Pinchas Cohen, M.D.

Office Address:
10833 Le Conte Ave.
CHS 22-315
Campus - 175217
Los Angeles, CA 90095

Affiliations
Affiliations
Professor, Pediatrics
Biography

Dr. Cohen graduated with highest honors in 1986 from the Technion Medical School in Israel, and trained in Pediatrics and Endocrinology at Stanford University until 1992. He was until 1998 an Associate Professor and Pediatric Endocrinology Program Director at the University of Pennsylvania & Children?s Hospital of Philadelphia. He is currently a Professor and Chief of Pediatric Endocrinology at UCLA and the associate director of the UCSD/UCLA Diabetes/Endocrinology Research Center. He was inducted into both the Society of Pediatric Research and the American Pediatric Society (APS). He is the recipient of the American Diabetes Association, Pediatric Endocrine Society, Eli-Lilly & Ross awards, and most recently, the APS Best Science Award. Dr. Cohen published over 250 papers focusing on cancer, aging, growth disorders, diabetes, GH/IGF biology and the emerging science of mitochondrial-derived peptides. He received grants from the National Institutes of Health (NIH), FDA, and various foundations including the Prostate cancer Foundation. He recently received a EUREKA-Award and the NIH-Director-Transformative RO1-Grant. He serves on several NIH study sections and his editorial services include being an associate editor of Pediatric Research and a member of the editorial boards of Journal of Clinical Endocrinology and Metabolism, Endocrinology, and the Journal of GH and IGF Research as well as being an executive officer of the GH Research society, the IGF society and the Endocrine Society Steering Committee.

Publications
Cohen Pinchas, Rogol Alan D, Weng Wayne, Kappelgaard Anne-Marie, Rosenfeld Ron G, Germak John, Germak John Efficacy of IGF-based growth hormone (GH) dosing in nonGH-deficient (nonGHD) short stature children with low IGF-I is not related to basal IGF-I levels. Clinical endocrinology. 2013; 78(3): 405-14.
Wan JunXiang, Atzmon Gil, Hwang David, Barzlai Nir, Kratzsch Jurgen, Cohen Pinchas Growth hormone receptor (GHR) exon 3 polymorphism status detection by dual-enzyme-linked immunosorbent assay (ELISA). The Journal of clinical endocrinology and metabolism. 2013; 98(1): E77-81.
Lee Changhan, Yen Kelvin, Cohen Pinchas Humanin: a harbinger of mitochondrial-derived peptides?. Trends in endocrinology and metabolism: TEM. 2013; 24(5): 222-8.
Seligson David B, Yu Hong, Tze Sheila, Said Jonathan, Pantuck Allan J, Cohen Pinchas, Lee Kuk-Wha IGFBP-3 nuclear localization predicts human prostate cancer recurrence. Hormones & cancer. 2013; 4(1): 12-23.
Parrella Edoardo, Maxim Tom, Maialetti Francesca, Zhang Lu, Wan Junxiang, Wei Min, Cohen Pinchas, Fontana Luigi, Longo Valter D Protein restriction cycles reduce IGF-1 and phosphorylated Tau, and improve behavioral performance in an Alzheimer's disease mouse model. Aging cell. 2013; 12(2): 257-68.
Dean James P, Sprenger Cynthia C, Wan Junxiang, Haugk Kathleen, Ellis William J, Lin Daniel W, Corman John M, Dalkin Bruce L, Mostaghel Elahe, Nelson Peter S, Cohen Pinchas, Montgomery Bruce, Plymate Stephen R Response of the Insulin-Like Growth Factor (IGF) System to IGF-IR Inhibition and Androgen Deprivation in a Neoadjuvant Prostate Cancer Trial: Effects of Obesity and Androgen Deprivation. The Journal of clinical endocrinology and metabolism. 2013; 98(5): E820-8.
Klink Joseph C, Tewari Alok K, Masko Elizabeth M, Antonelli Jodi, Febbo Phillip G, Cohen Pinchas, Dewhirst Mark W, Pizzo Salvatore V, Freedland Stephen J Resveratrol worsens survival in SCID mice with prostate cancer xenografts in a cell-line specific manner, through paradoxical effects on oncogenic pathways. The Prostate. 2013; 73(7): 754-62.
Yen Kelvin, Lee Changhan, Mehta Hemal, Cohen Pinchas The emerging role of the mitochondrial-derived peptide humanin in stress resistance. Journal of molecular endocrinology. 2013; 50(1): R11-9.
