical Engineering from Northwestern University and her M.D. from Stanford University. She obtained her Masters in Clinical Research and PhD in Molecular, Cellular, and Integrative Physiology from UCLA and completed her residency in Internal Medicine, cardiology fellowship and cardiac electrophysiology fellowship at UCLA. Her lab has done extensive work characterizing pathophysiological mechanisms behind the cardiac autonomic nervous system remodeling that predisposes to ventricular arrhythmias and sudden death. She is an investigator on multiple National Institute of Health studies and serves on editorial board of American Journal of Physiology Heart and Circulatory Physiology and Heart Rhythm Journal.

Publications

A selected list of publications:

Krokhaleva Y, Vaseghi M.   How to evaluate for and manage inflammatory and infiltrative cardiomyopathies that require ventricular tachycardia ablation Curr Cardiovasc Risk Rep, 2017; 11: 1-13.
Kung Geoffrey L, Vaseghi Marmar, Gahm Jin K, Shevtsov Jane, Garfinkel Alan, Shivkumar Kalyanam, Ennis Daniel B   Microstructural Infarct Border Zone Remodeling in the Post-infarct Swine Heart Measured by Diffusion Tensor MRI Frontiers in physiology, 2018; 9(23): 826.
Hoang Jonathan D, Vaseghi Marmar   No sympathy for the hypoxic: the role of fetal oxygenation in autonomic dysfunction The Journal of physiology, 2018; 596(23): 5507-5508.
Vaseghi Marmar, Hu Tiffany Y, Tung Roderick, Vergara Pasquale, Frankel David S, Di Biase Luigi, Tedrow Usha B, Gornbein Jeffrey A, Yu Ricky, Mathuria Nilesh, Nakahara Shiro, Tzou Wendy S, Sauer William H, Burkhardt J David, Tholakanahalli Venkatakrishna N, Dickfeld Timm-Michael, Weiss J Peter, Bunch T Jared, Reddy Madhu, Callans David J, Lakkireddy Dhanunjaya R, Natale Andrea, Marchlinski Francis E, Stevenson William G, Della Bella Paolo, Shivkumar Kalyanam   Outcomes of Catheter Ablation of Ventricular Tachycardia Based on Etiology in Nonischemic Heart Disease: An International Ventricular Tachycardia Ablation Center Collaborative Study JACC. Clinical electrophysiology, 2018; 4(9): 1141-1150.
Yamaguchi Naoko, Yamakawa Kentaro, Rajendran Pradeep S, Takamiya Tatsuo, Vaseghi Marmar   Antiarrhythmic effects of vagal nerve stimulation after cardiac sympathetic denervation in the setting of chronic myocardial infarction Heart rhythm, 2018; 15(8): 1214-1222.
Huang William A, Dunipace Eric A, Sorg Julie M, Vaseghi Marmar   Liver Disease as a Predictor of New-Onset Atrial Fibrillation Journal of the American Heart Association, 2018; 7(15): e008703.
Bradfield Jason S, Ajijola Olujimi A, Vaseghi Marmar, Shivkumar Kalyanam   Mechanisms and management of refractory ventricular arrhythmias in the age of autonomic modulation Heart rhythm, 2018; 15(8): 1252-1260.
Hoang Jonathan D, Vaseghi Marmar   A novel mechanism for regulation of cardiac Ca Heart rhythm, 2018; 15(5): 750-751.
Li Anthony, Hayase Justin, Do Duc, Buch Eric, Vaseghi Marmar, Ajijola Olujimi A, Macias Carlos, Krokhaleva Yuliya, Khakpour Houman, Boyle Noel G, Benharash Peyman, Biniwale Reshma, Shivkumar Kalyanam, Bradfield Jason S   Hybrid surgical vs percutaneous access epicardial ventricular tachycardia ablation Heart rhythm, 2018; 15(4): 512-519.
