Yi-Rong Peng, Ph.D.
Assistant Professor, Ophthalmology
Member, Genetics & Genomics GPB Home Area, Molecular, Cellular & Integrative Physiology GPB Home Area, Neuroscience GPB Home Area

Dr. Peng received her PhD in neurobiology from the Institute of Neuroscience, Chinese Academy of Sciences, Shanghai, China in 2011. Her doctoral research examined the role of functional interactions between inhibitory and excitatory synapses that maintain the stability of neural networks. She then joined the laboratory of Dr. Joshua Sanes at Harvard University, where she was a postdoctoral fellow until 2019. In her postdoctoral work, she leveraged high throughput single-cell transcriptomic methods to uncover key transcriptional factors that control the specification of retinal cell types.

At the Stein Eye Institute she will continue to develop state-of-the-art transcriptomic and genomic tools to uncover the molecular underpinnings of the formation of retinal circuits and the pathogenesis of retinal diseases.


A selected list of publications:

van Zyl Tavé, Yan Wenjun, McAdams Alexi, Peng Yi-Rong, Shekhar Karthik, Regev Aviv, Juric Dejan, Sanes Joshua R   Cell atlas of aqueous humor outflow pathways in eyes of humans and four model species provides insight into glaucoma pathogenesis Proceedings of the National Academy of Sciences of the United States of America, 2020; 117(19): 10339-10349.
Peng Yi-Rong, Sampath Alapakkam P   LRR-ning the Rules: Synapse Organization in the Primary Rod Pathway Neuron, 2020; 105(6): 949-951.
Peng Yi-Rong, James Rebecca E, Yan Wenjun, Kay Jeremy N, Kolodkin Alex L, Sanes Joshua R   Binary Fate Choice between Closely Related Interneuronal Types Is Determined by a Fezf1-Dependent Postmitotic Transcriptional Switch Neuron, 2020; 105(3): 464-474.e6.
Peng Yi-Rong, Shekhar Karthik, Yan Wenjun, Herrmann Dustin, Sappington Anna, Bryman Gregory S, van Zyl Tavé, Do Michael Tri H, Regev Aviv, Sanes Joshua R   Molecular Classification and Comparative Taxonomics of Foveal and Peripheral Cells in Primate Retina Cell, 2019; 176(5): 1222-1237.e22.
Duan Xin, Krishnaswamy Arjun, Laboulaye Mallory A, Liu Jinyue, Peng Yi-Rong, Yamagata Masahito, Toma Kenichi, Sanes Joshua R   Cadherin Combinations Recruit Dendrites of Distinct Retinal Neurons to a Shared Interneuronal Scaffold Neuron, 2018; 99(6): 1145-1154.e6.
Peng Yi-Rong, Tran Nicholas M, Krishnaswamy Arjun, Kostadinov Dimitar, Martersteck Emily M, Sanes Joshua R   Satb1 Regulates Contactin 5 to Pattern Dendrites of a Mammalian Retinal Ganglion Cell Neuron, 2017; 95(4): 869-883.e6.
Peng Yi-Rong, Hou Zai-Hua, Yu Xiang   The kinase activity of EphA4 mediates homeostatic scaling-down of synaptic strength via activation of Cdk5 Neuropharmacology, 2013; 65(4): 232-43.
Peng Yi-Rong, Zeng Si-Yu, Song He-Ling, Li Min-Yin, Yamada Maki K, Yu Xiang   Postsynaptic spiking homeostatically induces cell-autonomous regulation of inhibitory inputs via retrograde signaling The Journal of neuroscience : the official journal of the Society for Neuroscience, 2010; 30(48): 16220-31.
Peng Yi-Rong, He Shan, Marie Helene, Zeng Si-Yu, Ma Jun, Tan Zhu-Jun, Lee Soo Yeun, Malenka Robert C, Yu Xiang   Coordinated changes in dendritic arborization and synaptic strength during neural circuit development Neuron, 2009; 61(1): 71-84.