Konijeti Ramdev, Koyama Satomi, Gray Ashley, Barnard R James, Said Jonathan W, Castor Brandon, Elashoff David, Wan Junxiang, Beltran Pedro J, Calzone Frank J, Cohen Pinchas, Galet Colette, Aronson William J Effect of a low-fat diet combined with IGF-1 receptor blockade on 22Rv1 prostate cancer xenografts. Molecular cancer therapeutics. 2012; 11(7): 1539-46.
Pawlikowska-Haddal Anna, Cohen Pinchas, Cook David M How useful are serum IGF-I measurements for managing GH replacement therapy in adults and children?. Pituitary. 2012; 15(2): 126-34.
Zhang Xin, Urbieta-Caceres Victor H, Eirin Alfonso, Bell Caitlin C, Crane John A, Tang Hui, Jordan Kyra L, Oh Yun-Kyu, Zhu Xiang-Yang, Korsmo Michael J, Bachar Adi R, Cohen Pinchas, Lerman Amir, Lerman Lilach O Humanin prevents intra-renal microvascular remodeling and inflammation in hypercholesterolemic ApoE deficient mice. Life sciences. 2012; 91(5-6): 199-206.
Zacharias David G, Kim Sung Gyun, Massat Alfonso Eirin, Bachar Adi R, Oh Yun K, Herrmann Joerg, Rodriguez-Porcel Martin, Cohen Pinchas, Lerman Lilach O, Lerman Amir Humanin, a cytoprotective peptide, is expressed in carotid atherosclerotic [corrected] plaques in humans. PloS one. 2012; 7(2): e31065.
Rosenfeld Ron G, Cohen Pinchas, Robison Leslie L, Bercu Barry B, Clayton Peter, Hoffman Andrew R, Radovick Sally, Saenger Paul, Savage Martin O, Wit Jan M Long-term surveillance of growth hormone therapy. The Journal of clinical endocrinology and metabolism. 2012; 97(1): 68-72.
Williams Nolann G, Interlichia Jillian P, Jackson Melissa F, Hwang David, Cohen Pinchas, Rodgers Buel D Endocrine actions of myostatin: systemic regulation of the IGF and IGF binding protein axis. Endocrinology. 2011; 152(1): 172-80.
Gray Ashley, Aronson William J, Barnard R James, Mehta Hemal, Wan Junxiang, Said Jonathan, Cohen Pinchas, Galet Colette Global Igfbp1 deletion does not affect prostate cancer development in a c-Myc transgenic mouse model. The Journal of endocrinology. 2011; 211(3): 297-304.
Guevara-Aguirre Jaime, Balasubramanian Priya, Guevara-Aguirre Marco, Wei Min, Madia Federica, Cheng Chia-Wei, Hwang David, Martin-Montalvo Alejandro, Saavedra Jannette, Ingles Sue, de Cabo Rafael, Cohen Pinchas, Longo Valter D Growth hormone receptor deficiency is associated with a major reduction in pro-aging signaling, cancer, and diabetes in humans. Science translational medicine. 2011; 3(70): 70ra13.
Oh Yun K, Bachar Adi R, Zacharias David G, Kim Sung Gyun, Wan Junxiang, Cobb Laura J, Lerman Lilach O, Cohen Pinchas, Lerman Amir Humanin preserves endothelial function and prevents atherosclerotic plaque progression in hypercholesterolemic ApoE deficient mice. Atherosclerosis. 2011; 219(1): 65-73.
Mehta Hemal H, Gao Qinglei, Galet Colette, Paharkova Vladislava, Wan Junxiang, Said Jonathan, Sohn Joanne J, Lawson Gregory, Cohen Pinchas, Cobb Laura J, Lee Kuk-Wha IGFBP-3 is a metastasis suppression gene in prostate cancer. Cancer research. 2011; 71(15): 5154-63.
Mason Emily J, Grell Jacquelyn A, Wan Junxiang, Cohen Pinchas, Conover Cheryl A Insulin-like growth factor (IGF)-I and IGF-II contribute differentially to the phenotype of pregnancy associated plasma protein-A knock-out mice. Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society. 2011; 21(5): 243-7.
Aronson William J, Kobayashi Naoko, Barnard R James, Henning Susanne, Huang Min, Jardack Patricia M, Liu Bingrong, Gray Ashley, Wan Junxiang, Konijeti Ramdev, Freedland Stephen J, Castor Brandon, Heber David, Elashoff David, Said Jonathan, Cohen Pinchas, Galet Colette Phase II prospective randomized trial of a low-fat diet with fish oil supplementation in men undergoing radical prostatectomy. Cancer prevention research (Philadelphia, Pa.). 2011; 4(12): 2062-71.