Vergara Pasquale, Tung Roderick, Vaseghi Marmar, Brombin Chiara, Frankel David S, Di Biase Luigi, Nagashima Koichi, Tedrow Usha, Tzou Wendy S, Sauer William H, Mathuria Nilesh, Nakahara Shiro, Vakil Kairav, Tholakanahalli Venkat, Bunch T Jared, Weiss J Peter, Dickfeld Timm, Vunnam Rama, Lakireddy Dhanunjaya, Burkhardt J David, Correra Anna, Santangeli Pasquale, Callans David, Natale Andrea, Marchlinski Francis, Stevenson William G, Shivkumar Kalyanam, Della Bella Paolo   Successful ventricular tachycardia ablation in patients with electrical storm reduces recurrences and improves survival Heart rhythm, 2018; 15(1): 48-55.
Huang William A, Boyle Noel G, Vaseghi Marmar   Cardiac Innervation and the Autonomic Nervous System in Sudden Cardiac Death Cardiac electrophysiology clinics, 2017; 9(4): 665-679.
Turagam Mohit K, Vuddanda Venkat, Atkins Donita, Santangeli Pasquale, Frankel David S, Tung Roderick, Vaseghi Marmar, Sauer William H, Tzou Wendy, Mathuria Nilesh, Nakahara Shiro, Dickfeld Timm M, Bunch T Jared, Weiss Peter, Di Biase Luigi, Tholakanahalli Venkat, Vakil Kairav, Tedrow Usha B, Stevenson William G, Della Bella Paolo, Shivkumar Kalyanam, Marchlinski Francis E, Callans David J, Natale Andrea, Reddy Madhu, Lakkireddy Dhanunjaya   Hemodynamic Support in Ventricular Tachycardia Ablation: An International VT Ablation Center Collaborative Group Study JACC. Clinical electrophysiology, 2017; 3(13): 1534-1543.
Vakil Kairav, Garcia Santiago, Tung Roderick, Vaseghi Marmar, Tedrow Usha, Della Bella Paolo, Frankel David S, Vergara Pasquale, Di Biase Luigi, Nagashima Koichi, Nakahara Shiro, Tzou Wendy S, Burkhardt J David, Dickfeld Timm, Weiss J Peter, Bunch Jared, Callans David, Lakkireddy Dhanunjaya, Natale Andrea, Sauer William H, Stevenson William G, Marchlinski Francis, Shivkumar Kalyanam, Tholakanahalli Venkatakrishna N   Ventricular Tachycardia Ablation in the Elderly: An International Ventricular Tachycardia Center Collaborative Group Analysis Circulation. Arrhythmia and electrophysiology, 2017; 10(12): .
Hanna Peter, Rajendran Pradeep S, Ajijola Olujimi A, Vaseghi Marmar, Andrew Armour J, Ardell Jefrrey L, Shivkumar Kalyanam   Cardiac neuroanatomy - Imaging nerves to define functional control Autonomic neuroscience : basic & clinical, 2017; 207(4): 48-58.
Do Duc H, Bradfield Jason, Ajijola Olujimi A, Vaseghi Marmar, Le John, Rahman Siamak, Mahajan Aman, Nogami Akihiko, Boyle Noel G, Shivkumar Kalyanam   Thoracic Epidural Anesthesia Can Be Effective for the Short-Term Management of Ventricular Tachycardia Storm Journal of the American Heart Association, 2017; 6(11): .
Vaseghi Marmar, Salavatian Siamak, Rajendran Pradeep S, Yagishita Daigo, Woodward William R, Hamon David, Yamakawa Kentaro, Irie Tadanobu, Habecker Beth A, Shivkumar Kalyanam   Parasympathetic dysfunction and antiarrhythmic effect of vagal nerve stimulation following myocardial infarction JCI insight, 2017; 2(16): 3070-3080.
Khakpour Houman, Vaseghi Marmar   Risk Stratification and Sudden Cardiac Death: Is It Time to Include Autonomic Variables? Circulation. Cardiovascular imaging, 2017; 10(8): 3070-3080.
