Junyoung O Park, Ph.D.

Laboratory Address:
Boelter Hall, 7535
420 Westwood Plaza
Los Angeles, CA 90095

Office Address:
Boelter Hall, 5531
420 Westwood Plaza
Los Angeles, CA 90095

Assistant Professor, Chemical and Biomolecular Engineering
Research Interests

Central carbon metabolism supplies energy and carbon backbones necessary for biomass and bioproduct synthesis. Despite its importance in proper cellular functioning and biotechnology, controlling the flux through central carbon metabolic pathways remains challenging. A key limitation is the incomplete understanding of how different regulatory mechanisms come together to control pathway fluxes. In conjunction with regulations by molecular interactions, shifting thermodynamic driving forces in pathway steps contributes to changing the pathway flux. Thus, by quantifying the Gibbs free energy of reaction (ΔG) values of constituent reactions in a pathway, the Park lab aims to determine the physiological role of each reaction step in modulating pathway fluxes during perturbations. The Park lab uses mass spectrometry, stable isotope tracing, and quantitative modeling of metabolism to measure metabolic fluxes and thermodynamic driving force. The Park lab applies this knowledge to engineer microorganisms for enhanced bioproduct synthesis and to selectively impair metabolism of cancer cells.


Dr. Junyoung Park is Assistant Professor of Chemical and Biomolecular Engineering at UCLA. His research focus is on systems-level analysis of metabolic networks to elucidate key metabolic control points. Using this knowledge, he aims to engineer microorganisms for enhanced bioproduct synthesis and to selectively impair metabolism of cancer cells. Before moving to Los Angeles, Dr. Park conducted postdoctoral research at MIT. Dr. Park received his Ph.D. and master’s in Chemical Engineering from Princeton University, and bachelor’s degrees in Mathematics and Bioengineering from UC San Diego.


View a up-to-date publication list: Park's selected publications

A selected list of publications:

Park Junyoung O, Tanner Lukas B, Wei Monica H, Khana Daven B, Jacobson Tyler B, Zhang Zheyun, Rubin Sara A, Li Sophia Hsin-Jung, Higgins Meytal B, Stevenson David M, Amador-Noguez Daniel, Rabinowitz Joshua D   Near-equilibrium glycolysis supports metabolic homeostasis and energy yield Nature chemical biology, 2019; 15(10): 1001-1008.
Schober Andrew F, Mathis Andrew D, Ingle Christine, Park Junyoung O, Chen Li, Rabinowitz Joshua D, Junier Ivan, Rivoire Olivier, Reynolds Kimberly A   A Two-Enzyme Adaptive Unit within Bacterial Folate Metabolism Cell reports, 2019; 27(11): 3359-3370.e7.
Song Yonghyun, Park Junyoung O, Tanner Lukas, Nagano Yatsuhisa, Rabinowitz Joshua D, Shvartsman Stanislav Y   Energy budget of Drosophila embryogenesis Current biology : CB, 2019; 29(12): R566-R567.
Li Sophia Hsin-Jung, Li Zhiyuan, Park Junyoung O, King Christopher G, Rabinowitz Joshua D, Wingreen Ned S, Gitai Zemer   Escherichia coli translation strategies differ across carbon, nitrogen and phosphorus limitation conditions Nature microbiology, 2018; 3(8): 939-947.
Tanner Lukas Bahati, Goglia Alexander G, Wei Monica H, Sehgal Talen, Parsons Lance R, Park Junyoung O, White Eileen, Toettcher Jared E, Rabinowitz Joshua D   Four Key Steps Control Glycolytic Flux in Mammalian Cells Cell systems, 2018; 7(1): 49-62.e8.
Miller Russell A, Shi Yuji, Lu Wenyun, Pirman David A, Jatkar Aditi, Blatnik Matthew, Wu Hong, Cárdenas César, Wan Min, Foskett J Kevin, Park Junyoung O, Zhang Yiyi, Holland William L, Rabinowitz Joshua D, Birnbaum Morris J   Targeting hepatic glutaminase activity to ameliorate hyperglycemia Nature medicine, 2018; 24(4): 518-524.
Song Yonghyun, Marmion Robert A, Park Junyoung O, Biswas Debopriyo, Rabinowitz Joshua D, Shvartsman Stanislav Y   Dynamic Control of dNTP Synthesis in Early Embryos Developmental cell, 2017; 42(3): 301-308.e3.
Hackett Sean R, Zanotelli Vito R T, Xu Wenxin, Goya Jonathan, Park Junyoung O, Perlman David H, Gibney Patrick A, Botstein David, Storey John D, Rabinowitz Joshua D   Systems-level analysis of mechanisms regulating yeast metabolic flux Science (New York, N.Y.), 2016; 354(6311): 301-308.e3.
Park Junyoung O, Rubin Sara A, Xu Yi-Fan, Amador-Noguez Daniel, Fan Jing, Shlomi Tomer, Rabinowitz Joshua D   Metabolite concentrations, fluxes and free energies imply efficient enzyme usage Nature chemical biology, 2016; 12(7): 482-9.
Liu Ling, Shah Supriya, Fan Jing, Park Junyoung O, Wellen Kathryn E, Rabinowitz Joshua D   Malic enzyme tracers reveal hypoxia-induced switch in adipocyte NADPH pathway usage Nature chemical biology, 2016; 12(5): 345-52.