Konijeti Ramdev, Henning Susanne, Moro Aune, Sheikh Ahmed, Elashoff David, Shapiro Ari, Ku Melvin, Said Jonathan W, Heber David, Cohen Pinchas, Aronson William J Chemoprevention of prostate cancer with lycopene in the TRAMP model. The Prostate. 2010; 70(14): 1547-54.
Buschemeyer W Cooper, Klink Joseph C, Mavropoulos John C, Poulton Susan H, Demark-Wahnefried Wendy, Hursting Stephen D, Cohen Pinchas, Hwang David, Johnson Tracy L, Freedland Stephen J Effect of intermittent fasting with or without caloric restriction on prostate cancer growth and survival in SCID mice. The Prostate. 2010; 70(10): 1037-43.
Aronson William J, Barnard R James, Freedland Stephen J, Henning Susanne, Elashoff David, Jardack Patricia M, Cohen Pinchas, Heber David, Kobayashi Naoko Growth inhibitory effect of low fat diet on prostate cancer cells: results of a prospective, randomized dietary intervention trial in men with prostate cancer. The Journal of urology. 2010; 183(1): 345-50.
Bachar Adi R, Scheffer Lea, Schroeder Andreas S, Nakamura Hiromi K, Cobb Laura J, Oh Yun K, Lerman Lilach O, Pagano Richard E, Cohen Pinchas, Lerman Amir Humanin is expressed in human vascular walls and has a cytoprotective effect against oxidized LDL-induced oxidative stress. Cardiovascular research. 2010; 88(2): 360-6.
Jia Yue, Lee Kuk-Wha, Swerdloff Ronald, Hwang David, Cobb Laura J, Sinha Hikim Amiya, Lue Yan He, Cohen Pinchas, Wang Christina Interaction of insulin-like growth factor-binding protein-3 and BAX in mitochondria promotes male germ cell apoptosis. The Journal of biological chemistry. 2010; 285(3): 1726-32.
Lue YanHe, Swerdloff Ronald, Liu QingHai, Mehta Hemal, Hikim Amiya Sinha, Lee Kuk-Wha, Jia Yue, Hwang David, Cobb Laura J, Cohen Pinchas, Wang Christina Opposing roles of insulin-like growth factor binding protein 3 and humanin in the regulation of testicular germ cell apoptosis. Endocrinology. 2010; 151(1): 350-7.
Koyama Satomi, Cobb Laura J, Mehta Hemal H, Seeram Navindra P, Heber David, Pantuck Allan J, Cohen Pinchas Pomegranate extract induces apoptosis in human prostate cancer cells by modulation of the IGF-IGFBP axis. Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society. 2010; 20(1): 55-62.
Lee Changhan, Safdie Fernando M, Raffaghello Lizzia, Wei Min, Madia Federica, Parrella Edoardo, Hwang David, Cohen Pinchas, Bianchi Giovanna, Longo Valter D Reduced levels of IGF-I mediate differential protection of normal and cancer cells in response to fasting and improve chemotherapeutic index. Cancer research. 2010; 70(4): 1564-72.
Hoang Phuong T, Park Patricia, Cobb Laura J, Paharkova-Vatchkova Valdislava, Hakimi Michael, Cohen Pinchas, Lee Kuk-Wha The neurosurvival factor Humanin inhibits beta-cell apoptosis via signal transducer and activator of transcription 3 activation and delays and ameliorates diabetes in nonobese diabetic mice. Metabolism: clinical and experimental. 2010; 59(3): 343-9.
Cohen Pinchas, Germak John, Rogol Alan D, Weng Wayne, Kappelgaard Anne-Marie, Rosenfeld Ron G, Rosenfeld Ron G Variable degree of growth hormone (GH) and insulin-like growth factor (IGF) sensitivity in children with idiopathic short stature compared with GH-deficient patients: evidence from an IGF-based dosing study of short children. The Journal of clinical endocrinology and metabolism. 2010; 95(5): 2089-98.
Cohen Pinchas Clinical management of growth hormone therapy for children. Managed care (Langhorne, Pa.). 2009; 18(8 Suppl 6): 4-9.
Cobb Laura J, Mehta Hemal, Cohen Pinchas Enhancing the apoptotic potential of insulin-like growth factor-binding protein-3 in prostate cancer by modulation of CK2 phosphorylation. Molecular endocrinology (Baltimore, Md.). 2009; 23(10): 1624-33.
Safdie Fernando M, Dorff Tanya, Quinn David, Fontana Luigi, Wei Min, Lee Changhan, Cohen Pinchas, Longo Valter D Fasting and cancer treatment in humans: A case series report. Aging. 2009; 1(12): 988-1007.