Vaseghi Marmar, Barwad Parag, Malavassi Corrales Federico J, Tandri Harikrishna, Mathuria Nilesh, Shah Rushil, Sorg Julie M, Gima Jean, Mandal Kaushik, Sàenz Morales Luis C, Lokhandwala Yash, Shivkumar Kalyanam   Cardiac Sympathetic Denervation for Refractory Ventricular Arrhythmias Journal of the American College of Cardiology, 2017; 69(25): 3070-3080.
Santangeli Pasquale, Frankel David S, Tung Roderick, Vaseghi Marmar, Sauer William H, Tzou Wendy S, Mathuria Nilesh, Nakahara Shiro, Dickfeldt Timm M, Lakkireddy Dhanunjaya, Bunch T Jared, Di Biase Luigi, Natale Andrea, Tholakanahalli Venkat, Tedrow Usha B, Kumar Saurabh, Stevenson William G, Della Bella Paolo, Shivkumar Kalyanam, Marchlinski Francis E, Callans David J, Callans David J   Early Mortality After Catheter Ablation of Ventricular Tachycardia in Patients With Structural Heart Disease Journal of the American College of Cardiology, 2017; 69(17): 2105-2115.
Hamon David, Rajendran Pradeep S, Chui Ray W, Ajijola Olujimi A, Irie Tadanobu, Talebi Ramin, Salavatian Siamak, Vaseghi Marmar, Bradfield Jason S, Armour J Andrew, Ardell Jeffrey L, Shivkumar Kalyanam   Premature Ventricular Contraction Coupling Interval Variability Destabilizes Cardiac Neuronal and Electrophysiological Control: Insights From Simultaneous Cardioneural Mapping Circulation. Arrhythmia and electrophysiology, 2017; 10(4): .
Irie Tadanobu, Yamakawa Kentaro, Hamon David, Nakamura Keijiro, Shivkumar Kalyanam, Vaseghi Marmar   Cardiac sympathetic innervation via middle cervical and stellate ganglia and antiarrhythmic mechanism of bilateral stellectomy American journal of physiology. Heart and circulatory physiology, 2017; 312(3): H392-H405.
Guerra Federico, Bonelli Paolo, Flori Marco, Cipolletta Laura, Carbucicchio Corrado, Izquierdo Maite, Kozluk Edward, Shivkumar Kalyanam, Vaseghi Marmar, Patani Francesca, Cupido Claudio, Pala Salvatore, Ruiz-Granell Ricardo, Ferrero Angel, Tondo Claudio, Capucci Alessandro   Temporal Trends and Temperature-Related Incidence of Electrical Storm: The TEMPEST Study (Temperature-Related Incidence of Electrical Storm) Circulation. Arrhythmia and electrophysiology, 2017; 10(3): .
Tzou Wendy S, Tung Roderick, Frankel David S, Vaseghi Marmar, Bunch T Jared, Di Biase Luigi, Tholakanahalli Venkatakrishna N, Lakkireddy Dhanunjaya, Dickfeld Timm, Saliaris Anastasios, Weiss J Peter, Mathuria Nilesh, Tedrow Usha, Afzal Mohammed R, Vergara Pasquale, Nagashima Koichi, Patel Mehul, Nakahara Shiro, Vakil Kairav, Burkhardt J David, Tseng Chi-Hong, Natale Andrea, Shivkumar Kalyanam, Callans David J, Stevenson William G, Della Bella Paolo, Marchlinski Francis E, Sauer William H   Ventricular Tachycardia Ablation in Severe Heart Failure: An International Ventricular Tachycardia Ablation Center Collaboration Analysis Circulation. Arrhythmia and electrophysiology, 2017; 10(1): 938-944.
Frankel David S, Tung Roderick, Santangeli Pasquale, Tzou Wendy S, Vaseghi Marmar, Di Biase Luigi, Nagashima Koichi, Tedrow Usha, Bunch T Jared, Tholakanahalli Venkatakrishna N, Dendi Raghuveer, Reddy Madhu, Lakkireddy Dhanunjaya, Dickfeld Timm, Weiss J Peter, Mathuria Nilesh, Vergara Pasquale, Patel Mehul, Nakahara Shiro, Vakil Kairav, Sauer William H, Callans David J, Natale Andrea, Stevenson William G, Della Bella Paolo, Shivkumar Kalyanam, Marchlinski Francis E   Sex and Catheter Ablation for Ventricular Tachycardia: An International Ventricular Tachycardia Ablation Center Collaborative Group Study JAMA cardiology, 2016; 1(8): 938-944.
Hoffman Jonathan, Vaseghi Marmar   Editorial Commentary: Chronic obstructive pulmonary disease and sudden cardiac death: Cause and effect or simply an association? Trends in cardiovascular medicine, 2016; 26(7): 614-5.
Tung Roderick, Kim Steve, Yagishita Daigo, Vaseghi Marmar, Ennis Daniel B, Ouadah Sarah, Ajijola Olujimi A, Bradfield Jason S, Mahapatra Srijoy, Finn Paul, Shivkumar Kalyanam   Scar voltage threshold determination using ex vivo magnetic resonance imaging integration in a porcine infarct model: Influence of interelectrode distances and three-dimensional spatial effects of scar Heart rhythm, 2016; 13(10): 1993-2002.
Saenz Luis Carlos, Corrales Federico Malavassi, Bautista William, Traina Mahmoud, Meymandi Sheba, Rodriguez Diego A, Tellez Luis J, Vaseghi Marmar, Garcia Fermin, Shivkumar Kalyanam, Bradfield Jason S   Cardiac sympathetic denervation for intractable ventricular arrhythmias in Chagas disease Heart rhythm, 2016; 13(7): 1388-94.
Shivkumar Kalyanam, Ajijola Olujimi A, Anand Inder, Armour J Andrew, Chen Peng-Sheng, Esler Murray, De Ferrari Gaetano M, Fishbein Michael C, Goldberger Jeffrey J, Harper Ronald M, Joyner Michael J, Khalsa Sahib S, Kumar Rajesh, Lane Richard, Mahajan Aman, Po Sunny, Schwartz Peter J, Somers Virend K, Valderrabano Miguel, Vaseghi Marmar, Zipes Douglas P   Clinical neurocardiology defining the value of neuroscience-based cardiovascular therapeutics The Journal of physiology, 2016; 594(14): 3911-54.
Yamakawa Kentaro, Howard-Quijano Kimberly, Zhou Wei, Rajendran Pradeep, Yagishita Daigo, Vaseghi Marmar, Ajijola Olujimi A, Armour J Andrew, Shivkumar Kalyanam, Ardell Jeffrey L, Mahajan Aman   Central vs. peripheral neuraxial sympathetic control of porcine ventricular electrophysiology American journal of physiology. Regulatory, integrative and comparative physiology, 2016; 310(5): R414-21.
Rajendran Pradeep S, Nakamura Keijiro, Ajijola Olujimi A, Vaseghi Marmar, Armour J Andrew, Ardell Jeffrey L, Shivkumar Kalyanam   Myocardial infarction induces structural and functional remodelling of the intrinsic cardiac nervous system The Journal of physiology, 2016; 594(2): 321-41.
Yamakawa Kentaro, Rajendran Pradeep S, Takamiya Tatsuo, Yagishita Daigo, So Eileen L, Mahajan Aman, Shivkumar Kalyanam, Vaseghi Marmar   Vagal nerve stimulation activates vagal afferent fibers that reduce cardiac efferent parasympathetic effects American journal of physiology. Heart and circulatory physiology, 2015; 309(9): H1579-90.