Cohen Pinchas Growth hormone treatment: evidence, practice, and emerging issues. Managed care (Langhorne, Pa.). 2009; 18(8 Suppl 6): 2-3.
Muzumdar Radhika H, Huffman Derek M, Atzmon Gil, Buettner Christoph, Cobb Laura J, Fishman Sigal, Budagov Temuri, Cui Lingguang, Einstein Francine H, Poduval Aruna, Hwang David, Barzilai Nir, Cohen Pinchas Humanin: a novel central regulator of peripheral insulin action. PloS one. 2009; 4(7): e6334.
Fan Yong, Menon Ram K, Cohen Pinchas, Hwang David, Clemens Thomas, DiGirolamo Douglas J, Kopchick John J, Le Roith Derek, Trucco Massimo, Sperling Mark A Liver-specific deletion of the growth hormone receptor reveals essential role of growth hormone signaling in hepatic lipid metabolism. The Journal of biological chemistry. 2009; 284(30): 19937-44.
Keni Jyotsna, Cohen Pinchas Optimizing growth hormone dosing in children with idiopathic short stature. Hormone research. 2009; 71 Suppl 1(3): 70-4.
Miyako Kenichi, Cobb Laura J, Francis Malik, Huang Alden, Peng Bonnie, Pintar John E, Ariga Hiroyoshi, Cohen Pinchas PAPA-1 Is a nuclear binding partner of IGFBP-2 and modulates its growth-promoting actions. Molecular endocrinology (Baltimore, Md.). 2009; 23(2): 169-75.
Yakar Shoshana, Rosen Clifford J, Bouxsein Mary L, Sun Hui, Mejia Wilson, Kawashima Yuki, Wu Yingjie, Emerton Kelly, Williams Valerie, Jepsen Karl, Schaffler Mitchell B, Majeska Robert J, Gavrilova Oksana, Gutierrez Mariana, Hwang David, Pennisi Patricia, Frystyk Jan, Boisclair Yves, Pintar John, Jasper Héctor, Domene Horacio, Cohen Pinchas, Clemmons David, LeRoith Derek Serum complexes of insulin-like growth factor-1 modulate skeletal integrity and carbohydrate metabolism. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2009; 23(3): 709-19.
Mavropoulos John C, Buschemeyer W Cooper, Tewari Alok K, Rokhfeld Dmitriy, Pollak Michael, Zhao Yunhua, Febbo Phillip G, Cohen Pinchas, Hwang David, Devi Gayathri, Demark-Wahnefried Wendy, Westman Eric C, Peterson Bercedis L, Pizzo Salvatore V, Freedland Stephen J The effects of varying dietary carbohydrate and fat content on survival in a murine LNCaP prostate cancer xenograft model. Cancer prevention research (Philadelphia, Pa.). 2009; 2(6): 557-65.
Freedland Stephen J, Mavropoulos John, Wang Amy, Darshan Medha, Demark-Wahnefried Wendy, Aronson William J, Cohen Pinchas, Hwang David, Peterson Bercedis, Fields Timothy, Pizzo Salvatore V, Isaacs William B Carbohydrate restriction, prostate cancer growth, and the insulin-like growth factor axis. The Prostate. 2008; 68(1): 11-9.
Kobayashi Naoko, Barnard R James, Said Jonathan, Hong-Gonzalez Jenny, Corman Dan M, Ku Melvin, Doan Ngan Bao, Gui Dorina, Elashoff David, Cohen Pinchas, Aronson William J Effect of low-fat diet on development of prostate cancer and Akt phosphorylation in the Hi-Myc transgenic mouse model. Cancer research. 2008; 68(8): 3066-73.
Suh Yousin, Atzmon Gil, Cho Mi-Ook, Hwang David, Liu Bingrong, Leahy Daniel J, Barzilai Nir, Cohen Pinchas Functionally significant insulin-like growth factor I receptor mutations in centenarians. Proceedings of the National Academy of Sciences of the United States of America. 2008; 105(9): 3438-42.
Park Jung Yoon, Cho Mi-Ook, Leonard Shanique, Calder Brent, Mian I Saira, Kim Woo Ho, Wijnhoven Susan, van Steeg Harry, Mitchell James, van der Horst Gijsbertus T J, Hoeijmakers Jan, Cohen Pinchas, Vijg Jan, Suh Yousin Homeostatic imbalance between apoptosis and cell renewal in the liver of premature aging Xpd mice. PloS one. 2008; 3(6): e2346.