Tung Roderick, Vaseghi Marmar, Frankel David S, Vergara Pasquale, Di Biase Luigi, Nagashima Koichi, Yu Ricky, Vangala Sitaram, Tseng Chi-Hong, Choi Eue-Keun, Khurshid Shaan, Patel Mehul, Mathuria Nilesh, Nakahara Shiro, Tzou Wendy S, Sauer William H, Vakil Kairav, Tedrow Usha, Burkhardt J David, Tholakanahalli Venkatakrishna N, Saliaris Anastasios, Dickfeld Timm, Weiss J Peter, Bunch T Jared, Reddy Madhu, Kanmanthareddy Arun, Callans David J, Lakkireddy Dhanunjaya, Natale Andrea, Marchlinski Francis, Stevenson William G, Della Bella Paolo, Shivkumar Kalyanam   Freedom from recurrent ventricular tachycardia after catheter ablation is associated with improved survival in patients with structural heart disease: An International VT Ablation Center Collaborative Group study Heart rhythm, 2015; 12(9): 1997-2007.
Huang William A, Shivkumar Kalyanam, Vaseghi Marmar   Device-based autonomic modulation in arrhythmia patients: the role of vagal nerve stimulation Current treatment options in cardiovascular medicine, 2015; 17(5): 379.
Irie Tadanobu, Yu Ricky, Bradfield Jason S, Vaseghi Marmar, Buch Eric F, Ajijola Olujimi, Macias Carlos, Fujimura Osamu, Mandapati Ravi, Boyle Noel G, Shivkumar Kalyanam, Tung Roderick   Relationship between sinus rhythm late activation zones and critical sites for scar-related ventricular tachycardia: systematic analysis of isochronal late activation mapping Circulation. Arrhythmia and electrophysiology, 2015; 8(2): 390-9.
Mao Jessica, Moriarty John M, Mandapati Ravi, Boyle Noel G, Shivkumar Kalyanam, Vaseghi Marmar   Catheter ablation of accessory pathways near the coronary sinus: value of defining coronary arterial anatomy Heart rhythm, 2015; 12(3): 508-514.
Yagishita Daigo, Chui Ray W, Yamakawa Kentaro, Rajendran Pradeep S, Ajijola Olujimi A, Nakamura Keijiro, So Eileen L, Mahajan Aman, Shivkumar Kalyanam, Vaseghi Marmar   Sympathetic nerve stimulation, not circulating norepinephrine, modulates T-peak to T-end interval by increasing global dispersion of repolarization Circulation. Arrhythmia and electrophysiology, 2015; 8(1): 174-85.
Yu Ricky, Ma Sootkeng, Tung Roderick, Stevens Steven, Macias Carlos, Bradfield Jason, Buch Eric, Vaseghi Marmar, Fujimura Osama, Gornbein Jeffrey, Mandapati Ravi, Shivkumar Kalyanam, Boyle Noel G   Catheter ablation of scar-based ventricular tachycardia: Relationship of procedure duration to outcomes and hospital mortality Heart rhythm, 2015; 12(1): 86-94.
Yamakawa Kentaro, So Eileen L, Rajendran Pradeep S, Hoang Jonathan D, Makkar Nupur, Mahajan Aman, Shivkumar Kalyanam, Vaseghi Marmar   Electrophysiological effects of right and left vagal nerve stimulation on the ventricular myocardium American journal of physiology. Heart and circulatory physiology, 2014; 307(5): H722-31.
Bradfield Jason S, Vaseghi Marmar, Shivkumar Kalyanam   Renal denervation for refractory ventricular arrhythmias Trends in cardiovascular medicine, 2014; 24(5): 206-13.
Vaseghi Marmar, Gima Jean, Kanaan Christopher, Ajijola Olujimi A, Marmureanu Alexander, Mahajan Aman, Shivkumar Kalyanam   Cardiac sympathetic denervation in patients with refractory ventricular arrhythmias or electrical storm: intermediate and long-term follow-up Heart rhythm, 2014; 11(3): 360-6.