Salusky Isidro B, Cohen Pinchas Lost in translation?. Pediatric research. 2008; 64(3): 225.
Hwang David L, Lee Phillip D K, Cohen Pinchas Quantitative ontogeny of murine insulin-like growth factor (IGF)-I, IGF-binding protein-3 and the IGF-related acid-labile subunit. Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society. 2008; 18(1): 65-74.
Ding Feng, Li Hong Hua, Zhang Shengwen, Solomon Nicola M, Camper Sally A, Cohen Pinchas, Francke Uta SnoRNA Snord116 (Pwcr1/MBII-85) deletion causes growth deficiency and hyperphagia in mice. PloS one. 2008; 3(3): e1709.
Cohen Pinchas Statement 1: a serum insulin-like growth factor I (IGF-I) level should be part of the evaluation of children with short stature. Pediatric endocrinology reviews : PER. 2008; 5 Suppl 3(8): 834-6.
Hernández Maria Isabel, Cohen Pinchas Surprising new height regulating genes: beyond growth hormone and IGF-I. Pediatric research. 2008; 64(5): 461.
Anzo Makoto, Cobb Laura J, Hwang David L, Mehta Hemal, Said Jonathan W, Yakar Shoshana, LeRoith Derek, Cohen Pinchas Targeted deletion of hepatic Igf1 in TRAMP mice leads to dramatic alterations in the circulating insulin-like growth factor axis but does not reduce tumor progression. Cancer research. 2008; 68(9): 3342-9.
Barnard R James, Leung Pak Shan, Aronson William J, Cohen Pinchas, Golding Lawrence A A mechanism to explain how regular exercise might reduce the risk for clinical prostate cancer. European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP). 2007; 16(5): 415-21.
Lee Kuk-Wha, Cobb Laura J, Paharkova-Vatchkova Vladislava, Liu Bingrong, Milbrandt Jeffrey, Cohen Pinchas Contribution of the orphan nuclear receptor Nur77 to the apoptotic action of IGFBP-3. Carcinogenesis. 2007; 28(8): 1653-8.
Raina Komal, Blouin Marie-José, Singh Rana P, Majeed Noreen, Deep Gagan, Varghese Leyon, Glodé L Michael, Greenberg Norman M, Hwang David, Cohen Pinchas, Pollak Michael N, Agarwal Rajesh Dietary feeding of silibinin inhibits prostate tumor growth and progression in transgenic adenocarcinoma of the mouse prostate model. Cancer research. 2007; 67(22): 11083-91.
Ali Omar, Shim Melanie, Fowler Eileen, Greenberg Marcia, Perkins Donna, Oppenheim William, Cohen Pinchas Growth hormone therapy improves bone mineral density in children with cerebral palsy: a preliminary pilot study. The Journal of clinical endocrinology and metabolism. 2007; 92(3): 932-7.
Degraff David J, Malik Manisha, Chen Qian, Miyako Kenichi, Rejto Lidia, Aguiar Adam A, Bancroft Diccon R E, Cohen Pinchas, Sikes Robert A Hormonal regulation of IGFBP-2 proteolysis is attenuated with progression to androgen insensitivity in the LNCaP progression model. Journal of cellular physiology. 2007; 213(1): 261-8.
Cohen Pinchas, Rogol Alan D, Howard Campbell P, Bright George M, Kappelgaard Anne-Marie, Rosenfeld Ron G, Rosenfeld Ron G Insulin growth factor-based dosing of growth hormone therapy in children: a randomized, controlled study. The Journal of clinical endocrinology and metabolism. 2007; 92(7): 2480-6.
Kim Hae Soon, Ali Omar, Shim Melanie, Lee Kuk-Wha, Vuguin Patricia, Muzumdar Radhika, Barzilai Nir, Cohen Pinchas Insulin-like growth factor binding protein-3 induces insulin resistance in adipocytes in vitro and in rats in vivo. Pediatric research. 2007; 61(2): 159-64.
Ali Omar, Shim Melanie, Fowler Eileen, Cohen Pinchas, Oppenheim William Spinal bone mineral density, IGF-1 and IGFBP-3 in children with cerebral palsy. Hormone research. 2007; 68(6): 316-20.
Kaplan Solomon A, Cohen Pinchas The somatomedin hypothesis 2007: 50 years later. The Journal of clinical endocrinology and metabolism. 2007; 92(12): 4529-35.
Rosenthal Stephen, Cohen Pinchas, Clayton Peter, Backeljauw Philippe, Bang Peter, Ten Svetlana Treatment perspectives in idiopathic short stature with a focus on IGF-I deficiency. Pediatric endocrinology reviews : PER. 2007; 4 Suppl 2(1): 252-71.
Pawlikowska-Haddal Anna, Cohen Pinchas Advances in pediatric growth hormone therapy: IGF-I-based dosing. Indian pediatrics. 2006; 43(7): 577-81.
Colón Eugenia, Strand Mona-Lisa, Carlsson-Skwirut Christine, Wahlgren Aida, Svechnikov Konstantin V, Cohen Pinchas, Söder Olle Anti-apoptotic factor humanin is expressed in the testis and prevents cell-death in leydig cells during the first wave of spermatogenesis. Journal of cellular physiology. 2006; 208(2): 373-85.
Muzumdar Radhika H, Ma Xiaohui, Fishman Sigal, Yang Xiaoman, Atzmon Gil, Vuguin Patricia, Einstein Francine H, Hwang David, Cohen Pinchas, Barzilai Nir Central and opposing effects of IGF-I and IGF-binding protein-3 on systemic insulin action. Diabetes. 2006; 55(10): 2788-96.
Cohen Pinchas Controversy in clinical endocrinology: problems with reclassification of insulin-like growth factor I production and action disorders. The Journal of clinical endocrinology and metabolism. 2006; 91(11): 4235-6.
Kobayashi Naoko, Barnard R James, Henning Susanne M, Elashoff David, Reddy Srinivasa T, Cohen Pinchas, Leung Pak, Hong-Gonzalez Jenny, Freedland Stephen J, Said Jonathan, Gui Dorina, Seeram Navindra P, Popoviciu Laura M, Bagga Dilprit, Heber David, Glaspy John A, Aronson William J Effect of altering dietary omega-6/omega-3 fatty acid ratios on prostate cancer membrane composition, cyclooxygenase-2, and prostaglandin E2. Clinical cancer research : an official journal of the American Association for Cancer Research. 2006; 12(15): 4662-70.
Oh Seung-Hyun, Kim Woo-Young, Kim Jai-Hyun, Younes Maher N, El-Naggar Adel K, Myers Jeffrey N, Kies Merril, Cohen Pinchas, Khuri Fadlo, Hong Waun K, Lee Ho-Young Identification of insulin-like growth factor binding protein-3 as a farnesyl transferase inhibitor SCH66336-induced negative regulator of angiogenesis in head and neck squamous cell carcinoma. Clinical cancer research : an official journal of the American Association for Cancer Research. 2006; 12(2): 653-61.
Benini Stefania, Zuntini Monia, Manara Maria Cristina, Cohen Pinchas, Nicoletti Giordano, Nanni Patrizia, Oh Youngman, Picci Piero, Scotlandi Katia Insulin-like growth factor binding protein 3 as an anticancer molecule in Ewing's sarcoma. International journal of cancer. Journal international du cancer. 2006; 119(5): 1039-46.
Cohen Pinchas Insulin-like growth factor binding protein-3: insulin-like growth factor independence comes of age. Endocrinology. 2006; 147(5): 2109-11.
Cohen Pinchas Overview of the IGF-I system. Hormone research. 2006; 65 Suppl 1(2): 3-8.
Cobb Laura J, Liu Bingrong, Lee Kuk-Wha, Cohen Pinchas Phosphorylation by DNA-dependent protein kinase is critical for apoptosis induction by insulin-like growth factor binding protein-3. Cancer research. 2006; 66(22): 10878-84.
Oufattole Mohammed, Lin Sally Wan-Jung, Liu Bingrong, Mascarenhas Desmond, Cohen Pinchas, Rodgers Buel D Ribonucleic acid polymerase II binding subunit 3 (Rpb3), a potential nuclear target of insulin-like growth factor binding protein-3. Endocrinology. 2006; 147(5): 2138-46.
Yakar Shoshana, Bouxsein Mary L, Canalis Ernesto, Sun Hui, Glatt Vaida, Gundberg Caren, Cohen Pinchas, Hwang David, Boisclair Yves, Leroith Derek, Rosen Clifford J The ternary IGF complex influences postnatal bone acquisition and the skeletal response to intermittent parathyroid hormone. The Journal of endocrinology. 2006; 189(2): 289-99.
Rosen Clifford J, Ackert-Bicknell Cheryl, Beamer Wesley G, Nelson Tracy, Adamo Martin, Cohen Pinchas, Bouxsein Mary L, Horowitz Mark C Allelic differences in a quantitative trait locus affecting insulin-like growth factor-I impact skeletal acquisition and body composition. Pediatric nephrology (Berlin, Germany). 2005; 20(3): 255-60.