Rashid Shams, Rapacchi Stanislas, Vaseghi Marmar, Tung Roderick, Shivkumar Kalyanam, Finn J Paul, Hu Peng   Improved late gadolinium enhancement MR imaging for patients with implanted cardiac devices Radiology, 2014; 270(1): 269-74.
Tung Roderick, Mathuria Nilesh S, Nagel Rich, Mandapati Ravi, Buch Eric F, Bradfield Jason S, Vaseghi Marmar, Boyle Noel G, Shivkumar Kalyanam   Impact of local ablation on interconnected channels within ventricular scar: mechanistic implications for substrate modification Circulation. Arrhythmia and electrophysiology, 2013; 6(6): 1131-8.
Vaseghi Marmar, Yamakawa Kentaro, Sinha Arjun, So Eileen L, Zhou Wei, Ajijola Olujimi A, Lux Robert L, Laks Michael, Shivkumar Kalyanam, Mahajan Aman   Modulation of regional dispersion of repolarization and T-peak to T-end interval by the right and left stellate ganglia American journal of physiology. Heart and circulatory physiology, 2013; 305(7): H1020-30.
Yagishita Daigo, Ajijola Olujimi A, Vaseghi Marmar, Nsair Ali, Zhou Wei, Yamakawa Kentaro, Tung Roderick, Mahajan Aman, Shivkumar Kalyanam   Electrical homogenization of ventricular scar by application of collagenase: a novel strategy for arrhythmia therapy Circulation. Arrhythmia and electrophysiology, 2013; 6(4): 776-83.
Vaseghi Marmar, Macias Carlos, Tung Roderick, Shivkumar Kalyanam   Percutaneous interventricular septal access in a patient with aortic and mitral mechanical valves: a novel technique for catheter ablation of ventricular tachycardia Heart rhythm, 2013; 10(7): 1069-73.
Tung Roderick, Michowitz Yoav, Yu Ricky, Mathuria Nilesh, Vaseghi Marmar, Buch Eric, Bradfield Jason, Fujimura Osamu, Gima Jean, Discepolo William, Mandapati Ravi, Shivkumar Kalyanam   Epicardial ablation of ventricular tachycardia: an institutional experience of safety and efficacy Heart rhythm, 2013; 10(4): 490-8.
Zhou Wei, Yamakawa Kentaro, Benharash Peyman, Ajijola Olujimi, Ennis Daniel, Hadaya Joseph, Vaseghi Marmar, Shivkumar Kalyanam, Mahajan Aman   Effect of stellate ganglia stimulation on global and regional left ventricular function as assessed by speckle tracking echocardiography American journal of physiology. Heart and circulatory physiology, 2013; 304(6): H840-7.
Ajijola Olujimi A, Vaseghi Marmar, Zhou Wei, Yamakawa Kentaro, Benharash Peyman, Hadaya Joseph, Lux Robert L, Mahajan Aman, Shivkumar Kalyanam   Functional differences between junctional and extrajunctional adrenergic receptor activation in mammalian ventricle American journal of physiology. Heart and circulatory physiology, 2013; 304(4): H579-88.
Vaseghi Marmar, Shivkumar Kalyanam   Neuraxial modulation for ventricular arrhythmias: a new hope Heart rhythm, 2012; 9(11): 1888-9.
Vaseghi Marmar, Zhou Wei, Shi James, Ajijola Olumiji A, Hadaya Joseph, Shivkumar Kalyanam, Mahajan Aman   Sympathetic innervation of the anterior left ventricular wall by the right and left stellate ganglia Heart rhythm, 2012; 9(8): 1303-9.
Vaseghi Marmar, Lux Robert L, Mahajan Aman, Shivkumar Kalyanam   Sympathetic stimulation increases dispersion of repolarization in humans with myocardial infarction American journal of physiology. Heart and circulatory physiology, 2012; 302(9): H1838-46.