Liu Bingrong, Lee Kuk-Wha, Li Heju, Ma Liqun, Lin George L, Chandraratna Roshantha A S, Cohen Pinchas Combination therapy of insulin-like growth factor binding protein-3 and retinoid X receptor ligands synergize on prostate cancer cell apoptosis in vitro and in vivo. Clinical cancer research : an official journal of the American Association for Cancer Research. 2005; 11(13): 4851-6.
Yang Joshua, Anzo Makoto, Cohen Pinchas Control of aging and longevity by IGF-I signaling. Experimental gerontology. 2005; 40(11): 867-72.
Park Patricia, Cohen Pinchas Insulin-like growth factor I (IGF-I) measurements in growth hormone (GH) therapy of idiopathic short stature (ISS). Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society. 2005; 15 Suppl A(13): S13-20.
Ferry Robert J, Cohen Pinchas, Levitt Katz Lorraine E Pharmacodynamic considerations with recombinant human insulin-like growth factor-I in children. Hormone research. 2005; 63(5): 220-7.
Freedland Stephen J, Aronson William J, Trock Bruce, Cohen Pinchas, Kane Christopher J, Amling Christopher L, Presti Joseph C, Terris Martha K, Terris Martha K Racial differences in prognostic value of adult height for biochemical progression following radical prostatectomy. Clinical cancer research : an official journal of the American Association for Cancer Research. 2005; 11(21): 7735-42.
Lee Kuk-Wha, Ma Liqun, Yan Xinmin, Liu Bingrong, Zhang Xiao-kun, Cohen Pinchas Rapid apoptosis induction by IGFBP-3 involves an insulin-like growth factor-independent nucleomitochondrial translocation of RXRalpha/Nur77. The Journal of biological chemistry. 2005; 280(17): 16942-8.
Randhawa Ruvdeep, Cohen Pinchas The role of the insulin-like growth factor system in prenatal growth. Molecular genetics and metabolism. 2005; 86(1-2): 84-90.
Grimberg Adda, Coleman Carrie M, Burns Timothy F, Himelstein Bruce P, Koch Cameron J, Cohen Pinchas, El-Deiry Wafik S p53-Dependent and p53-independent induction of insulin-like growth factor binding protein-3 by deoxyribonucleic acid damage and hypoxia. The Journal of clinical endocrinology and metabolism. 2005; 90(6): 3568-74.
Mikheev Andrei M, Mikheeva Svetlana A, Liu Binrong, Cohen Pinchas, Zarbl Helmut A functional genomics approach for the identification of putative tumor suppressor genes: Dickkopf-1 as suppressor of HeLa cell transformation. Carcinogenesis. 2004; 25(1): 47-59.
Lee Kuk-Wha, Liu Bingrong, Ma Liqun, Li Heju, Bang Peter, Koeffler H Phillip, Cohen Pinchas Cellular internalization of insulin-like growth factor binding protein-3: distinct endocytic pathways facilitate re-uptake and nuclear localization. The Journal of biological chemistry. 2004; 279(1): 469-76.
Prieur Alexandre, Tirode Franck, Cohen Pinchas, Delattre Olivier EWS/FLI-1 silencing and gene profiling of Ewing cells reveal downstream oncogenic pathways and a crucial role for repression of insulin-like growth factor binding protein 3. Molecular and cellular biology. 2004; 24(16): 7275-83.
Ikezoe Takayuki, Tanosaki Sakae, Krug Utz, Liu Bingrong, Cohen Pinchas, Taguchi Hirokuni, Koeffler H Phillip Insulin-like growth factor binding protein-3 antagonizes the effects of retinoids in myeloid leukemia cells. Blood. 2004; 104(1): 237-42.
Shim Melanie L, Levitt Katz Lorraine E, Davis Jason, Dotzler Whittney C, Cohen Pinchas, Ferry Robert J Insulin-like growth factor binding protein-3 is a novel mediator of apoptosis in insulin-secreting cells. Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society. 2004; 14(3): 216-25.
Shim Melanie L, Moshang Thomas, Oppenheim William L, Cohen Pinchas Is treatment with growth hormone effective in children with cerebral palsy?. Developmental medicine and child neurology. 2004; 46(8): 569-71.
Licinio Julio, Caglayan Sinan, Ozata Metin, Yildiz Bulent O, de Miranda Patricia B, O'Kirwan Fiona, Whitby Robert, Liang Liyin, Cohen Pinchas, Bhasin Shalender, Krauss Ronald M, Veldhuis Johannes D, Wagner Anthony J, DePaoli Alex M, McCann Samuel M, Wong Ma-Li Phenotypic effects of leptin replacement on morbid obesity, diabetes mellitus, hypogonadism, and behavior in leptin-deficient adults. Proceedings of the National Academy of Sciences of the United States of America. 2004; 101(13): 4531-6.
Park Patricia, Cohen Pinchas The role of insulin-like growth factor I monitoring in growth hormone-treated children. Hormone research. 2004; 62 Suppl 1(1): 59-65.
Ngo Tung H, Barnard R James, Cohen Pinchas, Freedland Stephen, Tran Chris, deGregorio Frank, Elshimali Yahya I, Heber David, Aronson William J Effect of isocaloric low-fat diet on human LAPC-4 prostate cancer xenografts in severe combined immunodeficient mice and the insulin-like growth factor axis. Clinical cancer research : an official journal of the American Association for Cancer Research. 2003; 9(7): 2734-43.
Lee Kuk-Wha, Cohen Pinchas Individualized growth hormone therapy in children: advances beyond weight-based dosing. Journal of pediatric endocrinology & metabolism : JPEM. 2003; 16 Suppl 3(1): 625-30.
Ngo Tung H, Barnard R James, Leung Pak-Shan, Cohen Pinchas, Aronson William J Insulin-like growth factor I (IGF-I) and IGF binding protein-1 modulate prostate cancer cell growth and apoptosis: possible mediators for the effects of diet and exercise on cancer cell survival. Endocrinology. 2003; 144(6): 2319-24.
Wetterau Lawrence A, Francis Malik J, Ma Liqun, Cohen Pinchas Insulin-like growth factor I stimulates telomerase activity in prostate cancer cells. The Journal of clinical endocrinology and metabolism. 2003; 88(7): 3354-9.
Ali Omar, Cohen Pinchas Insulin-like growth factors and their binding proteins in children born small for gestational age: implication for growth hormone therapy. Hormone research. 2003; 60 Suppl 3(2): 115-23.
Ikonen Maaria, Liu Bingrong, Hashimoto Yuichi, Ma Liqun, Lee Kuk-Wha, Niikura Takako, Nishimoto Ikuo, Cohen Pinchas Interaction between the Alzheimer's survival peptide humanin and insulin-like growth factor-binding protein 3 regulates cell survival and apoptosis. Proceedings of the National Academy of Sciences of the United States of America. 2003; 100(22): 13042-7.
Moore Michael G, Wetterau Lawrence A, Francis Malik J, Peehl Donna M, Cohen Pinchas Novel stimulatory role for insulin-like growth factor binding protein-2 in prostate cancer cells. International journal of cancer. Journal international du cancer. 2003; 105(1): 14-9.
Franklin Sherry Lynn, Ferry Robert J, Cohen Pinchas Rapid insulin-like growth factor (IGF)-independent effects of IGF binding protein-3 on endothelial cell survival. The Journal of clinical endocrinology and metabolism. 2003; 88(2): 900-7.
Liu Bingrong, Weinzimer Stuart A, Gibson Tara Beers, Mascarenhas Desmond, Cohen Pinchas Type Ialpha collagen is an IGFBP-3 binding protein. Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society. 2003; 13(2-3): 89-97.
Wilson Thomas A, Rose Susan R, Cohen Pinchas, Rogol Alan D, Backeljauw Philippe, Brown Rosalind, Hardin Dana S, Kemp Stephen F, Lawson Margaret, Radovick Sally, Rosenthal Stephen M, Silverman Lawrence, Speiser Phyllis, Speiser Phyllis Update of guidelines for the use of growth hormone in children: the Lawson Wilkins Pediatric Endocrinology Society Drug and Therapeutics Committee. The Journal of pediatrics. 2003; 143(4): 415-21.
Ngo Tung H, Barnard R James, Tymchuk Christopher N, Cohen Pinchas, Aronson William J Effect of diet and exercise on serum insulin, IGF-I, and IGFBP-1 levels and growth of LNCaP cells in vitro (United States). Cancer causes & control : CCC. 2002; 13(10): 929-35.
Cohen Pinchas, Bright George M, Rogol Alan D, Kappelgaard Anne-Marie, Rosenfeld Ron G, Rosenfeld Ron G Effects of dose and gender on the growth and growth factor response to GH in GH-deficient children: implications for efficacy and safety. The Journal of clinical endocrinology and metabolism. 2002; 87(1): 90-8.
Monzavi Roshanak, Cohen Pinchas IGFs and IGFBPs: role in health and disease. Best practice & research. Clinical endocrinology & metabolism. 2002; 16(3): 433-47.